Snake venom prothrombin activators homologous to blood coagulation factor Xa

Haemostasis

Volumn 31, Issue 3-6, 2001, Pages 234-240

  Joseph, Jeremiah S ^a,d   Kini, R Manjunatha ^b,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

Factor Xa; Procoagulants; Prothrombin activators; Snake venom

Indexed keywords

BLOOD CLOTTING FACTOR 10A; CALCIUM ION; ENZYME ACTIVATOR; PROTEINASE; PROTEINASE RECEPTOR 1; PROTHROMBIN; RECEPTOR; SERINE PROTEINASE; SNAKE VENOM; TROCARIN; UNCLASSIFIED DRUG; COAGULATING AGENT;

AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME STRUCTURE; GLYCOSYLATION; HEMOSTASIS; HYDROLYSIS; INFLAMMATION; KINETICS; MAMMAL; MOLECULAR MODEL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; SNAKE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TROPIDECHIS CARINATUS; ANIMAL; BINDING SITE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PROTEIN PROCESSING; REVIEW;

ANIMALS; BINDING SITES; COAGULANTS; FACTOR XA; HUMANS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTHROMBIN; SEQUENCE HOMOLOGY, NUCLEIC ACID; SNAKE VENOMS;

EID: 0035742908     PISSN: 03010147     EISSN: None     Source Type: Journal    
DOI: 10.1159/000048068     Document Type: Article

References (27)

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3. Snake venoms
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5. Classification and nomenclature of prothrombin activators isolated from snake venoms
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7. Isolation and characterization of carinactivase, a novel prothrombin activator in Echis carinatus venom with a unique catalytic mechanism
8. Purification and characterization of the prothrombin activator of the venom of Pseudonaja textiles
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10. Purification and properties of a prothrombin activator from the venom of Notechis scutatus scutatus
11. Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo
12. Coagulation factors X, Xa, and protein S as potent mitogens of cultured aortic smooth muscle cells
13. Coagulation factor Xa stimulates platelet-derived growth factor release and mitogenesis in cultured vascular smooth muscle cells of rat
14. A new trisaccharide sugar chain linked to a serine residue in bovine blood coagulation factors VII and IX
15. A new trisaccharide sugar chain linked to a serine residue in the first EGF-like domain of clotting factors VII and IX and protein Z
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17. Functional consequences of mutations in Ser-52 and Ser-60 in human blood coagulation factor VII
18. Structural basis for the chemical inhibition of human blood coagulation factor Xa
19. Structure-function relationships of epidermal growth factor modules in vitamin K-dependent clotting factors
20. 2-terminal EGF-like domain in coagulation factor X
21. 2-terminal epidermal growth factor-like module of factor X
22. The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X
23. Molecular recognition sites on factor Xa which participate in the prothrombinase complex
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25. 88 in factor Xa mediates ligand binding to effector cell protease receptor-1
26. Effector protease receptor 1 mediates the mitogenic activity if factor Xa for vascular smooth muscle cells in vitro and in vivo
27. Effector cell protease receptor-1 is a vascular receptor for coagulation factor Xa