Immunomodulatory effects of rosuvastatin on hepatic ischemia/reperfusion induced injury

Immunopharmacology and Immunotoxicology

Volumn 32, Issue 4, 2010, Pages 555-561

  Awad, Azza S ^a   Sharif, Amany El ^a  

^a Al Azhar University   (Egypt)

Author keywords

Cytokines; Immunomodulation; Ischemia reperfusion; Liver; Rosuvastatin

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; ROSUVASTATIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; IMMUNOMODULATION; LIVER ISCHEMIA; MALE; MULTIPLE ORGAN FAILURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; TISSUE LEVEL;

ANIMALS; BLOOD; CHEMOKINE CCL2; FLUOROBENZENES; HEART; IMMUNOLOGIC FACTORS; INTERLEUKIN-10; INTERLEUKIN-6; INTESTINES; KIDNEY; LIVER; LUNG; MALE; MULTIPLE ORGAN FAILURE; MYOCARDIUM; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SULFONAMIDES; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 78149239357     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923970903575716     Document Type: Article

References (40)

1. Han, J.Y., Fan, J.Y., Horie, Y., Miura, S., Cui, D.H., Ishii, H., Hibi, T., Tsuneki, H., Kimura, I. Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion. Pharmacol. Ther. 2008, 117, 280-295.
2. Jiang, H., Meng, F., Li, W., Tong, L., Qiao, H., Sun, X. Splenectomy ameliorates acute multiple organ damage induced by liver warm ischemia reperfusion in rats. Surgery 2007, 141, 32-40.
3. Shin, T., Kuboki, S., Huber, N., Eismann, T., Galloway, E., Schuster, R., Blanchard, J., Pritts, T.A., Lentsch, A.B. Activation of peroxisome proliferator-activated receptor-gamma during hepatic ischemia is age-dependent. J. Surg. Res. 2008, 147, 200-205.
4. van Gulik, T.M., de Graaf, W., Dinant, S., Busch, O.R., Gouma, D.J. Vascular occlusion techniques during liver resection. Dig. Surg. 2007,24,274-281.
5. He, X.S., Ma, Y., Wu, L.W., Wu, J.L., Hu, R.D., Chen, G.H., Huang, J.F. Dynamical changing patterns of glycogen and enzyme histochemical activities in rat liver graft undergoing warm ischemia injury. World J. Gastroenterol. 2005, 11, 2662-2665.
6. Lentsch, A.B., Kato, A., Yoshidome, H., McMasters, K.M., Edwards, M.J. Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury. Hepatology 2000, 32, 169-173.
7. Liu, T.Z., Lee, K.T., Chern, C.L., Cheng, J.T., Stern, A., Tsai, L.Y. Free radical-triggered hepatic injury of experimental obstructive jaundice of rats involves overproduction of proinflammatory cytokines and enhanced activation of nuclear factor kappaB. Ann. Clin. Lab. Sci. 2001, 31, 383-390.
8. Jaeschke, H. Reactive oxygen and mechanisms of inflammatory liver injury. J. Gastroenterol. Hepatol. 2000, 15, 718-724.
9. Weiss, S.J. Tissue destruction by neutrophils. N. Engl. J. Med. 1989, 320, 365-376.
10. Shao, H., Shen, Y., Liu, H., Dong, G., Qiang, J., Jing, H. Simvastatin suppresses lung inflammatory response in a rat cardiopulmonary bypass model. Ann. Thorac. Surg. 2007, 84, 2011-2018.
11. Manzoni, M., Rollini, M. Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs. Appl. Microbiol. Biotechnol. 2002, 58, 555-564.
12. Kwak, B., Mulhaupt, F., Myit, S., Mach, F. Statins as a newly recognized type of immunomodulator. Nat. Med. 2000, 6, 1399-1402.
13. Case, C.C., Ballantyne, C.M. Statins and inflammatory markers. Curr. Atheroscler. Rep. 2002, 4, 42-47.
14. Ikeda, Y., Young, L.H., Lefer, A.M. Rosuvastatin, a new HMG-CoA reductase inhibitor, protects ischemic reperfused myocardium in normocholesterolemic rats. J. Cardiovasc. Pharmacol. 2003, 41, 649-656.
15. Bulhak, A., Sjoquist, P., Pernow, J. Rosuvastatin protects the myocardium against ischaemia-reperfusion injury via inhibition of GGPP synthesis. Cardiovasc. J. S. Afr. 2004, 15, S11.
16. Weinberg, E.O., Scherrer-Crosbie, M., Picard, M.H., Nasseri, B.A., MacGillivray, C., Gannon, J., Lian, Q., Bloch, K.D., Lee, R.T. Rosuvastatin reduces experimental left ventricular infarct size after ischemia-reperfusion injury but not total coronary occlusion. Am. J. Physiol. Heart Circ. Physiol. 2005, 288, H1802-H1809.
17. Bulhak, A.A., Gourine, A.V., Gonon, A.T., Sjöquist, P.O., Valen, G., Pernow, J. Oral pre-treatment with rosuvastatin protects porcine myocardium from ischaemia/reperfusion injury via a mechanism related to nitric oxide but not to serum cholesterol level. Acta Physiol. Scand. 2005, 183, 151-159.
18. Di Napoli, P., Taccardi, A.A., Grilli, A., De Lutiis, M.A., Barsotti, A., Felaco, M., De Caterina, R. Chronic treatment with rosuvastatin modulates nitric oxide synthase expression and reduces ischemia-reperfusion injury in rat hearts. Cardiovasc. Res. 2005, 66, 462-471.
19. Dibazar, F., Hajipour, B., Hosseinian, M.M., Hemmati, M.R., Ghandiha, A. Simvastatin decreases hepatic ischaemia/reperfusion-induced liver and lung injury in rats. Folia Morphol. (Warsz) 2008, 67, 231-235.
20. Bouali, S., Evrard, A., Chastanet, M., Lesch, K.P., Hamon, M., Adrien, J. Sex hormone-dependent desensitization of 5-HT1A autoreceptors in knockout mice deficient in the 5-HT transporter. Eur. J. Neurosci. 2003, 18, 2203-2212.
21. Lukivskaya, O., Knas, M., Dudzik, D., Borzym-Kluczyk, M., Lis, R., Buko, V., Zwierz, K. Effects of statins on liver fibrosis reversibility and activities of lysosomal exoglycosidases E&C. Hepatology 2007, 3, 14-17.
22. Jaeschke, H., Farhood, A. Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver. Am. J. Physiol. 1991, 260, G355-G362.
23. McGown, C.C., Brookes, Z.L. Beneficial effects of statins on the microcirculation during sepsis: the role of nitric oxide. Br. J. Anaesth. 2007, 98, 163-175.
24. Locksley, R.M., Killeen, N., Lenardo, M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 2001, 104, 487-501.
25. Ishihara, K., Hirano, T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 2003, 13, 357-368.
26. Chello, M., Patti, G., Candura, D., Mastrobuoni, S., Di Sciascio, G., Agrò, F., Carassiti, M., Covino, E. Effects of atorvastatin on systemic inflammatory response after coronary bypass surgery. Crit. Care Med. 2006, 34, 660-667.
27. Souza Neto, J.L., Araújo Filho, I., Rego, A.C., Dominici, V.A., Azevedo, I.M., Egito, E.S., Brandão-Neto, J., Medeiros, A.C. Effects of simvastatin in abdominal sepsis in rats. Acta Cir. Bras. 2006, 21(Suppl. 4), 8-12.
28. Almeida, J.L., Sampietre, S.N., Mendonça Coelho, A.M., Trindade Molan, N.A., Machado, M.C., Monteiro da Cunha, J.E., Jukemura, J. Statin pretreatment in experimental acute pancreatitis. JOP 2008, 9, 431-439.
29. Li, W., Asagami, T., Matsushita, H., Lee, K.H., Tsao, P.S. Rosuvastatin attenuates monocyte-endothelial cell interactions and vascular free radical production in hypercholesterolemic mice. J. Pharmacol. Exp. Ther. 2005, 313, 557-562.
30. Weber, C., Schober, A., Zernecke, A. Chemokines: key regulators of mononuclear cell recruitment in atherosclerotic vascular disease. Arterioscler. Thromb. Vasc. Biol. 2004, 24, 1997-2008.
31. Sironi, L., Gianazza, E., Gelosa, P., Guerrini, U., Nobili, E., Gianella, A., Cremonesi, B., Paoletti, R., Tremoli, E. Rosuvastatin, but not simvastatin, provides end-organ protection in stroke-prone rats by antiinflammatory effects. Arterioscler. Thromb. Vasc. Biol. 2005, 25, 598-603.
32. de Mendonça-Filho, H.T., Pereira, K.C., Fontes, M., Vieira, D.A., de Mendonça, M.L., Campos, L.A., Castro-Faria-Neto, H.C. Circulating inflammatory mediators and organ dysfunction after cardiovascular surgery with cardiopulmonary bypass: a prospective observational study. Crit. Care 2006, 10, R46.
33. Eskdale, J., Kube, D., Tesch, H., Gallagher, G. Mapping of the human IL10 gene and further characterization of the 5' flanking sequence. Immunogenetics 1997, 46, 120-128.
34. Wang, Q., Fang, C.H., Hasselgren, P.O. Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001, 281, R1013-R1023.
35. Grimbaldeston, M.A., Nakae, S., Kalesnikoff, J., Tsai, M., Galli, S.J. Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Nat. Immunol. 2007, 8, 1095-1104.
36. Zhang, J., Cheng, X., Liao, Y., Lu, B., Yang, B., Ge, H., Wang, M., Liu, Y, Guo, Z., Zhang, L. Simvastatin regulates myocardial cytokine expression and improves ventricular remodeling in rats after acute myocardial infarction. Cardiovasc. Drugs Ther. 2005, 19, 13-21.
37. Karupiah, C. Cytokines and chemokines in infectious diseases handbook [Book Reviews]. Immunol. Cell Biol. 2003, 81, 496-498.
38. Palinski, W., Tsimikas, S. Immunomodulatory effects of statins: mechanisms and potential impact on arteriosclerosis. J. Am. Soc. Nephrol. 2002, 13, 1673-1681.
39. Van Laethem, J.L., Eskinazi, F., Louis, H., Rickaert, F., Robberecht, P., Devière, J. Multisystemic production of interleukin 10 limits the severity of acute pancreatitis in mice. Gut 1998, 43, 408-413.
40. Steffens, S., Mach, F. Drug insight: immunomodulatory effects of statins - potential benefits for renal patients? Nat. Clin. Pract. Nephrol. 2006, 2, 378-387.