Leiomyoma and Vascular Endothelial Growth Factor Gene Polymorphisms: A Systematic Review

Taiwanese Journal of Obstetrics and Gynecology

Volumn 49, Issue 3, 2010, Pages 247-253

  Chang, Chi Chen ^a,c   Hsieh, Yao Yuan ^b,c   Lin, Wen Hsin ^d   Lin, Chih Sheng ^a  

^a NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^b School of Chinese Medicine   (Taiwan)

^c Hsieh Yao Yuan Womens' Hospital   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Leiomyoma; Polymorphism; Vascular endothelial growth factor

Indexed keywords

ANGIOGENIC FACTOR; VASCULOTROPIN;

ANGIOGENESIS; CELL DIFFERENTIATION; CELL GROWTH; DISEASE ASSOCIATION; DNA POLYMORPHISM; FEMALE; GENETIC VARIABILITY; HUMAN; LEIOMYOMA; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SYSTEMATIC REVIEW; TUMOR GROWTH;

FEMALE; HUMANS; LEIOMYOMA; LEIOMYOMATOSIS; POLYMORPHISM, GENETIC; UTERINE NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 78149315837     PISSN: 10284559     EISSN: 10284559     Source Type: Journal    
DOI: 10.1016/S1028-4559(10)60056-3     Document Type: Review

References (97)

1. Miura S, Khan KN, Kitajima M, et al. Differential infiltration of macrophages and prostaglandin production by different uterine leiomyomas. Hum Reprod 2006, 21:2545-2554.
2. El-Badry OM, Helman LJ, Chatten J, Steinberg SM, Evans AE, Israel MA Insulin-like growth factor II-mediated proliferation of human neuroblastoma. J Clin Invest 1991, 87:648-657.
3. Kim MR, Park DW, Lee JH, Choi DS, Hwang KJ, Ryu HS, Min CK Progesterone-dependent release of transforming growth factor-beta1 from epithelial cells enhances the endometrial decidualization by turning on the Smad signalling in stromal cells. Mol Hum Reprod 2005, 11:801-808.
4. Jacob F, Ries F, Dicato M Genomic imprinting and its relevance for oncology. Biomed Pharmacother 1993, 47:127-129.
5. Di Lieto A, De Falco M, Pollio F, et al. Clinical response, vascular change, and angiogenesis in gonadotropin-releasing hormone analogue-treated women with uterine myomas. J Soc Gynecol Investig 2005, 12:123-128.
6. Strawn EY, Novy MJ, Burry KA, Bethea CL Insulin-like growth factor I promotes leiomyoma cell growth in vitro. Am J Obstet Gynecol 1995, 172:1837-1844.
7. Vu TH, Yballe C, Boonyanit S, Hoffman AR Insulin-like growth factor II in uterine smooth-muscle tumors: maintenance of genomic imprinting in leiomyomata and loss of imprinting in leiomyosarcomata. J Clin Endocrinol Metab 1995, 80:1670-1676.
8. Sharara FI, Nieman LK Growth hormone receptor messenger ribonucleic acid expression in leiomyoma and surrounding myometrium. Am J Obstet Gynecol 1995, 173:814-819.
9. Ghahary A, Murphy LJ Uterine insulin-like growth factor-I receptors: regulation by estrogen and variation throughout the estrous cycle. Endocrinology 1989, 125:597-604.
10. Magri KA, Benedict MR, Ewton DZ, Florini JR Negative feedback regulation of insulin-like growth factor-II gene expression in differentiating myoblasts in vitro. Endocrinology 1994, 135:53-62.
11. Friedman AJ, Rein MS, Pandian MR, Barbieri RL Fasting serum growth hormone and insulin-like growth factor-I and -II concentrations in women with leiomyomata uteri treated with leuprolide acetate or placebo. Fertil Steril 1990, 53:250-253.
12. Tommola P, Pekonen F, Rutanen EM Binding of epidermal growth factor and insulin-like growth factor I in human myo-metrium and leiomyomata. Obstet Gynecol 1989, 74:658-662.
13. Bourlev V, Volkov N, Pavlovitch S, Lets N, Larsson A, Olovsson M The relationship between microvessel density, proliferative activity and expression of vascular endothelial growth factor-A and its receptors in eutopic endometrium and endometriotic lesions. Reproduction 2006, 132:501-509.
14. Hyder SM, Huang JC, Nawaz Z, Boettger-Tong H, Makela S, Chiappetta C, Stancel GM Regulation of vascular endothelial growth factor expression by estrogens and progestins. Environ Health Perspect 2000, 108:785-790.
15. Fernando NT, Koch M, Rothrock C, Gollogly LK, D'Amore PA, Ryeom S, Yoon SS Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors. Clin Cancer Res 2008, 14:1529-1539.
16. Kranz A, Mattfeldt T, Waltenberger J Molecular mediators of tumor angiogenesis: enhanced expression and activation of vascular endothelial growth factor receptor KDR in primary breast cancer. Int J Cancer 1999, 84:293-298.
17. Kumar-Singh S, Weyler J, Martin MJ, Vermeulen PB, Van Marck E Angiogenic cytokines in mesothelioma: a study of VEGF, FGF-1 and -2, and TGF beta expression. J Pathol 1999, 189:72-78.
18. Fragoso R, Pereira T, Wu Y, Zhu Z, Cabeçadas J, Dias S VEGFR-1 (FLT-1) activation modulates acute lymphoblastic leukemia localization and survival within the bone marrow, determining the onset of extramedullary disease. Blood 2006, 107:1608-1616.
19. Joseph IB, Nelson JB, Denmeade SR, Isaacs JT Androgens regulate vascular endothelial growth factor content in normal and malignant prostatic tissue. Clin Cancer Res 1997, 3:2507-2511.
20. Larcher F, Robles AI, Duran H, et al. Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels. Cancer Res 1996, 56:5391-5396.
21. Salven P, Ruotsalainen T, Mattson K, Joensuu H High pre-treatment serum level of vascular endothelial growth factor (VEGF) is associated with poor outcome in small-cell lung cancer. Int J Cancer 1998, 79:144-146.
22. Stewart M, Turley H, Cook N, et al. The angiogenic receptor KDR is widely distributed in human tissues and tumours and relocates intracellularly on phosphorylation. An immuno-histochemical study. Histopathology 2003, 43:33-39.
23. Mueller MD, Vigne JL, Minchenko A, Lebovic DI, Leitman DC, Taylor RN Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors alpha and beta. Proc Natl Acad Sci USA 2000, 97:10972-10977.
24. Adams J, Carder PJ, Downey S, et al. Vascular endothelial growth factor (VEGF) in breast cancer: comparison of plasma, serum, and tissue VEGF and microvessel density and effects of tamoxifen. Cancer Res 2000, 60:2898-2905.
25. Papapetropoulos A, García-Cardeña G, Madri JA, et al. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest 1997, 100:3131-3139.
26. Uchida S, Shimada Y, Watanabe G, et al. In oesophageal squamous cell carcinoma vascular endothelial growth factor is associated with p53 mutation, advanced stage and poor prognosis. Br J Cancer 1998, 77:1704-1709.
27. Charnock-Jones S, Sharkey AS, Rajput-Williams J, et al. Identification and localization of alternately spliced mRNAs for vascular endothelial growth factor in human uterus and estrogen regulation in endometrial carcinoma cell lines. Biol Reprod 1993, 48:1120-1128.
28. Houck KA, Ferrara N, Winer J, Cachianes G, Leung DW The vascular endothelial growth factor family. Identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 1991, 5:1806-1814.
29. Gordon JD, Messiano S, Zaloudek CJ, Jaffe RB Vascular endothelial growth factor localization in human ovary and fallopian tubes: possible role in reproductive function and ovarian cyst formation. J Clin Endocrinol Metabol 1996, 81:353-359.
30. Shweiki D, Itin A, Neufeld G, Gitay-Goren H, Keshet E Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggests a role in hor-monally regulated angiogenesis. J Clin Invest 1993, 91:2235-2243.
31. Jakeman LB, Armanini M, Phillips HS, Ferrara N Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis. Endocrinology 1993, 133:848-859.
32. Kashida S, Sugino N, Takiguchi S, et al. Regulation and role of vascular endothelial growth factor in the corpus luteum during mid-pregnancy in rats. Biol Reprod 2001, 64:317-323.
33. Machado DE, Abrao MS, Berardo PT, Takiya CM, Nasciutti LE Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum. Fertil Steril 2007, 90:148-155.
34. Robinson CJ, Stringer SE The splice variants of vascular endothelial growth factor (VEGF) and their receptors. J Cell Sci 2001, 114:853-865.
35. Gentry CC, Okolo SO, Fong LF, Crow JC, Maclean AB, Perrett CW Quantification of vascular endothelial growth factor-A in leiomyomas and adjacent myometrium. Clin Sci (Lond) 2001, 101:691-695.
36. Renner W, Kotschan S, Hoffmann C, Obermayer-Pietsch B, Pilger E A common 936 C/T mutation in the gene for vascular endothelial growth factor is associated with vascular endothelial growth factor plasma levels. J Vasc Res 2000, 37:443-448.
37. Kang MA, Kim KY, Seol JY, Kim KC, Nam MJ The growth inhibition of hepatoma by gene transfer of antisense vascular endothelial growth factor. J Gene Med 2000, 2:289-296.
38. Meiron M, Anunu R, Scheinman EJ, Hashmueli S, Levi BZ New isoforms of VEGF are translated from alternative initiation CUG codons located in its 5'UTR. Biochem Biophys Res Commun 2001, 282:1053-1060.
39. Wang H, Keiser JA Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: role of flt-1. Circ Res 1998, 83:832-840.
40. Hood JD, Meininger CJ, Ziche M, et al. VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells. Am J Physiol 1998, 274:H1054-H1058.
41. Ferrara N Molecular and biological properties of vascular endothelial growth factor. J Mol Med 1999, 77:527-543.
42. Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999, 13:9-22.
43. Watson CJ, Webb NJA, Bottomley MJ, Brenchley PEC Peripheral mononuclear cells express VEGF and the VEGF receptor flt-1. J Am Soc Nephrol 1996, 7:A2390.
44. Claffey KP, Robinson GS Regulation of VEGF/VPF expression in tumor cells: consequences for tumor growth and metastasis. Cancer Metastasis Rev 1996, 15:165-176.
45. Koch AE, Harlow LA, Haines GK, Amento EP, Unemori EN, Wong WL, Pope RM, Ferrara N Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis. J Immunol 1994, 152:4149-4156.
46. Miller JW, Adamis AP, Aiello LP Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy. Diabetes Metab Rev 1997, 13:37-50.
47. Schultz A, Lavie L, Hochberg I, et al. Interindividual heterogeneity in the hypoxic regulation of VEGF: significance for the development of the coronary artery collateral circulation. Circulation 1999, 100:547-552.
48. Hsieh YY, Chang CC, Tsai FJ, Wu JY, Tsai CC, Tsai HD Androgen receptor trinucleotide polymorphism in endo-metriosis. Fertil Steril 2001, 76:412-413.
49. Hsieh YY, Tsai FJ, Chang CC, Chen WC, Tsai CH, Tsai HD, Lin CC p21 gene codon 31 arginine/serine polymorphism: Non-association with endometriosis. J Clin Lab Anal 2001, 15:184-187.
50. Chang CC, Hsieh YY, Tsai FJ, Hsu Y, Shi YR, Tsai HD, Tsai CH Polymorphisms for interleukin-4 (IL-4) -590 promoter, IL-4 intron3 and tumour necrosis factor alpha-308 promoter: non-association with endometriosis. J Clin Lab Anal 2002, 16:121-126.
51. Chang CC, Hsieh YY, Tsai FJ, Tsai CH, Tsai HD, Lin CC Proline form of p53 codon 72 polymorphism: associated with endometriosis. Fertil Steril 2002, 77:43-45.
52. Wei MH, Popescu NC, Lerman MI, Merrill MJ, Zimonjic DB Localization of the human vascular endothelial growth factor gene, VEGF, at chromosome 6p12. Hum Genet 1996, 97:794-797.
53. Amant F, Dorfling CM, de Brabanter J, Vandewalle J, Vergote I, Lindeque BG, van Rensburg EJ A possible role of the cytochrome P450c17alpha gene (CYP17) polymorphism in the pathobiology of uterine leiomyomas from black South African women: a pilot study. Acta Obstet Gynecol Scand 2004, 83:234-239.
54. Hsieh YY, Chang CC, Tsai FJ, Tsai HD, Yeh LS, Lin CC, Tsai CH Estrogen receptor thymine-adenine dinucleotide repeat polymorphism is associated with susceptibility to leiomyoma. Fertil Steril 2003, 79:96-99.
55. Hashimoto K, Azuma C, Kamiura S, et al. Maintenance of imprinting of the insulin-like growth factor II gene (IGF2) and the small nuclear ribonucleoprotein polypeptide N gene (SNRPN) in the human uterus and leiomyoma. Gynecol Obstet Invest 1996, 41:50-54.
56. Harrison-Woolrych ML, Sharkey AM, Charnock-Jones DS, Smith SK Localization and quantification of vascular endothelial growth factor messenger ribonucleic acid in human myometrium and leiomyomata. J Clin Endocrinol Metab 1995, 80:1853-1858.
57. Hsieh YY, Chang CC, Tsai FJ, Lin CC, Tsai CH T allele for VEGF-460 gene polymorphism at 5'-untranslated region is associated with higher susceptibility of leiomyoma. Biochem Genet 2008, 46:356-361.
58. Yun K, Fukumoto M, Jinno Y Monoallelic expression of the insulin-like growth factor-2 gene in ovarian cancer. Am J Pathol 1996, 148:1081-1087.
59. Kim HT, Choi BH, Niikawa N, Lee TS, Chang SI Frequent loss of imprinting of the H19 and IGF-II genes in ovarian tumors. Am J Med Genet 1998, 80:391-395.
60. Feinberg AP Genomic imprinting and gene activation in cancer. Nat Genet 1993, 4:110-113.
61. Hsiao PJ, Lu MY, Chiang FY, Shin SJ, Tai YD, Juo SH Vascular endothelial growth factor gene polymorphisms in thyroid cancer. J Endocrinol 2007, 195:265-270.
62. Schneider BP, Radovich M, Sledge GW, et al. Association of polymorphisms of angiogenesis genes with breast cancer. Breast Cancer Res Treat 2008, 111:157-163.
63. Kong SY, Park JW, Lee JA, Park JE, Park KW, Hong EK, Kim CM Association between vascular endothelial growth factor gene polymorphisms and survival in hepatocellular carcinoma patients. Hepatology 2007, 46:446-455.
64. Tzanakis N, Gazouli M, Rallis G, et al. Vascular endothelial growth factor polymorphisms in gastric cancer development, prognosis, and survival. J Surg Oncol 2006, 94:624-630.
65. Park HM, Hong SH, Kim JW, et al. Gender-specific association of the VEGF -2578C >A polymorphism in Korean patients with colon cancer. Anticancer Res 2007, 27:2535-2539.
66. Ferrante M, Pierik M, Henckaerts L, et al. The role of vascular endothelial growth factor (VEGF) in inflammatory bowel disease. Inflamm Bowel Dis 2006, 12:870-878.
67. Jacobs EJ, Feigelson HS, Bain EB, et al. Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort. Breast Cancer Res 2006, 8:R22.
68. Suganthalakshmi B, Anand R, Kim R, Mahalakshmi R, Karthikprakash S, Namperumalsamy P, Sundaresan P Association of VEGF and eNOS gene polymorphisms in type 2 diabetic retinopathy. Mol Vis 2006, 12:336-341.
69. Coulam CB, Jeyendran RS Vascular endothelial growth factor gene polymorphisms and recurrent pregnancy loss. Am J Reprod Immunol 2008, 59:301-305.
70. Unal ZN, Unal M, Bagdatoglu OT, Polat G, Atik U Genetic polymorphism of VEGF-1154 (A/G) in laryngeal squamous cell carcinoma. Arch Med Res 2008, 39:209-211.
71. Freathy RM, Weedon MN, Shields B, et al. Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population. JOP 2006, 7:295-302.
72. Kim DH, Lee NY, Lee MH, Sohn SK, Do YR, Park JY Vascular endothelial growth factor (VEGF) gene (VEGFA) polymorphism can predict the prognosis in acute myeloid leukaemia patients. Br J Haematol 2008, 140:71-79.
73. Hsueh KC, Lin YJ, Chang JS, et al. Association of vascular endothelial growth factor C-634 g polymorphism in Taiwanese children with Kawasaki disease. Pediatr Cardiol 2008, 29:292-296.
74. Szaflik JP, Wysocki T, Kowalski M, Majsterek I, Borucka AI, Blasiak J, Szaflik J An association between vascular endo-thelial growth factor gene promoter polymorphisms and diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 2008, 246:39-43.
75. Langsenlehner U, Wolf G, Langsenlehner T, et al. Genetic polymorphisms in the vascular endothelial growth factor gene and breast cancer risk. The Austrian "Tumor of breast tissue: incidence, genetics, and environmental risk factors" study. Breast Cancer Res Treat 2008, 109:297-304.
76. Xie J, Yi L, Xu ZF, et al. VEGF C-634G polymorphism is associated with protection from isolated ventricular septal defect: case-control and TDT studies. Eur J Hum Genet 2007, 15:1246-1251.
77. Uthra S, Raman R, Mukesh BN, et al. Association of VEGF gene polymorphisms with diabetic retinopathy in a south Indian cohort. Ophthalmic Genet 2008, 29:11-15.
78. Bau DT, Chiang CC, Tsai YY, et al. Evaluation of transforming growth factor and vascular endothelial growth factor polymorphisms in Taiwan Chinese patients with pterygium. Eur J Ophthalmol 2008, 18:21-26.
79. Debrah AY, Mand S, Toliat MR, et al. Plasma vascular endothelial growth factor-A (VEGF-A) and VEGF-A gene polymorphism are associated with hydrocele development in lymphatic filariasis. Am J Trop Med Hyg 2007, 77:601-608.
80. Fukuda H, Tsuchiya N, Narita S, et al. Clinical implication of vascular endothelial growth factor T-460C polymorphism in the risk and progression of prostate cancer. Oncol Rep 2007, 18:1155-1163.
81. Yim HE, Bae IS, Yoo KH, Hong YS, Lee JW Genetic control of VEGF and TGF-beta1 gene polymorphisms in childhood urinary tract infection and vesicoureteral reflux. Pediatr Res 2007, 62:183-187.
82. Kim JG, Sohn SK, Chae YS, et al. Vascular endothelial growth factor gene polymorphisms associated with prognosis for patients with gastric cancer. Ann Oncol 2007, 18:1030-1036.
83. Heist RS, Zhai R, Liu G, et al. VEGF polymorphisms and survival in early-stage non-small-cell lung cancer. J Clin Oncol 2008, 26:856-862.
84. Zhai R, Liu G, Zhou W, et al. Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer. Clin Cancer Res 2008, 14:612-617.
85. Chae YS, Kim JG, Sohn SK, et al. Investigation of vascular endothelial growth factor gene polymorphisms and its association with clinicopathologic characteristics in gastric cancer. Oncology 2006, 71:266-272.
86. Konac E, Onen HI, Metindir J, Alp E, Biri AA, Ekmekci A Lack of association between -460 C/T and 936 C/T of the vascular endothelial growth factor and angiopoietin-2 exon 4 G/A polymorphisms and ovarian, cervical, and endome-trial cancers. DNA Cell Biol 2007, 26:453-463.
87. Polterauer S, Grimm C, Mustea A, et al. Vascular endothe-lial growth factor gene polymorphisms in ovarian cancer. Gynecol Oncol 2007, 105:385-389.
88. Gentilini D, Somigliana E, Vigano P, Vignali M, Busacca M, Di Blasio AM The vascular endothelial growth factor + 405G>C polymorphism in endometriosis. Hum Reprod 2008, 23:211-215.
89. Bányász I, Bokodi G, Vásárhelyi B, et al. Genetic polymorphisms for vascular endothelial growth factor in perinatal complications. Eur Cytokine Netw 2006, 17:266-270.
90. Seyhan EC, Cetinkaya E, Günlüoglu Z, Altin S, Yüksel V, Issever H Vascular endothelial growth factor and tumor necrosis factor genes polymorphisms in Turkish patients with sarcoidosis. Tuberk Toraks 2008, 56:5-14.
91. Morohashi K, Takada T, Omori K, Suzuki E, Gejyo F Vascular endothelial growth factor gene polymorphisms in Japanese patients with sarcoidosis. Chest 2003, 123:1520-1526.
92. Cheng CY, Chang CS, Liu CJ, Kao SY Vascular endothelial growth factor 936 C/T polymorphism is associated with vascular invasion in oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008, 106:79-84.
93. Jakubowska A, Gronwald J, Menkiszak J, et al. The VEGF-936-C>T 3'UTR polymorphism reduces BRCA1-associated breast cancer risk in Polish women. Cancer Lett 2008, 262:71-76.
94. Ikuhashi Y, Yoshida S, Kennedy S, et al. Vascular endothelial growth factor+936 C/T polymorphism is associated with an increased risk of endometriosis in a Japanese population. Acta Obstet Gynecol Scand 2007, 86:1352-1358.
95. Shim JY, Jun JK, Jung BK, Kim SH, Won HS, Lee PR, Kim A Vascular endothelial growth factor gene+ 936 C/T polymorphism is associated with preeclampsia in Korean women. Am J Obstet Gynecol 2007, 197:271.e1-271.e4.
96. Yapijakis C, Vairaktaris E, Vassiliou S, et al. The low VEGF production allele of the +936C/T polymorphism is strongly associated with increased risk for oral cancer. J Cancer Res Clin Oncol 2007, 133:787-791.
97. Gunesacar R, Erken E, Ozer HT, Bozkurt B, Dinkci S, Deveci D Analysis of vascular endothelial growth factor gene 936 C/T polymorphism in patients with familial Mediterranean fever. Int J Immunogenet 2008, 35:33-36.