Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 41, 2010, Pages 17557-17562

  Lee, Jin Hee ^a   Bae, Brian ^b   Kuemin, Michael ^a   Circello, Benjamin T ^a,b   Metcalf, William W ^a,b   Nair, Satish K ^a,b   Van Der Donk, Wilfred A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Antibiotics; Bioengineering; Conformational change; Domain swap; X ray crystallography

Indexed keywords

1 HYDROXYETHYLPHOSPHONATE; 1,2 DIHYDROXYETHYLPHOSPHONATE; ACETYL 1 AMINOETHYLPHOSPHONATE; DEHYDROPHOS; PHOSPHONATE O METHYLTRANSFERASE; PHOSPHONIC ACID DERIVATIVE; PROTEIN METHYLTRANSFERASE; S ADENOSYLMETHIONINE; TRIPEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE CLUSTER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METHYLATION; SITE DIRECTED MUTAGENESIS;

BIOENGINEERING; BIOSYNTHETIC PATHWAYS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; ESTERIFICATION; FOSFOMYCIN; KINETICS; MASS SPECTROMETRY; METHYLATION; METHYLTRANSFERASES; MOLECULAR STRUCTURE; PHOSPHONIC ACIDS; S-ADENOSYLMETHIONINE; STREPTOMYCES; SUBSTRATE SPECIFICITY;

EID: 78049274321     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1006848107     Document Type: Article

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