Effects of oxidation on structural stability and remodeling of human very low density lipoprotein

Biochemistry

Volumn 49, Issue 44, 2010, Pages 9584-9593

  Guha, Madhumita ^a   Gursky, Olga ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED OXIDATION; APOLIPOPROTEINS; CIRCULAR DICHROISM; GEL ELECTROPHORESIS; HIGH-DENSITY LIPOPROTEINS; IN-VIVO; KEY ENZYMES; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEINS; MILD OXIDATION; PARTICLE SURFACE; PROTEIN COMPOSITION; PROTEIN CROSSLINKING; RISK FACTORS; STRUCTURAL STABILITIES; VERY LOW DENSITY LIPOPROTEINS;

DICHROISM; ELECTROPHORESIS; LIPIDS; METABOLISM; PROTEINS; PROTEOLYSIS; STABILITY; TURBIDITY;

OXIDATION;

APOLIPOPROTEIN E; COPPER; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN LIPASE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; ATHEROSCLEROSIS; CIRCULAR DICHROISM; ELECTRON MICROSCOPY; HUMAN; HYDROLYSIS; IN VIVO STUDY; LIPID METABOLISM; LIPID OXIDATION; PRIORITY JOURNAL; PROTEIN STABILITY; PROTEIN STRUCTURE; RISK FACTOR; TURBIDITY;

HUMANS; LIPOPROTEINS, VLDL; OXIDATION-REDUCTION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY;

EID: 78149335655     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101391z     Document Type: Article

References (60)

1. Adiels, M., Olofsson, S. O., Taskinen, M. R., and Borén, J. (2008) Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome Arterioscler., Thromb., Vasc. Biol. 28 (7) 1225-1236
2. Therond, P. (2009) Catabolism of lipoproteins and metabolic syndrome Curr. Opin. Clin. Nutr. Metab. Care 12 (4) 366-371
3. Roberts, C. K. and Sindhu, K. K. (2009) Oxidative stress and metabolic syndrome Life Sci. 84 (21) 705-712
4. Havel, R. J. (2010) Triglyceride-rich lipoproteins and plasma lipid transport Arterioscler., Thromb., Vasc. Biol. 30 (1) 9-19
5. Cannon, C. P. (2008) Mixed dyslipidemia, metabolic syndrome, diabetes mellitus, and cardiovascular disease: clinical implications Am. J. Cardiol. 102 (12A) 5L-9L
6. Ginsberg, H. N. and MacCallum, P. R. (2009) The obesity, metabolic syndrome, and type 2 diabetes mellitus pandemic: Part I. Increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and type 2 diabetes mellitus J. Cardiometab. Syndr. 4 (2) 113-119
7. Krauss, R. M. (1998) Atherogenicity of triglyceride-rich lipoproteins Am. J. Cardiol. 81 (4A) 13B-17B
8. Skalen, K., Gustafsson, M., Rydberg, E. K., Hulten, L. M., Wiklund, O., Innerarity, T. L., and Boren, J. (2002) Sub-endothelial retention of atherogenic lipoproteins in early atherosclerosis Nature 417, 750-754
9. Olofsson, S. O. and Boren, J. (2005) Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis J. Intern. Med. 258 (5) 395-410
10. Kannel, W. B. and Vasan, R. S. (2009) Triglycerides as vascular risk factors: new epidemiologic insights Curr. Opin. Cardiol. 24, 345-350
11. Dallinga-Thie, G. M., Franssen, R., Mooij, H. L., Visser, M. E., Hassing, H. C., Peelman, F., Kastelein, J. J., Péterfy, M., and Nieuwdorp, M. (2010) The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight Atherosclerosis 211 (1) 1-8
12. Farmer, J. A. and Gotto, A. M., Jr. (1995) Currently available hypolipidaemic drugs and future therapeutic developments Baillieres Clin. Endocrinol. Metab. 9 (4) 825-847
13. Nesto, R. W. (2005) Beyond low-density lipoprotein: addressing the atherogenic lipid triad in type 2 diabetes mellitus and the metabolic syndrome Am. J. Cardiovasc. Drugs 5 (6) 379-387
14. Davidson, M. H. (2006) Mechanisms for the hypotriglyceridemic effect of marine omega-3 fatty acids Am. J. Cardiol. 98 (4A) 27i-33i
15. Segrest, J. P., Jones, M. K., De Loof., H., and Dashti, N. (2001) Structure of apolipoprotein B-100 in low density lipoproteins J. Lipid Res. 42 (9) 1346-1367
16. Merkel, M., Eckel, R. H., and Goldberg, I. J. (2002) Lipoprotein lipase: genetics, lipid uptake, and regulation J. Lipid Res. 43 (12) 1997-2006
17. Otarod, J. K. and Goldberg, I. J. (2004) Lipoprotein lipase and its role in regulation of plasma lipoproteins and cardiac risk Curr. Atheroscler. Rep. 6 (5) 335-342
18. Wang, H. and Eckel, R. H. (2009) Lipoprotein lipase: from gene to obesity Am. J. Physiol. Endocrinol. Metab. 297 (2) E271-E288
19. Kolovou, G. D., Kostakou, P. M., Anagnostopoulou, K. K., and Cokkinos, D. V. (2008) Therapeutic effects of fibrates in postprandial lipemia Am. J. Cardiovasc. Drugs 8 (4) 243-255
20. Breckenridge, W. C. (1985) The catabolism of very low density lipoproteins Can. J. Biochem. Cell Biol. 63 (8) 890-897
21. Musliner, T. A., Long, M. D., Forte, T. M., Nichols, A. V., Gong, E. L., Blanche, P. J., and Krauss, R. M. (1991) Dissociation of high density lipoprotein precursors from apolipoprotein B-containing lipoproteins in the presence of unesterified fatty acids and a source of apolipoprotein A-I J. Lipid Res. 32 (6) 917-933
22. Krimbou, L., Marcil, M., Chiba, H., and Genest, J., Jr. (2003) Structural and functional properties of human plasma high density-sized lipoprotein containing only apoE particles J. Lipid Res. 44 (5) 884-892
23. Williams, K. J. and Fisher, E. A. (2005) Oxidation, lipoproteins, and atherosclerosis: which is wrong, the antioxidants or the theory? Curr. Opin. Clin. Nutr. Metab. Care 8 (2) 139-146
24. Steinberg, D (1997) Low density lipoprotein oxidation and its pathobiological significance J. Biol. Chem. 272, 20963-20966
25. Schaefer, E. J. (2002) Lipoproteins, nutrition, and heart disease Am. J. Clin. Nutr. 75, 191-212
26. Mohr, D. and Stocker, R. (1994) Radical-mediated oxidation of isolated human very-low-density lipoprotein Arterioscler. Thromb. 14 (7) 1186-1192
27. Whitman, S. C., Sawyez, C. G., Miller, D. B., Wolfe, B. M., and Huff, M. W. (1998) Oxidized type IV hypertriglyceridemic VLDL-remnants cause greater macrophage cholesteryl ester accumulation than oxidized LDL J. Lipid Res. 39 (5) 1008-1020
28. Whitman, S. C., Hazen, S. L., Miller, D. B., Hegele, R. A., Heinecke, J. W., and Huff, M. W. (1999) Modification of type III VLDL, their remnants, and VLDL from apoE-knockout mice by p-hydroxyphenylacetaldehyde, a product of myeloperoxidase activity, causes marked cholesteryl ester accumulation in macrophages Arterioscler., Thromb., Vasc. Biol. 19 (5) 1238-1249
29. Matsuura, E., Hughes, G. R., and Khamashta, M. A. (2008) Oxidation of LDL and its clinical implication Autoimmun. Rev. 7, 558-566
30. Bonomini, F., Tengattini, S., Fabiano, A., Bianchi, R., and Rezzani, R. (2008) Atherosclerosis and oxidative stress Histol. Histopathol. 23, 381-390
31. Kaneto, H., Katakami, N., Kawamori, D., Miyatsuka, T., Sakamoto, K., Matsuoka, T. A., Matsuhisa, M., and Yamasaki, Y. (2007) Involvement of oxidative stress in the pathogenesis of diabetes Antioxid. Redox Signal. 9, 355-366
32. Heinecke, J. W. (2001) Is the emperor wearing clothes? Clinical trials of vitamin E and the LDL oxidation hypothesis Arterioscler., Thromb., Vasc. Biol. 21 (8) 1261-1264
33. Parthasarathy, S., Raghavamenon, A., Garelnabi, M. O., and Santanam, N. (2010) Oxidized low-density lipoprotein Methods Mol. Biol. 610, 403-417
34. Plaisance, E. P., Grandjean, P. W., and Mahurin, A. J. (2009) Independent and combined effects of aerobic exercise and pharmacological strategies on serum triglyceride concentrations: a qualitative review Phys. Sportsmed. 37 (1) 11-19
35. Mehta, R., Gantz, D. L., and Gursky, O. (2003) Human plasma high-density lipoproteins are stabilized by kinetic factors J. Mol. Biol. 328 (1) 183-192
36. Jayaraman, S., Gantz, D. L., and Gursky, O. (2005) Structural basis for thermal stability of human low-density lipoprotein Biochemistry 44 (10) 3965-3971
37. Guha, M., England, C. O., Herscovitz, H., and Gursky, O. (2007) Thermal transitions in human very low-density lipoprotein: fusion, rupture and dissociation of HDL-like particles Biochemistry 46 (20) 6043-6049
38. Chung, B. H., Tallis, G., Yalamoori, V., Anantharamaiah, G. M., and Segrest, J. P. (1994) Liposome-like particles isolated from human atherosclerotic plaques are structurally and compositionally similar to surface remnants of triglyceride-rich lipoproteins Arterioscler. Thromb. 14 (4) 622-635
39. Arai, H., Kashivagi, S., Nagasaka, Y., Uchida, K., Hoshii, Y., and Nakamura, K. (1999) Oxidative modification of apolipoprotein E in human very low-density lipoprotein and its inhibition by glycosaminoglycans Arch. Biochem. Biophys. 367, 1-8 (Pubitemid 29394186)
40. Esterbauer, H., Striegl, G., Puhl, H., and Rotheneder, M. (1989) Continuous monitoring of in vitro oxidation of human low density lipoprotein Free Radical Res. Commun. 6 (1) 67-75
41. Burkitt, M. J. (2001) A critical overview of the chemistry of copper-dependent low density lipoprotein oxidation: roles of lipid hydroperoxides, alpha-tocopherol, thiols, and ceruloplasmin Arch. Biochem. Biophys. 394 (1) 117-135
42. Malle, E., Marsche, G., Arnhold, J., and Davies, M. J. (2006) Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid Biochim. Biophys. Acta 1761 (4) 392-415
43. Schumaker, V. N. and Puppione, D. L. (1986) Sequential flotation ultracentrifugation Methods Enzymol. 128, 155-170
44. Gao, X., Jayaraman, S., and Gursky, O. (2008) Mild oxidation promotes and advanced oxidation prevents protein dissociation and remodeling of human plasma high-density lipoprotein in vitro J. Mol. Biol. 376 (4) 997-1007
45. Jayaraman, S., Gantz, D. L., and Gursky, O. (2007) Effects of oxidation on the structure and stability of human low-density lipoprotein Biochemistry 46 (19) 5790-5797
46. Whitman, S. C., Miller, D. B., Wolfe, B. M., Hegele, R. A., and Huff, M. W. (1997) Uptake of type III hypertriglyceridemic VLDL by macrophages is enhanced by oxidation, especially after remnant formation Arterioscler., Thromb., Vasc. Biol. 17 (9) 1707-1715
47. Benjwal, S., Verma, S., Röhm, K. H., and Gursky, O. (2006) Monitoring protein aggregation during thermal unfolding in circular dichroism experiments Protein Sci. 15, 635-639
48. Parasassi, T., Bittolo-Bon, G., Brunelli, R., Cazzolato, G., Krasnowska, E. K., Mei, G., Sevanian, A., and Ursini, F. (2001)) Loss of apoB-100 secondary structure and conformation in hydroperoxide rich, electronegative LDL(-) Free Radical Biol. Med. 31 (1) 82-89
49. Zhang, L., Song, J., Newhouse, Y., Zhang, S., Weisgraber, K. H., and Ren, G. (2010) An optimized negative-staining protocol of electron microscopy for apoE4 POPC lipoprotein J. Lipid Res. 51 (5) 1228-1236
50. Jolivalt, C., Leininger-Muller, B., Drozdz, R., Naskalski, J. W., and Siest, G. (1996) Apolipoprotein E is highly susceptible to oxidation by myeloperoxidase, an enzyme present in the brain Neurosci. Lett. 210 (1) 61-64
51. Jayaraman, S., Gantz, D. L., and Gursky, O. (2008) Effects of protein oxidation on the structure and stability of model discoidal high-density lipoproteins Biochemistry 47 (12) 3875-3882
52. Anantharamaiah, G. M., Hughes, T. A., Iqbal, M., Gawish, A., Neame, P. J., Medley, M. F., and Segrest, J. P. (1988) Effect of oxidation on the properties of apolipoproteins A-I and A-II J. Lipid Res. 29, 309-318
53. Jayaraman, S., Gantz, D. L., and Gursky, O. (2005) Kinetic stabilization and fusion of discoidal lipoproteins containing human apoA-2 and DMPC: Comparison with apoA-1 and C-1 Biophys. J. 88 (4) 2907-2918
54. 2 induces particle fusion and enhances the retention of LDL to human aortic proteoglycans Arterioscler., Thromb., Vasc. Biol. 21, 1053-1058
55. Kozlovsky, Y. and Kozlov, M. M. (2003) Membrane fission: model for intermediate structures Biophys. J. 85 (1) 85-96
56. Han, H.-S. and Kim, H. (1994) Spontaneous fragmentation of dimyristoylphosphatidylcholine vesicles into a discoidal form at low pH J. Biochem. 115 (1) 26-31
57. Haque, M. E. and Lentz, B. R. (2004) Roles of curvature and hydrophobic interstice energy in fusion: studies of lipid perturbant effects Biochemistry 43 (12) 3507-3517
58. Burack, W. R. and Biltonen, R. L. (1994) Lipid bilayer heterogeneities and modulation of phospholipase A2 activity Chem. Phys. Lipids 73 (1-2) 209-222
59. Ray, S., Scott, J. L., and Tatulian, S. A. (2007) Effects of lipid phase transition and membrane surface charge on the interfacial activation of phospholipase A2 Biochemistry 46 (45) 13089-13100
60. Guha, M., Gao, X., Jayaraman, S., and Gursky, O. (2008) Structural stability and functional remodeling of high-density lipoproteins: The importance of being disordered Biochemistry 47 (44) 11393-11397