Bone micro-architecture and determinants of strength in the radius and tibia: Age-related changes in a population-based study of normal adults measured with high-resolution pQCT

Osteoporosis International

Volumn 20, Issue 10, 2009, Pages 1683-1694

  Dalzell, N ^a,b   Kaptoge, S ^a   Morris, N ^c   Berthier, A ^d   Koller, B ^e   Braak, L ^d   Van Rietbergen, B ^f   Reeve, J ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c Hethersett Surgery   (United Kingdom)

^d MEDES   (France)

^e Scanco ^*  (Switzerland)

^f EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

Bone quality; Bone structure; Finite element analysis; Micro architecture; Normal ranges; Osteoporosis; PQCT; XtremeCT

Indexed keywords

ADULT; AGE; AGED; AGING; ARTICLE; BONE DENSITY; BONE STRENGTH; BONE STRUCTURE; COMPUTER ASSISTED TOMOGRAPHY; CORTICAL BONE; CROSS-SECTIONAL STUDY; FEMALE; HIP FRACTURE; HUMAN; HUMAN EXPERIMENT; LINEAR REGRESSION ANALYSIS; MALE; NORMAL HUMAN; PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY; PRIORITY JOURNAL; RADIUS; SEX DIFFERENCE; TIBIA; TRABECULAR BONE; WRIST;

ABSORPTIOMETRY, PHOTON; ADULT; AGED; AGING; EPIDEMIOLOGIC METHODS; FEMALE; HUMANS; MALE; MIDDLE AGED; RADIUS; REFERENCE VALUES; SEX CHARACTERISTICS; TIBIA; TOMOGRAPHY, X-RAY COMPUTED; YOUNG ADULT;

EID: 69949148444     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-008-0833-6     Document Type: Article

References (31)

1. H Sievanen P Kannus TL Jarvinen 2007 Bone quality: an empty term PLoS Med 4 3 e27
2. A Laib HJ Hauselmann P Ruegsegger 1998 In vivo high resolution 3D-QCT of the human forearm Technol Health Care 6 5-6 329 337
3. CM Bagi N Hanson C Andresen R Pero R Lariviere CH Turner, et al. 2006 The use of micro-CT to evaluate cortical bone geometry and strength in nude rats: correlation with mechanical testing, pQCT and DXA Bone 38 1 136 144 Epub 2005 Nov 18
4. FW Wehrli 2007 Structural and functional assessment of trabecular and cortical bone by micro magnetic resonance imaging J Magn Reson Imaging 25 2 390 409
5. S Khosla BL Riggs EJ Atkinson AL Oberg LJ [tmp] McDaniel M Holets, et al. 2006 Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment J Bone Miner Res 21 1 124 131 Epub 2005 Oct 3
6. TW O'Neill C Cooper D Algra HAP Pols D Agnusdei J Dequeker, et al. 1995 Design and development of a questionnaire for use in a multicentre study of vertebral osteoporosis in Europe: The European Vertebral Osteoporosis Study (EVOS) Rheumatology in Europe 24 2 75 81
7. L Vico M Zouch A Amirouche D Frere N Laroche B Koller, et al. 2008 High-resolution peripheral quantitative computed tomography analysis at the distal radius and tibia discriminates patients with recent wrist and femoral neck fractures J Bone Miner Res 23 11 1741 1750
8. SK Kaptoge N Dalzell N Loveridge TJ Beck K-T Khaw J Reeve 2003 Effects of gender, anthropometric variables and aging on the evolution of hip strength in men and women aged over 65 Bone 32 5 561 570
9. S Boutroy B Van Rietbergen E Sornay-Rendu F Munoz ML Bouxsein PD Delmas 2008 Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women J Bone Miner Res 23 3 392 399
10. W Pistoia B van Rietbergen EM Lochmuller CA Lill F Eckstein P Ruegsegger 2004 Image-based micro-finite-element modeling for improved distal radius strength diagnosis: moving from bench to bedside J Clin Densitom 7 2 153 160
11. HR Buie GM Campbell RJ Klinck JA [tmp] MacNeil SK Boyd 2007 Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis Bone 41 4 505 515 Epub 2007 Jul 18
12. W Pistoia B van Rietbergen EM Lochmuller CA Lill F Eckstein P Ruegsegger 2002 Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images Bone 30 6 842 848
13. J Chiu SN Robinovitch 1998 Prediction of upper extremity impact forces during falls on the outstretched hand J Biomech 31 12 1169 1176
14. LJ Melton 3rd BL Riggs GH van Lenthe SJ Achenbach R Muller ML Bouxsein, et al. 2007 Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal women J Bone Miner Res 22 9 1442 1448
15. BL Riggs LJ Melton 3rd RA Robb JJ Camp EJ Atkinson AL Oberg, et al. 2006 Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures J Bone Miner Res 21 2 315 323 Epub 2005 Oct 31
16. TM Keaveny ML Bouxsein 2008 Theoretical implications of the biomechanical fracture threshold J Bone Miner Res 23 10 1541 1547
17. WA Kalender D Felsenberg HK Genant M Fischer J Dequeker J Reeve 1995 The European Spine Phantom-a tool for standardization and quality control in spinal bone mineral measurements by DXA and QCT Eur J Radiol 20 83 92
18. MB Brown B Forsythe 1974 Robust tests for the equality of variances J Am Stat Assoc 69 346 364 367
19. G Holt KT Khaw DM Reid JE Compston A Bhalla AD Woolf, et al. 2002 Prevalence of osteoporotic bone mineral density at the hip in Britain differs substantially from the US over 50 years of age: implications for clinical densitometry Br J Radiol 75 736 742
20. KL Bell N Loveridge J Power N Garrahan M Stanton M Lunt, et al. 1999 Structure of the femoral neck in hip fracture: cortical bone loss in the inferoanterior to superoposterior axis J Bone Miner Res 14 1 111 119
21. PM Mayhew CD Thomas JG Clement N Loveridge TJ Beck W Bonfield, et al. 2005 Relation between age, femoral neck cortical stability, and hip fracture risk Lancet 366 9480 129 135 (Pubitemid 40991213)
22. M Lunt D Felsenberg J Adams L Benevolenskaya J Cannata J Dequeker, et al. 1997 Population-based geographic variations in DXA bone density in Europe: the EVOS study Osteoporosis Int 7 175 189
23. S Kaptoge DM Reid C Scheidt-Nave G Poor HA Pols KT Khaw, et al. 2007 Geographic and other determinants of BMD change in European men and women at the hip and spine. A population-based study from the Network in Europe for Male Osteoporosis (NEMO) Bone 40 3 662 673
24. U Elsasser B Wilkins R Hesp DI Thurnham J Reeve BM Ansell 1982 Bone rarefaction and crush fractures in juvenile chronic arthritis Arch Dis Child 57 5 377 380
25. BL Riggs LJ Melton III 3rd RA Robb JJ Camp EJ Atkinson JM Peterson, et al. 2004 Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites J Bone Miner Res 19 12 1945 1954 Epub 2004 Sep 20
26. TL Mueller GH van Lenthe M Stauber C Gratzke F Eckstein R Muller 2006 Non-destructive prediction of individual bone strength as assessed by high-resolution 3D-pQCT in a population study of the human radius J Bone Miner Res 21 S232 S232 Abstracts 28th Annual Meeting ASBMR, Philadelphia, USA
27. JA Macneil SK Boyd 2008 Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method Bone 42 6 1203 1213 Epub 2008 Feb 13
28. MR Bosisio M Talmant W Skalli P Laugier D Mitton 2007 Apparent Young's modulus of human radius using inverse finite-element method J Biomech 40 9 2022 2028 Epub 2006 Nov 13
29. Mueller TL, van Lenthe GH, Stauber M, Gratzke C, Eckstein F, Muller R (2006) Non-destructive prediction of individual bone strength as assessed by high-resolution 3D-pQCT. (Abstracts 17th International Bone Densitometry Workshop, Kyoto, Japan, November 5-9, 2006)
30. MacNeil JAM, Boyd SK (2007) Fracture strength of the distal radius can be estimated by non-linear finite element analysis using 3D HR-pQCT. J Bone Miner Res 22(Abstracts 29th Annual Meeting ASBMR, Honolulu, Hawaii, USA)
31. JD Currey 1988 The effect of porosity and mineral content on the Young's modulus of elasticity of compact bone J Biomech 21 2 131 139