Historical perspective on HIV-exposed seronegative individuals: Has nature done the experiment for us?

Journal of Infectious Diseases

Volumn 202, Issue SUPP.3, 2010, Pages

  Shearer, Gene ^a   Clerici, Mario ^b,c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF MILAN   (Italy)

^c IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOGLOBULIN A;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADAPTIVE IMMUNITY; ANTIVIRAL SUSCEPTIBILITY; CD8+ T LYMPHOCYTE; CELL ASSAY; CELLULAR IMMUNITY; COHORT ANALYSIS; CONFERENCE PAPER; CYTOTOXIC T LYMPHOCYTE; DISEASE ASSOCIATION; DRUG ABUSE; EXPOSURE; GENETIC PARAMETERS; HEALTH CARE PERSONNEL; HELPER CELL; HEMOPHILIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOLOGICAL PARAMETERS; IMMUNOPATHOGENESIS; INFECTION RESISTANCE; INNATE IMMUNITY; INTRAVENOUS DRUG ABUSE; LABORATORY PERSONNEL; NATURAL KILLER CELL; NEEDLESTICK INJURY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SERODIAGNOSIS; SEXUAL BEHAVIOR; SEXUALITY; SIMIAN IMMUNODEFICIENCY VIRUS; VERTICAL TRANSMISSION; VIRUS ISOLATION; VIRUS RESISTANCE; VIRUS TITRATION; VIRUS TRANSMISSION; DISEASE PREDISPOSITION; DISEASE TRANSMISSION; GENETICS; HISTORY; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; REVIEW; RISK FACTOR;

COHORT STUDIES; DISEASE SUSCEPTIBILITY; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, INNATE; RISK FACTORS;

EID: 78049442075     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/655974     Document Type: Conference Paper

References (25)

1. Inagawa DT, Lee MH, Wolinsky SM, et al. Human immunodeficiency virus type 1 infection in homosexual med who remain seronegative for prolonged periods. N Engl J Med 1989; 320:1458-62.
2. Plummer F, Fowke K, Nagelkerke NJ, Simonsen JN, Bwayo J, Ngugi E. Evidence for resistance to HIV among continuously exposed prostitutes in Nairobi, Kenya. Presented at: 9th International AIDS Conference / 4th STD World Congress; June 1993; Berlin, Germany. Abstract WA-A07-3.
3. Fowke KR, Nagelkerke NJD, Kimani J, et al. Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya. Lancet 1996; 348:1347-1351. (Pubitemid 26383775)
4. Ranki A, Mattinen S, Yorchoan R, et al. T cell responses towards HIV in infected individuals with and without zidovudine therapy, and in HIV-exposed sexual partners. AIDS 1989; 3:63-69.
5. Cleric M, Giorgi JV, Chou CC, et al. Cell-mediated immune responses to human immunodeficiency virus (HIV) type 1 in seronegative homosexual men with recent sexual exposure to HIV-1. J Infect Dis 1992; 165:1012-1019.
6. Shearer GM, Clerici M. Protective immunity against HIV infection: has nature done the experiment for us? Immunol Today 1996; 17:21-24.
7. Barcellini W, Rizzardi GP, Velati C, et al. In vitro production of type 1 and type 2 cytokines by peripheral blood mononuclear cells from high-risk-negative intravenous use drug users. AIDS 1995; 9:691-694.
8. Langlade-Demoyen P, Ngo-Giang-Huong N, Ferchal F, Oksenhendler E. Human immunodeficiency virus (HIV) nef-specific cytotoxic T lymphocytes in noninfected heterosexual contact of HIV-infected patients. J Clin Invest 1994; 93:1293-1297.
9. Clerici M, Sisson AV, Berzofsky JA, et al. Cellular immune factors associated with mother-to-infant transmission of HIV. AIDS 1993; 7:1427-1433.
10. Cheyneir R, Langlade-Demoyen P, Marescot, MR, et al. Cytotoxic T lymphocyte responses in the peripheral blood of children born to human immunodeficiency virus-1-infected mothers. Eur J Immunol 1992; 22:2211-2217.
11. Mazzoli S, Trabattoni D, Caputo SL, et al. HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individuals. Nature Med 1997; 3:1250-1257.
12. Devito C, Hinkula J, Kaul R, et al. Mucosal and plasma IgA from HIV-exposed seronegative individuals neutralize a primary HIV-1 isolate. AIDS 2000; 14:1917-1920.
13. Scott-Algara D,Truong LK, Versmisse P, et al. Cutting edge: increased NK cell activity in HIV-1-exposed but uninfected Vietnamese intravascular drug users. J Immunol 2003; 171:5663-5667.
14. Clerici M, Levin JM, Kessler HA, et al. HIV-specific T-helper activity in seronegative health care workers exposed to contaminated blood. JAMA 1994; 271:42-46.
15. Pinto LA, Sullivan J Berzofsky JA, et al. ENV-specific cytotoxic T lymphocyte responses in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids. J Clin Invest 1995; 96:867-876.
16. Kaul R, Rowland-Jones SL, Kimani J, et al. Late seroconversion in HIV-resistant Nairobi prostitutes despite pre-existing HIV-specific CD8+ responses. J Clin Invest 2001; 107:341-349.
17. Clerici M, Clark EA, Polacino P, et al. T-cell proliferation to subinfectious SIV correlates with lack of infection after challenge of macaques. AIDS 1994; 8:1391-1395.
18. Haase A. Targeting early infection to prevent HIV-1 mucosal transmission. Nature 2010; 464:217-223.
19. Goh W, Markee J, Akridge RE, et al. Protection against human immunodeficiency virus type 1infection in persons with repeated exposures: evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects. J Infect Dis 1999; 179:548-557.
20. MacDonald KS, Embree J, Njenga S, et al. Mother-child class I HLA concordance increases perinatal human immunodeficiency virus type I transmission. J Infect Dis 1998; 177:551-556.
21. Clerici M, Shearer GM. A TH1→TH2 switch is a critical step in the etiology of HIV infection. Immunol Today 1993; 14:107-111. (Pubitemid 23068292)
22. Herbeuval JP, Shearer GM. HIV-1 immunopathogenesis: how good interferon turns bad. Clin Immunol 2007; 123:121-128.
23. Boasso A, Shearer GM. Chronic innate immune activation as a cause of HIV-1 immunopathogenesis. Clin Immunol 2008; 126:235-242. (Pubitemid 351221427)
24. Jacquelin B, Mayau V, Targat B, et al. Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response. J Clin Invest 2009; 119:3544-3555.
25. Bosinger SE, Li Q, Gordon SN, et al. Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys. J Clin Invest 2009; 119:3556-3572.