Metabolism of 1′- and 4-hydroxymidazolam by glucuronide conjugation is largely mediated by UDP-glucuronosyltransferases 1A4, 2B4, and 2B7

Drug Metabolism and Disposition

Volumn 38, Issue 11, 2010, Pages 2007-2013

  Seo, Kyung Ah ^a   Bae, Soo Kyung ^a,b   Choi, Young Kil ^b   Choi, Chang Soo ^b   Liu, Kwang Hyeon ^a   Shin, Jae Gook ^a,b  

^a Inje University College of Medicine   (South Korea)

^b Inje University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYMIDAZOLAM; ALPHA HYDROXYMIDAZOLAM; DICLOFENAC; DRUG METABOLITE; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A4; GLUCURONOSYLTRANSFERASE 2B4; GLUCURONOSYLTRANSFERASE 2B7; HECOGENIN; LAMOTRIGINE; UNCLASSIFIED DRUG; 1-HYDROXYMETHYLMIDAZOLAM; 4-HYDROXYMIDAZOLAM; BILIRUBIN GLUCURONOSIDE GLUCURONOSYLTRANSFERASE; DRUG DERIVATIVE; MIDAZOLAM; RECOMBINANT PROTEIN; UGT2B4 PROTEIN, HUMAN; UGT2B7 PROTEIN, HUMAN;

ARTICLE; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME KINETICS; GLUCURONIDATION; HUMAN; HUMAN CELL; LIVER MICROSOME; PRIORITY JOURNAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DETOXIFICATION; ENZYMOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; IN VITRO STUDY; METABOLISM; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; HYDROXYLATION; METABOLIC DETOXICATION, PHASE II; MICROSOMES, LIVER; MIDAZOLAM; MOLECULAR STRUCTURE; RECOMBINANT PROTEINS; TANDEM MASS SPECTROMETRY;

EID: 78049364078     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.035295     Document Type: Article

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