Factor deficiencies in venom-induced consumption coagulopathy resulting from Australian elapid envenomation: Australian Snakebite Project (ASP-10)

Journal of Thrombosis and Haemostasis

Volumn 8, Issue 11, 2010, Pages 2504-2513

  Isbister, G K ^a,b,c   Scorgie, F E ^b   O'leary, M A ^b   Seldon, M ^b   Brown, S G A ^d   Lincz, L F ^a,b  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b CALVARY MATER NEWCASTLE HOSPITAL   (Australia)

^c MENZIES SCHOOL OF HEALTH RESEARCH   (Australia)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Clotting factors; Coagulopathy; Prothrombin activator; Snake envenomation; Venom

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 5A; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; D DIMER; FIBRINOGEN; PROTHROMBIN; SNAKE VENOM; SNAKE VENOM ANTISERUM; VON WILLEBRAND FACTOR;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING FACTOR DEFICIENCY; CHILD; CONTROLLED STUDY; DISSEMINATED INTRAVASCULAR CLOTTING; ENVENOMATION; HUMAN; INTERNATIONAL NORMALIZED RATIO; MAJOR CLINICAL STUDY; PARTIAL THROMBOPLASTIN TIME; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCHOOL CHILD; SNAKEBITE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTIVENINS; AUSTRALIA; BLOOD COAGULATION; BLOOD COAGULATION FACTORS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DISSEMINATED INTRAVASCULAR COAGULATION; FEMALE; HUMANS; INTERNATIONAL NORMALIZED RATIO; MALE; MIDDLE AGED; PARTIAL THROMBOPLASTIN TIME; SNAKE BITES; TIME FACTORS; VENOMS;

EID: 78149269171     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2010.04050.x     Document Type: Article

References (28)

1. Isbister GK. Procoagulant snake toxins: laboratory studies, diagnosis, and understanding snakebite coagulopathy. Semin Thromb Hemost 2009; 35: 93-103.
2. Joseph JS, Kini RM. Snake venom prothrombin activators homologous to blood coagulation factor Xa. Haemostasis 2001; 31: 234-40.
3. Isbister GK, Woods D, Alley S, O'Leary MA, Seldon M, Lincz LF. Endogenous thrombin potential as a novel method for the characterization of procoagulant snake venoms and the efficacy of antivenom. Toxicon 2010; 56: 75-85.
4. Rosing J, Tans G. Structural and functional properties of snake venom prothrombin activators. Toxicon 1992; 30: 1515-27.
5. Kini RM, Rao VS, Joseph JS. Procoagulant proteins from snake venoms. Haemostasis 2001; 31: 218-24.
6. Isbister GK, Duffull SB, Brown SG. Failure of antivenom to improve recovery in Australian snakebite coagulopathy. QJM 2009; 102: 563-8.
7. Rao VS, Kini RM. Pseutarin C, a prothrombin activator from Pseudonaja textilis venom: its structural and functional similarity to mammalian coagulation factor Xa-Va complex. Thromb Haemost 2002; 88: 611-9.
8. Bos MH, Boltz M, St Pierre L, Masci PP, De Jersey J, Lavin MF, Camire RM. Venom factor V from the common brown snake escapes hemostatic regulation through procoagulant adaptations. Blood 2009; 114: 686-92.
9. Isbister GK, Brown SG, MacDonald E, White J, Currie BJ. Current use of Australian snake antivenoms and frequency of immediate-type hypersensitivity reactions and anaphylaxis. Med J Aust 2008; 188: 473-6.
10. O'Leary MA, Isbister GK, Schneider JJ, Brown SG, Currie BJ. Enzyme immunoassays in brown snake (Pseudonaja spp.) envenoming: Detecting venom, antivenom and venom-antivenom complexes. Toxicon 2006; 48: 4-11.
11. Kulawickrama S, O'Leary MA, Hodgson WC, Brown SG, Jacoby T, Davern K, Isbister GK. Development of a sensitive enzyme immunoassay for measuring taipan venom in serum. Toxicon 2010; 55: 1510-8.
12. Tanos PP, Isbister GK, Lalloo DG, Kirkpatrick CM, Duffull SB. A model for venom-induced consumptive coagulopathy in snake bite. Toxicon 2008; 52: 769-80.
13. White J, Duncan B, Wilson C, Williams V, Lloyd J. Coagulopathy following Australian elapid snakebite: a review of 20 cases. In: Gopalakrishnakone P, Tan CK, eds. Recent Advances in Toxinology Research. Singapore: Venom and Toxin Research Group, National University Singapore, 1992: 337-44.
14. Parkin JD, Ibrahim K, Dauer RJ, Braitberg G. Prothrombin activation in eastern tiger snake bite. Pathology 2002; 34: 162-6.
15. Warrell DA, Davidson NM, Greenwood BM, Ormerod LD, Pope HM, Watkins BJ, Prentice CR. Poisoning by bites of the saw-scaled or carpet viper (Echis carinatus) in Nigeria. Q J Med 1977; 46: 33-62.
16. Lalloo DG, Trevett AJ, Owens D, Minei J, Naraqi S, Saweri A, Hutton RA, Theakston RD, Warrell DA. Coagulopathy following bites by the Papuan taipan (Oxyuranus scutellatus canni). Blood Coagul Fibrinolysis 1995; 6: 65-72.
17. Sano-Martins IS, Tomy SC, Campolina D, Dias MB, De Castro SC, De Sousa-e-Silva MC, Amaral CF, Rezende NA, Kamiguti AS, Warrell DA, Theakston RD. Coagulopathy following lethal and non-lethal envenoming of humans by the South American rattlesnake (Crotalus durissus) in Brazil. QJM 2001; 94: 551-9.
18. Herrmann RP, Davey MG, Skidmore PH. The coagulation defect after envenomation by the bite of the dugite (Demansia nuchalis affinis), a Western Australian brown snake. Med J Aust 1972; 2: 183-6.
19. Gillissen A, Theakston RD, Barth J, May B, Krieg M, Warrell DA. Neurotoxicity, haemostatic disturbances and haemolytic anaemia after a bite by a Tunisian saw-scaled or carpet viper (Echis 'pyramidum'-complex): failure of antivenom treatment. Toxicon 1994; 32: 937-44.
20. Wajima T, Isbister GK, Duffull SB. A comprehensive model for the humoral coagulation network in humans. Clin Pharmacol Ther 2009; 86: 290-8.
21. Lalloo DG, Trevett AJ, Korinhona A, Nwokolo N, Laurenson IF, Paul M, Black J, Naraqi S, Mavo B, Saweri A. Snake bites by the Papuan taipan (Oxyuranus scutellatus canni): paralysis, hemostatic and electrocardiographic abnormalities, and effects of antivenom. Am J Trop Med Hyg 1995; 52: 525-31.
22. Isbister GK, O'Leary MA, Schneider JJ, Brown SG, Currie BJ. Efficacy of antivenom against the procoagulant effect of Australian brown snake (Pseudonaja sp.) venom: in vivo and in vitro studies. Toxicon 2007; 49: 57-67.
23. Gan M, O'Leary MA, Brown SG, Jacoby T, Spain D, Tankel A, Gavaghan C, Garrett P, Isbister GK. Envenoming by the rough-scaled snake (Tropidechis carinatus): a series of confirmed cases. Med J Aust 2009; 191: 183-6.
24. Bouchard BA, Williams JL, Meisler NT, Long MW, Tracy PB. Endocytosis of plasma-derived factor V by megakaryocytes occurs via a clathrin-dependent, specific membrane binding event. J Thromb Haemost 2005; 3: 541-51.
25. White J CSL Antivenom Handbook, 2nd edn. Melbourne: CSL Ltd, 2001.
26. Brown SG, Caruso N, Borland ML, McCoubrie DL, Celenza A, Isbister GK. Clotting factor replacement and recovery from snake venom-induced consumptive coagulopathy. Intensive Care Med 2009; 35: 1532-8.
27. White J. Patterns of Elapid Envenomation and Treatment in South Australia. Toxicon 1983; 3: 489-91.
28. Jelinek GA, Hamilton T, Hirsch RL. Admissions for suspected snake bite to the Perth adult teaching hospitals, 1979 to 1988. Med J Aust 1991; 155: 761-4.