Molecular mechanisms of RIP, an effective inhibitor of chronic infections

International Journal of Artificial Organs

Volumn 33, Issue 9, 2010, Pages 582-589

  Lopez Leban, Florencia ^a   Kiran, Madanahally Divakar ^a,b   Wolcott, Randall ^c   Balaban, Naomi ^a,d,e  

^a TUFTS UNIVERSITY   (United States)

^b IQUUM Inc   (United States)

^c Southwest Regional Wound Care Center Lubbock   (United States)

^d Yale University   (United States)

^e NONE   (United States)

Author keywords

Biofilm; Infection; RNAIII inhibiting peptide (RIP); Staphylococci; Wound

Indexed keywords

BACTERIA; BIOFILMS; ENZYME INHIBITION; GENE EXPRESSION;

BACTERIAL INFECTIONS; CHRONIC INFECTION; CONVENTIONAL TREATMENT MODALITIES; HEPTAPEPTIDES; HOST IMMUNE RESPONSE; INFECTION; MOLECULAR MECHANISM; RNAIII INHIBITING PEPTIDE; STAPHYLOCOCCUS; WOUND;

PEPTIDES;

DAPTOMYCIN; HEPTAPEPTIDE; LACTOFERRIN; LINEZOLID; RNAIII INHIBITING PEPTIDE; TRICLOSAN; UNCLASSIFIED DRUG; XYLITOL;

ADULT; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL INFECTION; BIOFILM; CASE REPORT; DIABETIC FOOT; DRUG EFFICACY; DRUG MECHANISM; DRUG TREATMENT FAILURE; GANGRENE; GEL; GENE EXPRESSION REGULATION; HUMAN; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROARRAY ANALYSIS; NONHUMAN; STAPHYLOCOCCUS AUREUS; TREATMENT OUTCOME;

EID: 78049481605     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139881003300904     Document Type: Article

References (35)

1. Wolcott RD, Rhoads DD, Bennett ME, Wolcott BM, Gogokhia L, Costerton JW, Dowd SE. Chronic wounds and the medical biofilm paradigm. J Wound Care 2010; 19: 45-6, 48-50, 52-3.
2. Gontcharova V, Youn E, Sun Y, Wolcott RD, Dowd SE. A comparison of bacterial composition in diabetic ulcers and contralateral intact skin. Open Microbiol J 2010; 4:8-19.
3. Wolcott RD, Rhoads DD. A study of biofilm-based wound management in subjects with critical limb ischaemia. J Wound Care 2008; 17: 145-8, 150-2, 154-5.
4. Ziegler-Graham K. Estimating the Prevalence of Limb Loss in the United States - 2005 to 2050. Archives of Physical Medicine and Rehabilitation 2008; 89: 422-429. (Pubitemid 351273168)
5. Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science 1999; 284: 1318-22.
6. James GA, Swogger E, Wolcott R, et al. Biofilms in chronic wounds. Wound Repair Regen 2008; 16: 37-44.
7. Lowy FD. Staphylococcus aureus infections. N Engl J Med 1998; 339: 520-32.
8. Balaban N, Novick RP. Autocrine regulation of toxin synthesis by Staphylococcus aureus. Proc Natl Acad Sci U S A 1995; 92: 1619-23.
9. Wolcott RD. Clinical Wound Healing Using Signal Inhibitors. In: The control of Biofilm Infections by Signal Manipulation. Balaban N, Ed. Springer. (2008) p. 157-70.
10. Balaban N, Stoodley P, Fux CA, Wilson S, Costerton JW, Dell'Acqua G. Prevention of staphylococcal biofilm-associated infections by the quorum sensing inhibitor RIP. Clin Orthop Relat Res 2005; 437: 48-54. (Pubitemid 41099065)
11. Kiran MD, Giacometti A, Cirioni O, Balaban N. Suppression of biofilm related, device-associated infections by staphylococcal quorum sensing inhibitors. Int J Artif Organs 2008; 31: 761-70.
12. Kiran MD, Adikesavan NV, Cirioni O, et al. Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening. Mol Pharmacol 2008; 73: 1578-86. (Pubitemid 351574847)
13. Vieira-da-Motta O, Ribeiro PD, Dias da Silva W, Medina-Acosta E. RNAIII inhibiting peptide (RIP) inhibits agr-regulated toxin production. Peptides 2001; 22: 1621-7. (Pubitemid 32918241)
14. Balaban N, Goldkorn T, Gov Y, et al. Regulation of Staphylococcus aureus pathogenesis via target of RNAIII-activating Protein (TRAP). J Biol Chem 2001; 276: 2658-67.
15. Gov Y, Borovok I, Korem M, et al. Quorum sensing in Staphylococci is regulated via phosphorylation of three conserved histidine residues. J Biol Chem 2004; 279: 14665-72. (Pubitemid 38618855)
16. Kiran MD, Bala S, Hirshberg M, Balaban N. YhgC protects Bacillus anthracis from oxidative stress. Int J Artif Organs 2010 33 (9); 590-607.
17. Kiran MD, Balaban N. TRAP plays a role in stress response in Staphylococcus aureus. Int J Artif Organs 2009; 32: 592-9.
18. Korem M, Sheoran AS, Gov Y, Tzipori S, Borovok I, Balaban N. Characterization of RAP, a quorum sensing activator of Staphylococcus aureus. FEMS Microbiol Lett 2003; 223: 167-75.
19. Dunman PM, Murphy E, Haney S, et al. Transcription profiling-based identification of Staphylococcus aureus genes regulated by the agr and/or sarA loci. J Bacteriol 2001; 183: 7341-53.
20. Beenken KE, Dunman PM, McAleese F, et al. Global gene expression in Staphylococcus aureus biofilms. J Bacteriol 2004; 186: 4665-84.
21. Boor KJ. Bacterial stress responses: what doesn't kill them can make then stronger. PLoS Biol 2006; 4: e23.
22. Derre I, Rapoport G, Msadek T. CtsR, a novel regulator of stress and heat shock response, controls clp and molecular chaperone gene expression in gram-positive bacteria. Mol Microbiol 1999; 31: 117-31.
23. Clements MO, Foster SJ. Stress resistance in Staphylococcus aureus. Trends Microbiol 1999; 7: 458-62.
24. Cirioni O, Giacometti A, Ghiselli R, et al. RNAIII-inhibiting peptide significantly reduces bacterial load and enhances the effect of antibiotics in the treatment of central venous catheter-associated Staphylococcus aureus infections. J Infect Dis 2006; 193: 180-6.
25. Balaban N, Stoodley P, Fux CA, Wilson S, Costerton JW, Dell'Acqua G. Prevention of staphylococcal biofilm-associated infections by the quorum sensing inhibitor RIP. Clin Orthop Relat Res 2005; 437: 48-54.
26. Makhlin J, Kofman T, Borovok I, et al. Staphylococcus aureus ArcR controls expression of the arginine deiminase operon. J Bacteriol 2007;189: 5976-86.
27. Schlag S, Fuchs S, Nerz C, et al. Characterization of the oxygen-responsive NreABC regulon of Staphylococcus aureus. J Bacteriol 2008;190: 7847-58.
28. Harrison JJ, Turner RJ, Joo DA, et al. Copper and quaternary ammonium cations exert synergistic bactericidal and antibiofilm activity against Pseudomonas aeruginosa. Antimicrob Agents Chemother 2008; 52: 2870-81.
29. Ammons MC, Ward LS, Fisher ST, Wolcott RD, James GA. In vitro susceptibility of established biofilms composed of a clinical wound isolate of Pseudomonas aeruginosa treated with lactoferrin and xylitol. Int J Antimicrob Agents. 2009; 33: 230-6.
30. Narisawa N, Haruta S, Arai H, Ishii M, Igarashi Y. Coexistence of antibiotic-producing and antibiotic-sensitive bacteria in biofilms is mediated by resistant bacteria. Appl Environ Microbiol 2008; 74: 3887-94.
31. O'Connell HA, Kottkamp GS, Eppelbaum JL, Stubblefield BA, Gilbert SE, Gilbert ES. Influences of biofilm structure and antibiotic resistance mechanisms on indirect pathogenicity in a model polymicrobial biofilm. Appl Environ Microbiol 2006; 72: 5013-9.
32. Hetrick EM, Shin JH, Paul HS, Schoenfisch MH. Anti-biofilm efficacy of nitric oxide-releasing silica nanoparticles. Biomaterials 2009; 30: 2782-9.
33. Bjarnsholt T, Kirketerp-Moller K, Kristiansen S, et al. Silver against Pseudomonas aeruginosa biofilms. APMIS 2007;115: 921-8.
34. Baker J, Sitthisak S, Sengupta M, Johnson M, Jayaswal RK, Morrissey JA. Copper stress induces a global stress response in Staphylococcus aureus and represses sae and agr expression and biofilm formation. Appl Environ Microbiol 2010; 76: 150-60.
35. Schierle CF, De la Garza M, Mustoe TA, Galiano RD. Staphylococcal biofilms impair wound healing by delaying reepithelialization in a murine cutaneous wound model. Wound Rep Reg 2009; 17: 354-59.