Raphanus sativus extract prevents and ameliorates zearalenone-induced peroxidative hepatic damage in Balb/c mice

Journal of Pharmacy and Pharmacology

Volumn 61, Issue 11, 2009, Pages 1545-1554

  Salah Abbès, Jalila Ben ^a   Abbès, Samir ^a   Haous, Zohra ^b   Oueslati, Ridha ^a  

^a University of Carthage   (Tunisia)

^b UNIVERSITY OF MONASTIR   (Tunisia)

Author keywords

Antioxidants; Hepatoprotectant; Hepatotoxicity; Raphanus sativus; Zearalenone

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CATALASE; CHOLESTEROL; DNA; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LACTATE DEHYDROGENASE; LIPID PEROXIDE; MYCOTOXIN; OLIVE OIL; PLANT EXTRACT; PROTEIN; RAPHANUS SATIVUS EXTRACT; RNA; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; URIC ACID; ZEARALENONE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BAGG ALBINO MOUSE; CONTROLLED STUDY; DNA CONTENT; DRUG EFFICACY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIPID PEROXIDATION; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; RADISH; TREATMENT DURATION;

ANIMALS; DNA; DRUG-INDUCED LIVER INJURY; LIPID PEROXIDATION; LIVER; MALE; MICE; MICE, INBRED BALB C; PHYTOTHERAPY; PLANT EXTRACTS; RAPHANUS; RNA; SUPEROXIDES; ZEARALENONE;

EID: 75749135311     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp/61.11.0015     Document Type: Article

References (69)

1. Bennett JW, Klich M. Mycotoxins. Clin Microbiol Rev 2003; 16: 497-516.
2. CCFAC. Codex Committee on Food Additives and Contaminants. Posting date. Joint FAO/WHO Expert Committee on Food Additives: Position paper on zearalenone. Publication CCFAC 00/19. Codex Alimentarius Commission, Rome, Italy, 2000.
3. Hussein HS, Brasel JM. Toxicity, metabolism, and impact of mycotoxins on humans and animals. Toxicology 2001; 167: 101-134.
4. Bilgrami KS, Choudhary AK. Mycotoxins in preharvest contamination of agricultural crops. In: Sinha KK, Bhatnagar D, eds. Mycotoxins, Agriculture, and Food Safety. New York: Marcel Dekker, 1998.
5. Abbès S et al. The protective effect of hydrated sodium calcium aluminosilicate against haematological, biochemical and pathological changes induced by zearalenone in mice. Toxicon 2006; 47: 567-574.
6. Abbès S et al. Preventive role of phyllosilicate clay on the immunological and biochemical toxicity of zearalenone in balb/c mice. Int Immunopharmacol 2006; 6: 1251-1258.
7. Abbès S et al. Preventive role of aluminosilicate clay against induction of micronuclei and chromosome aberrations in bonemarrow cells of Balb/c mice treated with zearalenone. Mutat Res 2007; 631: 85-92.
8. National Toxicology Program USA. Technical report on the Carcinogenesis Bioassay of zearalenone in F 344/N rats and B6C3F1 Mice (Feed Study). Research Triangle Park, NC: NIH publ. No 83, 1982: 1791.
9. Ben Salah-Abbès J et al. Raphanus sativus extract protects against zearalenone induced reproductive toxicity, oxidative stress and mutagenic alterations in male Balb/c mice. Toxicon 2009; 53: 525-533.
10. Tiemann U et al. The effect of feeding a diet naturally contaminated with deoxynivalenol (DON) and zearalenone (ZON) on the spleen and liver of sow and fetus from day 35 to 70 of gestation. Toxicol Lett 2008; 179: 113-117.
11. Pittet A. Natural occurrence of mycotoxins in foods and feeds -an update review. Rev Med Vet 1998; 149: 479-492.
12. Placinta CM et al. A review of worldwide contamination of cereal grains and animal feed with Fusarium mycotoxins. Anim Feed Sci Technol 1999; 78: 21-37.
13. Lombaert GA et al. Mycotoxins in infant cereal foods from the Canadian retail market. Food Addit Contam 2003; 20: 494-504.
14. Ghali R et al. Incidence of aflatoxins, ochratoxin A and zearalenone in tunisian foods. Food Control 2008; 19: 921-924.
15. McKenzie KS et al. Oxidative degradation and detoxification of mycotoxins using a novel source of ozone. Food Chem Toxicol 1997; 35: 807-820.
16. Abd Alla ES. Zearalenone: toxigenic fungi and chemical decontamination in Egyptian cereals. Nahrung 1997; 41: 362-365.
17. Ben Salah-Abbès J et al. Investigation of Tunisian radish extract (Raphanus sativus) as antioxidants and radical scavenging properties against Zeralenone toxicity in Balb/c mice. J Appl Toxicol 2007; 28: 6-14.
18. Takaya Y et al. Antioxidant constituents of radish sprout (Kaiware-Daikon), Raphanus sativus. J Agric Food Chem 2003; 51: 8061-8066.
19. Gill CI et al. The effect of cruciferous and leguminous sprouts on genotoxicity, in vitro and in vivo. Cancer Epidemiol Biomarkers Prev 2004; 13: 1199-1205.
20. Jeffery EH, Jarrell V. Cruciferous vegetables and cancer prevention. In: Wildman REC, ed. Handbook of Nutraceuticals and Functional Foods. Boca Raton, FL: CRC Press, 2001: 169-192.
21. Prestera T et al. The electrophile counterattack response: protection against neoplasia and toxicity. Adv Enzyme Regul 1993; 33: 281-296.
22. Suh SJ et al. Raphanus sativus and its isothiocyanates inhibit vascular smooth muscle cells proliferation and induce G1 cell cycle. Phytother Res Arrest 2006; 6: 854-861.
23. Hashimoto T et al. Effect of combined administration of quercetin, rutin, and extract of white radish sprout rich in kaempherol glucosides on the metabolism in rats. Biosci Adv Biochem Eng Biotechnol 2006; 70: 279-281.
24. Ben Salah-Abbès J et al. Zearalenone induces immunotoxicity in mice: possible protective effects of Radish extract (Raphanus sativus). J Pharm Pharmacol 2008; 60: 1-10.
25. Cuénod A. Flore de la Tunisie: cryptogames vasculaires, gymnospermes et monocotylédones. Office de l'expérimentation de la vulgarisation agricoles de Tunisie, 2ème édition. Tunis: Elfarabi Press, 1954: 233-248.
26. Wang L et al. Purification and cloning of a Chinese red radish peroxidase that metabolises pelargonidin and forms a gene family in Brassicaceae. Gene 2004; 343: 323-335.
27. Tona L et al. Antiamoebic and phytochemical screening of some congolese medical plants. J Ethnopharmacol 1998; 61: 57-65.
28. Ohinishi M et al. Inhibitory effects of chlorogenic acids on linoleic acid peroxidation and haemolysis. Phytochemistry 1994; 36: 579-583.
29. Litchfield JT, Wilcoxon F. A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 1949; 96: 99-113.
30. Siddhurrajir P et al. Studies on the antioxidant activity of Indian laburnum (Cassia fistula L.): a preliminary assessment of crude extracts from stem bark, leaves, flowers and fruit pulp. Food Chem 2002; 79: 61-67.
31. Organisation for Economic Co-operation and Development (OECD) Test no. 474: mammalian erythrocyte micronucleus test. Guideline for the Testing of Chemicals. Paris: OECD Publishing, 21 July 1997.
32. Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972; 47: 389-394.
33. Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974; 47: 469-474.
34. Rotruck JT et al. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973; 179: 588-590.
35. Staal GE et al. Purification and properties of glutathione reductase of human erythrocytes. Biochim Biophys Acta 1969; 185: 39-48.
36. Habig WH et al. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974; 249: 7130-7139.
37. Moron MS et al. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta 1979; 582: 67-78.
38. Beutler E. Active transport of glutathione disulfide from erythrocytes. In: Larson A et al. eds. Functions of Glutathione-Biochemical, Physiological, Toxicological and Clinical Aspects. New York: Raven Press, 1983: 65.
39. Sambrook KJ et al. Extraction and isolation of nucleic acids (DNA and RNA) from mammalian cells. In: Sambrook J et al. eds. Molecular Cloning. A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press; 1989: 15-45.
40. Durton K. The conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J 1956; 62: 315-318.
41. FAO/WHO. Expert Committee on Food Additives. Evaluation of certain mycotoxins in food. Fifty-sixth report of the Joint World Health Organ. Tech Rep Ser (906) i-viii, 2002: 1-62.
42. Labuda R et al. Incidence of trichothecenes and zearalenone in poultry feed mixtures from Slovakia. Int J Food Microbiol 2005; 105: 19-25.
43. Schollenberger M et al. Natural occurrence of 16 Fusarium toxins in grains and feedstuffs of plant origin from Germany. Mycopathologia 2006; 161: 43-52.
44. Abid-Essefi S et al. DNA fragmentation, apoptosis and cell cycle arrest induced by zearalenone in cultured DOK, Vero and Caco-2 cells: prevention by Vitamin E. Toxicology 2003; 192: 237-248.
45. Tomaszewski J et al. Tissue zearalenone concentration in normal, hyperplastic and neoplastic human endometrium. Ginekol Pol 1998; 69: 363-366.
46. Li X, Kushad MM. Correlation of glucosinolate content to myrosinase activity in horseradish (Armoracia rusticana). J Agric Food Chem 2004; 52: 6950-6955.
47. Kim HJ et al. Effect of methyl jasmonate on phenolics, isothiocyanate, and metabolic enzymes in radish sprout (Raphanus sativus L.). J Agric Food Chem 2006; 54: 7263-7269.
48. Shon YH, Nam KS. Protective effect of Moutan Cortex extract on acetaminophen-induced hepatotoxicity in mice. J Ethnopharmacol 2004; 90: 415-419.
49. Samapundo S et al. Interaction of water activity and bicarbonate salts in the inhibition of growth and mycotoxin production by Fusarium and Aspergillus species of importance to corn. Int J Food Microbiol 2007; 116: 266-274.
50. Wong SH et al. The adaptive changes of dietary fish and safflower oil on lipid and lipoprotein metabolism in perfused rat liver. Biochim Biophys Acta 1984; 792: 103-109.
51. Harris WS. Fish oils and plasma lipids and lipoprotein metabolism in humans: a critical review. J Lipid Res 1989; 30: 785-807.
52. Kaneko JJ. Clinical Chemistry of Domestic Animals, 4th edn. San Diego, CA: Academic Press, 1989.
53. Homolka J. Clinic Biochemistry. Prague, Czech: SZN, 1969: 434.
54. Horejsi J et al. Basis Biochemistry of Clinic Biochemistry in Internal Medicine, 4th edn. Prague, Czech: Avicenum, 1989: 724.
55. Conkova E et al. The effect of zearalenone on some enzymatic parameters in rabbits. Toxicol Lett 2001; 121: 145-149.
56. Niki E et al. Lipid peroxidation: mechanisms, inhibition, and biological effects. Biochem Biophys Res Commun 2005; 338: 668-676.
57. Zourgui L et al. Cactus (Opuntia ficus-indica) cladodes prevent oxidative damage induced by the mycotoxin zearalenone in Balb/C mice. Food Chem Toxicol 2008; 46: 1817-1824.
58. Janssen YM et al. Cell and tissue responses to oxidative damage. Lab Invest 1993; 69: 261-274.
59. Raney KD et al. Glutathione conjugation of aflatoxin B1 exo-and endo-epoxides by rat and human glutathione S-transferases. Chem Res Toxicol 1992; 5: 470-478.
60. Johnson F, Giulivi C. Superoxide dismutases and their impact upon human health. Mol Aspects Med 2005; 26: 340-352.
61. Roebuck BD, Maxuitenko YY. Biochemical mechanisms and biological implications of aflatoxins as related to aflatoxin carcinogenesis. In: Eaton DL, Groopman JD, eds. The Toxicology of Aflatoxins: Human Health, Veterinary, and Agricultural Significance. Boston: Academic Press, 1994: 27-43.
62. Jaeschke H. Mechanisms of oxidant stress-induced acute tissue injury. Proc Soc Exp Biol Med 1995; 209: 104-111.
63. Liu S et al. Design, synthesis, and anti-tumor activity of (2-O-alkyloxime-3-phenyl)-propionyl-1-O-acetyl britannil actone esters. Bioorg Med Chem 2005; 13: 2783-2789.
64. Sunitha S et al. Hepatoprotective effect of lupeol and lupeol linoleate on tissue antioxidant defence system in cadmium-induced hepatotoxicity in rats. Fitoterapia 2001; 72: 516-523.
65. Kouadio J et al. Effects of combinations of Fusarium mycotoxins on the inhibition of macromolecular synthesis, malondialdehyde levels, DNA methylation and fragmentation, and viability in Caco-2 cells. Toxicon 2007; 49: 306-317.
66. Barillari J et al. Isolation of 4-methylthio-3-butenyl glucosinolate from Raphanus sativus L. sprouts (Kaiware-Daikon) and its redox properties. J Agric Food Chem 2005; 53: 9890-9896.
67. Shklar G. Mechanisms of cancer inhibition by antioxidant nutrients. Oral Oncol 1998; 34: 24-29.
68. Chance B et al. Hydroperoxide metabolism in mammalian organs. Phys Rev 1979; 59: 527-605.
69. Halliwell B. Free radicals, antioxidants, and human diseases: curiosity, cause or consequence? Lancet 1994; 344: 721-724.