Prevention of glutamate excitotoxicity in motor neurons by 5,6-dihydrocyclopenta-1,2-dithiole-3-thione: Implication to the development of neuroprotective drugs

Cellular and Molecular Life Sciences

Volumn 64, Issue 14, 2007, Pages 1861-1869

  Li, C Y ^a,b   Liu, X Y ^a,b   Bu, H ^a,b   Li, Z ^a   Li, B ^a   Sun, M M ^a   Guo, Y S ^a,b   Liu, Y L ^a,b   Zhang, Y ^a,c  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Institute of Cardiocerebrovascular Disease   (China)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

5,6 dihydrocyclopenta 1,2 dithiole 3 thione; Cytoprotection; Glutamate excitotoxicity; Motor neuron; Nrf2; Phase 2 gene

Indexed keywords

5,6 DIHYDROCYCLOPENTA 1,2 DITHIOLE 3 THIONE; GLUTAMIC ACID; NEUROPROTECTIVE AGENT; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; EXCITOTOXICITY; EXPLANT; GENE ACTIVATION; GENE TARGETING; MITOCHONDRIAL MEMBRANE; MOTONEURON; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; RAT; SPINAL CORD;

ANIMALS; BIOLOGICAL TRANSPORT; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION REGULATION; GLUTAMATES; MOTOR NEURONS; NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SULFHYDRYL COMPOUNDS; THIONES;

RATTUS;

EID: 34447650071     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-007-7189-5     Document Type: Article

References (34)

1. Van Den Bosch, L., Van Damme, P., Bogaert, E. and Robberecht, W. (2006) The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis. Biochim. Biophys. Acta 1762, 1068-1082.
2. Coyle, J. T. and Puttfarcken, P. (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262, 689-695.
3. Lipton, S. A. and Rosenberg, P. A. (1994) Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330, 613-622.
4. Choi, D. W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623-634.
5. Carriedo, S. G., Sensi, S. L., Yin, H. Z. and Weiss, J. H. (2000) AMPA exposures induce mitochondrial Ca(2+) overload and ROS generation in spinal motor neurons in vitro. J. Neurosci. 20, 240-250.
6. 2+ rises and consequent oxygen radical production. J. Neurosci. 18, 7727-7738.
7. Ankarcrona, M., Dypbukt, J. M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S. A. and Nicotera, P. (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15, 961-973.
8. Guegan, C., Vila, M., Rosoklija, G., Hays, A. P. and Przedborski, S. (2001) Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis. J. Neurosci. 21, 6569-6576.
9. Rao, S. D., Yin, H. Z. and Weiss, J. H. (2003) Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons. J. Neurosci. 23, 2627-2633.
10. Rushmore, T. H., Morton, M. R. and Pickett, C. B. (1991) The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J. Biol. Chem. 266, 11632-11639.
11. Nguyen, T., Sherratt, P. J. and Pickett, C. B. (2003) Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu. Rev. Pharmacol. Toxicol. 43, 233-260.
12. Primiano, T., Sutter, T. R. and Kensler, T. W. (1997) Antioxidant-inducible genes. Adv. Pharmacol. 38, 293-328.
13. Zhang, Y. and Gordon, G. B. (2004) A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway. Mol. Cancer Ther. 3, 885-893.
14. Fahey, J. W., Haristoy, X., Dolan, P. M., Kensler, T. W., Scholtus, I., Stephenson, K. K., Talalay, P. and Lozniewski, A. (2002) Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc. Natl. Acad. Sci. USA 99, 7610-7615.
15. Iida, K., Itoh, K., Kumagai, Y., Oyasu, R., Hattori, K., Kawai, K., Shimazui, T., Akaza, H. and Yamamoto, M. (2004) Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis. Cancer Res. 64, 6424-6431.
16. Chan, K. and Kan, Y. W. (1999) Nrf2 is essential for protection against acute pulmonary injury in mice. Proc. Natl. Acad. Sci. USA 96, 12731-12736.
17. Khor, T. O., Huang, M. T., Kwon, K. H., Chan, J. Y., Reddy, B. S. and Kong, A. N. (2006) Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. Cancer Res. 66, 11580-11584.
18. Shih, A. Y., Imbeault, S., Barakauskas, V., Erb, H., Jiang, L., Li, P. and Murphy, T. H. (2005) Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo. J. Biol. Chem. 280, 22925-22936.
19. Egner, P. A., Kensler, T. W., Prestera, T., Talalay, P., Libby, A. H., Joyner, H. H. and Curphey, T. J. (1994) Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones. Carcinogenesis 15, 177-181.
20. Munday, R., Zhang, Y., Munday, C. M. and Li, J. (2006) Structure-activity relationships in the induction of Phase II enzymes by derivatives of 3H-1,2-dithiole-3-thione in rats. Chem. Biol. Interact. 160, 115-122.
21. Rothstein, J. D., Jin, L., Dykes-Hoberg, M. and Kuncl, R. W. (1993) Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc. Natl. Acad. Sci. USA 90, 6591-6595.
22. Kamencic, H., Lyon, A., Paterson, P. G. and Juurlink, B. H. (2000) Monochlorobimane fluorometric method to measure tissue glutathione. Anal. Biochem. 286, 35-37.
23. Graham, L. T. Jr. and Aprison, M. H. (1966) Fluorometric determination of aspartate, glutamate, and gamma-aminobutyrate in nerve tissue using enzymic methods. Anal. Biochem. 15, 487-497.
24. 2+. Biochem. J. 269, 513-519.
25. Wild, A. C., Moinova, H. R. and Mulcahy, R. T. (1999) Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2. J. Biol. Chem. 274, 33627-33636.
26. Kwak, M. K., Wakabayashi, N., Itoh, K., Motohashi, H., Yamamoto, M. and Kensler, T. W. (2003) Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J. Biol. Chem. 278, 8135-8145.
27. Prestera, T., Talalay, P., Alam, J., Ahn, Y. I., Lee, P. J. and Choi, A. M. (1995) Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE). Mol. Med. 1, 827-837.
28. Prestera, T. and Talalay, P. (1995) Electrophile and antioxidant regulation of enzymes that detoxify carcinogens. Proc. Natl. Acad. Sci. USA 92, 8965-8969.
29. Dinkova-Kostova, A. T., Holtzclaw, W. D. and Kensler, T. W. (2005) The role of Keap1 in cellular protective responses. Chem. Res. Toxicol. 18, 1779-1791.
30. Kwak, M. K., Itoh, K., Yamamoto, M. and Kensler, T. W. (2002) Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Mol. Cell. Biol. 22, 2883-2892.
31. Tanaka, K., Watase, K., Manabe, T., Yamada, K., Watanabe, M., Takahashi, K., Iwama, H., Nishikawa, T., Ichihara, N., Kikuchi, T., Okuyama, S., Kawashima, N., Nori, S., Takimoto, M. and Wade, K. (1997) Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276, 1699-1702.
32. +]coupled L-glutamate transporter purified from rat brain is located in glial cell processes. Neuroscience 51, 295-310.
33. Doble, A. (1996) The pharmacology and mechanism of action of Riluzole. Neurology 47, S233-241.
34. Lee, J. M., Shih, A. Y., Murphy, T. H. and Johnson, J. A. (2003) NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons. J. Biol. Chem. 278, 37948-37956.