The N domain of human angiotensin-I-converting enzyme: The role of N-glycosylation and the crystal structure in complex with an N domain-specific phosphinic inhibitor, RXP407

Journal of Biological Chemistry

Volumn 285, Issue 46, 2010, Pages 35685-35693

  Anthony, Colin S ^a   Corradi, Hazel R ^b   Schwager, Sylva L U ^a   Redelinghuys, Pierre ^c   Georgiadis, Dimitris ^d   Dive, Vincent ^e   Acharya, K Ravi ^b   Sturrock, Edward D ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b University of Bath   (United Kingdom)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

^d UNIVERSITY OF ATHENS   (Greece)

^e SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BREATHING MOTIONS; C-DOMAIN; CHO CELL; CONVERTING ENZYME; DEGLYCOSYLATION; DOMAIN SPECIFIC; ENZYMATIC ACTIVITIES; GLYCOSYLATED; LIMITED PROTEOLYSIS; N-GLYCOSYLATION; N-LINKED GLYCANS; N-TERMINALS; SITE DIRECTED MUTAGENESIS; STRUCTURAL STUDIES; SUBSTRATE BINDING; SURFACE GLYCOSYLATION; TERMINAL SITE; THERMAL STABILITY; TWO DOMAINS;

BLOOD PRESSURE; CRYSTALLIZATION; ENZYMES; ESTERIFICATION; GLYCOSYLATION; LAWS AND LEGISLATION; MASS SPECTROMETRY; THERMODYNAMIC STABILITY;

CRYSTAL STRUCTURE;

DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PHOSPHINIC ACID DERIVATIVE; RXP 407; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHO CELL; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG PROTEIN BINDING; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME GLYCOSYLATION; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; THERMOSTABILITY;

ANIMALS; BINDING SITES; BIOCATALYSIS; BLOTTING, WESTERN; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; GLYCOSYLATION; HUMANS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; OLIGOPEPTIDES; PEPTIDYL-DIPEPTIDASE A; PHOSPHINIC ACIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TEMPERATURE;

EID: 78149236201     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.167866     Document Type: Article

References (37)

1. Junot, C., Gonzales, M. F., Ezan, E., Cotton, J., Vazeux, G., Michaud, A., Azizi, M., Vassiliou, S., Yiotakis, A., Corvol, P., and Dive, V. (2001) J. Pharmacol. Exp. Ther. 297, 606-611
2. Fuchs, S., Xiao, H. D., Hubert, C., Michaud, A., Campbell, D. J., Adams, J. W., Capecchi, M. R., Corvol, P., and Bernstein, K. E. (2008) Hypertension 51, 267-274
3. Jaspard, E., Wei, L., and Alhenc-Gelas, F. (1993) J. Biol. Chem. 268, 9496-9503
4. Rousseau, A., Michaud, A., Chauvet, M. T., Lenfant, M., and Corvol, P. (1995) J. Biol. Chem. 270, 3656-3661
5. Sharma, U., Rhaleb, N. E., Pokharel, S., Harding, P., Rasoul, S., Peng, H., and Carretero, O. A. (2008) Am. J. Physiol. Heart Circ. Physiol. 294, H1226-H1232
6. Peng, H., Carretero, O. A., Liao, T. D., Peterson, E. L., and Rhaleb, N. E. (2007) Hypertension 49, 695-703
7. Dive, V., Cotton, J., Yiotakis, A., Michaud, A., Vassiliou, S., Jiracek, J., Vazeux, G., Chauvet, M. T., Cuniasse, P., and Corvol, P. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 4330-4335
8. Kröger, W. L., Douglas, R. G., O'Neill, H. G., Dive, V., and Sturrock, E. D. (2009) Biochemistry 48, 8405-8412
9. Yu, X. C., Sturrock, E. D., Wu, Z., Biemann, K., Ehlers, M. R., and Riordan, J. F. (1997) J. Biol. Chem. 272, 3511-3519
10. O'Neill, H. G., Redelinghuys, P., Schwager, S. L., and Sturrock, E. D. (2008) Biol. Chem. 389, 1153-1161
11. Hammond, C., Braakman, I., and Helenius, A. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 913-917
12. Helenius, A., and Aebi, M. (2004) Annu. Rev. Biochem. 73, 1019-1049
13. Sadhukhan, R., and Sen, I. (1996) J. Biol. Chem. 271, 6429-6434
14. Voronov, S., Zueva, N., Orlov, V., Arutyunyan, A., and Kost, O. (2002) FEBS Lett. 522, 77-82
15. Corradi, H. R., Schwager, S. L., Nchinda, A. T., Sturrock, E. D., and Acharya, K. R. (2006) J. Mol. Biol. 357, 964-974
16. Ehlers, M. R., Chen, Y. N., and Riordan, J. F. (1991) Protein Expr. Purif. 2, 1-9
17. Deddish, P. A., Wang, J., Michel, B., Morris, P. W., Davidson, N. O., Skidgel, R. A., and Erdös, E. G. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 7807-7811
18. Kost, O. A., Balyasnikova, I. V., Chemodanova, E. E., Nikolskaya, I. I., Albrecht, R. F., 2nd, and Danilov, S. M. (2003) Biochemistry 42, 6965-6976
19. Papworth, C., Bauer, J. C., Braman, J., and Wright, D. A. (1996) Strategies 9, 3-4
20. Friedland, J., and Silverstein, E. (1976) Am. J. Clin. Pathol. 66, 416-424
21. Schwager, S. L., Carmona, A. K., and Sturrock, E. D. (2006) Nat. Protoc. 1, 1961-1964
22. Gordon, K., Redelinghuys, P., Schwager, S. L., Ehlers, M. R., Papageorgiou, A. C., Natesh, R., Acharya, K. R., and Sturrock, E. D. (2003) Biochem. J. 371, 437-442
23. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
24. Collaborative Computational Project 4 (1994) Acta Crystallogr. D Biol. Crystallogr. 50, 760-763
25. McCoy, A. J., Grosse-Kunstleve, R. W., Adams, P. D., Winn, M. D., Storoni, L. C., and Read, R. J. (2007) J. Appl. Crystallogr. 40, 658-674
26. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta Crystallogr. D Biol. Crystallogr. 53, 240-255
27. Brünger, A. T. (1992) Nature 355, 472-475
28. Emsley, P., and Cowtan, K. (2004) Acta Crystallogr. D Biol. Crystallogr. 60, 2126-2132
29. Davis, I. W., Leaver-Fay, A., Chen, V. B., Block, J. N., Kapral, G. J., Wang, X., Murray, L. W., Arendall, W. B., 3rd, Snoeyink, J., Richardson, J. S., and Richardson, D. C. (2007) Nucleic Acids Res. 35, W375-W383
30. Schüttelkopf, A. W., and van Aalten, D. M. (2004) Acta Crystallogr. D Biol. Crystallogr. 60, 1355-1363
31. Painter, J., and Merritt, E. A. (2006) Acta Crystallogr. D Biol. Crystallogr. 62, 439-450
32. McDonald, I. K., and Thornton, J. M. (1994) J. Mol. Biol. 238, 777-793
33. Krissinel, E., and Henrick, K. (2007) J. Mol. Biol. 372, 774-797
34. Watermeyer, J. M., Sewell, B. T., Schwager, S. L., Natesh, R., Corradi, H. R., Acharya, K. R., and Sturrock, E. D. (2006) Biochemistry 45, 12654-12663
35. Eyal, E., Yang, L. W., and Bahar, I. (2006) Bioinformatics 22, 2619-2627
36. Hayward, S., Kitao, A., and Berendsen, H. J. (1997) Proteins 27, 425-437
37. Akif, M., Georgiadis, D., Mahajan, A., Dive, V., Sturrock, E. D., Isaac, R. E., and Acharya, K. R. (2010) J. Mol. Biol. 400, 502-517