메뉴 건너뛰기




Volumn 137, Issue 3, 2010, Pages 422-432

The clinical course of EAE is reflected by the dynamics of the neuroantigen-specific T cell compartment in the blood

Author keywords

Cytokines; EAE; ELISPOT; Immune monitoring; MS

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17;

EID: 78149283317     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2010.09.004     Document Type: Article
Times cited : (21)

References (46)
  • 1
    • 0029851099 scopus 로고    scopus 로고
    • Rodent models of experimental allergic encephalomyelitis applied to the study of multiple sclerosis
    • Goverman J., Brabb T. Rodent models of experimental allergic encephalomyelitis applied to the study of multiple sclerosis. Lab. Anim. Sci. 1996, 46:482-492.
    • (1996) Lab. Anim. Sci. , vol.46 , pp. 482-492
    • Goverman, J.1    Brabb, T.2
  • 2
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M., Martin R. Immunology of multiple sclerosis. Annu. Rev. Immunol. 2005, 23:683-747.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 3
    • 33745728404 scopus 로고    scopus 로고
    • How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis
    • Steinman L., Zamvil S.S. How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann. Neurol. 2006, 60:12-21.
    • (2006) Ann. Neurol. , vol.60 , pp. 12-21
    • Steinman, L.1    Zamvil, S.S.2
  • 4
    • 33746729791 scopus 로고    scopus 로고
    • Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70years of merits and culprits in experimental autoimmune encephalomyelitis research
    • Gold R., Linington C., Lassmann H. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 2006, 129:1953-1971.
    • (2006) Brain , vol.129 , pp. 1953-1971
    • Gold, R.1    Linington, C.2    Lassmann, H.3
  • 5
    • 0024504033 scopus 로고
    • Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice
    • Tuohy V.K., Lu Z., Sobel R.A., Laursen R.A., Lees M.B. Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J. Immunol. 1989, 142:1523-1527.
    • (1989) J. Immunol. , vol.142 , pp. 1523-1527
    • Tuohy, V.K.1    Lu, Z.2    Sobel, R.A.3    Laursen, R.A.4    Lees, M.B.5
  • 6
    • 0025091679 scopus 로고
    • Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide of myelin proteolipid protein
    • Sobel R.A., Tuohy V.K., Lu Z.J., Laursen R.A., Lees M.B. Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide of myelin proteolipid protein. J. Neuropathol. Exp. Neurol. 1990, 49:468-479.
    • (1990) J. Neuropathol. Exp. Neurol. , vol.49 , pp. 468-479
    • Sobel, R.A.1    Tuohy, V.K.2    Lu, Z.J.3    Laursen, R.A.4    Lees, M.B.5
  • 7
    • 0029038922 scopus 로고
    • A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells
    • Mendel I., de Rosbo N.K., Ben Nun A. A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells. Eur. J. Immunol. 1995, 25:1951-1959.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1951-1959
    • Mendel, I.1    de Rosbo, N.K.2    Ben Nun, A.3
  • 8
    • 10244219871 scopus 로고    scopus 로고
    • Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse V beta usage by T cells recognizing the core epitope encephalitogenic for T cell receptor V beta b and T cell receptor V beta in H-2b mice
    • Mendel I., de Rosbo N.K., Ben Nun A. Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse V beta usage by T cells recognizing the core epitope encephalitogenic for T cell receptor V beta b and T cell receptor V beta in H-2b mice. Eur. J. Immunol. 1996, 26:2470-2479.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 2470-2479
    • Mendel, I.1    de Rosbo, N.K.2    Ben Nun, A.3
  • 9
    • 0028125774 scopus 로고
    • Humoral immune recognition of proteolipid protein (PLP)-specific epitopes in the SJL/J mouse
    • Potter N.T., Stephens T.S. Humoral immune recognition of proteolipid protein (PLP)-specific epitopes in the SJL/J mouse. J. Neurosci. Res. 1994, 37:15-22.
    • (1994) J. Neurosci. Res. , vol.37 , pp. 15-22
    • Potter, N.T.1    Stephens, T.S.2
  • 10
    • 0028085836 scopus 로고
    • Fine specificity of CD4+ T cell responses to the dominant encephalitogenic PLP 139-151 peptide in SJL/J mice
    • McRae B.L., Miller S.D. Fine specificity of CD4+ T cell responses to the dominant encephalitogenic PLP 139-151 peptide in SJL/J mice. Neurochem. Res. 1994, 19:997-1004.
    • (1994) Neurochem. Res. , vol.19 , pp. 997-1004
    • McRae, B.L.1    Miller, S.D.2
  • 11
    • 0032209673 scopus 로고    scopus 로고
    • B-cell deficient mice develop experimental autoimmune encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization
    • Hjelmstrom P., Juedes A.E., Fjell J., Ruddle N.H. B-cell deficient mice develop experimental autoimmune encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization. J. Immunol. 1998, 161:4480-4483.
    • (1998) J. Immunol. , vol.161 , pp. 4480-4483
    • Hjelmstrom, P.1    Juedes, A.E.2    Fjell, J.3    Ruddle, N.H.4
  • 12
    • 0038643518 scopus 로고    scopus 로고
    • Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice
    • Oliver A.R., Lyon G.M., Ruddle N.H. Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice. J. Immunol. 2003, 171:462-468.
    • (2003) J. Immunol. , vol.171 , pp. 462-468
    • Oliver, A.R.1    Lyon, G.M.2    Ruddle, N.H.3
  • 13
    • 0026601932 scopus 로고
    • Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice
    • Merrill J.E., Kono D.H., Clayton J., Ando D.G., Hinton D.R., Hofman F.M. Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice. Proc. Natl Acad. Sci. USA 1992, 89:574-578.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 574-578
    • Merrill, J.E.1    Kono, D.H.2    Clayton, J.3    Ando, D.G.4    Hinton, D.R.5    Hofman, F.M.6
  • 14
    • 0029762023 scopus 로고    scopus 로고
    • Review: cytokines and the pathogenesis of multiple sclerosis
    • Navikas V., Link H. Review: cytokines and the pathogenesis of multiple sclerosis. J. Neurosci. Res. 1996, 45:322-333.
    • (1996) J. Neurosci. Res. , vol.45 , pp. 322-333
    • Navikas, V.1    Link, H.2
  • 16
    • 77953124358 scopus 로고    scopus 로고
    • Kinetics of IL-17- and interferon-gamma producing PLPp-specific CD4 T cells in EAE induced by coinjection of PLP/IFA with pertussis toxin in SJL mice
    • Hofstetter H.H., Forsthuber T.G. Kinetics of IL-17- and interferon-gamma producing PLPp-specific CD4 T cells in EAE induced by coinjection of PLP/IFA with pertussis toxin in SJL mice. Neurosci. Lett. 2010, 476:150-155.
    • (2010) Neurosci. Lett. , vol.476 , pp. 150-155
    • Hofstetter, H.H.1    Forsthuber, T.G.2
  • 18
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., Cua D.J., Littman D.R. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006, 126:1121-1133.
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6    Cua, D.J.7    Littman, D.R.8
  • 20
    • 17044364407 scopus 로고    scopus 로고
    • Does the frequency and the avidity spectrum of the neuroantigen-specific T cells in the blood mirror the autoimmune process in the central nervous system of mice undergoing experimental allergic encephalomyelitis?
    • Hofstetter H.H., Targoni O.S., Karulin A.Y., Forsthuber T.G., Tary-Lehmann M., Lehmann P.V. Does the frequency and the avidity spectrum of the neuroantigen-specific T cells in the blood mirror the autoimmune process in the central nervous system of mice undergoing experimental allergic encephalomyelitis?. J. Immunol. 2005, 174:4598-4605.
    • (2005) J. Immunol. , vol.174 , pp. 4598-4605
    • Hofstetter, H.H.1    Targoni, O.S.2    Karulin, A.Y.3    Forsthuber, T.G.4    Tary-Lehmann, M.5    Lehmann, P.V.6
  • 22
    • 0037356713 scopus 로고    scopus 로고
    • Longitudinal study of chemokine receptor expression on peripheral lymphocytes in multiple sclerosis: CXCR3 upregulation is associated with relapse
    • Mahad D.J., Lawry J., Howell S.J.L., Woodroofe M.N. Longitudinal study of chemokine receptor expression on peripheral lymphocytes in multiple sclerosis: CXCR3 upregulation is associated with relapse. Mult. Scler. 2003, 9:189-198.
    • (2003) Mult. Scler. , vol.9 , pp. 189-198
    • Mahad, D.J.1    Lawry, J.2    Howell, S.J.L.3    Woodroofe, M.N.4
  • 23
    • 3142556134 scopus 로고    scopus 로고
    • Development of biomarkers in multiple sclerosis
    • Bielekova B., Martin R. Development of biomarkers in multiple sclerosis. Brain 2004, 127:1463-1478.
    • (2004) Brain , vol.127 , pp. 1463-1478
    • Bielekova, B.1    Martin, R.2
  • 24
    • 30644479847 scopus 로고    scopus 로고
    • Immunological markers in multiple sclerosis: tackling the missing elements
    • Rinaldi L., Gallo P. Immunological markers in multiple sclerosis: tackling the missing elements. Neurol. Sci. 2005, 26:S215-S217.
    • (2005) Neurol. Sci. , vol.26
    • Rinaldi, L.1    Gallo, P.2
  • 25
    • 33750633465 scopus 로고    scopus 로고
    • Antibodies as biological markers for pathophysiological processes in multiple sclerosis
    • Reindl M., Khalil M., Berger T. Antibodies as biological markers for pathophysiological processes in multiple sclerosis. J. Neuroimmunol. 2006, 180:50-62.
    • (2006) J. Neuroimmunol. , vol.180 , pp. 50-62
    • Reindl, M.1    Khalil, M.2    Berger, T.3
  • 26
    • 34547666647 scopus 로고    scopus 로고
    • Biological markers for multiple sclerosis
    • Lutterotti A., Berger T., Reindl M. Biological markers for multiple sclerosis. Curr. Med. Chem. 2007, 14:1956-1965.
    • (2007) Curr. Med. Chem. , vol.14 , pp. 1956-1965
    • Lutterotti, A.1    Berger, T.2    Reindl, M.3
  • 27
    • 56749098922 scopus 로고    scopus 로고
    • Multiple sclerosis: chemokine receptor expression on circulating lymphocytes in correlation with radiographic measures of tissue injury
    • Fox R.J., Kivisakk P., Fisher E., Tucky B., Lee J.C., Rudick R.A., Ransohoff R.M. Multiple sclerosis: chemokine receptor expression on circulating lymphocytes in correlation with radiographic measures of tissue injury. Mult. Scler. 2008, 14:1036-1043.
    • (2008) Mult. Scler. , vol.14 , pp. 1036-1043
    • Fox, R.J.1    Kivisakk, P.2    Fisher, E.3    Tucky, B.4    Lee, J.C.5    Rudick, R.A.6    Ransohoff, R.M.7
  • 30
    • 0034254825 scopus 로고    scopus 로고
    • Quantification of self-recognition in multiple sclerosis by single-cell analysis of cytokine production
    • Pelfrey C.M., Rudick R.A., Cotleur A.C., Lee J.C., Tary-Lehmann M., Lehmann P.V. Quantification of self-recognition in multiple sclerosis by single-cell analysis of cytokine production. J. Immunol. 2000, 165:1641-1651.
    • (2000) J. Immunol. , vol.165 , pp. 1641-1651
    • Pelfrey, C.M.1    Rudick, R.A.2    Cotleur, A.C.3    Lee, J.C.4    Tary-Lehmann, M.5    Lehmann, P.V.6
  • 31
    • 5144235394 scopus 로고    scopus 로고
    • Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines
    • Hohlfeld R., Wekerle H. Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines. Proc. Natl Acad. Sci. USA 2004, 101:14599-14606.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 14599-14606
    • Hohlfeld, R.1    Wekerle, H.2
  • 32
    • 0026664422 scopus 로고
    • Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen
    • Lehmann P.V., Forsthuber T., Miller A., Sercarz E.E. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 1992, 358:155-157.
    • (1992) Nature , vol.358 , pp. 155-157
    • Lehmann, P.V.1    Forsthuber, T.2    Miller, A.3    Sercarz, E.E.4
  • 33
    • 0029000750 scopus 로고
    • Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis
    • McRae B.L., Vanderlugt C.L., Dal Canto M.C., Miller S.D. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis. J. Exp. Med. 1995, 182:75-85.
    • (1995) J. Exp. Med. , vol.182 , pp. 75-85
    • McRae, B.L.1    Vanderlugt, C.L.2    Dal Canto, M.C.3    Miller, S.D.4
  • 35
    • 0034650422 scopus 로고    scopus 로고
    • Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing remitting experimental autoimmune encephalomyelitis
    • Vanderlugt C.L., Neville K.L., Nikcevich K.M., Eagar T.N., Bluestone J.A., Miller S.D. Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing remitting experimental autoimmune encephalomyelitis. J. Immunol. 2000, 164:670-678.
    • (2000) J. Immunol. , vol.164 , pp. 670-678
    • Vanderlugt, C.L.1    Neville, K.L.2    Nikcevich, K.M.3    Eagar, T.N.4    Bluestone, J.A.5    Miller, S.D.6
  • 37
    • 0032532022 scopus 로고    scopus 로고
    • Differential expression of inflammatory cytokines parallels progression of central nervous system pathology in two clinically distinct models of multiple sclerosis
    • Begolka W.S., Vanderlugt C.L., Rahbe S.M., Miller S.D. Differential expression of inflammatory cytokines parallels progression of central nervous system pathology in two clinically distinct models of multiple sclerosis. J. Immunol. 1998, 161:4437-4446.
    • (1998) J. Immunol. , vol.161 , pp. 4437-4446
    • Begolka, W.S.1    Vanderlugt, C.L.2    Rahbe, S.M.3    Miller, S.D.4
  • 38
    • 0027504747 scopus 로고
    • The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems
    • Pribyl T.M., Campagnoni C.W., Kampf K., Kashima T., Handley V.W., McMahon J., Campagnoni A.T. The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems. Proc. Natl Acad. Sci. USA 1993, 90:10695-10699.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 10695-10699
    • Pribyl, T.M.1    Campagnoni, C.W.2    Kampf, K.3    Kashima, T.4    Handley, V.W.5    McMahon, J.6    Campagnoni, A.T.7
  • 40
    • 0028959535 scopus 로고
    • Thymic expression of the golli-myelin basic protein gene in the SJL/J mouse
    • Fritz R.B., Kalvakolanu I. Thymic expression of the golli-myelin basic protein gene in the SJL/J mouse. J. Neuroimmunol. 1995, 57:93-99.
    • (1995) J. Neuroimmunol. , vol.57 , pp. 93-99
    • Fritz, R.B.1    Kalvakolanu, I.2
  • 42
    • 33845302957 scopus 로고    scopus 로고
    • Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis
    • Astier A.L., Meiffren G., Freeman S., Hafler D.A. Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. J. Clin. Invest. 2006, 116:3252-3257.
    • (2006) J. Clin. Invest. , vol.116 , pp. 3252-3257
    • Astier, A.L.1    Meiffren, G.2    Freeman, S.3    Hafler, D.A.4
  • 43
    • 48949116961 scopus 로고    scopus 로고
    • The role of regulatory T cells in multiple sclerosis
    • Zozulya A.L., Wiendl H. The role of regulatory T cells in multiple sclerosis. Nat. Clin. Pract. Neurol. 2008, 4:384-398.
    • (2008) Nat. Clin. Pract. Neurol. , vol.4 , pp. 384-398
    • Zozulya, A.L.1    Wiendl, H.2
  • 44
    • 63549119572 scopus 로고    scopus 로고
    • Dysfunction of IL-10-producing type 1 regulatory T cells and CD4(+)CD25(+) regulatory T cells in a mimic model of human multiple sclerosis in Cynomolgus monkey
    • Ma A., Xiong Z., Hu Y., Qi S., Song L., Dun H., Zhang L., Lou D., Yang P., Zhao Z., Wang X., Zhang D., Daloze P., Chen H. Dysfunction of IL-10-producing type 1 regulatory T cells and CD4(+)CD25(+) regulatory T cells in a mimic model of human multiple sclerosis in Cynomolgus monkey. Int. Immunopharmacol. 2009, 9:599-608.
    • (2009) Int. Immunopharmacol. , vol.9 , pp. 599-608
    • Ma, A.1    Xiong, Z.2    Hu, Y.3    Qi, S.4    Song, L.5    Dun, H.6    Zhang, L.7    Lou, D.8    Yang, P.9    Zhao, Z.10    Wang, X.11    Zhang, D.12    Daloze, P.13    Chen, H.14
  • 45
    • 34248650931 scopus 로고    scopus 로고
    • Passive induction of experimental allergic encephalomyelitis
    • Stromnes I.M., Goverman J.M. Passive induction of experimental allergic encephalomyelitis. Nat. Prot. 2006, 1:1952-1960.
    • (2006) Nat. Prot. , vol.1 , pp. 1952-1960
    • Stromnes, I.M.1    Goverman, J.M.2
  • 46
    • 58149190437 scopus 로고    scopus 로고
    • Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells
    • Shi G., Cox C.A., Vistica B.P., Wawrousek E.F., Gery I. Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells. J. Immunol. 2008, 181:7205-7213.
    • (2008) J. Immunol. , vol.181 , pp. 7205-7213
    • Shi, G.1    Cox, C.A.2    Vistica, B.P.3    Wawrousek, E.F.4    Gery, I.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.