Molecular mediators of tumor angiogenesis: Enhanced expression and activation of vascular endothelial growth factor receptor KDR in primary breast cancer

International Journal of Cancer

Volumn 84, Issue 3, 1999, Pages 293-298

  Kranz, Andrea ^a   Mattfeldt, Torsten ^a   Waltenberger, Johannes ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; ARTICLE; BREAST CARCINOMA; CANCER GRADING; CANCER GROWTH; CANCER STAGING; CONTROLLED STUDY; FEMALE; FIBROADENOMA; FIBROCYSTIC BREAST DISEASE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; METASTASIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TISSUE DISTRIBUTION;

ANTIGENS, CD31; BREAST NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; NEOVASCULARIZATION, PATHOLOGIC; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR;

EID: 0033032991     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990621)84:3<293::AID-IJC16>3.0.CO;2-T     Document Type: Article

References (25)

1. BERSE, B., BROWN, L.F., VAN DE WATER, L., DVORAK, H.F. and SENGER, D.R., Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol. Biol. Cell, 3, 211-220 (1992).
2. BROWN, L.F., BERSE, B., JACKMAN, R.W., TOGNAZZI, K., GUIDI, A.J., DVORAK, H.F., SENGER, D.R., CONNOLLY, J.L. and SCHNITT, S.J., Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum. Pathol., 26, 86-91 (1995).
3. CLAUSS, M., WEICH, H., BREIER, G., KNIES, U., RÖCKL, W., WALTENBERGER, J. and RISAU, W., The vascular endothelial growth factor receptor FLT-1 mediates biological activities: implications for a functional role of placenta growth factor in monocyte activation and chemotaxis. J. biol. Chem., 271, 17629-17634 (1996).
4. DVORAK, H.F., SIOUSSAT, T.M., BROWN, L.F., BERSE, B., NAGY, J.A., SOTREL, A., MANSEAU, E.J., VAN DE WATER, L. and SENGER, D.R., Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels. J. exp. Med., 174, 1275-1278 (1991).
5. FERRARA, N. and DAVIS-SMYTH, T., The biology of vascular endothelial growth factor. Endocrine Rev., 18, 4-25 (1997).
6. FOLKMAN, J., New perspectives in clinical oncology from angiogenesis research. Europ. J. Cancer, 32A, 2534-2539 (1996).
7. GASPARINI, G. and HARRIS, A.L., Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool. J. clin. Oncol., 13, 765-782 (1995).
8. GOLDMAN, C.K., KENDALL, R.L., CABRERA, G., SOROCEANU, L., HEIKE, Y., GILLESPIE, G.Y., SIEGAL, G.P., MAO, X.Z., BETT, A.J., HUCKLE, W.R., THOMAS, K.A. and CURIEL, D.T., Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate. Proc. nat. Acad. Sci. (Wash.), 95, 8795-8800 (1998).
9. GUINEBRETIÉRE, J.-M., LE MONIQUE, G., GAVOILLE, A. and BAHI, J., Angiogenesis and the risk of breast cancer in women with fibrocystic disease. J. nat. Cancer Inst., 86, 635-636 (1994).
10. HIRATSUKA, S., MINOWA, O., KUNO, J., NODA, T. and SHIBUYA, M., Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc. nat. Acad. Sci. (Wash.), 95, 9349-9354 (1998).
11. KREMER, C., BREIER, G., RISAU, W. and PLATE, K.H., Up-regulation of flk-1/vascular endothelial growth factor receptor 2 by its ligand in a cerebral slice culture system. Cancer Res., 57, 3852-3859 (1997).
12. LIN, P.N., BUXTON, J.A., ACHESON, A., RADZIEJEWSKI, C., MAISONPIERRE, P.C., YANCOPOULOS, G.D., CHANNON, K.M., HALE, L.P., DEWHIRST, M.W., GEORGE, S.E. and PETERS, K.G., Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2. Proc. nat. Acad. Sci. (Wash.), 95, 8829-8834 (1998).
13. LUO, J.C., TOYODA, M. and SHIBUYA, M., Differential inhibition of fluid accumulation and tumor growth in two mouse ascites tumors by an antivascular endothelial growth factor/permeability factor neutralizing antibody. Cancer Res., 58, 2594-2600 (1998).
14. ÖBERG, C., WALTENBERGER, J., CLAESSON-WELSH, L. and WELSH, M., Expression of protein tyrosine kinases in islet cells: possible role of the flk-1 receptor for β-cell maturation from duct cells. Growth Factors, 10, 115-126 (1994).
15. OSBORNE, C.K., Prognostic factors in breast cancer: have they met their promise? J. clin. Oncol., 10, 679-682 (1992).
16. PETERS, K.G., COOGAN, A., BERRY, D., MARKS, J., IGLEHART, J.D., KONTOS, C.D., RAO, P., SANKAR, S. and TROGAN, E., Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis. Brit. J. Cancer, 77, 51-56 (1998).
17. PLATE, K.H., BREIER, G., WEICH, H.A. and RISAU, W., Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo. Nature (Lond.), 359, 845-848 (1992).
18. RELF, M., LEJEUNE, S., SCOTT, P.A.E., FOX, S., SMITH, K., LEEK, R., MOGHADDAM, A., WHITEHOUSE, R., BICKNELL, R. and HARRIS, A.L., Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res., 57, 963-969 (1997).
19. SOKER, S., TAKASHIMA, S., MIAO, H.Q., NEUFELD, G. and KLAGSBRUN, M., Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell, 92, 735-745 (1998).
20. TOI, M., HOSHINA, S., TAKAYANAGI, T. and TOMINAGA, T., Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer. Jpn. J. Cancer Res., 85, 1045-1049 (1994).
21. VUCKOVIC, M., PONTING, J., TERMAN, B.I., NIKETIC, V., SEIF, M.W. and KUMAR, S., Expression of the vascular endothelial growth factor receptor, KDR, in human placenta. J. Anat., 188, 361-366 (1996).
22. WALTENBERGER, J., CLAESSON-WELSH, L., SIEGBAHN, A., SHIBUYA, M. and HELDIN, C.-H., Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J. biol. Chem., 269, 26988-26995 (1994).
23. WALTENBERGER, J., MAYR, U., PENTZ, S. and HOMBACH, V., Functional upregulation of the vascular endothelial growth factor receptor KDR by hypoxia. Circulation, 94, 1647-1654 (1996).
24. WEIDNER, N., FOLKMAN, J., POZZA, F., BEVILACQUA, P., ALLRED, E.N., MOORE, D.H., MELI, S. and GASPARINI, G., Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J. nat. Cancer Inst., 84, 1875-1887 (1992).
25. YOSHIJI, H., GOMEZ, D.E., SHIBUYA, M. and THORGEIRSSON, U.P., Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer. Cancer Res., 56, 2013-2016 (1996).