Effect of food on bioavailability of a single oral dose of clopidogrel in healthy male subjects

Arzneimittel-Forschung/Drug Research

Volumn 56, Issue 11, 2006, Pages 735-739

  Nirogi, Ramakrishna V S ^a   Kandikere, Vishwottam N ^a   Mudigonda, Koteshwara ^a  

^a SUVEN LIFE SCIENCES LTD   (India)

Author keywords

CAS 113665 84 2; Clopidogrel, clinical trial, effect of food on the pharmacokinetics; Platelet aggregation inhibitor

Indexed keywords

CAS 113665 84 2; CLOPIDOGREL;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG HALF LIFE; FOOD DRUG INTERACTION; FOOD INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; POSITIVE ION ELECTROSPRAY; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY;

EID: 33845391586     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296783     Document Type: Article

References (16)

1. PLAVIX™, RxMed: Pharmaceutical Information Sanofi/Bristol-Mayers Squibb
2. Clarke, T. A., Waskell, L. A. The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin. Drug Metab. Dispos. 31, 53 (2003)
3. Pereillo, J., Maftouh, M., Andrieu, A. et al., Structure and stereochemistry of the active metabolite of clopidogrel. Drug Metab. Dispos. 30, 1288 (2002)
4. Caplain, H., Donat, F., Gaud, C. et al., Pharmacokinetics of clopidogrel. Semin. Thromb. Hemost. 25 (Suppl. 2), 25 (1999)
5. Nirogi, R. V. S., Kandikere, V. N., Shukla, M. et al., Quantification of clopidogrel in human plasma by sensitive liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 20, 1695 (2006)
6. Bramer, B. L., Forbes, W. P. Relative bioavailability and effects of a high fat meal on single dose cilostazol pharmacokinetics. Clin. Pharmacokinet. 37 (Suppl. 2), 13 (1999)
7. Lettieri, J., Vargas, R., Agarwal, V. et al., Effect of food on the pharmacokinetics of a single oral dose of moxifloxacin 400 mgin healthy male volunteers. Clin. Pharmacokinet. 40 (Suppl. 1), 19 (2001)
8. Welling, P. G., Tse, F. L., The influence of food on the absorption of antimicrobial agents. J. Antimicrob. Chemother. 9, 7 (1982)
9. Adkin, J. C., Faulds, D., Micronized fenofibrate: a review of its pharmacodynamic properties and clinical efficacy in the management of dyslipidaemia. Drugs 54, 615 (1997)
10. Zeman, M., Zak, A., Vecka, M. et al., Treatment of hyperglyceridemia with fenofibrate, fatty acid composition of plasma and LDL, and their relations to parameters of lipoperoxidation of LDL. Ann. NY Acad. Sci. 967, 336 (2002)
11. Yun, H., Lee, E. J., Chung, S. Y. et al., The effects of food on the bioavailability of fenofibrate administered orally in healthy volunteers via sustained-release capsule. Clin. Pharmacokinet. 45, 425 (2006)
12. Lecocq, B., Funck-Brentano, C., Lecocq, V. et al., Influence of food on the pharmacokinetics of perindopril and the time course of angiotensin- converting enzyme inhibition in serum. Clin. Pharmacol. Ther. 47, 397 (1990)
13. McEwen, J., Strauch, G., Perles, P. et al., clopidogrel bioavailability: absence of influence of food or antacids. Semin. Thromb. Hemost. 25 (Suppl. 2), 47 (1999)
14. rd ed., Applied Therapeutics, Vancouver (1992)
15. Slugg, P. H., Much, D. R., Smith, W. B. et al., Cirrhosis does not affect the pharmacokinetics and pharmacodynamics of clopidogrel. J. Clin. Pharmacol. 40, 396 (2000)
16. Leonard, W., Judith, A., Davud, T. The influence of food on the absorption and metabolism of drugs. Clin. Nutr. 77, 815 (1993)