Mechanical forces induce scar remodeling: Study in non-pressure- treated versus pressure-treated hypertrophic scars

American Journal of Pathology

Volumn 155, Issue 5, 1999, Pages 1671-1679

  Costa, Andréa Monte Alto ^a,b   Peyrol, Simone ^c   Pôrto, Luís Cristóvão ^b   Comparin, Jean Pierre ^d   Foyatier, Jean Louis ^d   Desmouliére, Alexis ^a,e  

^a INSTITUT DE BIOLOGIE ET CHIMIE DES PROTÉINES   (France)

^b STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c UNIVERSITÉ LYON 1   (France)

^d CENTRE HOSPITALIER SAINT JOSEPH SAINT LUC   (France)

^e INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; ELASTIN;

ADULT; ARTICLE; BURN; CLINICAL ARTICLE; COLLAGEN METABOLISM; FEMALE; HUMAN; HYPERTROPHIC SCAR; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; PROTEIN DETERMINATION; SCAR FORMATION; SKIN BIOPSY; TRANSMISSION ELECTRON MICROSCOPY;

EID: 0032706667     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65482-X     Document Type: Article

References (37)

1. Linares HA: Pathophysiology of the burn scar. Total Burn Care. Edited by Herndon DN. London, Saunders, 1996, pp 383-397
2. Ehrlich HP, Desmoulière A, Diegelman RF, Cohen IK, Compton CC, Garner WL, Kapanci Y, Gabbiani G: Morphological and immunochemical differences between keloid and hypertrophic scar. Am J Pathol 1994, 145:105-113
3. Gabbiani G, Ryan GB, Majno G: Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia 1971, 27:549-550
4. Desmoulière A, Gabbiani G: The role of the myofibroblast in wound healing and fibrocontractive diseases. The Molecular and Cellular Biology of Wound Repair. Edited by Clark RAF. New York, Plenum Press, 1996, pp 391-423
5. Grinnell F: Fibroblasts, myofibroblasts, and wound contraction: J Cell Biol 1994, 124:401-404
6. Baur PS, Larson DL, Stacey TR: The observation of myofibroblasts in hypertrophic scars. Surg Gynecol Obstet 1975, 141:22-26
7. Desmoulière A, Redard M, Darby I, Gabbiani G: Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol 1995, 146:56-66
8. Muir IFK: On the nature of keloids and hypertrophic scars. Br J Plast Surg 1990, 43:61-69
9. Larson DL, Abston S, Evans EB, Dobrkovsky M, Linares HA: Techniques for decreasing scar formation and contractures in the burned patient. J Trauma 1971, 11:807-823
10. Tanaka M, Ho H, Adachi S, Akimoto H, Nishikawa T, Kasajima T, Marumo F, Hiroe M: Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes. Circ Res 1994, 75:426-433
11. Kischer CW, Shetlar MR, Shetlar CL: Alteration of hypertrophic scars induced by mechanical pressure. Arch Dermatol 1975, 111:60-64
12. Kischer CW: Contributions of electron microscopy to the study of the hypertrophic scar and related lesions. Scanning Microsc 1993, 7:921-931
13. Gailit J, Clark RAF: Wound repair in the context of extracellular matrix. Curr Opin Cell Biol 1994, 6:717-725
14. Cotta-Pereira G, Rodrigo FG, Bittencourt-Sampaio S: Oxytalan, elaunin, and elastic fibers in human skin. J Invest Dermatol 1976, 66:143-148
15. Ashcroft GS, Kielty CM, Horan MA, Ferguson M: Age-related changes in the temporal and spatial distributions of fibrillin and elastin mRNAs and proteins in acute cutaneous wounds of healthy humans. J Pathol 1997, 183:80-89
16. Bhangoo KS, Quinlivan JK, Connely JR: Elastic fibers in scar tissue. Plastic Reconstr Surg 1976, 57:308-313
17. Williams G: The late phases of wound healing: histological and ultrastructural studies of collagen and elastic-tissue formation. J Pathol 1970, 102:61-68
18. Tsuji T, Sawabe M: Elastic fibers in scar tissue: scanning and transmission electron microscopic studies. J Cutan Pathol 1987, 14:106-113
19. Mackie EJ, Halfter W, Liverani D: Induction of tenascin in healing wounds. J Cell Biol 1988, 107:2757-2767
20. Lightner VA, Gumkowski F, Bigner DD, Erickson HP: Tenascin/hexabrachion in human skin: biochemical identification and localization by light and electron microscopy. J Cell Biol 1989, 108:2483-2493
21. Chuong CM, Chen HM: Enhanced expression of neural adhesion molecules and tenascin (cytotactin) during wound healing. Am J Pathol 1991, 138:427-440
22. Sahl WJ, Clever H: Cutaneous scars: part 1. Int J Dermatol 1994, 33:681-691
23. Skalli O, Ropraz P, Trzeciak A, Benzonana G, Gillessen D, Gabbiani G: A monoclonal antibody against α-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol 1986, 103:2787-2796
24. Linares HA, Kischer CW, Dobrkovsky M, Larson DL: The histiotypic organization of the hypertrophic scars in humans. J Invest Dermatol 1972, 59:323-331
25. McMillan JR, Mc Grath JA, Tidman MJ, Eady RAJ: Hemidesmosomes show abnormal association wit the keratin filament network in junctional forms of epidermolysis bullosa. J Invest Dermatol 1998, 110: 132-137
26. Garbin S, Pittet B, Montandon D, Gabbiani G, Desmoulière A: Covering by a flap induces apoptosis of granulation tissue myofibroblasts and vascular cells. Wound Rep Reg 1996, 4:244-251
27. Kischer CW, Thies AC, Chvapil M: Perivascular myofibroblasts and microvascular occlusion in hypertrophic scars and keloids. Hum Pathol 1982, 13:819-824
28. Baur PS, Larson DL, Stacey TR, Barral GF, Dobrkovsky M: Ultrastructural analysis of pressure-treated human hypertrophic scars. J Trauma 1976, 16:958-967
29. Davidson JM, Giro G, Quaglino D: Elastin repair. Wound Repair: Biomedical and Clinical Aspects. Edited by Cohen IK, Lindblad WJ and Diegelman RF. Philadelphia, WB Saunders, 1992, pp 223-236
30. Raghunath M, Bachi T, Meuli M, Altermatt S, Gobet R, Brucker-Tuderman L, Steinmann B: Fibrillin and elastin expression in skin regenerating from cultured keratinocytes autografts: morphogenesis of microfibrils begins at the dermo-epidermal junction and precedes elastic fiber formation. J Invest Dermatol 1996, 106:1090-1095
31. Desmoulière A, Darby I, Costa AMA, Raccurt M, Tuchweber B, Sommer P, Gabbiani G: Extracellular matrix deposition, lysyl oxidase expression, and myofibroblastic differentiation during the initial stages of cholestatic fibrosis in the rat. Lab Invest 1997, 76:765-778
32. Fleischmajer R, Jacobs L, Schwartz E, Sakai, LY: Extracellular microfibrils are increased in localized and systemic scleroderma in skin. Lab Invest 1991, 64:791-798
33. Mommaas AM, Teepe RGC, Leigh IM, Mulder AA, Koebrugge EJ, Vermeer BJ: Ontogenesis of the basement membrane zone after grafting cultured human epithelium: a morphologic and immunoelectron microscopic study. J Invest Dermatol 1992, 99:71-77
34. Gavrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992, 119:493-501
35. Costa AMA, Porto LC: Distribution of elastic system fibers in human fetal liver. J Anat 1996, 88:645-650
36. Lambert CA, Soudant EP, Nusgens BV, Lapière CM: Pretranslational regulation of extracellular matrix macromolecules and collagenase expression in fibroblasts by mechanical forces. Lab Invest 1992, 66:444-451
37. Fluck J, Querfeld C, Cremer A, Niland S, Krieg T, Sollberg S: Normal human primary fibroblasts undergo apoptosis in three-dimensional contractile collagen gels. J Invest Dermatol 1998, 110:153-157