Caspase dependence of the death of neonatal retinal ganglion cells induced by axon damage and induction of autophagy as a survival mechanism

Brazilian Journal of Medical and Biological Research

Volumn 43, Issue 10, 2010, Pages 950-956

  Sternberg, C ^a   Benchimol, M ^b   Linden, R ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSIDADE SANTA ÚRSULA   (Brazil)

Author keywords

Apoptosis; Autophagy; Caspases; Central nervous system; Retina

Indexed keywords

3 METHYLADENINE; CASPASE 3; CASPASE 6; CASPASE 9;

ANIMAL TISSUE; ANTIBODY SPECIFICITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL SURVIVAL; CELL ULTRASTRUCTURE; ELECTRON MICROSCOPY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EX VIVO STUDY; IMMUNOHISTOCHEMISTRY; NERVE CELL DEGENERATION; NERVE FIBER; NERVE FIBER DEGENERATION; NERVE FIBER TRANSECTION; NONHUMAN; RAT; RETINA GANGLION CELL;

EID: 78149268335     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2010007500082     Document Type: Article

References (39)

1. Berkelaar M, Clarke DB, Wang YC, Bray GM, Aguayo AJ. Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J Neurosci 1994; 14: 4368-4374.
2. Garcia-Valenzuela E, Gorczyca W, Darzynkiewicz Z, Sharma SC. Apoptosis in adult retinal ganglion cells after axotomy. J Neurobiol 1994; 25: 431-438.
3. Levin LA, Louhab A. Apoptosis of retinal ganglion cells in anterior ischemic optic neuropathy. Arch Ophthalmol 1996; 114: 488-491.
4. Manabe S, Kashii S, Honda Y, Yamamoto R, Katsuki H, Akaike A. Quantifcation of axotomized ganglion cell death by explant culture of the rat retina. Neurosci Lett 2002; 334: 33-36.
5. Aguayo AJ, Clarke DB, Jelsma TN, Kittlerova P, Friedman HC, Bray GM. Effects of neurotrophins on the survival and regrowth of injured retinal neurons. Ciba Found Symp 1996; 196: 135-144.
6. Peinado-Ramon P, Salvador M, Villegas-Perez M P, Vidal-Sanz M. Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study. Invest Ophthalmol Vis Sci 1996; 37: 489-500.
7. Rajan P, Stewart CL, Fink JS. LIF-mediated activation of STAT proteins after neuronal injury in vivo. Neuroreport 1995; 6: 2240-2244.
8. Chaudhary P, Ahmed F, Quebada P, Sharma SC. Caspase inhibitors block the retinal ganglion cell death following optic nerve transection. Brain Res Mol Brain Res 1999; 67: 36-45.
9. Kermer P, Ankerhold R, Klocker N, Krajewski S, Reed JC, Bahr M. Caspase-9: involvement in secondary death of axotomized rat retinal ganglion cells in vivo. Brain Res Mol Brain Res 2000; 85: 144-150.
10. McKinnon SJ, Lehman DM, Kerrigan-Baumrind LA, Merges CA, Pease ME, Kerrigan DF, et al. Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. Invest Ophthalmol Vis Sci 2002; 43: 1077-1087.
11. Singh M, Savitz SI, Hoque R, Gupta G, Roth S, Rosenbaum PS, et al. Cell-specifc caspase expression by different neu-ronal phenotypes in transient retinal ischemia. J Neurochem 2001; 77: 466-475.
12. Yoshizawa K, Nambu H, Yang J, Oishi Y, Senzaki H, Shikata N, et al. Mechanisms of photoreceptor cell apoptosis induced by N-methyl-N-nitrosourea in Sprague-Dawley rats. Lab Invest 1999; 79: 1359-1367.
13. Hisatomi T, Sakamoto T, Murata T, Yamanaka I, Oshima Y, Hata Y, et al. Relocalization of apoptosis-inducing factor in photoreceptor apoptosis induced by retinal detachment in vivo. Am J Pathol 2001; 158: 1271-1278.
14. Rehen SK, Ary-Pires R, Linden R. Intraretinal neurotrophic activity prevents the degeneration of ganglion cells in retinal explants. Braz J Med Biol Res 1993; 26: 955-959.
15. Rabacchi SA, Bonfanti L, Liu XH, Maffei L. Apoptotic cell death induced by optic nerve lesion in the neonatal rat. J Neurosci 1994; 14: 5292-5301.
16. Rehen SK, Neves DD, Fragel-Madeira L, Britto LR, Linden R. Selective sensitivity of early postmitotic retinal cells to apoptosis induced by inhibition of protein synthesis. Eur J Neurosci 1999; 11: 4349-4356.
17. Ary-Pires R, Nakatani M, Rehen SK, Linden R. Developmen-tally regulated release of intraretinal neurotrophic factors in vitro. Int J Dev Neurosci 1997; 15: 239-255.
18. Geiger LK, Kortuem KR, Alexejun C, Levin LA. Reduced re-dox state allows prolonged survival of axotomized neonatal retinal ganglion cells. Neuroscience 2002; 109: 635-642.
19. Bonfanti L, Strettoi E, Chierzi S, Cenni MC, Liu XH, Martinou J-C, et al. Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2. J Neurosci 1996; 16: 4186-4194.
20. McKernan DP, Caplis C, Donovan M, O'Brien CJ, Cotter TG. Age-dependent susceptibility of the retinal ganglion cell layer to cell death. Invest Ophthalmol Vis Sci 2006; 47: 807-814.
21. Spalding KL, Dharmarajan AM, Harvey AR. Caspase-independent retinal ganglion cell death after target ablation in the neonatal rat. Eur J Neurosci 2005; 21: 33-45.
22. Assuncao GC, Linden R. Programmed cell deaths. Apopto-sis and alternative deathstyles. Eur J Biochem 2004; 271: 1638-1650.
23. Tait SW, Green DR. Caspase-independent cell death: leaving the set without the fnal cut. Oncogene 2008; 27: 6452-6461.
24. Moriya M, Baker BN, Williams T P. Progression and reversibility of early light-induced alterations in rat retinal rods. Cell Tissue Res 1986; 246: 607-621.
25. White KE, Davies VJ, Hogan VE, Piechota MJ, Nichols PP, Turnbull DM, et al. OPA1 defciency associated with increased autophagy in retinal ganglion cells in a murine model of dominant optic atrophy. Invest Ophthalmol Vis Sci 2009; 50: 2567-2571.
26. Kim SH, Munemasa Y, Kwong JM, Ahn JH, Mareninov S, Gordon LK, et al. Activation of autophagy in retinal ganglion cells. J Neurosci Res 2008; 86: 2943-2951.
27. Cusato K, Stagg SB, Reese BE. Two phases of increased cell death in the inner retina following early elimination of the ganglion cell population. J Comp Neurol 2001; 439: 440-449.
28. de Araujo EG, Linden R. Trophic factors produced by retinal cells increase the survival of retinal ganglion cells in vitro. Eur J Neurosci 1993; 5: 1181-1188.
29. Guimaraes CA, Benchimol M, Amarante-Mendes GP, Linden R. Alternative programs of cell death in developing retinal tissue. J Biol Chem 2003; 278: 41938-41946.
30. Petersen A, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P, et al. Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-medi-ated striatal neuron autophagy and degeneration. Hum Mol Genet 2001; 10: 1243-1254.
31. Reme CE, Wolfrum U, Imsand C, Hafezi F, Williams T P. Pho-toreceptor autophagy: effects of light history on number and opsin content of degradative vacuoles. Invest Ophthalmol Vis Sci 1999; 40: 2398-2404.
32. Boellaard JW, Kao M, Schlote W, Diringer H. Neuronal autophagy in experimental scrapie. Acta Neuropathol 1991; 82: 225-228.
33. Cataldo AM, Hamilton DJ, Barnett JL, Paskevich PA, Nixon RA. Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. J Neurosci 1996; 16: 186-199.
34. Anglade P, Vyas S, Javoy-Agid F, Herrero MT, Michel P P, Marquez J, et al. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol Histopathol 1997; 12: 25-31.
35. Stefanis L, Larsen KE, Rideout HJ, Sulzer D, Greene LA. Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and au-tophagic cell death. J Neurosci 2001; 21: 9549-9560.
36. Bauvy C, Gane P, Arico S, Codogno P, Ogier-Denis E. Autophagy delays sulindac sulfde-induced apoptosis in the human intestinal colon cancer cell line HT-29. Exp Cell Res 2001; 268: 139-149.
37. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, et al. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta 1998; 1366: 177-196.
38. Xue L, Fletcher GC, Tolkovsky AM. Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis. Curr Biol 2001; 11: 361-365.
39. Tolkovsky AM, Xue L, Fletcher GC, Borutaite V. Mitochondri-al disappearance from cells: a clue to the role of autophagy in programmed cell death and disease? Biochimie 2002; 84: 233-240.