Regional, age and gender differences in architectural measures of bone quality and their correlation to bone mechanical competence in the human radius of an elderly population

Bone

Volumn 45, Issue 5, 2009, Pages 882-891

  Mueller, Thomas L ^a   van Lenthe, G Harry ^a,b   Stauber, Martin ^a   Gratzke, Christian ^c   Eckstein, Felix ^d   Müller, Ralph ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY OF MUNICH   (Germany)

^d PARACELSUS MEDICAL UNIVERSITY   (Austria)

Author keywords

Bone morphometry; Bone quality; Bone strength; High resolution pQCT; Human radius

Indexed keywords

AGE; AGED; ARTICLE; BIOMECHANICS; BONE PLATE; BONE STRENGTH; CADAVER; COMPRESSIVE STRENGTH; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; MORPHOMETRICS; RADIUS; SEX DIFFERENCE;

ABSORPTIOMETRY, PHOTON; AGED; AGING; ANTHROPOMETRY; BIOMECHANICS; FEMALE; HEALTH; HUMANS; MALE; ORGAN SPECIFICITY; RADIUS; REGRESSION ANALYSIS; SEX CHARACTERISTICS; TOMOGRAPHY, X-RAY COMPUTED; WEIGHT-BEARING;

EID: 70349299824     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.06.031     Document Type: Article

References (57)

1. Burge R., Dawson-Hughes B., Solomon D.H., Wong J.B., King A., and Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J. Bone Miner. Res. 22 (2007) 465-475
2. Riggs B.L., and Melton III L.J. The worldwide problem of osteoporosis: insights afforded by epidemiology. Bone 17 (1995) 505S-511S
3. Kleerekoper M., Villanueva A.R., Stanciu J., Rao D.S., and Parfitt A.M. The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures. Calcif. Tissue Int. 37 (1985) 594-597
4. Mosekilde L., Mosekilde L., and Danielsen C.C. Biomechanical competence of vertebral trabecular bone in relation to ash density and age in normal individuals. Bone 8 (1987) 79-85
5. Müller R., Hannan M., Smith S.Y., and Bauss F. Intermittent ibandronate preserves bone quality and bone strength in the lumbar spine after 16 months of treatment in the ovariectomized cynomolgus monkey. J. Bone Miner. Res. 19 (2004) 1787-1796
6. Stauber M., Rapillard L., van Lenthe G.H., Zysset P., and Müller R. Importance of individual rods and plates in the assessment of bone quality and their contribution to bone stiffness. J. Bone Miner. Res. 21 (2006) 586-595
7. Turner C.H., Cowin S.C., Rho J.Y., Ashman R.B., and Rice J.C. The fabric dependence of the orthotropic elastic constants of cancellous bone. J. Biomech. 23 (1990) 549-561
8. Finsen V., and Benum P. Colles' fracture as an indicator of increased risk of hip fracture. An epidemiological study. Ann. Chir. Gynaecol. 76 (1987) 114-118
9. Haentjens P., Autier P., Collins J., Velkeniers B., Vanderschueren D., and Boonen S. Colles fracture, spine fracture, and subsequent risk of hip fracture in men and women. A meta-analysis. J. Bone Joint Surg. Am. 85-A (2003) 1936-1943
10. Müller R. The Zurich experience: one decade of three-dimensional high-resolution computed tomography. Top. Magn. Reson. Imaging 13 (2002) 307-322
11. Müller R., Hildebrand T., and Rüegsegger P. Non-invasive bone biopsy: a new method to analyse and display the three-dimensional structure of trabecular bone. Phys. Med. Biol. 39 (1994) 145-164
12. Boutroy S., Bouxsein M.L., Munoz F., and Delmas P.D. In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J. Clin. Endocrinol. Metab. 90 (2005) 6508-6515
13. Khosla S., Riggs B.L., Atkinson E.J., Oberg A.L., McDaniel L.J., Holets M., et al. Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment. J. Bone Miner. Res. 21 (2006) 124-131
14. Boutroy S., Van Rietbergen B., Sornay-Rendu E., Munoz F., Bouxsein M.L., and Delmas P.D. Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women. J. Bone Miner. Res. 23 (2008) 392-399
15. MacNeil J.A., and Boyd S.K. Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method. Bone 42 (2008) 1203-1213
16. Eckstein F., Matsuura M., Kuhn V., Priemel M., Müller R., Link T.M., et al. Sex differences of human trabecular bone microstructure in aging are site-dependent. J. Bone Miner. Res. 22 (2007) 817-824
17. Hudelmaier M., Kollstedt A., Lochmüller E.M., Kuhn V., Eckstein F., and Link T.M. Gender differences in trabecular bone architecture of the distal radius assessed with magnetic resonance imaging and implications for mechanical competence. Osteoporos. Int. 16 (2005) 1124-1133
18. Lochmüller E.M., Kristin J., Matsuura M., Kuhn V., Hudelmaier M., Link T.M., et al. Measurement of trabecular bone microstructure does not improve prediction of mechanical failure loads at the distal radius compared with bone mass alone. Calcif. Tissue Int. 83 (2008) 293-299
19. Lochmüller E.M., Matsuura M., Bauer J., Hitzl W., Link T.M., Müller R., et al. Site-specific deterioration of trabecular bone architecture in men and women with advancing age. J. Bone Miner. Res. 23 (2008) 1964-1973
20. Lochmüller E.M., Lill C.A., Kuhn V., Schneider E., and Eckstein F. Radius bone strength in bending, compression, and falling and its correlation with clinical densitometry at multiple sites. J. Bone Miner. Res. 17 (2002) 1629-1638
21. Lochmüller E.M., Müller R., Kuhn V., Lill C.A., and Eckstein F. Can novel clinical densitometric techniques replace or improve DXA in predicting bone strength in osteoporosis at the hip and other skeletal sites?. J. Bone Miner. Res. 18 (2003) 906-912
22. Hudelmaier M., Kuhn V., Lochmüller E.M., Well H., Priemel M., Link T.M., et al. Can geometry-based parameters from pQCT and material parameters from quantitative ultrasound (QUS) improve the prediction of radial bone strength over that by bone mass (DXA)?. Osteoporos. Int. 15 (2004) 375-381
23. MacNeil J.A., and Boyd S.K. Load distribution and the predictive power of morphological indices in the distal radius and tibia by high resolution peripheral quantitative computed tomography. Bone 41 (2007) 129-137
24. MacNeil J.A., and Boyd S.K. Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med. Eng. Phys. 29 (2007) 1096-1105
25. MacNeil J.A., and Boyd S.K. Improved reproducibility of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med. Eng. Phys. 30 (2008) 792-799
26. Mueller T.L., Stauber M., Kohler T., Eckstein F., Müller R., and van Lenthe G.H. Non-invasive bone competence analysis by high-resolution pQCT: an in vitro reproducibility study on structural and mechanical properties at the human radius. Bone 44 (2009) 364-371
27. Laib A., and Rüegsegger P. Comparison of structure extraction methods for in vivo trabecular bone measurements. Comput. Med. Imaging Graph. 23 (1999) 69-74
28. MacNeil J.A., and Boyd S.K. Improved reproducibility of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med. Eng. Phys. (2007)
29. Hildebrand T., Laib A., Müller R., Dequeker J., and Rüegsegger P. Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus. J. Bone Miner. Res. 14 (1999) 1167-1174
30. Metz S., Kuhn V., Kettler M., Hudelmaier M., Bonel H.M., Waldt S., et al. Comparison of different radiography systems in an experimental study for detection of forearm fractures and evaluation of the Muller-AO and Frykman classification for distal radius fractures. Invest. Radiol. 41 (2006) 681-690
31. Dalzell N., Kaptoge S., Morris N., Berthier A., Koller B., Braak L., et al. Bone micro-architecture and determinants of strength in the radius and tibia: age-related changes in a population-based study of normal adults measured with high-resolution pQCT. Osteoporos. Int. (2009)
32. Khosla S., Melton III L.J., Achenbach S.J., Oberg A.L., and Riggs B.L. Hormonal and biochemical determinants of trabecular microstructure at the ultradistal radius in women and men. J. Clin. Endocrinol. Metab. 91 (2006) 885-891
33. Lochmüller E.M., Krefting N., Burklein D., and Eckstein F. Effect of fixation, soft-tissues, and scan projection on bone mineral measurements with dual energy X-ray absorptiometry (DXA). Calcif. Tissue Int. 68 (2001) 140-145
34. Melton III L.J., Riggs B.L., van Lenthe G.H., Achenbach S.J., Müller R., Bouxsein M.L., et al. Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal women. J. Bone Miner. Res. 22 (2007) 1442-1448
35. Hasegawa Y., Schneider P., and Reiners C. Age, sex, and grip strength determine architectural bone parameters assessed by peripheral quantitative computed tomography (pQCT) at the human radius. J. Biomech. 34 (2001) 497-503
36. Pistoia W., van Rietbergen B., Lochmüller E.M., Lill C.A., Eckstein F., and Rüegsegger P. Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images. Bone 30 (2002) 842-848
37. Beck J.S., and Nordin B.E. Histological assessment of osteoporosis by iliac crest biopsy. J. Pathol. Bacteriol. 80 (1960) 391-397
38. Bromley R.G., Dockum N.L., Arnold J.S., and Jee W.S. Quantitative histological study of human lumbar vertebrae. J. Gerontol. 21 (1966) 537-543
39. Caldwell R.A. Observations on the incidence, aetiology, and pathology of senile osteoporosis. J. Clin. Pathol. 15 (1962) 421-431
40. Chalmers J., and Weaver J.K. Cancellous bone: its strength and changes with aging and an evaluation of some methods for measuring its mineral content: II. An evaluation of some methods for measuring osteoporosis. J. Bone Joint Surg. Am. 48 (1966) 299-308
41. Cummings S.R., Black D.M., Nevitt M.C., Browner W.S., Cauley J.A., Genant H.K., Mascioli S.R., Scott J.C., Seeley D.G., Steiger P., et al. Appendicular bone density and age predict hip fracture in women. The Study of Osteoporotic Fractures Research Group. Jama 263 (1990) 665-668
42. Ding M., Odgaard A., Linde F., and Hvid I. Age-related variations in the microstructure of human tibial cancellous bone. J. Orthop. Res. 20 (2002) 615-621
43. Dunnill M.S., Anderson J.A., and Whitehead R. Quantitative histological studies on age changes in bone. J. Pathol. Bacteriol. 94 (1967) 275-291
44. Ellis H.A., and Peart K.M. Quantitative observations on mineralized and non-mineralized bone in the iliac crest. J. Clin. Pathol. 25 (1972) 277-286
45. Lindahl O., and Lindgren A.G. Grading of osteoporosis in autopsy specimens. A new method. Acta Orthop. Scand. 32 (1962) 85-100
46. Melsen F., Melsen B., Mosekilde L., and Bergmann S. Histomorphometric analysis of normal bone from the iliac crest. Acta Pathol. Microbiol. Scand. [A] 86 (1978) 70-81
47. Mosekilde L. Sex differences in age-related loss of vertebral trabecular bone mass and structure-biomechanical consequences. Bone 10 (1989) 425-432
48. Riggs B.L., Melton Iii III L.J., Robb R.A., Camp J.J., Atkinson E.J., Peterson J.M., et al. Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites. J. Bone Miner. Res. 19 (2004) 1945-1954
49. Trotter M., Broman G.E., and Peterson R.R. Density of cervical vertebrae and comparison with densities of other bones. Am. J. Phys. Anthropol. 17 (1959) 19-25
50. Trotter M., Broman G.E., and Peterson R.R. Densites of bones of white and Negro skeletons. J. Bone Joint Surg. Am. 42-A (1960) 50-58
51. Vedi S., Compston J.E., Webb A., and Tighe J.R. Histomorphometric analysis of bone biopsies from the iliac crest of normal British subjects. Metab. Bone Dis. Relat. Res. 4 (1982) 231-236
52. Wakamatsu E., and Sissons H.A. The cancellous bone of the iliac crest. Calcif. Tissue Res. 4 (1969) 147-161
53. McCalden R.W., McGeough J.A., and Court-Brown C.M. Age-related changes in the compressive strength of cancellous bone. The relative importance of changes in density and trabecular architecture. J. Bone Joint Surg. Am. 79 (1997) 421-427
54. Parfitt A.M., Mathews C.H., Villanueva A.R., Kleerekoper M., Frame B., and Rao D.S. Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss. J. Clin. Invest. 72 (1983) 1396-1409
55. Weinstein R.S., and Hutson M.S. Decreased trabecular width and increased trabecular spacing contribute to bone loss with aging. Bone 8 (1987) 137-142
56. Bergot C., Laval-Jeantet A.M., Preteux F., and Meunier A. Measurement of anisotropic vertebral trabecular bone loss during aging by quantitative image analysis. Calcif. Tissue Int. 43 (1988) 143-149
57. Atkinson P.J. Variation in trabecular structure of vertebrae with age. Calcif. Tissue Res. 1 (1967) 24-32