The micrograft concept for wound healing: Strategies and applications

Journal of Diabetes Science and Technology

Volumn 4, Issue 4, 2010, Pages 808-819

  Biswas, Atanu ^a   Bharara, Manish ^a   Hurst, Craig ^a   Armstrong, David G ^a   Rilo, Horacio ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Diabetic foot ulcers; Micrografting; Wound healing

Indexed keywords

FUNCTIONS OF THE SKIN AND ITS APPENDAGES; HISTORY; HUMAN; METHODOLOGY; PHYSIOLOGY; REVIEW; SKIN TRANSPLANTATION; WOUND HEALING;

HISTORY, 19TH CENTURY; HISTORY, 20TH CENTURY; HUMANS; SKIN PHYSIOLOGICAL PHENOMENA; SKIN TRANSPLANTATION; WOUND HEALING;

EID: 78049514586     PISSN: None     EISSN: 19322968     Source Type: Journal    
DOI: 10.1177/193229681000400407     Document Type: Conference Paper

References (109)

1. Reverdin JL. Graffe epidermique. Experience faite dans le service de M. le docteur Guyon, a l'hopital Necker. Bull Imp Soc Chir Paris. 1869;10:511-5.
2. Thiersch C. Ueber die feineren anatomischen Veränderungen bei Aufheilung von Haut auf Granulationen. Verhandlungen der deutschen Gesellschaft für Chirurgie. 1874;3:69-75.
3. Davis JS. Address of the president: the story of plastic surgery. Ann Surg. 1941;113(5):641-56.
4. Gabarro P. A new method of grafting. Br Med J. 1943;1:723-4.
5. Von Mangoldt F. Die Ueberhäutung von Wundflächen und Wundhöhlen durch Epithelaussaat, eine neue Methode der Transplantation. Dtsch Med Wchnschr. 1895;21(48):798-9.
6. Noesske K. Klinische und histologische Studien über Hautverpflanzung, besonders über Epithelaussaat. Dtsch Z Chir. 1906;83(3-4):213-53.
7. Reschke-Greifswold H. Epithelisierungsversuche. Arch F Klin Chir. 1922;121:233.
8. Billingham RE, Reynolds J. Transplantation studies on sheets of pure epidermal epithelium and on epidermal cell suspensions. Br J Plast Surg. 1952;5(1):25-36.
9. Tanner JC Jr, Vandeput J, Olley JF. The mesh skin graft. Plast Reconstr Surg. 1964;34:287-92.
10. Peeters R, Hubens A. The mesh skin graft - true expansion rate. Burns Incl Therm Inj. 1988;14(3):239-40.
11. Lin TW. The algebraic view-point in microskin grafting in burned patients. Burns. 1994;20(4):347-50.
12. Davis JS. The use of small deep skin grafts. JAMA. 1914;63:985-9.
13. Davis JS. The small deep graft: relationship to the true reverdin graft. Ann Surg. 1929;89(6):902-16.
14. Pontěn B. Plastic surgery treatment of chronic venous ulcers of the leg. Scand J Plast Reconstr Surg. 1972;6(1):74-82.
15. Ho LC, Bailey BN, Bajaj PB. Pinch grafts in treatment of chronic venous leg ulcers. Chirurgia Plastica. 1976;3(3):193-200.
16. Millard LG, Roberts MM, Gatecliffe M. Chronic leg ulcers treated by the pinch graft method. Br J Dermatol. 1977;97(3):289-95.
17. Christiansen J, Ek L, Tegner E. Pinch grafting of leg ulcers. A retrospective study of 412 treated ulcers in 146 patients. Acta Derm Venereol. 1997;77(6):471-3.
18. Ahnlide I, Bjellerup M. Efficacy of pinch grafting in leg ulcers of different aetiologies. Acta Derm Venereol. 1997;77(2):144-5.
19. Oien RF, Hansen BU, Håkansson A. Pinch grafting of leg ulcers in primary care. Acta Derm Venereol. 1998;78(6):438-9.
20. Oien RF, Håkansson A, Hansen BU. Leg ulcers in patients with rheumatoid arthritis - a prospective study of aetiology, wound healing and pain reduction after pinch grafting. Rheumatology (Oxford). 2001;40(7):816-20.
21. Oien RF, Håkansson A, Hansen BU, Bjellerup M. Pinch grafting of chronic leg ulcers in primary care: fourteen years' experience. Acta Derm Venereol. 2002;82(4):275-8.
22. Greenwood JE, Parry AD, Williams RM, McCollum CN. Trigger-fired pinch-graft harvester for use in chronic venous ulcers. Br J Surg. 1997;84(3):397-8.
23. Lewis GK. The use of the patch graft in extensive skin loss. Plast Reconstr Surg (1946). 1953;12(2):116-22.
24. Vandeput J, Tanner JC Jr, Carlisle JD. The ultra postage stamp skin graft. Plast Reconstr Surg. 1966;38(3):252-4.
25. Tanner JC Jr, Vandeput J, Lewis JR Jr. The scrap technique of skin grafting. Plast Reconstr Surg. 1968;41(2):182-3.
26. Meek CP. Successful microdermagrafting using the Meek-Wall microdermatome. Am J Surg. 1958;96(4):557-8.
27. Meek CP. Medical debridement and microdermagrafting of burns. South Med J. 1963;56:1074-6.
28. Meek CP. Extensive severe burn treated with enzymatic debridement and microdermagrafting: case report. Am Surg. 1963;29:61-4.
29. Meek CP. Microdermagrafting: the Meek technic. Hosp Top. 1965;43:114-6.
30. Yang CC, Shih TS, Chu TA, Hsu WS, Kuo SY, Chao YF. The intermingled transplantation of auto- and homografts in severe burns. Burns. 1980;6(3):141-5.
31. Yang CC, Shih TS, Xu WS. A Chinese concept of treatment of extensive third-degree burns. Plast Reconstr Surg. 1982;70(2):238-54.
32. Phipps AR, Clarke JA. The use of intermingled autograft and parental allograft skin in the treatment of major burns in children. Br J Plast Surg. 1991;44(8):608-11.
33. Zhang ML, Chang ZD, Han X, Zhu M. Microskin grafting. I. Animal experiments. Burns Incl Therm Inj. 1986;12(8):540-3.
34. Zhang ML, Wang CY, Chang ZD, Cao DX, Han X. Microskin grafting. II. Clinical report. Burns Incl Therm Inj. 1986;12(8):544-8.
35. Zhang ML, Chang ZD, Wang CY, Fang CH. Microskin grafting in the treatment of extensive burns: a preliminary report. J Trauma. 1988;28(6):804-7.
36. Fang CH, Yu GS, Fan YF, Wang K, Alexander JW. A preliminary report on transplantation of microskin autografts overlaid with sheet allograft in the treatment of large burns. J Burn Care Rehabil. 1988;9(6):629-33.
37. Fang CH, Yu GS, Zhang ML, Alexander JW. Burn treatment. Covering burn wounds with autologous microskin grafts. AORN J. 1989;49(2):526, 528, 530-4.
38. Sun Y, Pan Y, Chen S, Zhao Y, Wang Y, Zheng X. Clinical application of microskin grafting to repair granulation or decrustation wounds. J Burn Care Res. 2006;27(4):515-9.
39. Yeh FL, Yu GS, Fang CH, Carey M, Alexander JW, Robb EC. Comparison of scar contracture with the use of microskin and Chinese-type intermingled skin grafts on rats. J Burn Care Rehabil. 1990;11(3):221-3.
40. Fang CH, Alexander JW. Wound contraction following transplantation of microskin autografts with overlaid skin allograft in experimental animals. Burns. 1990;16(3):190-2.
41. Shvets VN, Malakhov SF, Egorov BB, Bautin EA, Vnukova ZE. Ability of microautotransplants to re-epithelialize deep and extensive skin injuries. Burns. 1991;17(3):243-9.
42. Svensjö T, Pomahac B, Yao F, Slama J, Wasif N, Eriksson E. Autologous skin transplantation: comparison of minced skin to other techniques. J Surg Res. 2002;103(1):19-29.
43. Livesey SA, Herndon DN, Hollyoak MA, Atkinson YH, Nag A. Transplanted acellular allograft dermal matrix. Potential as a template for the reconstruction of viable dermis. Transplantation. 1995;60(1):1-9.
44. Lin SD, Chou CK, Lai CS, Yang CC. Microskin grafting of rabbits with pigskin xenograft overlay. Burns. 1991;17(6):473-7.
45. Lin SD, Lai CS, Chou CK, Tsai CW, Wu KF, Chang CW. Microskin autograft with pigskin xenograft overlay: a preliminary report of studies on patients. Burns. 1992;18(4):321-5.
46. Lin SD, Lai CS, Chou CK, Tsai CW. Microskin grafting of rabbit skin wounds with Biobrane overlay. Burns. 1992;18(5):390-4.
47. Lin SD, Chai CY, Lai CS, Chou CK. Allogeneic microskin grafting of rabbits' skin wounds. Burns. 1993;19(3):208-14.
48. Lin SD, Chai CY, Lai CS, Chou CK. A mixture of allogeneic and autologous microskin grafting of rabbit skin wounds with Biobrane overlay. Burns. 1994;20(1):30-5.
49. Subrahmanyam M. Amniotic membrane as a cover for microskin grafts. Br J Plast Surg. 1995;48(7):477-8.
50. Greenwood JE, Clausen J, Kavanagh S. Experience with biobrane: uses and caveats for success. Eplasty. 2009;9:e25.
51. Chen XL, Xia ZF, Fang LS, Wang YJ, Wang CH. Co-graft of acellular dermal matrix and autogenous microskin in a child with extensive burns. Ann Burns Fire Disasters. 2008;21(2).
52. Lin TW, Horng SY. A new method of microskin mincing. Burns. 1994;20(6):526-8.
53. Lin TW. An alternative method of skin grafting: the scalp microdermis graft. Burns. 1995;21(5):374-8.
54. Mardovin W, Miller SF, Eppinger M, Finley RK. Micrografts: the "super" expansion graft. J Burn Care Rehabil. 1992;13(5):556-9.
55. Nelson CV, Miller SF, Eppinger M, Finley RK. Micrografts. II: Evaluation of 25:1, 50:1, and 100:1 expansion skin grafts in the porcine model. J Burn Care Rehabil. 1995;16(1):31-5.
56. Blair SD, Nanchahal J, Backhouse CM, Harper R, McCollum CN. Microscopic split-skin grafts: a new technique for 30-fold expansion. Lancet. 1987;2(8557):483-4.
57. Nanchahal J. Stretching skin to the limit: a novel technique for split skin graft expansion. Br J Plast Surg. 1989;42(1):88-91.
58. Kreis RW, Vloemans AF, Hoekstra MJ, Mackie DP, Hermans RP. The use of non-viable glycerol-preserved cadaver skin combined with widely expanded autografts in the treatment of extensive third-degree burns. J Trauma. 1989;29(1):51-4.
59. Kreis RW, Mackie DP, Vloemans AW, Hermans RP, Hoekstra MJ. Widely expanded postage stamp skin grafts using a modified Meek technique in combination with an allograft overlay. Burns. 1993;19(2):142-5.
60. Kreis RW, Mackie DP, Hermans RR, Vloemans AR. Expansion techniques for skin grafts: comparison between mesh and Meek island (sandwich-) grafts. Burns. 1994;20 Suppl 1:S39-42.
61. Raff T, Hartmann B, Wagner H, Germann G. Experience with the modified Meek technique. Acta Chir Plast. 1996;38(4):142-6.
62. Zermani RG, Zarabini A, Trivisonno A. Micrografting in the treatment of severely burned patients. Burns. 1997;23(7-8):604-7.
63. Lari AR, Gang RK. Expansion technique for skin grafts (Meek technique) in the treatment of severely burned patients. Burns. 2001;27(1):61-6.
64. Hsieh CS, Schuong JY, Huang WS, Huang TT. Five years' experience of the modified Meek technique in the management of extensive burns. Burns. 2008;34(3):350-4.
65. Lumenta DB, Kamolz LP, Frey M. Adult burn patients with more than 60% TBSA involved-Meek and other techniques to overcome restricted skin harvest availability - the Viennese Concept. J Burn Care Res. 2009;30(2):231-42.
66. Baux S, Mimoun M, Saade H, Lioret N, Esteve M, Nolland XB, Bertiere MN. Burns in the elderly. Burns. 1989;15(4):239-40.
67. Papp A, Härmä M. A collagen based dermal substitute and the modified Meek technique in extensive burns. Report of three cases. Burns. 2003;29(2):167-71.
68. Kopp J, Magnus Noah E, Rübben A, Merk HF, Pallua N. Radical resection of giant congenital melanocytic nevus and reconstruction with meek-graft covered integra dermal template. Dermatol Surg. 2003;29(6):653-7.
69. Chang LY, Yang JY. Clinical experience of postage stamp autograft with porcine skin onlay dressing in extensive burns. Burns. 1998;24(3):264-9.
70. Lee SS, Tsai CC, Lai CS, Lin SD. An easy method for preparation of postage stamp autografts. Burns. 2000;26(8):741-9.
71. Lee SS, Lin TM, Chen YH, Lin SD, Lai CS. "Flypaper technique" a modified expansion method for preparation of postage stamp autografts. Burns. 2005;31(6):753-7.
72. Lee SS, Chen YH, Sun IF, Chen MC, Lin SD, Lai CS. "Shift to right flypaper technique" a refined method for postage stamp autografting preparation. Burns. 2007;33(6):764-9.
73. Najarian JS, McCorkle HJ. Experimental grafting of a suspension of skin particles. Surg Forum. 1957;7:125-9.
74. Najarian JS, Crane JT, McCorkle HJ. An experimental study of the grafting of a suspension of skin particles. Surgery. 1957;42(1):218-27.
75. Cox WA, Nichol WW. Evaluation of the fine-particle skin autograft technique. AMA Arch Surg. 1958;77(6):870-4.
76. Rissin Y, Fodor L, Talmon G, Fishelson O, Ullmann Y. Investigating human microskin grafting technique in a new experimental model. Burns. 2009;35(5):681-6.
77. Xie W, Wang L, Tan H, Wang D, Liu J, Hu B, Huang W, Ren S, Sun K. [Microskin grafting by spraying in burn management]. Zhonghua Shao Shang Za Zhi. 2002;18(1):26-8.
78. Petri JB, König S, Haupt B, Haustein UF, Herrmann K. Molecular analysis of different phases in human wound healing. Exp Dermatol. 1997;6(3):133-9.
79. Hayashi N, Takehara K, Soma Y. Differential chemotactic responses mediated by platelet-derived growth factor alpha- and beta-receptors. Arch Biochem Biophys. 1995;322(2):423-8.
80. Ashcroft GS, Horan MA, Ferguson MW. The effects of ageing on cutaneous wound healing in mammals. J Anat. 1995;187(Pt 1):1-26.
81. Hengge UR, Chan EF, Foster RA, Walker PS, Vogel JC. Cytokine gene expression in epidermis with biological effects following injection of naked DNA. Nat Genet. 1995;10(2):161-6.
82. Meuli M, Liu Y, Liggitt D, Kashani-Sabet M, Knauer S, Meuli-Simmen C, Harrison MR, Adzick NS, Heath TD, Debs RJ. Efficient gene expression in skin wound sites following local plasmid injection. J Invest Dermatol. 2001;116(1):131-5.
83. Sun L, Xu L, Chang H, Henry FA, Miller RM, Harmon JM, Nielsen TB. Transfection with aFGF cDNA improves wound healing. J Invest Dermatol. 1997;108(3):313-8.
84. Ciernik IF, Krayenbühl BH, Carbone DP. Puncture-mediated gene transfer to the skin. Hum Gene Ther. 1996;7(8):893-9.
85. Eriksson E, Yao F, Svensjö T, Winkler T, Slama J, Macklin MD, Andree C, McGregor M, Hinshaw V, Swain WF. In vivo gene transfer to skin and wound by microseeding. J Surg Res. 1998;78(2):85-91.
86. Andree C, Swain WF, Page CP, Macklin MD, Slama J, Hatzis D, Eriksson E. In vivo transfer and expression of a human epidermal growth factor gene accelerates wound repair. Proc Natl Acad Sci U S A. 1994;91(25):12188-92.
87. Ghazizadeh S, Harrington R, Taichman L. In vivo transduction of mouse epidermis with recombinant retroviral vectors: implications for cutaneous gene therapy. Gene Ther. 1999;6(7):1267-75.
88. Gruss CJ, Satyamoorthy K, Berking C, Lininger J, Nesbit M, Schaider H, Liu ZJ, Oka M, Hsu MY, Shirakawa T, Li G, Bogenrieder T, Carmeliet P, El-Deiry WS, Eck SL, Rao JS, Baker AH, Bennet JT, Crombleholme TM, Velazquez O, Karmacharya J, Margolis DJ, Wilson JM, Detmar M, Skobe M, Robbins PD, Buck C, Herlyn M. Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice. J Invest Dermatol. 2003;120(4):683-92.
89. Eming SA, Whitsitt JS, He L, Krieg T, Morgan JR, Davidson JM. Particle-mediated gene transfer of PDGF isoforms promotes wound repair. J Invest Dermatol. 1999;112(3):297-302.
90. Benn SI, Whitsitt JS, Broadley KN, Nanney LB, Perkins D, He L, Patel M, Morgan JR, Swain WF, Davidson JM. Particle-mediated gene transfer with transforming growth factor-beta1 cDNAs enhances wound repair in rat skin. J Clin Invest. 1996;98(12):2894-902.
91. Jeschke MG, Richter G, Herndon DN, Geissler EK, Hartl M, Hofstätter F, Jauch KW, Perez-Polo JR. Therapeutic success and efficacy of nonviral liposomal cDNA gene transfer to the skin in vivo is dose dependent. Gene Ther. 2001;8(23):1777-84.
92. Renò F, Sabbatini M, Lombardi F, Stella M, Pezzuto C, Magliacani G, Cannas M. In vitro mechanical compression induces apoptosis and regulates cytokines release in hypertrophic scars. Wound Repair Regen. 2003;11(5):331-6.
93. Van den Kerckhove E, Stappaerts K, Fieuws S, Laperre J, Massage P, Flour M, Boeckx W. The assessment of erythema and thickness on burn related scars during pressure garment therapy as a preventive measure for hypertrophic scarring. Burns. 2005;31(6):696-702.
94. Parks DH, Evans EB, Larson DL. Prevention and correction of deformity after severe burns. Surg Clin North Am. 1978;58(6):1279-89.
95. Costa AM, Peyrol S, Pôrto LC, Comparin JP, Foyatier JL, Desmoulière A. Mechanical forces induce scar remodeling. Study in non-pressure-treated versus pressure-treated hypertrophic scars. Am J Pathol. 1999;155(5):1671-9.
96. Williams F, Knapp D, Wallen M. Comparison of the characteristics and features of pressure garments used in the management of burn scars. Burns. 1998;24(4):329-35.
97. Horswell BB. Scar modification. Techniques for revision and camouflage. Atlas Oral Maxillofac Surg Clin North Am. 1998;6(2):55-72.
98. Giovinco NA, Bui TD, Fisher T, Mills JL, Armstrong DG. Wound chemotherapy by the use of negative pressure wound therapy and infusion. Eplasty. 2010;10:e9.
99. Körber A, Franckson T, Grabbe S, Dissemond J. Vacuum assisted closure device improves the take of mesh grafts in chronic leg ulcer patients. Dermatology. 2008;216(3):250-6.
100. Hinchliffe RJ, Valk GD, Apelqvist J, Armstrong DG, Bakker K, Game FL, Hartemann-Heurtier A, Löndahl M, Price PE, van Houtum WH, Jeffcoate WJ. A systematic review of the effectiveness of interventions to enhance the healing of chronic ulcers of the foot in diabetes. Diabetes Metab Res Rev. 2008;24 Suppl 1:S119-44.
101. Armstrong DG, Lavery LA, Diabetic Foot Study Consortium. Negative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial. Lancet. 2005;366(9498):1704-10.
102. Blackburn JH II, Boemi L, Hall WW, Jeffords K, Hauck RM, Banducci DR, Graham WP IV. Negative-pressure dressings as a bolster for skin grafts. Ann Plast Surg. 1998;40(5):453-7.
103. Moisidis E, Heath T, Boorer C, Ho K, Deva AK. A prospective, blinded, randomized, controlled clinical trial of topical negative pressure use in skin grafting. Plast Reconstr Surg. 2004;114(4):917-22.
104. Dorai AA, Lim CK, Fareha AC, Halim AS. Cultured epidermal autografts in combination with MEEK Micrografting technique in the treatment of major burn injuries. Med J Malaysia. 2008;63 Suppl A:44.
105. Nair LS, Laurencin CT. Polymers as biomaterials for tissue engineering and controlled drug delivery. Adv Biochem Eng Biotechnol. 2006;102:47-90.
106. Barnes CP, Sell SA, Boland ED, Simpson DG, Bowlin GL. Nanofiber technology: designing the next generation of tissue engineering scaffolds. Adv Drug Deliv Rev. 2007;59(14):1413-33.
107. Burd A. Evaluating the use of hydrogel sheet dressings in comprehensive burn wound care. Ostomy Wound Manage. 2007;53(3):52-62.
108. Akita S, Akino K, Imaizumi T, Tanaka K, Anraku K, Yano H, Hirano A. A polyurethane dressing is beneficial for split-thickness skin-graft donor wound healing. Burns. 2006;32(4):447-51.
109. Kiyozumi T, Kanatani Y, Ishihara M, Saitoh D, Shimizu J, Yura H, Suzuki S, Okada Y, Kikuchi M. Medium (DMEM/F12)-containing chitosan hydrogel as adhesive and dressing in autologous skin grafts and accelerator in the healing process. J Biomed Mater Res B Appl Biomater. 2006;79(1):129-36.