Late seroconversion in HIV-resistant Nairobi prostitutes despite pre-existing HIV-specific CD8+ responses

Journal of Clinical Investigation

Volumn 107, Issue 3, 2001, Pages 341-349

  Kaul, Rupert ^a,b   Rowland Jones, Sarah L ^b   Kimani, Joshua ^a   Dong, Tao ^b   Yang, Hong Bing ^b   Kiama, Peter ^a   Rostron, Timothy ^b   Njagi, Ephantus ^a   Bwayo, Job J ^a   MacDonald, Kelly S ^c   McMichael, Andrew J ^b   Plummer, Francis A ^a,d  

^a UNIVERSITY OF NAIROBI   (Kenya)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CLINICAL ARTICLE; FEMALE; GENE MUTATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; KENYA; PRIORITY JOURNAL; PROSTITUTION; SEROCONVERSION;

EID: 0035134669     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI10714     Document Type: Article

References (38)

1. Correlates of protection in HIV infection and the progression of HIV infection to AIDS
2. Toward an understanding of the correlates of protective immunity to HIV infection
3. Immune responses in HIV-exposed seronegatives: Have they repelled the virus?
4. Progress in the development of an HIV-1 vaccine
5. Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy
6. Molecular tracking of an Human Immunodeficiency Virus nef specific cytotoxic T-cell clone shows persistence of clone-specific T-cell receptor DNA but not mRNA following early combination antiretroviral therapy
7. Evolution of cytotoxic T lymphocyte responses to human immunodeficiency virus type 1 in patients with symptomatic primary infection receiving antiretroviral triple therapy
8. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
9. Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy
10. Frequency of class I HLA-restricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART)
11. Memory CD8+ T cells in HIV infection
12. ENV-specific cytotoxic T lymphocyte responses in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids
13. HIV-1 specific cellular immune responses among HIV-1-resistant sex workers
14. Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte activity in HIV-exposed seronegative persons
15. Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: Evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects
16. Human immunodeficiency virus (HIV) nef-specific cytotoxic T lymphocytes in noninfected heterosexual contact of HIV-infected patients
17. HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women
18. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi
19. On the role of antigen in maintaining cytotoxic T-cell memory
20. Selection of virus variants and emergence of virus escape mutants after immunization with an epitope vaccine
21. Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus
22. Escape of human immunodeficiency virus from immune control
23. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection
24. Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya
25. HIV type 1 resistance in Kenyan sex workers is not associated with altered cellular susceptibility to HIV type 1 infection or enhanced beta-chemokine production
26. Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection
27. HIV-1 specific mucosal CD8+ lymphocyte responses in the cervix of HIV-1 resistant prostitutes in Nairobi
28. HIV-1-specific mucosal IgA in a cohort of HIV-1-resistant Kenyan sex workers
29. Prevention of transmission of human immunodeficiency virus in Africa: Effectiveness of condom promotion and health education among prostitutes
30. HIV infection among lower socioeconomic strata prostitutes in Nairobi
31. Development of oligonucleotide primers and probes against structural and regulatory genes of human immunodeficiency virus type 1 (HIV-1) and their use for amplification of HIV-1 provirus by using polymerase chain reaction
32. Phototyping: Comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP)
33. HIV CTL epitope alignments
34. Resistance to HIV-1 infection among highly exposed sex workers in Nairobi: What mediates protection and why does it develop?
35. Preparation for AIDS vaccine evaluation in Mombasa, Kenya: Establishment of seronegative cohorts of commercial sex workers and trucking company employees
36. A recombinant vaccinia virus based ELISPOT assay detects high frequencies of Pol-specific CD8 T cells in HIV-1-positive individuals
37. Immunologic memory and protective immunity: Understanding their relation