Bioanalytical method development and validation using incurred samples-Simultaneous quantitation of ramipril and ramiprilat in human EDTA plasma by LC-MS/MS

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 29, 2009, Pages 3673-3680

  Tan, Aimin ^a   Jin, Wen ^a   Deng, Fu ^a   Hussain, Saleh ^a   Musuku, Adrien ^a   Massé, Robert ^a  

^a Anapharm Canada   (Canada)

Author keywords

Incurred samples; LC MS MS; Metabolite back conversion; Method development and validation; Ramipril; Ramiprilat

Indexed keywords

ANALYTES; AUTOSAMPLERS; BASELINE SEPARATION; BIOANALYTICAL METHODS; CHROMATOGRAPHIC CONDITIONS; CLINICAL STUDY; CONCENTRATION RANGES; CONVERSION METHODS; DERIVATIZATIONS; FREEZE/THAW; GLUCURONIDES; INCURRED SAMPLES; LC-MS/MS; METHOD DEVELOPMENT; METHOD VALIDATIONS; NEW APPROACHES; PEAK SHAPES; PILOT STUDIES; REANALYSIS; SAMPLE EXTRACTION; SAMPLE PROCESSING; VALIDATION APPROACH; VALIDATION PROCESS;

BIOMOLECULES; METABOLISM; METABOLITES; PROCESSING;

EXTRACTION;

DRUG METABOLITE; RAMIPRIL; RAMIPRIL ACYL GLUCURONIDE; RAMIPRILAT; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; BIOEQUIVALENCE; CLINICAL ARTICLE; CONTROLLED STUDY; DERIVATIZATION; DRUG BLOOD LEVEL; DRUG STABILITY; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; VALIDATION STUDY;

CHROMATOGRAPHY, LIQUID; HUMANS; RAMIPRIL; TANDEM MASS SPECTROMETRY;

EID: 72049109197     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.09.017     Document Type: Article

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