The impact of childhood sexual abuse on activation of immunological and neuroendocrine response

Aggression and Violent Behavior

Volumn 15, Issue 6, 2010, Pages 440-445

  Nunes, Sandra Odebrecht Vargas ^a   Watanabe, Maria Angelica Ehara ^b   Morimoto, Helena K ^b   Moriya, Renato ^c   Reiche, Edna Maria Vissoci ^b  

^a Department of Psychiatry   (Brazil)

^b Department of Pathological Sciences ^*  (Brazil)

^c Pediatrician Health Sciences Center (UEL)   (Brazil)

Author keywords

Childhood sexual abuse; Immunological response; Neuroendocrine

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; CYTOKINE; HYDROCORTISONE; INTERLEUKIN 1; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

AMYGDALOID NUCLEUS; AUTONOMIC NERVOUS SYSTEM; CHILD SEXUAL ABUSE; CORTICOTROPIN BLOOD LEVEL; DATA BASE; HIPPOCAMPUS; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE RESPONSE; MACROPHAGE; MEDLINE; MENTAL STRESS; NEUROENDOCRINE SYSTEM; PRIORITY JOURNAL; REVIEW;

EID: 78049428840     PISSN: 13591789     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.avb.2010.07.006     Document Type: Review

References (31)

1. Altermus M., Cloitre M., Dhabhar F. Enhanced cellular immune response in women with PTSD related to childhood abuse. The American Journal of Psychiatry 2003, 160(9):1705-1707.
2. American Academy of Pediatrics Guidelines for the evaluation of sexual abuse of children. Pediatrics 1991, 87:254-260.
3. Bicanic I.A., Meijer G., Sinnema E.M., van de Putte E.M., Olff M. Neuroendocrine dysregulations in sexually abused children and adolescents: A systematic review. Progress in Brain Research 2008, 167:303-306.
4. Bremmer J.D., Vythilingam M., Anderson G., Vermetten E., McGlashan T., et al. Assessment of the hypothalamic-pituitary-adrenal axis over a 24-hour diurnal period and in response to neuroendocrine challenges in women with and without childhood sexual abuse and posttraumatic stress disorder. Biological Psychiatry 2003 b, 54(7):710-718.
5. Bremmer J.D., Vythilingam M., Vermetten E., Southwick S.M., McGlashan T., Nazeer A., et al. MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder. The American Journal of Psychiatry 2003, 160(5):924-932.
6. Bremmer D., Yermetten E., Kelley M.E. Cortisol, dehydroepiandrosterone, and estradiol measured over 24 hours in women with childhood sexual abuse-related posttraumatic stress disorder. The Journal of Nervous and Mental Disease 2007, 195(11):919-927.
7. Charmandari E., Kino T., Souvatzoglou E., Chrousos G. Pediatric stress: Hormonal mediators and human. Development Hormone Research 2003, 59(4):161-179.
8. Cicchetti D., Rogosch T.A. The impact of child maltreatment and psychopathology on neuroendocrine functioning. Development and Psychopathology 2001, 13(4):783-804.
9. De Bellis M.D., Chrousus G.P., Dorn L.D., Burke L., Helmers K., Kling M.A., et al. Hypothalamic-pituitary-adrenal axis dysregulation in sexually abused girls. The Journal of Clinical Endocrinology and Metabolism 1994, 78(2):249-255.
10. Grassi-Oliveira R., Ashy M., Stein L. Psychobiology of childhood maltreatment: Effects of allostatic load?. Revista Brasileira de Psiquiatria 2008, 30:60-68.
11. Heim C., Nemeroff C. The impact of early adverse experiences on brain systems involved in pathophysiology of anxiety and affective disorders. Biological Psychiatry 1999, 46(11):1509-1522.
12. Heim C., Newport J., Bonsall R., Miller A., Nemeroff C. Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. The American Journal of Psychiatry 2001, 158(4):575-581.
13. Heim C., Newport J., Heit S., Graham Y., Wilcox M., Bonsal R., et al. Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. Journal of the American Medical Association 2000, 284(5):592-597.
14. Heim C., Plotsky P., Nemeroff C. Importance of studying the contributions of early adverse experience to neurobiological findings in depression. Neuropsychopharmacology 2004, 29:641-648.
15. Karten Y., Olariu A., Cameron H. Stress in early life inhibits neurogenesis in adulthood. Trends in Neurosciences 2005, 28(4):171-172.
16. Kim Y.K., Maes M. The role of the cytokine network in psychological stress. Acta Neuropsychiatrica 2003, 15(3):148-155.
17. King J.A., Mandansky D., King S., Fletcher K., Brewer J. Early sexual abuse and low cortisol. Psychiatry and Clinical Neurosciences 2001, 55:71-74.
18. Kronfol Z., Remick D. Cytokines and the brain: Implications for clinical psychiatry. The American Journal of Psychiatry 2000, 157(5):683-690.
19. Krug E.G., Dahlberg L., Mercy J., Zwi A., Lozano R. Child abuse and neglect by parents and other caregivers. World Health Organization. World Report on violence and health 2002, 59-81. World Health Organization, Geneva.
20. Lemieux A.M., Coe C.L. Abuse-related posttraumatic stress disorder: Evidence for chronic neuroendocrine activation in women. Psychosomatic Medicine 1995, 57(2):105-115.
21. Leserman J. Sexual abuse history: Prevalence, health effects, mediators, and psychological treatment. Psychosomatic Medicine 2005, 67(6):906-907.
22. MacEwen B. Seminars in medicine of Beth Israel Deaconess Medical Center: Protective and damaging effects of stress mediators. The New England Journal of Medicine 1998, 338(3):171-179.
23. Newport D.J., Heim C., Bonsall R., Miller A., Nemeroff C. Pituitary-adrenal response to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse. Biological Psychiatry 2004, 55(1):10-20.
24. Pace T., Mletzko T., Alagbe O., Musselman D., Nemeroff C., Miller A., et al. Increase stress-induced inflammatory response in male patients with major depression and increased early life stress. The American Journal of Psychiatry 2006, 163(9):1630-1633.
25. Putnam F.W., Trickett P.K. Psychobiological effects of sexual abuse. A longitudinal study. Annals of the New York Academy of Sciences 1997, 821:150-159.
26. Raison C.L., Miller A.H. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. The American Journal of Psychiatry 2003, 160(9):1554-1565.
27. Reiche E.M.V., Nunes S.O.V., Morimoto H.K. Stress, depression, the immune system, and cancer. The Lancet Oncology 2004, 5(10):617-625.
28. Stein M., Koverola C., Hanna C., Torchia M.G., McClarty B. Hippocampal volume in women victimized by childhood sexual abuse. Psychological Medicine 1997, 27:951-959.
29. Voorheers Van, Scarpa A. The effects of child maltreatment on the hypothalamic-pituitary-adrenal axis. Trauma, Violence & Abuse 2004, 5(4):333-352.
30. Zalsman G., Huang Y., Oquendo M., Burke A., Hu X., Brent D., et al. Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. The American Journal of Psychiatry 2006, 163(9):1588-1593.
31. Zink T., Klesges L., Stevens S., Decker P. The development of a sexual abuse severity score. Characteristics of childhood sexual abuse associated with trauma symptomatology, somatization, and alcohol abuse. Journal of Interpersonal Violence 2009, 24:537-546.