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Volumn 31, Issue 4, 2010, Pages 707-718

New synthetic antithrombotic agents for venous thromboembolism: Pentasaccharides, direct thrombin inhibitors, direct Xa inhibitors

Author keywords

Anticoagulation; Management; Pulmonary embolism; Venous thromboembolism

Indexed keywords

ACENOCOUMAROL; ANTICOAGULANT AGENT; ANTIVITAMIN K; APIXABAN; BETRIXABAN; BLOOD CLOTTING FACTOR 10A INHIBITOR; DABIGATRAN; DABIGATRAN ETEXILATE; ENOXAPARIN; FONDAPARINUX; HEPARIN; IDRAPARINUX; LOW MOLECULAR WEIGHT HEPARIN; PENTASACCHARIDE; PLACEBO; RIVAROXABAN; THROMBIN INHIBITOR; WARFARIN;

EID: 78049476607     PISSN: 02725231     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccm.2010.06.006     Document Type: Review
Times cited : (9)

References (57)
  • 1
    • 0141609865 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia
    • Chong B.H. Heparin-induced thrombocytopenia. J Thromb Haemost 2003, 1:1471-1478.
    • (2003) J Thromb Haemost , vol.1 , pp. 1471-1478
    • Chong, B.H.1
  • 2
    • 0032958624 scopus 로고    scopus 로고
    • Antigens involved in heparin-induced thrombocytopenia
    • Amiral J. Antigens involved in heparin-induced thrombocytopenia. Semin Hematol 1999, 36:7-11.
    • (1999) Semin Hematol , vol.36 , pp. 7-11
    • Amiral, J.1
  • 3
    • 0032728857 scopus 로고    scopus 로고
    • Further characterization of antibody and antigen in heparin-induced thrombocytopenia
    • Newman P.M., Chong B.H. Further characterization of antibody and antigen in heparin-induced thrombocytopenia. Br J Haematol 1999, 107:303-309.
    • (1999) Br J Haematol , vol.107 , pp. 303-309
    • Newman, P.M.1    Chong, B.H.2
  • 4
    • 0034079490 scopus 로고    scopus 로고
    • Affinity purification of heparin-dependent antibodies to platelet factor 4 developed in heparin-induced thrombocytopenia: biological characteristics and effects on platelet activation
    • Amiral J., Pouplard C., Vissac A.M., et al. Affinity purification of heparin-dependent antibodies to platelet factor 4 developed in heparin-induced thrombocytopenia: biological characteristics and effects on platelet activation. Br J Haematol 2000, 109:336-341.
    • (2000) Br J Haematol , vol.109 , pp. 336-341
    • Amiral, J.1    Pouplard, C.2    Vissac, A.M.3
  • 5
    • 0034081558 scopus 로고    scopus 로고
    • Investigation of a platelet factor 4 polymorphism on the immune response in patients with heparin-induced thrombocytopenia
    • Horsewood P., Kelton J.G. Investigation of a platelet factor 4 polymorphism on the immune response in patients with heparin-induced thrombocytopenia. Platelets 2000, 11:23-27.
    • (2000) Platelets , vol.11 , pp. 23-27
    • Horsewood, P.1    Kelton, J.G.2
  • 6
    • 0032747473 scopus 로고    scopus 로고
    • Functional heterogeneity of antiheparin-platelet factor 4 antibodies: implications in the pathogenesis of the HIT syndrome
    • Ahmad S., Walenga J.M., Jeske W.P., et al. Functional heterogeneity of antiheparin-platelet factor 4 antibodies: implications in the pathogenesis of the HIT syndrome. Clin Appl Thromb Hemost 1999, 5(Suppl 1):S32-S37.
    • (1999) Clin Appl Thromb Hemost , vol.5 , Issue.SUPPL 1
    • Ahmad, S.1    Walenga, J.M.2    Jeske, W.P.3
  • 7
    • 0032211182 scopus 로고    scopus 로고
    • Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia
    • Ziporen L., Li Z.Q., Park K.S., et al. Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia. Blood 1998, 92:3250-3259.
    • (1998) Blood , vol.92 , pp. 3250-3259
    • Ziporen, L.1    Li, Z.Q.2    Park, K.S.3
  • 8
    • 0029819851 scopus 로고    scopus 로고
    • The epitope specificity of heparin-induced thrombocytopenia
    • Horsewood P., Warkentin T.E., Hayward C.P., et al. The epitope specificity of heparin-induced thrombocytopenia. Br J Haematol 1996, 95:161-167.
    • (1996) Br J Haematol , vol.95 , pp. 161-167
    • Horsewood, P.1    Warkentin, T.E.2    Hayward, C.P.3
  • 9
    • 0030703541 scopus 로고    scopus 로고
    • Differences in specificity of heparin-dependent antibodies developed in heparin-induced thrombocytopenia and consequences on cross-reactivity with danaparoid sodium
    • Pouplard C., Amiral J., Borg J.Y., et al. Differences in specificity of heparin-dependent antibodies developed in heparin-induced thrombocytopenia and consequences on cross-reactivity with danaparoid sodium. Br J Haematol 1997, 99:273-280.
    • (1997) Br J Haematol , vol.99 , pp. 273-280
    • Pouplard, C.1    Amiral, J.2    Borg, J.Y.3
  • 10
    • 0030136628 scopus 로고    scopus 로고
    • Platelet binding of IgG from patients with heparin-induced thrombocytopenia
    • [see comments]
    • Horne M.K., Alkins B.R. Platelet binding of IgG from patients with heparin-induced thrombocytopenia. J Lab Clin Med 1996, 127:435-442. [see comments].
    • (1996) J Lab Clin Med , vol.127 , pp. 435-442
    • Horne, M.K.1    Alkins, B.R.2
  • 11
    • 35448956532 scopus 로고    scopus 로고
    • No difference in risk for thrombocytopenia during treatment of pulmonary embolism and deep venous thrombosis with either low-molecular-weight heparin or unfractionated heparin: a meta-analysis
    • Morris T.A., Castrejon S., Devendra G., et al. No difference in risk for thrombocytopenia during treatment of pulmonary embolism and deep venous thrombosis with either low-molecular-weight heparin or unfractionated heparin: a meta-analysis. Chest 2007, 132:1131-1139.
    • (2007) Chest , vol.132 , pp. 1131-1139
    • Morris, T.A.1    Castrejon, S.2    Devendra, G.3
  • 12
    • 0033029056 scopus 로고    scopus 로고
    • Failure of early heparin cessation as treatment for heparin-induced thrombocytopenia
    • Wallis D.E., Workman D.L., Lewis B.E., et al. Failure of early heparin cessation as treatment for heparin-induced thrombocytopenia. Am J Med 1999, 106:629-635.
    • (1999) Am J Med , vol.106 , pp. 629-635
    • Wallis, D.E.1    Workman, D.L.2    Lewis, B.E.3
  • 13
    • 45949103154 scopus 로고    scopus 로고
    • Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition)
    • Warkentin T.E., Greinacher A., Koster A., et al. Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest 2008, 133:340S-380S.
    • (2008) Chest , vol.133
    • Warkentin, T.E.1    Greinacher, A.2    Koster, A.3
  • 14
    • 0038285887 scopus 로고    scopus 로고
    • Argatroban anticoagulation in patients with heparin-induced thrombocytopenia
    • Lewis B.E., Wallis D.E., Leya F., et al. Argatroban anticoagulation in patients with heparin-induced thrombocytopenia. Arch Intern Med 2003, 163:1849-1856.
    • (2003) Arch Intern Med , vol.163 , pp. 1849-1856
    • Lewis, B.E.1    Wallis, D.E.2    Leya, F.3
  • 16
    • 0025204512 scopus 로고
    • Pharmacology of low molecular weight heparins
    • Harenberg J. Pharmacology of low molecular weight heparins. Semin Thromb Hemost 1990, 16(Suppl):12-18.
    • (1990) Semin Thromb Hemost , vol.16 , Issue.SUPPL , pp. 12-18
    • Harenberg, J.1
  • 17
    • 0026690347 scopus 로고
    • Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement
    • Olson S.T., Bjork I., Sheffer R., et al. Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement. J Biol Chem JID -2985121R 1992, 267:12528-12538.
    • (1992) J Biol Chem JID -2985121R , vol.267 , pp. 12528-12538
    • Olson, S.T.1    Bjork, I.2    Sheffer, R.3
  • 18
    • 0024339952 scopus 로고
    • The action of a synthetic pentasaccharide on thrombin generation in whole plasma
    • Beguin S., Choay J., Hemker H.C. The action of a synthetic pentasaccharide on thrombin generation in whole plasma. Thromb Haemost 1989, 61:397-401.
    • (1989) Thromb Haemost , vol.61 , pp. 397-401
    • Beguin, S.1    Choay, J.2    Hemker, H.C.3
  • 19
    • 2642617786 scopus 로고    scopus 로고
    • Biochemical and pharmacological properties of SANORG 34006, a potent and long-acting synthetic pentasaccharide
    • Herbert J.M., Herault J.P., Bernat A., et al. Biochemical and pharmacological properties of SANORG 34006, a potent and long-acting synthetic pentasaccharide. Blood 1998, 91:4197-4205.
    • (1998) Blood , vol.91 , pp. 4197-4205
    • Herbert, J.M.1    Herault, J.P.2    Bernat, A.3
  • 20
    • 0026593425 scopus 로고
    • Low molecular weight heparin
    • Hirsh J., Levine M.N. Low molecular weight heparin. Blood 1992, 79:1-17.
    • (1992) Blood , vol.79 , pp. 1-17
    • Hirsh, J.1    Levine, M.N.2
  • 21
    • 9644265348 scopus 로고    scopus 로고
    • Pharmacokinetics of UH and LMWH are similar with respect to antithrombin activity
    • Morris T.A., Jacobson A., Marsh J.J., et al. Pharmacokinetics of UH and LMWH are similar with respect to antithrombin activity. Thromb Res 2005, 115:45-51.
    • (2005) Thromb Res , vol.115 , pp. 45-51
    • Morris, T.A.1    Jacobson, A.2    Marsh, J.J.3
  • 22
    • 33747592631 scopus 로고    scopus 로고
    • Comparison of fixed-dose weight-adjusted unfractionated heparin and low-molecular-weight heparin for acute treatment of venous thromboembolism
    • Kearon C., Ginsberg J.S., Julian J.A., et al. Comparison of fixed-dose weight-adjusted unfractionated heparin and low-molecular-weight heparin for acute treatment of venous thromboembolism. JAMA 2006, 296:935-942.
    • (2006) JAMA , vol.296 , pp. 935-942
    • Kearon, C.1    Ginsberg, J.S.2    Julian, J.A.3
  • 23
    • 0035522304 scopus 로고    scopus 로고
    • Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after elective major knee surgery
    • Bauer K.A., Eriksson B.I., Lassen M.R., et al. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after elective major knee surgery. N Engl J Med JID -0255562 2001, 345:1305-1310.
    • (2001) N Engl J Med JID -0255562 , vol.345 , pp. 1305-1310
    • Bauer, K.A.1    Eriksson, B.I.2    Lassen, M.R.3
  • 24
    • 0035522302 scopus 로고    scopus 로고
    • Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery
    • Eriksson B.I., Bauer K.A., Lassen M.R., et al. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery. N Engl J Med 2001, 345:1298-1304.
    • (2001) N Engl J Med , vol.345 , pp. 1298-1304
    • Eriksson, B.I.1    Bauer, K.A.2    Lassen, M.R.3
  • 25
    • 0037129742 scopus 로고    scopus 로고
    • Postoperative fondaparinux versus preoperative enoxaparin for prevention of venous thromboembolism in elective hip-replacement surgery: a randomised double-blind comparison
    • Lassen M.R., Bauer K.A., Eriksson B.I., et al. Postoperative fondaparinux versus preoperative enoxaparin for prevention of venous thromboembolism in elective hip-replacement surgery: a randomised double-blind comparison. Lancet JID -2985213R 2002, 359:1715-1720.
    • (2002) Lancet JID -2985213R , vol.359 , pp. 1715-1720
    • Lassen, M.R.1    Bauer, K.A.2    Eriksson, B.I.3
  • 26
    • 0037129720 scopus 로고    scopus 로고
    • Postoperative fondaparinux versus postoperative enoxaparin for prevention of venous thromboembolism after elective hip-replacement surgery: a randomised double-blind trial
    • Turpie A.G., Bauer K.A., Eriksson B.I., et al. Postoperative fondaparinux versus postoperative enoxaparin for prevention of venous thromboembolism after elective hip-replacement surgery: a randomised double-blind trial. Lancet JID -2985213R 2002, 359:1721-1726.
    • (2002) Lancet JID -2985213R , vol.359 , pp. 1721-1726
    • Turpie, A.G.1    Bauer, K.A.2    Eriksson, B.I.3
  • 27
    • 0038010814 scopus 로고    scopus 로고
    • Duration of prophylaxis against venous thromboembolism with fondaparinux after hip fracture surgery: a multicenter, randomized, placebo-controlled, double-blind study
    • Eriksson B.I., Lassen M.R. Duration of prophylaxis against venous thromboembolism with fondaparinux after hip fracture surgery: a multicenter, randomized, placebo-controlled, double-blind study. Arch Intern Med 2003, 163:1337-1342.
    • (2003) Arch Intern Med , vol.163 , pp. 1337-1342
    • Eriksson, B.I.1    Lassen, M.R.2
  • 28
    • 2542424669 scopus 로고    scopus 로고
    • Fondaparinux or enoxaparin for the initial treatment of symptomatic deep venous thrombosis: a randomized trial
    • Buller H.R., Davidson B.L., Decousus H., et al. Fondaparinux or enoxaparin for the initial treatment of symptomatic deep venous thrombosis: a randomized trial. Ann Intern Med 2004, 140:867-873.
    • (2004) Ann Intern Med , vol.140 , pp. 867-873
    • Buller, H.R.1    Davidson, B.L.2    Decousus, H.3
  • 29
    • 0142182561 scopus 로고    scopus 로고
    • Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism
    • Buller H.R., Davidson B.L., Decousus H., et al. Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism. N Engl J Med 2003, 349:1695-1702.
    • (2003) N Engl J Med , vol.349 , pp. 1695-1702
    • Buller, H.R.1    Davidson, B.L.2    Decousus, H.3
  • 30
    • 78049468403 scopus 로고    scopus 로고
    • Prescribing label for ARIXTRA, NDA no. 021345. Approved 12/23/2009, in Administration FaD (ed)
    • Prescribing label for ARIXTRA, NDA no. 021345. Approved 12/23/2009, in Administration FaD (ed), 2009.
    • (2009)
  • 31
    • 34250749333 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia associated with fondaparinux
    • [discussion 2655]
    • Warkentin T.E., Maurer B.T., Aster R.H. Heparin-induced thrombocytopenia associated with fondaparinux. N Engl J Med 2007, 356:2653-2655. [discussion 2655].
    • (2007) N Engl J Med , vol.356 , pp. 2653-2655
    • Warkentin, T.E.1    Maurer, B.T.2    Aster, R.H.3
  • 32
    • 43749116913 scopus 로고    scopus 로고
    • Fondaparinux-related thrombocytopenia in a previous low-molecular-weight heparin (LMWH)-induced heparin-induced thrombocytopenia (HIT)
    • Rota E., Bazzan M., Fantino G. Fondaparinux-related thrombocytopenia in a previous low-molecular-weight heparin (LMWH)-induced heparin-induced thrombocytopenia (HIT). Thromb Haemost 2008, 99:779-781.
    • (2008) Thromb Haemost , vol.99 , pp. 779-781
    • Rota, E.1    Bazzan, M.2    Fantino, G.3
  • 33
    • 0037239007 scopus 로고    scopus 로고
    • Evaluation of the pharmacological properties and clinical results of the synthetic pentasaccharide (fondaparinux)
    • Samama M.M., Gerotziafas G.T. Evaluation of the pharmacological properties and clinical results of the synthetic pentasaccharide (fondaparinux). Thromb Res 2003, 109:1-11.
    • (2003) Thromb Res , vol.109 , pp. 1-11
    • Samama, M.M.1    Gerotziafas, G.T.2
  • 34
    • 34548768174 scopus 로고    scopus 로고
    • Idraparinux versus standard therapy for venous thromboembolic disease
    • Buller H.R., Cohen A.T., Davidson B., et al. Idraparinux versus standard therapy for venous thromboembolic disease. N Engl J Med 2007, 357:1094-1104.
    • (2007) N Engl J Med , vol.357 , pp. 1094-1104
    • Buller, H.R.1    Cohen, A.T.2    Davidson, B.3
  • 35
    • 34548712332 scopus 로고    scopus 로고
    • Extended prophylaxis of venous thromboembolism with idraparinux
    • Buller H.R., Cohen A.T., Davidson B., et al. Extended prophylaxis of venous thromboembolism with idraparinux. N Engl J Med 2007, 357:1105-1112.
    • (2007) N Engl J Med , vol.357 , pp. 1105-1112
    • Buller, H.R.1    Cohen, A.T.2    Davidson, B.3
  • 36
    • 77952703086 scopus 로고    scopus 로고
    • Reversibility of the anti-FXa activity of idrabiotaparinux (biotinylated idraparinux) by intravenous avidin infusion
    • Paty I., Trellu M., Destors J.M., et al. Reversibility of the anti-FXa activity of idrabiotaparinux (biotinylated idraparinux) by intravenous avidin infusion. J Thromb Haemost 2010, 8(4):722-729.
    • (2010) J Thromb Haemost , vol.8 , Issue.4 , pp. 722-729
    • Paty, I.1    Trellu, M.2    Destors, J.M.3
  • 37
    • 0037171819 scopus 로고    scopus 로고
    • Structure-based design of novel potent nonpeptide thrombin inhibitors
    • Hauel N.H., Nar H., Priepke H., et al. Structure-based design of novel potent nonpeptide thrombin inhibitors. J Med Chem 2002, 45:1757-1766.
    • (2002) J Med Chem , vol.45 , pp. 1757-1766
    • Hauel, N.H.1    Nar, H.2    Priepke, H.3
  • 38
    • 34548575058 scopus 로고    scopus 로고
    • Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial
    • Eriksson B.I., Dahl O.E., Rosencher N., et al. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial. Lancet 2007, 370:949-956.
    • (2007) Lancet , vol.370 , pp. 949-956
    • Eriksson, B.I.1    Dahl, O.E.2    Rosencher, N.3
  • 39
    • 35449007749 scopus 로고    scopus 로고
    • Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial
    • Eriksson B.I., Dahl O.E., Rosencher N., et al. Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial. J Thromb Haemost 2007, 5:2178-2185.
    • (2007) J Thromb Haemost , vol.5 , pp. 2178-2185
    • Eriksson, B.I.1    Dahl, O.E.2    Rosencher, N.3
  • 40
    • 57649123692 scopus 로고    scopus 로고
    • Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery
    • Ginsberg J.S., Davidson B.L., Comp P.C., et al. Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery. J Arthroplasty 2009, 24:1-9.
    • (2009) J Arthroplasty , vol.24 , pp. 1-9
    • Ginsberg, J.S.1    Davidson, B.L.2    Comp, P.C.3
  • 41
    • 71849117615 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in the treatment of acute venous thromboembolism
    • Schulman S., Kearon C., Kakkar A.K., et al. Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med 2009, 361:2342-2352.
    • (2009) N Engl J Med , vol.361 , pp. 2342-2352
    • Schulman, S.1    Kearon, C.2    Kakkar, A.K.3
  • 42
    • 0142182558 scopus 로고    scopus 로고
    • Secondary prevention of venous thromboembolism with the oral direct thrombin inhibitor ximelagatran
    • Schulman S., Wahlander K., Lundstrom T., et al. Secondary prevention of venous thromboembolism with the oral direct thrombin inhibitor ximelagatran. N Engl J Med 2003, 349:1713-1721.
    • (2003) N Engl J Med , vol.349 , pp. 1713-1721
    • Schulman, S.1    Wahlander, K.2    Lundstrom, T.3
  • 43
    • 24944536065 scopus 로고    scopus 로고
    • Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor
    • Roehrig S., Straub A., Pohlmann J., et al. Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor. J Med Chem 2005, 48:5900-5908.
    • (2005) J Med Chem , vol.48 , pp. 5900-5908
    • Roehrig, S.1    Straub, A.2    Pohlmann, J.3
  • 44
    • 22844442726 scopus 로고    scopus 로고
    • In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939-an oral, direct Factor Xa inhibitor
    • Perzborn E., Strassburger J., Wilmen A., et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939-an oral, direct Factor Xa inhibitor. J Thromb Haemost 2005, 3:514-521.
    • (2005) J Thromb Haemost , vol.3 , pp. 514-521
    • Perzborn, E.1    Strassburger, J.2    Wilmen, A.3
  • 45
    • 51349095537 scopus 로고    scopus 로고
    • Population pharmacokinetics and pharmacodynamics of once- and twice-daily rivaroxaban for the prevention of venous thromboembolism in patients undergoing total hip replacement
    • Mueck W., Borris L.C., Dahl O.E., et al. Population pharmacokinetics and pharmacodynamics of once- and twice-daily rivaroxaban for the prevention of venous thromboembolism in patients undergoing total hip replacement. Thromb Haemost 2008, 100:453-461.
    • (2008) Thromb Haemost , vol.100 , pp. 453-461
    • Mueck, W.1    Borris, L.C.2    Dahl, O.E.3
  • 46
    • 42949123582 scopus 로고    scopus 로고
    • Population pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct factor Xa inhibitor-in patients undergoing major orthopaedic surgery
    • Mueck W., Eriksson B.I., Bauer K.A., et al. Population pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct factor Xa inhibitor-in patients undergoing major orthopaedic surgery. Clin Pharmacokinet 2008, 47:203-216.
    • (2008) Clin Pharmacokinet , vol.47 , pp. 203-216
    • Mueck, W.1    Eriksson, B.I.2    Bauer, K.A.3
  • 47
    • 45949099359 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty
    • Eriksson B.I., Borris L.C., Friedman R.J., et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty. N Engl J Med 2008, 358:2765-2775.
    • (2008) N Engl J Med , vol.358 , pp. 2765-2775
    • Eriksson, B.I.1    Borris, L.C.2    Friedman, R.J.3
  • 48
    • 46049106502 scopus 로고    scopus 로고
    • Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial
    • Kakkar A.K., Brenner B., Dahl O.E., et al. Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial. Lancet 2008, 372:31-39.
    • (2008) Lancet , vol.372 , pp. 31-39
    • Kakkar, A.K.1    Brenner, B.2    Dahl, O.E.3
  • 49
    • 45949103416 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty
    • Lassen M.R., Ageno W., Borris L.C., et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med 2008, 358:2776-2786.
    • (2008) N Engl J Med , vol.358 , pp. 2776-2786
    • Lassen, M.R.1    Ageno, W.2    Borris, L.C.3
  • 50
    • 34447317298 scopus 로고    scopus 로고
    • Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939): the ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) study
    • Agnelli G., Gallus A., Goldhaber S.Z., et al. Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939): the ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) study. Circulation 2007, 116:180-187.
    • (2007) Circulation , vol.116 , pp. 180-187
    • Agnelli, G.1    Gallus, A.2    Goldhaber, S.Z.3
  • 51
    • 53849123533 scopus 로고    scopus 로고
    • A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: the Einstein-DVT Dose-Ranging Study
    • Buller H.R., Lensing A.W., Prins M.H., et al. A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: the Einstein-DVT Dose-Ranging Study. Blood 2008, 112:2242-2247.
    • (2008) Blood , vol.112 , pp. 2242-2247
    • Buller, H.R.1    Lensing, A.W.2    Prins, M.H.3
  • 52
    • 35848929515 scopus 로고    scopus 로고
    • Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrah ydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa
    • Pinto D.J., Orwat M.J., Koch S., et al. Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrah ydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. J Med Chem 2007, 50:5339-5356.
    • (2007) J Med Chem , vol.50 , pp. 5339-5356
    • Pinto, D.J.1    Orwat, M.J.2    Koch, S.3
  • 53
    • 58149458160 scopus 로고    scopus 로고
    • Apixaban metabolism and pharmacokinetics after oral administration to humans
    • Raghavan N., Frost C.E., Yu Z., et al. Apixaban metabolism and pharmacokinetics after oral administration to humans. Drug Metab Dispos 2009, 37:74-81.
    • (2009) Drug Metab Dispos , vol.37 , pp. 74-81
    • Raghavan, N.1    Frost, C.E.2    Yu, Z.3
  • 54
    • 68249158084 scopus 로고    scopus 로고
    • Apixaban or enoxaparin for thromboprophylaxis after knee replacement
    • Lassen M.R., Raskob G.E., Gallus A., et al. Apixaban or enoxaparin for thromboprophylaxis after knee replacement. N Engl J Med 2009, 361:594-604.
    • (2009) N Engl J Med , vol.361 , pp. 594-604
    • Lassen, M.R.1    Raskob, G.E.2    Gallus, A.3
  • 55
    • 47649098524 scopus 로고    scopus 로고
    • Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep vein thrombosis. The Botticelli DVT dose-ranging study
    • Buller H., Deitchman D., Prins M., et al. Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep vein thrombosis. The Botticelli DVT dose-ranging study. J Thromb Haemost 2008, 6:1313-1318.
    • (2008) J Thromb Haemost , vol.6 , pp. 1313-1318
    • Buller, H.1    Deitchman, D.2    Prins, M.3
  • 56
    • 63149141508 scopus 로고    scopus 로고
    • Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N, N-dimethylcarbamimidoyl)benzamido)-5-meth oxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor
    • Zhang P., Huang W., Wang L., et al. Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N, N-dimethylcarbamimidoyl)benzamido)-5-meth oxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor. Bioorg Med Chem Lett 2009, 19:2179-2185.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 2179-2185
    • Zhang, P.1    Huang, W.2    Wang, L.3
  • 57
    • 60849097858 scopus 로고    scopus 로고
    • A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT)
    • Turpie A.G., Bauer K.A., Davidson B.L., et al. A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT). Thromb Haemost 2009, 101:68-76.
    • (2009) Thromb Haemost , vol.101 , pp. 68-76
    • Turpie, A.G.1    Bauer, K.A.2    Davidson, B.L.3


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