Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 23, 2010, Pages 7080-7084

  Wheatley, Nicole C ^a   Andrews, Katherine T ^b,c   Tran, Truc L ^b,c   Lucke, Andrew J ^a   Reid, Robert C ^a   Fairlie, David P ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b GRIFFITH UNIVERSITY   (Australia)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

HDAC inhibitor; Histone; Malaria; NSAID; Plasmodium falciparum

Indexed keywords

ACETYLSALICYLIC ACID; ANTIMALARIAL AGENT; APICIDIN; CINNAMIC ACID; DICLOFENAC; FLURBIPROFEN; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITOR; INDOMETACIN; INDOPROFEN; MEFENAMIC ACID; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; SULINDAC; TOLMETIN; TRICHOSTATIN A; VORINOSTAT;

ANTIMALARIAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; MALARIA; PLASMODIUM FALCIPARUM;

ACETYLATION; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIMALARIALS; BINDING SITES; CINNAMATES; ENZYME INHIBITORS; HISTONE DEACETYLASE INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PLASMODIUM FALCIPARUM; PROTEIN BINDING;

PLASMODIUM FALCIPARUM;

EID: 78149283647     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.09.096     Document Type: Article

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