Neurocognitive and endothelial dysfunction in children with obstructive sleep apnea

Pediatrics

Volumn 126, Issue 5, 2010, Pages

  Gozal, David ^a,b   Kheirandish Gozal, Leila ^a,b   Bhattacharjee, Rakesh ^b   Spruyt, Karen ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

Atherosclerosis; Endothelial function; Endothelial progenitor cells; Serum lipids; Sleep apnea

Indexed keywords

OXYHEMOGLOBIN;

ARTERIAL PRESSURE; ARTICLE; BODY MASS; CHILD; CLINICAL EVALUATION; COGNITION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; END TIDAL CARBON DIOXIDE TENSION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM; FAMILY HISTORY; FEMALE; HUMAN; HYPEREMIA; LATENT PERIOD; MAJOR CLINICAL STUDY; MALE; OXYGEN SATURATION; PREDICTION; PRIORITY JOURNAL; REM SLEEP; SLEEP APNEA SYNDROME; SLEEP TIME; SPHYGMOMANOMETRY; SYSTOLIC BLOOD PRESSURE;

BLOOD PRESSURE DETERMINATION; BODY MASS INDEX; CHILD; CHILD, PRESCHOOL; COGNITION DISORDERS; COMORBIDITY; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; HYPEREMIA; MALE; MICROCIRCULATION; NEUROPSYCHOLOGICAL TESTS; POLYSOMNOGRAPHY; RISK ASSESSMENT; RISK FACTORS; SLEEP APNEA, OBSTRUCTIVE;

EID: 78049438897     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2010-0688     Document Type: Article

References (47)

1. Lumeng JC, Chervin RD. Epidemiology of pediatric obstructive sleep apnea. Proc Am Thorac Soc. 2008;5(2):242-252 (Pubitemid 351237884)
2. Gozal D. Sleep-disordered breathing and school performance in children. Pediatrics. 1998;102(3 pt 1):616-620 (Pubitemid 28409262)
3. O'Brien LM, Mervis CB, Holbrook CR, et al. Neurobehavioral correlates of sleep disordered breathing in children. J Sleep Res. 2004;13(2):165-172 (Pubitemid 38829898)
4. Montgomery-Downs HE, Crabtree VM, Gozal D. Cognition sleep and respiration in at-risk children treated for obstructive sleep apnea. Eur Respir J. 2005;25(2):336-342 (Pubitemid 40246536)
5. Gozal D, Capdevila OS, Kheirandish-Gozal L. Metabolic alterations and systemic inflammation in obstructive sleep apnea among nonobese and obese prepubertal children. Am J Respir Crit Care Med. 2008;177(10): 1142-1149 (Pubitemid 351717574)
6. Amin R, Somers VK, McConnell K, et al. Activity-adjusted 24-hour ambulatory blood pressure and cardiac remodeling in children with sleep disordered breathing. Hypertension. 2008;51(1):84-91 (Pubitemid 350307108)
7. McConnell K, Somers VK, Kimball T, et al. Baroreflex gain in children with obstructive sleep apnea. Am J Respir Crit Care Med. 2009;180(1):42-48
8. Gozal D, Kheirandish-Gozal L, Serpero LD, Sans Capdevila O, Dayyat E. Obstructive sleep apnea and endothelial function in school-aged non-obese children: effect of adenotonsillectomy. Circulation. 2007; 116(20):2307-2314 (Pubitemid 350100337)
9. Gozal D, McLaughlin Crabtree V, Sans Capdevila O, Witcher LA, Kheirandish-Gozal L. C reactive protein, obstructive sleep apnea, and cognitive dysfunction in school-aged children. Am J Respir Crit Care Med. 2007; 176(2):188-193 (Pubitemid 47057856)
10. Kheirandish-Gozal L, Bhattacharjee R, Kim J, Clair HB, Gozal D. Endothelial progenitor cells and vascular dysfunction in pediatric OSA. Am J Respir Crit Care Med. 2010;182(1): 92-97
11. Kheirandish L, Gozal D. Neurocognitive dysfunction in children with sleep disorders. Dev Sci. 2006;9(4):388-399 (Pubitemid 43855818)
12. Somers VK, White DP, Amin R, et al. Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing. Circulation. 2008;118(10):1080-1111
13. Bhattacharjee R, Kheirandish-Gozal L, Pillar G, Gozal D. Cardiovascular complications of obstructive sleep apnea syndrome: evidence from children. Prog Cardiovasc Dis. 2009;51(5):416-433
14. Gozal D, Kheirandish-Gozal L. Cardiovascular morbidity in obstructive sleep apnea: oxidative stress, inflammation, and much more. Am J Respir Crit Care Med. 2008; 177(4):369-375 (Pubitemid 351317579)
15. Kheirandish-Gozal, Bhattacharjee R, Gozal D. Autonomic alterations and endothelial dysfunction in pediatric obstructive sleep apnea. Sleep Med. 2010;11(7):714-720
16. Gozal D, Kheirandish-Gozal L. The multiple challenges of obstructive sleep apnea in children: morbidity and treatment. Curr Opin Pediatr. 2008;20(6):654-658
17. Gozal D, Sans Capdevila O, Kheirandish- Gozal L, McLaughlin Crabtree V. Apolipoprotein E ε4 allele, neurocognitive dysfunction, and obstructive sleep apnea in school-aged children. Neurology. 2007;69(3):243-249
18. Gozal D, Sans Capdevila O, McLaughlin Crabtree V, Serpero LD, Witcher LA, Kheirandish-Gozal L. Plasma insulin growth factor 1 levels and cognitive dysfunction in school-aged children with obstructive sleep apnea. Sleep Med. 2009;10(2):167-173
19. Montgomery-Downs HE, Krishna J, Roberts LJ 2nd, Gozal D. Urinary F2-isoprostane metabolite levels in children with sleep-disordered breathing. Sleep Breath. 2006; 10(4):211-215 (Pubitemid 44768848)
20. Verhulst SL, Van Hoeck K, Schrauwen N, et al. Sleep-disordered breathing and uric acid in overweight and obese children and adolescents. Chest. 2007;132(1):76-80 (Pubitemid 47068206)
21. Kaditis A, Gozal D, Snow AB, et al. Uric acid excretion in North American and Southeast European children with obstructive sleep apnea. Sleep Med. 2010;11(5):489-493
22. Sans Capdevila O, Kheirandish-Gozal L, Dayyat E, Gozal D. Pediatric obstructive sleep apnea: complications, management, and long-term outcomes. Proc Am Thorac Soc. 2008;5(2):274-282 (Pubitemid 351237887)
23. Halbower AC, Degaonkar M, Barker PB, et al. Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury. PLoS Med. 2006;3(8):e301
24. Hogan AM, Hill CM, Harrison D, Kirkham FJ. Cerebral blood flow velocity and cognition in children before and after adenotonsillectomy [published correction appears in Pediatrics. 2008;122(3):689-90]. Pediatrics. 2008;122(1):75-82
25. Kim J, Bhattacharjee R, Snow AB, Sans Capdevila O, Kheirandish-Gozal L, Gozal D. Myeloid related protein 8/14 levels in children with obstructive sleep apnea. Eur Respir J. 2010;35(4):843-850
26. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004; 114(2 suppl 4th report):555-576
27. Rechstschaffen A, Kales A. A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Los Angeles, CA: Brain Information Services/Brain Research Institute, University of California; 1968
28. Standards and indications for cardiopulmonary sleep studies in children: American Thoracic Society. Am J Respir Crit Care Med. 1996;153(2):866-878
29. Montgomery-Downs HE, O'Brien LM, Gulliver TE, Gozal D. Polysomnographic characteristics in normal preschool and early school-aged children. Pediatrics. 2006;117(3):741-753 (Pubitemid 46063216)
30. Iber C, Ancoli-Israel S, Chesson Jr AL, Quan SF. The AASM Manual for the Scoring of Sleep and Associated Events. Darien, IL: American Academy of Sleep Medicine; 2007
31. Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. EEG arousals: scoring rules and examples: a preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep. 1992;15(2): 173-184
32. Elliott CD. Differential Ability Scales: Handbook. San Antonio, TX: Psychological Corporation; 1990
33. Korkman M, Kirk U, Kemp S. NEPSY: A Developmental Neuropsychological Assessment Manual. San Antonio, TX: Psychological Corporation; 1998
34. Bhattacharjee R, Alotaibi WH, Kheirandish- Gozal L, Capdevila OS, Gozal D. Endothelial dysfunction in obese non-hypertensive children without evidence of sleep disordered breathing. BMC Pediatr. 2010;10:8
35. Wahlberg E, Olofsson P, Swendenborg J, Fagrell B. Changes in postocclusive reactive hyperaemic values as measured with laser Doppler fluxmetry after infrainguinal arterial reconstructions. Eur J Vasc Endovasc Surg. 1995;9(2):197-203
36. O'Brien LM, Mervis CB, Holbrook CR, et al. Neurobehavioral implications of habitual snoring in children. Pediatrics. 2004;114(1): 44-49
37. Khalyfa A, Capdevila OS, Buazza MO, Serpero LD, Kheirandish-Gozal L, Gozal D. Genomewide gene expression profiling in children with non-obese obstructive sleep apnea. Sleep Med. 2009;10(1):75-86
38. Snow AB, Khalyfa A, Serpero LD, et al. Catecholamine alterations in pediatric obstructive sleep apnea: effect of obesity. Pediatr Pulmonol. 2009;44(6):559-567
39. Kaditis AG, Alexopoulos EI, Damani E, et al. Urine levels of catecholamines in Greek children with obstructive sleep-disordered breathing. Pediatr Pulmonol. 2009;44(1): 38-45
40. Gozal D. Sleep, sleep disorders and inflammation in children. Sleep Med. 2009; 10(suppl 1):S12-S16
41. Khalyfa A, Bhushan B, Hegazi M, et al. Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels. Lipids Health Dis. 2010;9:18
42. Key AP, Molfese DL, O'Brien L, Gozal D. Sleep-disordered breathing affects auditory processing in 5-7-year-old children: evidence from brain recordings. Dev Neuropsychol. 2009;34(5):615-628
43. Barnes ME, Huss EA, Garrod KN, et al. Impairments in attention in occasionally snoring children: an event-related potential study. Dev Neuropsychol. 2009;34(5):629-649
44. Yaouhi K, Bertran F, Clochon P, et al. A combined neuropsychological and brain imaging study of obstructive sleep apnea. J Sleep Res. 2009;18(1):36-48
45. Ayalon L, Ancoli-Israel S, Aka AA, McKenna BS, Drummond SP. Relationship between obstructive sleep apnea severity and brain activation during a sustained attention task. Sleep. 2009;32(3):373-381
46. Castronovo V, Canessa N, Strambi LF, et al. Brain activation changes before and after PAP treatment in obstructive sleep apnea. Sleep. 2009;32(9):1161-1172
47. Hill CM, Hogan AM, Onugha N, et al. Increased cerebral blood flow velocity in children with mild sleep-disordered breathing: a possible association with abnormal neuropsychological function. Pediatrics. 2006; 118(4). Available at: www.pediatrics.org/ cgi/content/full/118/4/e1100