E. coli hypoxia-inducible factor ArcA mediates lifespan extension in a lipoic acid synthase mutant by suppressing acetyl-CoA synthetase

Biological Chemistry

Volumn 391, Issue 10, 2010, Pages 1139-1147

  Gonidakis, Stavros ^a   Finkel, Steven E ^a   Longo, Valter D ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

acetate; ATP; heat shock resistance; oxygen consumption; protein carbonylation

Indexed keywords

ACETYL COENZYME A SYNTHETASE; AEROBIC RESPIRATION CONTROL PROTEIN A; LIPOIC ACID SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CARBON SOURCE; ENZYME REPRESSION; GENE DELETION; HEAT SHOCK; LIFESPAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRESS;

ACETATE-COA LIGASE; ADENOSINE TRIPHOSPHATE; BACTERIAL OUTER MEMBRANE PROTEINS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; HEAT-SHOCK RESPONSE; LONGEVITY; MUTATION; OXYGEN; REPRESSOR PROTEINS; SULFURTRANSFERASES;

ARCA; ESCHERICHIA COLI; EUKARYOTA;

EID: 78049353596     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2010.120     Document Type: Article

References (36)

1. Baba, T., Ara, T., Hasegawa, M., Takai, Y., Okumura, Y., Baba, M., Datsenko, K.A., Tomita, M., Wanner, B.L., and Mori, H. (2006). Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol. Syst. Biol. 2, 1-11.
2. Buckstein, M.H., He, J., and Rubin, H. (2008). Characterization of nucleotide pools as a function of physiological state in Esche-richia coli. J. Bacteriol. 190, 718-726.
3. Clark, D.P. (1989). The fermentation pathways of Escherichia coli. FEMS Microbiol. Rev. 5, 223-234.
4. Cronan, J.E. and Laporte, D. (1996). Tricarboxylic acid cycle and glyoxylate bypass. In: Escherichia coli and Salmonella typhi-murium: Cellular and Molecular Biology, F.C. Neidhardt, ed. (Washington, DC, USA: ASM Press), pp. 206-216.
5. Cronan, J.E., Zhao, X., and Jiang, Y. (2005). Function, attachment and synthesis of lipoic acid in Escherichia coli. Adv. Microb. Physiol. 50, 103-146.
6. Dalle-Donne, I., Carini, M., Orioli, M., Vistoli, G., Regazzoni, L., Colombo, G., Rossi, R., Milzani, A., and Aldini, G. (2009). Protein carbonylation: 2,4-dinitrophenylhydrazine reacts with both aldehydes/ketones and sulfenic acids. Free Radic. Biol. Med. 46, 1411-1419.
7. Datsenko, K.A. and Wanner, B.L. (2000). One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. USA 97, 6640-6645.
8. Desnues, B., Cuny, C., Gregori, G., Dukan, S., Aguilaniu, H., and Nystrom, T. (2003). Differential oxidative damage and expression of stress defence regulons in culturable and non-culturable Escherichia coli cells. EMBO Rep. 4, 400-404.
9. Dukan, S. and Nystrom, T. (1998). Bacterial senescence: stasis results in increased and differential oxidation of cytoplasmic proteins leading to developmental induction of the heat shock regulon. Genes Dev. 12, 3431-3441.
10. Dukan, S. and Nystrom, T. (1999). Oxidative stress defense and deterioration of growth-arrested Escherichia coli cells. J. Biol. Chem. 274, 26027-26032.
11. Finkel, S.E. (2006). Long-term survival during stationary phase: evolution and the GASP phenotype. Nat. Rev. Microbiol. 4, 113-120.
12. Fontaine, F., Stewart, E.J., Lindner, A.B., and Taddei, F. (2008). Mutations in two global regulators lower individual mortality in Escherichia coli. Mol. Microbiol. 67, 2-14.
13. Gonidakis, S., Finkel, S.E., and Longo, V.D. (2010). Genome-wide screen identifies Escherichia coli TCA cycle-related mutants with extended chronological lifespan dependent on acetate metabolism and the hypoxia-inducible transcription factor ArcA. Aging Cell, in press.
14. Hara, K.Y., Shimodate, N., Ito, M., Baba, T., and Mori, H. (2009). Systematic genome-wide scanning for genes involved in ATP generation in Escherichia coli. Metab. Eng. 11, 1-7.
15. Iuchi, S. and Lin, E.C. (1991). Adaptation of Escherichia coli to respiratory conditions: regulation of gene expression. Cell 66, 5-7.
16. Kawano, H., Hirokawa, Y., and Mori, H. (2009). Long-term survival of Escherichia coli lacking the HipBA toxin-antitoxin system during prolonged cultivation. Biosci. Biotechnol. Biochem. 73, 117-123.
17. Kumari, S., Tishel, R., Eisenbach, M., and Wolfe, A.J. (1995). Cloning, characterization, and functional expression of acs, the gene which encodes acetyl coenzyme A synthetase in Escherichia coli. J. Bacteriol. 177, 2878-2886.
18. Kumari, S., Beatty, C.M., Browning, D.F., Busby, S.J., Simel, E.J., Hovel-Miner, G., and Wolfe, A.J. (2000). Regulation of acetyl coenzyme A synthetase in Escherichia coli. J. Bacteriol. 182, 4173-4179.
19. Levanon, S.S., San, K.Y., and Bennett, G.N. (2005). Effect of oxygen on the Escherichia coli ArcA and FNR regulation systems and metabolic responses. Biotechnol. Bioeng. 89, 556-564.
20. Liu, X. and De Wulf, P. (2004). Probing the ArcA-P modulon of Escherichia coli by whole genome transcriptional analysis and sequence recognition profiling. J. Biol. Chem. 279, 12588-12597.
21. Longo, V.D. and Finch, C.E. (2003). Evolutionary medicine: from dwarf model systems to healthy centenarians? Science 299, 1342-1346.
22. Lynch, A.S. and Lin, E.C. (1996). Transcriptional control mediated by the ArcA two-component response regulator protein of Escherichia coli: characterization of DNA binding at target promoters. J. Bacteriol. 178, 6238-6249.
23. Miller, J.R., Busby, R.W., Jordan, S.W., Cheek, J., Henshaw, T.F., Ashley, G.W., Broderick, J.B., Cronan, J.E. Jr., and Marletta, M.A. (2000). Escherichia coli LipA is a lipoyl synthase: in vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein. Biochemistry 39, 15166-15178.
24. Napolitano, M.J. and Shain, D.H. (2005). Quantitating adenylate nucleotides in diverse organisms. J. Biochem. Biophys. Methods 63, 69-77.
25. Nystrom, T. (2003). The free-radical hypothesis of aging goes pro-karyotic. Cell. Mol. Life Sci. 60, 1333-1341.
26. Nystrom, T. (2005). Role of oxidative carbonylation in protein quality control and senescence. EMBO J. 24, 1311-1317.
27. Nystrom, T., Larsson, C., and Gustafsson, L. (1996). Bacterial defense against aging: role of the Escherichia coli ArcA regulator in gene expression, readjusted energy flux and survival during stasis. EMBO J. 15, 3219-3228.
28. Pruss, B.M., Nelms, J.M., Park, C., and Wolfe, A.J. (1994). Mutations in NADH:ubiquinone oxidoreductase of Escherichia coli affect growth on mixed amino acids. J. Bacteriol. 176, 2143-2150.
29. Pudek, M.R. and Bragg, P.D. (1974). Inhibition by cyanide of the respiratory chain oxidases of Escherichia coli. Arch. Biochem. Biophys. 164, 682-693.
30. Salmon, K.A., Hung, S.P., Steffen, N.R., Krupp, R., Baldi, P., Hat-field, G.W., and Gunsalus, R.P. (2005). Global gene expression profiling in Escherichia coli K12: effects of oxygen availability and ArcA. J. Biol. Chem. 280, 15084-15096.
31. Schneider, D.A. and Gourse, R.L. (2004). Relationship between growth rate and ATP concentration in Escherichia coli: a bio-assay for available cellular ATP. J. Biol. Chem. 279, 8262-8268.
32. 31Px nuclear magnetic resonance of methylphosphonate and phosphate. Proc. Natl. Acad. Sci. USA 78, 6271-6275.
33. Vemuri, G.N., Eiteman, M.A., and Altman, E. (2006). Increased recombinant protein production in Escherichia coli strains with overexpressed water-forming NADH oxidase and a deleted ArcA regulatory protein. Biotechnol. Bioeng. 94, 538-542.
34. Vulic, M. and Kolter, R. (2002). Alcohol-induced delay of viability loss in stationary-phase cultures of Escherichia coli. J. Bacteriol. 184, 2898-2905.
35. Wolfe, A.J. (2005). The acetate switch. Microbiol. Mol. Biol. Rev. 69, 12-50.
36. Zambrano, M.M., Siegele, D.A., Almiron, M., Tormo, A., and Kol-ter, R. (1993). Microbial competition: Escherichia coli mutants that take over stationary phase cultures. Science 259, 1757-1760.