Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum

Fertility and Sterility

Volumn 90, Issue 1, 2008, Pages 148-155

  Machado, Daniel Escorsim ^a   Abrao, Maurício Simões ^b   Berardo, Plínio Tostes ^a   Takiya, Christina Maeda ^a   Nasciutti, Luiz Eurico ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b HOSPITAL SÍRIO LIBANÊS   (Brazil)

Author keywords

angiogenesis; Endometriosis; endometrium; vascularization; VEGF

Indexed keywords

VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; VON WILLEBRAND FACTOR;

ADULT; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; ENDOMETRIOSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; LAPAROSCOPIC SURGERY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN LOCALIZATION; RECTUM; UNIVERSITY HOSPITAL;

ADULT; CAPILLARIES; CASE-CONTROL STUDIES; ENDOMETRIOSIS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; NEOVASCULARIZATION, PATHOLOGIC; OVARIAN DISEASES; OVARY; PROSPECTIVE STUDIES; RECTAL DISEASES; RECTUM; URINARY BLADDER; URINARY BLADDER DISEASES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; VON WILLEBRAND FACTOR;

EID: 44949171444     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2007.05.076     Document Type: Article

References (33)

1. Wheeler J.M. Epidemiology and prevalence of endometriosis. Infertil Reprod Med Clin North Am 3 (1992) 545-549
2. Sampson J.A. Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol 14 (1927) 422-469
3. Donnez J., Smoes P., Gillerot S., Casanas-Roux F., and Nisolle M. Vascular endothelial growth factor in endometriosis. Hum Reprod 13 (1998) 1686-1690
4. Matsuzaki S., Canis M., Murakami T., Dechelotte P., Bruhat M.A., and Okamura K. Immunohistochemical analysis of the role of angiogenic status in the vasculature of peritoneal endometriosis. Fertil Steril 76 (2001) 712-716
5. Hull M.L., Charnock-Jones D.S., Chan C.L., Bruner-Tran K.L., Osteen K.G., Tom B.D., et al. Antiangiogenic agents are effective inhibitors of endometriosis. J Clin Endocrinol Metab 88 (2003) 2889-2899
6. Jondet M., Vacher-Lavenu M.C., and Chapron C. Image analysis measurements of the microvascularisation in endometrium, superficial and deep endometriotic tissues. Angiogenesis 9 (2006) 177-182
7. Ferrara N., Carver-Moore K., Chen H., Dowd M., Lu L., O'Shea K.S., et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380 (1996) 439-442
8. Benjamin L.E., Hemo I., and Keshet E. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development 125 (1998) 1591-1598
9. Ferrara N. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol 280 (2001) 1358-1366
10. Jakeman L.B., Winer J., Bennett G.L., Altar C.A., and Ferrara N. Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J Clin Invest 89 (1992) 244-253
11. Unemori E.N., Ferrara N., Bauer E.A., and Amento E.P. Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol 153 (1992) 557-562
12. McLaren J. Vascular endothelial growth factor and endometriotic angiogenesis. Hum Reprod Update 6 (2000) 45-55
13. Takehara M., Ueda M., Yamashita Y., Terai Y., Hung Y.C., and Ueki M. Vascular endothelial growth factor A and C gene expression in endometriosis. Hum Pathol 35 (2004) 1369-1375
14. Groothuis P.G., Nap A.W., Winterhager E., and Grümmer R. Vascular development in endometriosis. Angiogenesis 8 (2005) 147-156
15. Noyes R.W., Hertig A.T., and Rock J. Dating the endometrial biopsy. Fertil Steril 1 (1950) 3-25
16. Nap A.W., Griffioen A.W., Dunselman G.A., Bouma-Ter Steege J.C., Thijssen V.L., Evers J.L., et al. Antiangiogenesis therapy for endometriosis. J Clin Endocrinol Metab 89 (2004) 1089-1095
17. Fauconnier A., Chapron C., Dubuisson J.B., Vieira M., Dousset B., and Breart G. Relation between pain symptoms and the anatomic location of deep infiltrating endometriosis. Fertil Steril 78 (2002) 719-726
18. Anaf V., Simon P., El Nakadi I., Fayt I., Simonart T., Buxant F., et al. Hyperalgesia, nerve infiltration and nerve growth factor expression in deep adenomyotic nodules, peritoneal and ovarian endometriosis. Hum Reprod 17 (2002) 1895-1900
19. Koninckx P.R., and Martin D.C. Deep endometriosis: a consequence of infiltration or retraction or possibly adenomyosis externa?. Fertil Steril 58 (1992) 924-928
20. H2 immune response component. Hum Reprod 22 (2007) 1373-1379
21. Inan S., Kuscu N.K., Vatansever S., Ozbilgin K., Koyuncu F., and Sayhan S. Increased vascular surface density in ovarian endometriosis. Gynecol Endocrinol 17 (2003) 143-150
22. McLaren J., Prentice A., Charnock-Jones D.S., Millican S.A., Müller K.H., Sharkey A.M., et al. Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. J Clin Invest 98 (1996) 482-489
23. Fasciani A., D'Ambrogio G., Bocci G., Monti M., Genazzani A.R., and Artini P.G. High concentrations of the vascular endothelial growth factor and interleukin-8 in ovarian endometriomata. Mol Hum Reprod 6 (2000) 50-54
24. Goteri G., Lucarini G., Filosa A., Pierantoni A., Montik N., Biagini G., et al. Immunohistochemical analysis of vascular endothelial growth factor cellular expression in ovarian endometriomata. Fertil Steril 81 (2004) 1528-1533
25. Ferrara N., and Henzel W.J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161 (1989) 851-858
26. Ferrara N., Houck K., Jakeman L., and Leung D.W. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev 13 (1992) 18-32
27. Wang H.B., Lang J.H., Leng J.H., Zhu L., Liu Z.F., and Sun D.W. Expression of vascular endothelial growth factor receptors in the ectopic and eutopic endometrium of women with endometriosis. Zhonghua Yi Xue Za Zhi 85 (2005) 1555-1559
28. Nap A.W., Dunselman G.A., Griffioen A.W., Mayo K.H., Evers J.L., and Groothuis P.G. Angiostatic agents prevent the development of endometriosis-like lesions in the chicken chorioallantoic membrane. Fertil Steril 83 (2005) 793-795
29. Park A., Chang P., Ferin M., Xiao E., and Zeitoun K. Inhibition of endometriosis development in Rhesus monkeys by blocking VEGF receptor: a novel treatment for endometriosis. Fertil Steril 82 (2004) S71
30. Heilier J.F., Donnez O., Van Kerckhove V., Lison D., and Donnez J. Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum. Fertil Steril 85 (2006) 1516-1518
31. Brosens I.A., and Brosens J.J. Redefining endometriosis: is deep endometriosis a progressive disease?. Hum Reprod 15 (2000) 1-3
32. Abrao M.S., Neme R.M., and Averbach M. Rectovaginal septum endometriosis: a disease with specific diagnosis and treatment. Arch Gastroenterol 40 (2003) 192-197
33. Abrao M.S., Podgaec S., Dias J.A., Averbach M., Garry R., Ferraz Silva L.F., and Carvalho F.M. Deeply infiltrating endometriosis affecting in the rectum and lymph nodes. Fertil Steril 86 (2006) 543-547