Comparative evaluation of acute toxicity of ivermectin by two methods after single subcutaneous administration in rats

Regulatory Toxicology and Pharmacology

Volumn 47, Issue 3, 2007, Pages 257-260

  Dadarkar, S S ^a   Deore, M D ^a   Gatne, M M ^a  

^a BOMBAY VETERINARY COLLEGE   (India)

Author keywords

Acute toxicity; Ivermectin; LD50; Rats; Subcutaneous

Indexed keywords

IVERMECTIN;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; CONTROLLED STUDY; DRUG MEGADOSE; DRUG SAFETY; FEMALE; HISTOPATHOLOGY; INTERMETHOD COMPARISON; LD 50; LIVER CONGESTION; LIVER HEMORRHAGE; LIVER NECROSIS; LIVER TOXICITY; LOW DRUG DOSE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; TOXICITY TESTING;

ACUTE TOXICITY TESTS; ANIMALS; ANTIPARASITIC AGENTS; CENTRAL NERVOUS SYSTEM; FEMALE; INJECTIONS, SUBCUTANEOUS; IVERMECTIN; LETHAL DOSE 50; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 33947132729     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2006.10.009     Document Type: Article

References (7)

1. Benjamin M.M. Outline of Veterinary Clinical Pathology. third ed. (2001), Kalyani publishers, New Delhi
2. Campbell W.C., Fisher M.H., Schonberg E.A., and Jacob T.A. Ivermectin: a potent new antiparasitic agent. Science 221 (1983) 823-828
3. Finney D.J. Statistical Analysis (1971), Cambridge University Press
4. Gad S.C. Drug safety evaluation (2002), Wiley-Interscience Publication, USA
5. Lankas G.R., and Gordon L.R. Safety of ivermectin in target animals. Ivermectin and Abamectin (1989), Springer, NewYork 89-112
6. Mc Kellar Q.A., and Benchaoui H.A. Avermectin and milbemycins. J. Vet. Pharmacol. Therap. 19 (1996) 331-351
7. OECD [Organisation for Economic Co-operation and Development], 2002. OECD Guidelines for the Testing of Chemicals. Guideline 423 Acute Oral Toxicity-Acute Toxic Class Method. Paris: OECD.