Immunotoxicity of zearalenone in Balb/c mice in a high subchronic dosing study counteracted by Raphanus sativus extract

Immunopharmacology and Immunotoxicology

Volumn 32, Issue 4, 2010, Pages 628-636

  Salah Abbs, Jalila Ben ^a   Abbès, Samir ^a   Abdel Wahhab, Ma ^b   Oueslati, Ridha ^a  

^a University of Carthage   (Tunisia)

^b NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Antibody; Cytokines; Flavonoids; Hematology; Isothiocyanates; LPS; Radish; Spleen; Zearalenone

Indexed keywords

FLAVONOID; INTERLEUKIN 1BETA; ISOTHIOCYANIC ACID; LIPOPOLYSACCHARIDE; PLANT EXTRACT; RAPHANUS SATIVUS EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZEARALENONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; ATROPHY; BODY WEIGHT; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE RESPONSE; DRUG ISOLATION; ERYTHROCYTE COUNT; FEMALE; FUSAROTOXICOSIS; HISTOPATHOLOGY; IMMUNOTOXICITY; LYMPHOCYTE; LYMPHOID CELL; MOUSE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; RADISH; WEIGHT GAIN;

ADMINISTRATION, ORAL; ANIMAL STRUCTURES; ANIMALS; ANTIBODIES; ANTIBODY FORMATION; BLOOD; BODY WEIGHT; DRINKING; DRUG TOXICITY; EATING; ERYTHROCYTE COUNT; FEMALE; INTERLEUKIN-1BETA; LEUKOCYTE COUNT; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; MORTALITY; ORGAN SIZE; PLANT EXTRACTS; RAPHANUS; SPLEEN; TUMOR NECROSIS FACTOR-ALPHA; VACCINATION; ZEARALENONE;

ANIMALIA; MUS; RAPHANUS SATIVUS;

EID: 78149243215     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923971003660010     Document Type: Article

References (40)

1. Fink-Gremmels, J. Mycotoxins: their implications for human and animal health. Vet. Q. 1999, 21, 115-120.
2. The Commission of the European Communities. Commission recommendation of 17 August 2006: on the presence of deoxyni-valenol, zearalenone, ochratoxin A, T-2 and HT-2 and fumonisin in products intended for animal feeding. Off. J. European Union 2006, L229, 7-9.
3. Abbès, S., Ouanes, Z., ben Salah-Abbès, J., Houas, Z., Oueslati, R., Bacha, H., Othman, O. The protective effect of hydrated sodium calcium aluminosilicate against haematological, biochemical and pathological changes induced by Zearalenone in mice. Toxicon 2006, 47, 567-574.
4. Abbès, S., Salah-Abbès, J.B., Ouanes, Z., Houas, Z., Othman, O., Bacha, H., Abdel-Wahhab, M.A., Oueslati, R. Preventive role of phyllosilicate clay on the Immunological and Biochemical toxicity of zearalenone in Balb/c mice. Int. Immunopharmacol. 2006, 6, 1251-1258.
5. Ben Salah-Abbès, J., Abbès, S., Ouanes, Z., Houas, Z., Abdel-Wahhab, M.A., Bacha, H., Oueslati, R. Tunisian radish extract (Raphanus sativus) ameliorates the antioxidant status and mediates the oxidative stress of Zeralenone in Balb/c mice. J. Appl. Toxicol. 2008a, 28, 6-14.
6. Bondy, G.S., Pestka, J.J. Immunomodulation by fungal toxins. J. Toxicol. Environ. Health. B. Crit. Rev. 2000, 3, 109-143.
7. Marin, M.L., Murtha, J., Dong, W., Pestka, J.J. Effects of mycotoxins on cytokine production and proliferation in EL-4 thymoma cells. J. Toxicol. Environ. Health 1996, 48, 379-396.
8. Newman, D.J., Cragg, G.M., Snader, K.M. Natural products as sources of new drugs over the period 1981-2002. J. Nat. Prod. 2003, 66, 1022-1037.
9. Lee, K.H. Current developments in the discovery and design of new drug candidates from plant natural product leads. J. Nat. Prod. 2004, 67, 273-283.
10. Kapoor, L.D. Handbook of Ayurvedic medicinal plants. 1990;Boca Raton CRC Press.
11. Steinkellner, H., Rabot, S., Freywald, C., Nobis, E., Scharf, G., Chabicovsky, M., Knasmüller, S., Kassie, F. Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens. Mutat. Res. 2001, 480-481, 285-297.
12. Posner, G.H., Cho, C.G., Green, JV., Zhang, Y., Talalay, P. Design and synthesis of bifunctional isothiocyanate analogs of sulforap-hane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes. J. Med. Chem. 1994, 37, 170-176.
13. Ben Salah-Abbès, J., Abbès, S, Mossad, A. Abdel-Wahhab, Ridha Oueslati. In vitro free-radical scavenging, antiplorifilative and anti-zearalenone cytotoxicity effects of 4-(Methylthio)-3-butenyl isothiocyanate from (Tunisian) Raphanus sativus. In press Journal of Pharmacy and pharmacology 2009d.
14. Mithen, R.F., Dekker, M., Verkerk, R., Rabot, S., Johnson, I.T. The nutritional significance, biosynthesis and bioavailability of glucosinolates in human foods. J. Sci. Fd. Agric. 2000, 80, 967-984.
15. Manson, M.M., Ball, H.W., Barrett, M.C., Clark, H.L., Judah, D.J., Williamson, G., Neal, G.E. Mechanism of action of dietary che-moprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism. Carcinogenesis 1997, 18, 1729-1738.
16. Ben Salah-Abbès, J., Abbès, S., Ouanes, Z., Abdel-Wahhab, M.A., Bacha, H., Oueslati, R. Isothiocyanate from the Tunisian radish (Raphanus sativus) prevents genotoxicity of Zearalenone in vivo and in vitro. Mutat. Res. 2009, 677, 59-65.
17. Cuénod, A. Flore de la Tunisie: cryptogames vasculaires, gymnospermes et monocotylédones. Office de ['expérimentation de la vulgarisation agricoles de Tunisie, (1954) p 233-248. 2ème édition Elfarabi Press, Tunis.
18. Wang, L., Burhenne, K., Kristensen, B.K., Rasmussen, S.K. Purification and cloning of a Chinese red radish peroxidase that metabolise pelargonidin and forms a gene family in Brassicaceae. Gene 2004, 343, 323-335.
19. Ben Salah-Abbès, J, Abbès, S, Houas, Z, Abdel-Wahhab, M.A., Oueslati R. Zearalenone induces immunotoxicity in mice: possible protective effects of Radish Extract (Raphanus Sativus). J. Pharma. Pharmacol. 2008b, 60, 1-10.
20. Ben Salah-Abbès, J., Abbès, S., Abdel-Wahhab, M.A., Oueslati, R. Raphanus sativus extract protects against Zearalenone induced reproductive toxicity, oxidative stress and mutagenic alterations in male Balb/c mice. Toxicon 2009, 53, 525-533.
21. Salah-Abbès, J.B., Abbès, S., Haous, Z., Oueslati, R. Raphanus sativus extract prevents and ameliorates zearalenone-induced per-oxidative hepatic damage in Balb/c mice. J. Pharm. Pharmacol. 2009, 61, 1545-1554.
22. Howell, M.V., Taylor, P.W. Determination of aflatoxins, ochratoxin a, and zearalenone in mixed feeds, with detection by thin layer chromatography or high performance liquid chromatography. J. Assoc. Off. Anal. Chem. 1981, 64, 1356-1363.
23. Manolescu, N, Barza, A, Caprarin, H, Sinchievici, B. Ghid de Hematologie a animalelor in crestere intensiva. 2nd ed. Ed. Ceres, 1978;Bucharest, Romania.
24. NTP. Carcinogenicity bioassay of zearalenone in F344/N rats and F6C3F1 mice. National Toxicology Program Technical Reports Series 235. National Toxicology Program. Research Triangle Park, NC, 1982;USA.
25. Pfohl-Leszkowicz, A., Chekir-Ghedira, L., Bacha, H. Genotoxicity of zearalenone, an estrogenic mycotoxin: DNA adduct formation in female mouse tissues. Carcinogenesis 1995, 16, 2315-2320.
26. Ahamed, S., Foster, J.S., Bukovsky, A., Wimalasena, J. Signal transduction through the Ras/Erk pathway is essential for the mycoestrogen zearalenone-induced cell-cycle progression in MCF-7 cells. Mol. Carcinog. 2001, 30, 88-98.
27. Yu, Z., Zhang, L., Wu, D., Liu, F. Anti-apoptotic action of zearalenone in MCF-7 cells. Ecotoxicol. Environ. Saf. 2005, 62, 441-446.
28. FAO Worldwide regulations for mycotoxins in food and feed in 2003. FAO Food and Nutrition paper No. 81. Food and Agriculture Organization of the United Nations, Rome, 2004;Italy.
29. Ghali, F., Hmaissia-khlifa, K, Ghorbel, H, Maaroufi, K, Hedili, A. Incidence of aflatoxins, ochratoxin A and zearalenone in tunisian foods. Food Control 2008, 19, 921-924.
30. Zourgui, L., Colli, E.E., Bouaziz, C., Bacha, H., Hassen, W. Cactus (Opuntia ficus-indica) cladodes prevent oxidative damage induced by the mycotoxin zearalenone in Balb/C mice. Food Chem. Toxicol. 2008, 46, 1817-1824.
31. Conková, E., Laciaková, A., Pástorová, B., Seidel, H., Kovâ, G. The effect of zearalenone on some enzymatic parameters in rabbits. Toxicol. Lett. 2001, 121, 145-149.
32. Kaneko, J.J. Clinical Chemistry of Domestic animals, (4th Ed.), Academic Press, San Diego, 1989;CA.
33. Harvey, R.B., Phillips, T.D., Ellis, J.A., Kubena, L.F., Huff, W.E., Petersen, H.D. Effects on aflatoxin Ml residues in milk by addition of hydrated sodium calcium aluminosilicate to aflatoxin-contaminated diets of dairy cows. Am. J. Vet. Res. 1991, 52, 1556-1559.
34. Fernandez, A., Verde, M.T., Gomez, J., Gascon, M., Ramos, J.J. Changes in the prothrombin time, haematology and serum proteins during experimental aflatoxicosis in hens and broiler chickens. Res. Vet. Sci. 1995, 58, 119-122.
35. Joens, L.A., Pier, A.C., Cutlip, R.C. Effects of aflatoxin consumption on the clinical course of swine dysentery. Am. J. Vet. Res. 1981,42, 1170-1172.
36. Harvey, RB, Kubena, LF, Elissade, MH, Corrier, DE, Phillips, TD. Influence of the antibiotics lincomycin and tylosin on aflatoxicosis when added to aflatoxin-contaminated diets of growing swine J. Vet. Diagn. Invest. 1995, 7, 374-379.
37. de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C.G., deVries, J.E. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 1991, 174, 1209-1220.
38. Moon, E.Y., Rhee, D.K., Pyo, S. In vitro suppressive effect of aflatoxin B1 on murine peritoneal macrophage functions. Toxicology 1999, 133, 171-179.
39. Abbès, S., Ben Salah-Abbès, J., Hetta, M.M., Ibrahim, M., Abdel-Wahhab, M.A., Bacha, H., Oueslati, R. Efficacy of Tunisian montmorillonite for in vitro aflatoxin binding and in vivo amelioration of physiological alterations Appl. Clay. Science. 2008, 42, 151-157.
40. Guerra, J.A., Molina, M.F., Abad, M.J., Villar, A.M., Paulina, B. Inhibition of inducible nitric oxide synthase and cyclooxygen-ase-2 expression by flavonoids isolated from Tanacetum micro-phyllum. Int. Immunopharmacol. 2006, 6, 1723-1728.