Effect of glycyrrhetinic acid on 11β-hydroxysteroid dehydrogenase activity in normotensive and hypertensive subjects

Clinical Science

Volumn 102, Issue 2, 2002, Pages 203-211

  Van Uum, Stan H M ^a   Walker, Brian R ^a   Hermus, Ad R M M ^a   Sweep, C G J ^a   Smits, Paul ^a   De Leeuw, Peter W ^a   Lenders, Jacques W M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

11 hydroxysteroid dehydrogenase; Cortisol; Forearm; Glycyrrhetinic acid; Hypertension; Saliva

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTISONE; GLYCYRRHETINIC ACID; HYDROCORTISONE; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID RELEASE; DOUBLE BLIND PROCEDURE; ENZYME ACTIVITY; ENZYME ANALYSIS; FEMALE; FOREARM; HUMAN; HYPERTENSION; MALE; PATHOGENESIS; PRIORITY JOURNAL; SALIVA LEVEL;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ADULT; ANALYSIS OF VARIANCE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRACHIAL ARTERY; CASE-CONTROL STUDIES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CORTISONE; DOUBLE-BLIND METHOD; FEMALE; GLYCYRRHETINIC ACID; HUMANS; HYDROCORTISONE; HYDROXYSTEROID DEHYDROGENASES; HYPERTENSION; MALE; MIDDLE AGED; REGIONAL BLOOD FLOW; SALIVA;

EID: 0036185203     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20010194     Document Type: Article

References (39)

1. Purification and characterization of the corticosteroid 11 beta-dehydrogenase component of the rat liver 11 beta-hydroxysteroid dehydrogenase complex
2. Tissue-specific distribution of the NAD(+)-dependent isoform of 11 beta-hydroxysteroid dehydrogenase
3. 11 Beta-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress
4. Cloning of the 11 beta HSD type II enzyme from human kidney
5. Human kidney 11 beta-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform
6. Localization of 11 beta-hydroxysteroid dehydrogenase type II in human epithelial tissues
7. Detection of human 11 beta-hydroxysteroid dehydrogenase isoforms using reverse-transcriptase-polymerase chain reaction and localization of the type 2 isoform to renal collecting ducts
8. Mineralocorticoid action: Target tissue specificity is enzyme, not receptor, mediated
9. Localisation of 11 beta-hydroxysteroid dehydrogenase - Tissue specific protector of the mineralocorticoid receptor
10. Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle
11. Licorice inhibits corticosteroid 11 beta-dehydrogenase of rat kidney and liver: In vivo and in vitro studies
12. The influence of glycyrrhetinic acid on plasma cortisol and cortisone in healthy young volunteers
13. Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age
14. Mineralocorticoid excess and inhibition of 11 beta-hydroxysteroid dehydrogenase in patients with ectopic ACTH syndrome
15. Radioimmunoassay of cortisone in serum, urine, and saliva to assess the status of the cortisol-cortisone shuttle
16. 11 Beta-Hydroxysteroid dehydrogenase in vascular smooth muscle and heart: Implications for cardiovascular responses to glucocorticoids
17. Bidirectional activity of 11 beta-hydroxysteroid dehydrogenase in vascular smooth muscle cells
18. Vascular localization of the 11 beta-hydroxysteroid dehydrogenase type II enzyme
19. Studies on high affinity binding of mineralo- and glucocorticoids in rabbit aorta cytosol
20. Aldosterone and dexamethasone binding in human arterial smooth muscle cells
21. Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor
22. Deficient inactivation of cortisol by 11 beta-hydroxysteroid dehydrogenase in essential hypertension
23. Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid
24. Direct and indirect effects of carbenoxolone on responses to glucocorticoids and noradrenaline in rat aorta
25. Localization of 2 11beta-OH steroid dehydrogenase isoforms in aortic endothelial cells
26. The effect of oral contraceptive use and pregnancy on the daily rhythm of cortisol and cortisone
27. Steroid profile for urine: Reference values
28. Aldosterone secretion rate: Radioimmunoassay versus double isotope dilution derivative assay
29. A direct radioimmunoassay for aldosterone: Significance of endogenous cortisol
30. Solid-phase extraction of 18beta-glycyrrhetinic acid from plasma and subsequent analysis by high-performance liquid chromatography
31. Kinetics and dynamics of orally administered 18 beta-glycyrrhetinic acid in humans
32. An in vivo study of the cortisol-cortisone shuttle in subcutaneous abdominal adipose tissue
33. Arteriovenous studies on the uptake and metabolism of cortisol in the human forearm
34. Distinguishing activities of type 1 and type 2 11beta-hydroxysteroid dehydrogenases (11-HSDs) in man using deuterated cortisol
35. Evidence of coexisting changes in 11 beta-hydroxysteroid dehydrogenase and 5 beta-reductase activity in subjects with untreated essential hypertension
36. Molecular basis of human salt sensitivity: The role of the 11beta-hydroxysteroid dehydrogenase type 2
37. Impact of dietary Na+ on glycyrrhetinic acid-like factors (kidney 11beta-(HSD2)-GALFs) in human essential hypertension
38. The activities of 5 beta-reductase and 11 beta-hydroxysteroid dehydrogenase in essential hypertension
39. Endogenous renal 11 beta-hydroxysteroid dehydrogenase inhibitory factors in patients with low-renin essential hypertension