Impact of nonalcoholic fatty liver disease on insulin resistance in relation to HbA1c levels in nondiabetic subjects

American Journal of Gastroenterology

Volumn 105, Issue 11, 2010, Pages 2389-2395

  Bae, Ji Cheol ^a   Cho, Yong Kyun ^a   Lee, Won Young ^a   Seo, Hyun Il ^a   Rhee, Eun Jung ^a   Park, Se Eun ^a   Park, Cheol Young ^a   Oh, Ki Won ^a   Sung, Ki Chul ^a   Kim, Byung Ik ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN A1C;

ADULT; ARTICLE; BODY MASS; DISEASE ASSOCIATION; FEMALE; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; OBESITY; PATIENT SELECTION; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; SEX DIFFERENCE;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; BODY MASS INDEX; CHI-SQUARE DISTRIBUTION; CROSS-SECTIONAL STUDIES; FATTY LIVER; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; PREVALENCE;

EID: 78149284468     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2010.275     Document Type: Article

References (32)

1. Tolman KG , Fonseca V , Dalpiaz A et al. Spectrum of liver disease in type2 diabetes and management of patients with diabetes and liver disease. Diabetes Care 2007 ; 30 : 734-43.
2. Ide T , Shimano H , Yahagi N et al. SREBPs suppress IRS-2-mediated insulinsignalling in the liver. Nat Cell Biol 2004 ; 6 : 351-7.
3. Stefan N , Kantartzis K , Haring HU. Causes and metabolic consequences ofFatty liver. Endocr Rev 2008 ; 29 : 939-60.
4. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002 ; 346 : 1221-31.
5. Bugianesi E , Gastaldelli A , Vanni E et al. Insulin resistance in non-diabeticpatients with non-alcoholic fatty liver disease: sites and mechanisms. Diabetologia 2005 ; 48 : 634-42.
6. Sharma R , Sinha S , Danishad KA et al. Investigation of hepatic gluconeogenesispathway in non-diabetic Asian Indians with non-alcoholic fattyliver disease using in vivo ((31)P) phosphorus magnetic resonancespectroscopy. Atherosclerosis 2009 ; 203 : 291-7.
7. Musso G , Gambino R , Bo S et al. Should nonalcoholic fatty liver disease beincluded in the definition of metabolic syndrome? A cross-sectionalcomparison with Adult Treatment Panel III criteria in nonobese nondiabeticsubjects. Diabetes Care 2008 ; 31 : 562-8.
8. Shibata M , Kihara Y , Taguchi M et al. Nonalcoholic fatty liver disease is arisk factor for type 2 diabetes in middle-aged Japanese men. Diabetes Care2007 ; 30 : 2940-4.
9. American Diabetes Association. Diagnosis and classification of diabetesmellitus. Diabetes Care 2008 ; 31 (Suppl 1) : S55-60.
10. Piche ME , Arcand-Bosse JF , Despres JP et al. What is a normal glucosevalue? Differences in indexes of plasma glucose homeostasis in subjectswith normal fasting glucose. Diabetes Care 2004 ; 27 : 2470-7.
11. Nichols GA , Hillier TA , Brown JB. Normal fasting plasma glucose and riskof type 2 diabetes diagnosis. Am J Med 2008 ; 121 : 519-24.
12. Dilley J , Ganesan A , Deepa R et al. Association of A1C with cardiovasculardisease and metabolic syndrome in Asian Indians with normal glucosetolerance. Diabetes Care 2007 ; 30 : 1527-32.
13. Marchesini G , Bugianesi E , Forlani G et al. Nonalcoholic fatty liver,steatohepatitis, and the metabolic syndrome. Hepatology 2003 ; 37 :917-23.
14. Matthews DR , Hosker JP , Rudenski AS et al. Homeostasis model assessment:insulin resistance and beta-cell function from fasting plasma glucose andinsulin concentrations in man. Diabetologia 1985 ; 28 : 412-9.
15. Schwartz KL , Monsur JC , Bartoces MG et al. Correlation of same-visitHbA1c test with laboratory-based measurements: a MetroNet study. BMCFam Pract 2005 ; 6 : 28.
16. Saverymuttu SH , Joseph AE , Maxwell JD. Ultrasound scanning inthe detection of hepatic fibrosis and steatosis. Br Med J (Clin Res Ed)1986 ; 292 : 13-5.
17. Clark JM , Brancati fl, Diehl AM. Nonalcoholic fatty liver disease. Gastroenterology 2002 ; 122 : 1649-57
18. Jimba S , Nakagami T , Takahashi M et al. Prevalence of non-alcoholic fattyliver disease and its association with impaired glucose metabolism in Japaneseadults. Diabet Med 2005 ; 22 : 1141-5.
19. Bedogni G , Miglioli L , Masutti F et al. Prevalence of and risk factors fornonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology 2005 ; 42 : 44-52.
20. Mohan V , Farooq S , Deepa M et al. Prevalence of non-alcoholic fatty liverdisease in urban south Indians in relation to diff erent grades of glucoseintolerance and metabolic syndrome. Diabetes Res Clin Pract 2009 ; 84 : 84-91.
21. Caballeria L , Pera G , Auladell MA et al. Prevalence and factors associatedwith the presence of nonalcoholic fatty liver disease in an adult populationin Spain. Eur J Gastroenterol Hepatol 2010 ; 22 : 24-32.
22. Browning JD , Szczepaniak LS , Dobbins R et al. Prevalence of hepaticsteatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004 ; 40 : 1387-95.
23. Zelber-Sagi S , Nitzan-Kaluski D , Halpern Z et al. Prevalence of primary nonalcoholicfatty liver disease in a population-based study and its associationwith biochemical and anthropometric measures. Liver Int 2006 ; 26 : 856-63.
24. Ford ES , Giles WH , Dietz WH. Prevalence of the metabolic syndromeamong US adults: findings from the third National Health and NutritionExamination Survey. JAMA 2002 ; 287 : 356-9.
25. James PT , Rigby N , Leach R. The obesity epidemic, metabolic syndrome andfuture prevention strategies. Eur J Cardiovasc Prev Rehabil 2004 ; 11 : 3-8.
26. Ministry of Health and Welfare. The Third Korean National Health and Nutrition Examination Survey (KNHANES III), Korea Centers for DiseaseControl and Prevention: Seoul, Republic of Korea , 2005. Available at: http://knhanes.cdc. go.kr/ (accessed March 19, 2009).
27. Nishino M , Hayakawa K , Nakamura Y et al. Effects of tamoxifen on hepaticfat content and the development of hepatic steatosis in patients with breastcancer: high frequency of involvement and rapid reversal aft er completionof tamoxifen therapy. AJR Am J Roentgenol 2003 ; 180 : 129-34.
28. Denzer C , Th iere D , Muche R et al. Gender-specific prevalences of fattyliver in obese children and adolescents: roles of body fat distribution, sexsteroids, and insulin resistance. J Clin Endocrinol Metab 2009 ; 94 : 3872-81.
29. Meigs JB , Nathan DM , Wilson PW et al. Metabolic risk factors worsencontinuously across the spectrum of nondiabetic glucose tolerance. TheFramingham Off spring Study. Ann Intern Med 1998 ; 128 : 524-33.
30. International Expert Committee. International Expert Committee reporton the role of the A1C assay in the diagnosis of diabetes. Diabetes Care2009 ; 32 : 1327-34.
31. Seppala-Lindroos A , Vehkavaara S , Hakkinen AM et al. Fat accumulationin the liver is associated with defects in insulin suppression of glucose productionand serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 2002 ; 87 : 3023-8.
32. Kelley DE , McKolanis TM , Hegazi RA et al. Fatty liver in type 2 diabetesmellitus: relation to regional adiposity, fatty acids, and insulin resistance. Am J Physiol Endocrinol Metab 2003 ; 285 : E906-16.