Neuroprotective effect of CPDT on THA-induced cortical motor neuron death in an organotypic culture model

Brain Research Bulletin

Volumn 83, Issue 6, 2010, Pages 345-350

  Liu, Xiao Yun ^a,b   Li, Chun Yan ^a,b   Bu, Hui ^a,b   Li, Zhe ^a   Li, Bin ^a   Sun, Meng Meng ^a   Zhang, Li ^a   Tian, Miao ^a   Fan, Zhi Liang ^a   Ren, Wen Bo ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Institute of Cardiocerebrovascular Disease   (China)

Author keywords

5,6 Dihydrocyclopenta 1,2 dithiole 3 thione (CPDT); Cortical motoneuron (CMN); Heme oxygenase 1 (HO 1); NF E2 related factor (Nrf2); Threo hydroxyaspartate (THA)

Indexed keywords

1,2 DITHIOLE 3 THIONE DERIVATIVE; 3 HYDROXYASPARTIC ACID; 5,6 DIHYDROCYCLOPENTA 1,2 DITHIOLE 3 THIONE; ANTIOXIDANT; GLUTAMIC ACID; HEME OXYGENASE 1; NEUROPROTECTIVE AGENT; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CULTURE MEDIUM; EXCITOTOXICITY; MOTONEURON; MOTOR NEURON DISEASE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; STROKE; TRAUMATIC BRAIN INJURY;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; ASPARTIC ACID; BACTERIAL TOXINS; CELL DEATH; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GLUTAMIC ACID; HEME OXYGENASE-1; MOTOR CORTEX; MOTOR NEURONS; NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; ORGAN CULTURE TECHNIQUES; RATS;

EID: 78149280063     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2010.09.001     Document Type: Article

References (27)

1. Andreassen O.A., Jenkins B.G., Dedeoglu A., Ferrante K.L., Bogdanov M.B., Kaddurah-Daouk R., Beal M.F. Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation. J. Neurochem. 2001, 77(2):383-390.
2. Beal M.F. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann. Neurol. 1995, 38:357-366.
3. Canton T., Pratt J., Stutzmann J.-M. Glutamate uptake is decreased tardively in the spinal cord of FALS mice. Neuroreport 1998, 9:775-778.
4. Cao Z., Hallur S., Qiu H.Z., Peng X., Li Y. Induction of endogenous glutathione by the chemoprotective agent, 3H-1,2-dithiole-3-thione, in human neuroblastoma SH-SY5Y cells affords protection against peroxynitrite-induced cytotoxicity. Biochem. Biophys. Res. Commun. 2004, 316(4):1043-1049.
5. Chen K., Gunter K., Maines M.D. Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death. J. Neurochem. 2000, 75(1):304-313.
6. Cid C., Alvarez-Cermeno J.C., Regidor I., Salinas M., Alcazar A. Low concentrations of glutamate induce apoptosis in cultured neurons: implications for amyotrophic lateral sclerosis. J. Neurol. Sci. 2003, 206(1):91-95.
7. Foran E., Trotti D. Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis. Antioxid. Redox Signal. 2009, 11(7):1587-1602.
8. Heath P.R., Shaw P.J. Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis. Muscle Nerve 2002, 26(4):438-458.
9. Kaal E.C., Vlug A.S., Versleijen M.W., Kuilman M., Joosten E.A., Bär.P.R. Chronic mitochondrial inhibition induces selective motoneuron death in vitro: a new model for amyotrophic lateral sclerosis. J. Neurochem. 2000, 74:1158-1165.
10. Lewerenz J., Albrecht P., Tien M.L., Henke N., Karumbayaram S., Kornblum H.I., Wiedau-Pazos M., Schubert D., Maher P., Methner A. Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro. J. Neurochem. 2009, 111(2):332-343.
11. Li C.Y., Liu X.Y., Bu H., Li Z., Li B., Sun M.M., Guo Y.S., Liu Y.L., Zhang Y. Prevention of glutamate excitotoxicity in motor neurons by 5,6-dihydrocyclopenta-1,2-dithiole-3-thione: implication to the development of neuroprotective drugs. Cell. Mol. Life Sci. 2007, 64(14):1861-1869.
12. Maekawa S., AL-sarraj S., Kibble M., Landau S., Parnavelas J., Cotter D., Everall I., Leigh P.N. Cortical selective vulnerability in motor neuron disease: a morphonmetric study. Brain 2004, 127:1237-1251.
13. Mattson M.P., Mark Rj Excitotoxicity and excitoprotection in vitro. Adv. Neurol. 1996, 71:1-37.
14. Mclaughlin B.A., Nelson D., Silver I.A., Erecinska M., Chesselet M.F. Methylmalonate toxicity in primary neuronal cultures. Neuroscience 1998, 86:279-290.
15. Novelli A., Reilly J.A., Lysko P.G., Henneberry R.C. Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced. Brain Res. 1988, 451:205-212.
16. Rothstein J.D., Tsai G., Kuncl R.W. Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Ann. Neurol. 1990, 28:18-25.
17. Rothstein J.D., Martin L.J., Kuncl R.W. Decreased brain and spinal cord glutamate transport in amyotrophic lateral sclerosis. N. Engl. J. Med. 1992, 326:1464-1468.
18. Rothstein J.D., Van Kammen M., Levey A.I. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann. Neurol. 1995, 38:73-84.
19. Rothstein J.D., Patel S., Regan M.R., Haenggeli C., Huang Y.H., Bergles D.E., Jin L., Dykes Hoberg M., Vidensky S., Chung D.S., Toan S.V., Bruijn L.I., Su Z.Z., Gupta P., Fisher PB Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 2005, 433(7021):73-77.
20. Sheldon A.L., Robinson M.B. The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention. Neurochem. Int. 2007, 51:333-355.
21. Stoppini L., Buchs P.A., Muller D. A simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods 1991, 37:173-182.
22. Takuma H., Kwak S., Yoshizawa T. Reduction of GluR2 RNA editing, a molecular change that increases calcium influx through AMPA receptors, selective in the spinal ventral gray of patients with amyotrophic lateral sclerosis. Ann. Neurol. 1999, 46:806-815.
23. Wasserman W.W., Fahl W.E. Functional antioxidant responsive element. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:561-566.
24. Woitzik J., Lassel E., Hecht N., Schneider U.C., Schroeck H., Vajkoczy P., Graf R. Ischemia independent lesion evolution during focal stroke in rats. Exp. Neurol. 2009, 218(1):41-46.
25. Xiao X., Liu W., Li M., Ma Z., Li C. Effect of glutamate transporter inhibitor on rat cortical pyramidal cells in organotypic culture brain slice. Basic Clin. Med. 2006, (1):11-15.
26. Zhang Y., Gordon G.B. A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway. Mol. Cancer Ther. 2004, 3(7):885-893.
27. Zlotnik A., Gruenbaum S.E., Artru A.A., Rozet I., Dubilet M., Tkachov S., Brotfain E., Klin Y., Shapira Y., Teichberg V.I. The neuroprotective effects of oxaloacetate in closed head injury in rats is mediated by its blood glutamate scavenging activity: evidence from the use of maleate. J. Neurosurg. Anesthesiol. 2009, 21(3):235-241.