Diet (zinc)-gene interaction related to inflammatory/immune response in ageing: Possible link with frailty syndrome?

Biogerontology

Volumn 11, Issue 5, 2010, Pages 589-595

  Mocchegiani, Eugenio ^a   Basso, Andrea ^a   Giacconi, Robertina ^a   Piacenza, Francesco ^a   Costarelli, Laura ^a   Pierpaoli, Sara ^a   Malavolta, Marco ^a  

^a INRCA   (Italy)

Author keywords

Frailty; IL 6; Inflammation; Longevity; Metallothionein; Polymorphism; Zinc

Indexed keywords

CYANOCOBALAMIN; INTERLEUKIN 6; ZINC;

AGING; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; DIET; DIET SUPPLEMENTATION; DIETARY INTAKE; DNA POLYMORPHISM; ELDERLY CARE; FRAIL ELDERLY; GENE INTERACTION; GENE LOCUS; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GERIATRIC DISORDER; GERIATRIC NUTRITION; HUMAN; IMMUNE RESPONSE; INFLAMMATION; LONGEVITY; PRIORITY JOURNAL; REVIEW;

AGED; AGED, 80 AND OVER; DIET; EPISTASIS, GENETIC; FRAIL ELDERLY; HUMANS; INTERLEUKIN-6; POLYMORPHISM, GENETIC; ZINC;

EID: 78049262450     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-010-9276-5     Document Type: Review

References (31)

1. HW Baik RM Russell 1999 Vitamin B12 deficiency in the elderly Annu Rev Nutr 19 357 377 1:CAS:528:DyaK1MXlt1ejsLY%3D 10.1146/annurev.nutr.19.1.357 10448529 (Pubitemid 29380609)
2. M Bonafe F Olivieri L Cavallone S Giovagnetti F Mayegiani M Cardelli C Pieri M Marra R Antonicelli R Lisa MR Rizzo G Paolisso D Monti C Franceschi 2001 A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity Eur J Immunol 31 2357 2361 1:CAS:528: DC%2BD3MXmt1ens7o%3D 10.1002/1521-4141(200108)31:8<2357::AID-IMMU2357>3.0. CO;2-X 11500818 (Pubitemid 32785354)
3. I Darnton-Hill B Margetts R Deckelbaum 2004 Public health nutrition and genetics: implications for nutrition policy and promotion Proc Nutr Soc 63 173 185 1:CAS:528:DC%2BD2cXktFGlu7Y%3D 10.1079/PNS2003330 15070448 (Pubitemid 38543886)
4. D Di Bona S Vasto C Capurso L Christiansen L Deiana C Franceschi M Hurme E Mocchegiani M Rea D Lio G Candore C Caruso 2009 Effect of interleukin-6 polymorphisms on human longevity: a systematic review and meta-analysis Ageing Res Rev 8 36 42 10.1016/j.arr.2008.09.001 18930842
5. IE Dreosti 2001 Zinc and the gene Mutat Res 475 161 167 1:CAS:528:DC%2BD3MXitl2hsbc%3D 11295161
6. U Fagiolo A Cossarizza E Scala E Fanales-Belasio C Ortolani E Cozzi D Monti C Franceschi R Paganelli 1993 Increased cytokine production in mononuclear cells of healthy elderly people Eur J Immunol 23 2375 2378 1:CAS:528: DyaK3sXms1yltrk%3D 10.1002/eji.1830230950 8370415
7. L Ferrucci TB Harris JM Guralnik RP Tracy MC Corti HJ Cohen B Penninx M Pahor R Wallace RJ Havlik 1999 Serum IL-6 level and the development of disability in older persons J Am Geriatr Soc 47 639 646 1:STN:280: DyaK1M3pt1arsA%3D%3D 10366160
8. C Franceschi F Olivieri F Marchegiani M Cardelli L Cavallone M Capri S Salvioli S Valensin G De Benedictis A Di Iorio C Caruso G Paolisso D Monti 2005 Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians Mech Ageing Dev 126 351 361 1:CAS:528:DC%2BD2cXhtFGhsbzJ 10.1016/j.mad.2004.08.028 15621218 (Pubitemid 40038357)
9. C Franceschi M Capri D Monti S Giunta F Olivieri F Sevini MP Panourgia L Invidia L Celani M Scurti E Cevenini GC Castellani S Salvioli 2007 Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans Mech Ageing Dev 128 92 105 1:CAS:528: DC%2BD2sXmtVWqug%3D%3D 10.1016/j.mad.2006.11.016 17116321 (Pubitemid 46073065)
10. LP Fried L Ferrucci J Darer JD Williamson G Anderson 2004 Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care J Gerontol A Biol Sci Med Sci 59 255 263 15031310
11. R Giacconi C Cipriano F Albanese G Boccoli V Saba F Olivieri C Franceschi E Mocchegiani 2004 The -174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing Exp Gerontol 39 621 628 1:CAS:528:DC%2BD2cXisF2nu7o%3D 10.1016/j.exger.2003.12.013 15050298 (Pubitemid 38402089)
12. C Kapadia 2000 Cobalamin (Vitamin B12) deficiency: is it a problem for our aging population and is the problem compounded by drugs that inhibit gastric acid secretion? J Clin Gastroenterol 30 4 6 1:STN:280:DC%2BD3c7gtVWmuw%3D%3D 10.1097/00004836-200001000-00003 10636204 (Pubitemid 30032648)
13. TB Kirkwood 2002 Evolution of ageing Mech Ageing Dev 123 737 745 10.1016/S0047-6374(01)00419-5 11869731 (Pubitemid 34178486)
14. M Kuningas SP Mooijaart D van Heemst BJ Zwaan PE Slagboom RG Westendorp 2008 Genes encoding longevity: from model organisms to humans Aging Cell 7 270 280 1:CAS:528:DC%2BD1cXksFeiu7c%3D 10.1111/j.1474-9726.2008.00366.x 18208581 (Pubitemid 351359659)
15. SX Leng QL Xue J Tian JD Walston LP Fried 2007 Inflammation and frailty in older women J Am Geriatr Soc 55 864 871 10.1111/j.1532-5415.2007.01186.x 17537086 (Pubitemid 47011043)
16. Y Liu HK Sanoff H Cho CE Burd C Torrice KL Mohlke JG Ibrahim NE Thomas NE Sharpless 2009 INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis PLOS One 4 e5027 10.1371/journal.pone. 0005027 19343170
17. M Maggio JM Guralnik DL Longo L Ferrucci 2006 Interleukin-6 in aging and chronic disease: a magnificent pathway J Gerontol A Biol Sci Med Sci 61 575 584 16799139
18. Malavolta M, Giacconi R, Piacenza F, Santarelli L, Cipriano C, Costarelli L, Tesei S, Pierpaoli S, Basso A, Galeazzi R, Lattanzio F, Mocchegiani E (2009) Plasma copper/zinc ratio: an inflammatory/nutritional biomarker as predictor of all-cause mortality in elderly population. Biogerontology. doi: 10.1007/s10522-009-9251-1
19. AM Matteini JD Walston K Bandeen-Roche DE Arking RH Allen LP Fried A Chakravarti SP Stabler MD Fallin 2010 Transcobalamin-II variants, decreased vitamin B12 availability and increased risk of frailty J Nutr Health Aging 14 73 77 1:CAS:528:DC%2BC3cXislOhur8%3D 10.1007/s12603-010-0013-1 20082058
20. MP Mattson 2008 Dietary factors, hormesis and health Ageing Res Rev 7 43 48 10.1016/j.arr.2007.08.004 17913594
21. DJ Mazzatti M Malavolta AJ White L Costarelli R Giacconi E Muti C Cipriano JR Powell E Mocchegiani 2008 Effects of interleukin-6 -174C/G and metallothionein 1A +647A/C single-nucleotide polymorphisms on zinc-regulated gene expression in ageing Exp Gerontol 43 423 432 1:CAS:528:DC%2BD1cXkvFCqu78%3D 10.1016/j.exger.2008.01.007 18316168
22. AB Mitnitski JE Graham AJ Mogilner K Rockwood 2002 The mortality rate as a function of accumulated deficits in a frailty index Mech Ageing Dev 123 1457 1460 10.1016/S0047-6374(02)00082-9 12425952 (Pubitemid 35341153)
23. PN Mitrou V Kipnis AC Thiébaut J Reedy AF Subar E Wirfält A Flood T Mouw AR Hollenbeck MF Leitzmann A Schatzkin 2007 Mediterranean dietary pattern and prediction of all-cause mortality in a US population: results from the NIH-AARP Diet and Health Study Arch Intern Med 167 2461 2468 10.1001/archinte.167.22.2461 18071168 (Pubitemid 350254905)
24. E Mocchegiani L Costarelli R Giacconi C Cipriano E Muti S Tesei M Malavolta 2006 Nutrient-gene interaction in ageing and successful ageing. A single nutrient (zinc) and some target genes related to inflammatory/immune response Mech Ageing Dev 127 517 525 1:CAS:528:DC%2BD28XktVGiu7c%3D 10.1016/j.mad.2006.01.010 16513158
25. E Mocchegiani R Giacconi L Costarelli E Muti C Cipriano S Tesei S Pierpaoli C Giuli R Papa F Marcellini N Gasparini R Pierandrei F Piacenza E Mariani D Monti G Dedoussis S Kanoni G Herbein T Fulop L Rink J Jajte M Malavolta 2008 Zinc deficiency and IL-6 -174G/C polymorphism in old people from different European countries: effect of zinc supplementation. ZINCAGE study Exp Gerontol 43 433 444 1:CAS:528:DC%2BD1cXkvFCqu7o%3D 10.1016/j.exger.2008.01.001 18267353
26. F Olivieri M Bonafe L Cavallone S Giovanetti F Marchegiani M Cardelli E Mugianesi C Giampieri R Moresi R Stecconi R Lisa C Franceschi 2002 The -174C/G locus affects in vitro/in vivo IL-6 production during aging Exp Gerontol 37 309 314 1:CAS:528:DC%2BD38XitlGm 10.1016/S0531-5565(01)00197-8 11772517 (Pubitemid 34073548)
27. T Qu JD Walston N Yang NS Fedarko QL Xue BA Beamer L Ferrucci NR Rose SX Leng 2009 Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14+ monocytes in frail older adults Mech Ageing Dev 130 161 166 1:CAS:528:DC%2BD1MXhs1Cjsb8%3D 10.1016/j.mad.2008.10.005 19027777
28. IM Rea OA Ross M Armstrong S McNerlan DH Alexander MD Curran D Middleton 2003 Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study. Reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants Mech Ageing Dev 124 555 561 1:CAS:528:DC%2BD3sXjtVCqt7c%3D 10.1016/S0047-6374(03)00036-8 12714267 (Pubitemid 36514913)
29. PJ Stover 2006 Influence of human genetic variation on nutritional requirements Am J Clin Nutr 83 436S 442S 1:CAS:528:DC%2BD28Xhs1ehsr8%3D 16470009
30. CF Terry V Loukaci FR Green 2000 Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation J Biol Chem 275 18138 18144 1:CAS:528:DC%2BD3cXktlymtLw%3D 10.1074/jbc.M000379200 10747905 (Pubitemid 30414764)
31. XY Wang M Hurme M Jylha A Hervonen 2001 Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-alpha genes in Finnish nonagenarians Mech Ageing Dev 123 29 38 1:CAS:528:DC%2BD3MXnsF2hurY%3D 10.1016/S0047-6374(01)00338-4 11640949 (Pubitemid 32972256)