Photothermal multispectral image cytometry for quantitative histology of nanoparticles and micrometastasis in intact, stained and selectively burned tissues

Cytometry Part A

Volumn 77, Issue 11, 2010, Pages 1049-1058

  Nedosekin, Dmitry A ^a   Shashkov, Evgeny V ^a,b   Galanzha, Ekaterina I ^a   Hennings, Leah ^c   Zharov, Vladimir P ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b PROKHOROV GENERAL PHYSICS INSTITUTE   (Russian Federation)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Histology; Nanoparticles; Photoacoustic method; Photothermal imaging; Scanning cytometry; Spectral burning; Spectroscopy

Indexed keywords

CARBON NANOTUBE; GOLD; MELANIN; METAL NANOPARTICLE; TUMOR MARKER;

ANIMAL; ARTICLE; CANCER TRANSPLANTATION; CHEMISTRY; HEAT; IMAGE CYTOMETRY; LASER SCANNING CYTOMETRY; LYMPH NODE; LYMPH NODE METASTASIS; MELANOMA; METABOLISM; METASTASIS; METHODOLOGY; MOUSE; NUDE MOUSE; PATHOLOGY; PHOTOCHEMISTRY; SKIN TUMOR;

ANIMALS; GOLD; HOT TEMPERATURE; IMAGE CYTOMETRY; LASER SCANNING CYTOMETRY; LYMPH NODES; LYMPHATIC METASTASIS; MELANINS; MELANOMA; METAL NANOPARTICLES; MICE; MICE, NUDE; NANOTUBES, CARBON; NEOPLASM TRANSPLANTATION; PHOTOCHEMISTRY; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 77958605934     PISSN: 15524922     EISSN: 15524930     Source Type: Journal    
DOI: 10.1002/cyto.a.20977     Document Type: Article

References (57)

1. Greep RO, Weiss L, editors. Histology. New York: McGraw-Hill; 1977.
2. Pertsinidis A, Zhang Y, Chu S. Subnanometre single-molecule localization, registration and distance measurements. Nature 2010; 466: 647-651.
3. Scivetti M, Lucchese A, Ficarra G, Giuliani M, Lajolo C, Maiorano E, Favia G. Oral pulse granuloma: Histological Findings by confocal laser scanning microscopy. Ultrastruct Pathol 2009; 33: 155-159.
4. Boucheron LE, Bi ZQ, Harvey NR, Manjunath BS, Rimm DL. Utility of multispectral imaging for nuclear classification of routine clinical histopathology imagery. BMC Cell Biol 2007; 8: S8.
5. Min W, Lu SJ, Chong SS, Roy R, Holtom GR, Xie XS. Imaging chromophores with undetectable fluorescence by stimulated emission microscopy. Nature 2009; 461: 1105-1109.
6. Hutchings J, Kendall C, Smith B, Shepherd N, Barr H, Stone N. The potential for histological screening using a combination of rapid Raman mapping and principal component analysis. J Biophotonics 2009; 2: 91-103.
7. Meadowcroft MD, Zhang ST, Liu WZ, Park BS, Connor JR, Collins CM, Smith MB, Yang QX. Direct magnetic resonance imaging of histological tissue samples at 3.0T. Magn Reson Med 2007; 57: 835-841.
8. Zehbe R, Haibel A, Riesemeier H, Gross U, Kirkpatrick CJ, Schubert H, Brochhausen C. Going beyond histology. Synchrotron micro-computed tomography as a methodology for biological tissue characterization: From tissue morphology to individual cells. J R Soc Interface 2010; 7: 49-59.
9. Lin P, Chen J-W, Chang LW, Wu J-P, Redding L, Chang H, Yeh T-K, Yang CS, Tsai M-H, Wang H-J, Kuo YC, Yang R. Computational and ultrastructural toxicology of a nanoparticle, quantum dot 705, in mice. Environ Sci Technol 2008; 42: 6264-6270.
10. Schwamborn K, Wellmann A, Knuechel R, Krieg R. MALDI-imaging-A combination of histology with mass spectrometry for discovery of protein patterns with potential clinical impact. Cytometry Part A 2007; 71A: 58.
11. Kriegeskotte C, Cantz T, Haberland J, Zibert A, Haier J, Köhler G, Schöler HR, Schmidt HH-J, Arlinghaus HF. Laser secondary neutral mass spectrometry for copper detection in micro-scale biopsies. J Mass Spectr 2009; 44: 1417-1422.
12. Marquis BJ, Love SA, Braun KL, Haynes CL. Analytical methods to assess nanoparticle toxicity. Analyst 2009; 134: 425-439.
13. Azzazy HME, Mansour MMH. In vitro diagnostic prospects of nanoparticles. Clin Chim Acta 2009; 403: 1-8.
14. Jain KK. Applications of nanobiotechnology in clinical diagnostics. Clin Chem 2007; 53: 2002-2009.
15. Clift MJ, Gehr P, Rothen-Rutishauser B. Nanotoxicology: A perspective and discussion of whether or not in vitro testing is a valid alternative. Arch Toxicol; in press [DOI: 10.1007/s00204-010-0560-6].
16. Holl MMB. Nanotoxicology: A personal perspective. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2009; 1: 353-359.
17. Alexiou C, Arnold W, Hulin P, Klein RJ, Renz H, Parak FG, Bergemann C, Lubbe AS. Magnetic mitoxantrone nanoparticle detection by histology, X-ray and MRI after magnetic tumor targeting. J Magn Magn Mater 2001; 225: 187-193.
18. Al Faraj A, Cieslar K, Lacroix G, Gaillard S, Canot-Soulas E, Cremillieux Y. In vivo imaging of carbon nanotube biodistribution using magnetic resonance imaging. Nano Lett 2009; 9: 1023-1027.
19. Jain TK, Reddy MK, Morales MA, Leslie-Pelecky DL, Labhasetwar V. Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats. Mol Pharm 2008; 5: 316-327.
20. Zaman RT, Diagaradjane P, Wang JC, Schwartz J, Rajaram N, Gill-Sharp KL, Cho SH, Rylander HG, Payne JD, Krishnan S, Tunnell JW. In vivo detection of gold nanoshells in tumors using diffuse optical spectroscopy. IEEE J Sel Top Quantum Electron 2007; 13: 1715-1720.
21. Kirillin M, Shirmanova M, Sirotkina M, Bugrova M, Khlebtsov B, Zagaynova E. Contrasting properties of gold nanoshells and titanium dioxide nanoparticles for optical coherence tomography imaging of skin: Monte Carlo simulations and in vivo study. J Biomed Opt 2009; 14: 021017.
22. van Dijk MA, Tchebotareva AL, Orrit M, Lippitz M, Berciaud S, Lasne D, Cognet L, Lounis B. Absorption and scattering microscopy of single metal nanoparticles. Phys Chem Chem Phys 2006; 8: 3486-3495.
23. Wang LV, editor. Photoacoustic Imaging and Spectroscopy: Boca Raton, FL: CRC Press; 2009.
24. Cognet L, Lounis B. Ultra-sensitive detection of individual gold nanoparticles: Spectroscopy and applications to biology. Gold Bull 2008; 41: 139-146.
25. Kim JW, Galanzha EI, Shashkov EV, Moon HM, Zharov VP. Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents. Nat Nanotechnol 2009; 4: 688-694.
26. Zharov VP, Mercer KE, Galitovskaya EN, Smeltzer MS. Photothermal nanotherapeutics and nanodiagnostics for selective killing of bacteria targeted with gold nanoparticles. Biophys J 2006; 90: 619-627.
27. Shimizu H, Mawatari K, Kitamori T. Development of a differential interference contrast thermal lens microscope for sensitive individual nanoparticle detection in liquid. Anal Chem 2009; 81: 9802-9806.
28. Brusnichkin AV, Nedosekin DA, Galanzha EI, Vladimirov YA, Shevtsova EF, Proskurnin MA, Zharov VP. Ultrasensitive label-free photothermal imaging, spectral identification, and quantification of cytochrome c in mitochondria, live cells, and solution. J Biophotonics; in press [DOI: 10.1002/jbio.201000012].
29. Shashkov EV, Everts M, Galanzha EI, Zharov VP. Quantum dots as multimodal photoacoustic and photothermal contrast agents. Nano Lett 2008; 8: 3953-3958.
30. Kim C, Song KH, Gao F, Wang LHV. Sentinel lymph nodes and lymphatic vessels: Noninvasive dual-modality in vivo mapping by using indocyanine green in rats-volumetric spectroscopic photoacoustic imaging and planar fluorescence imaging. Radiology 2010; 255: 442-450.
31. Razansky D, Distel M, Vinegoni C, Ma R, Perrimon N, Koster RW, Ntziachristos V. Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo. Nat Photon 2009; 3: 412-417.
32. Ntziachristos V, Razansky D. Molecular imaging by means of multispectral optoacoustic tomography (MSOT). Chem Rev 2010; 110: 2783-2794.
33. Galanzha EI, Shashkov EV, Spring PM, Suen JY, Zharov VP. In vivo, noninvasive, label-free detection and eradication of circulating metastatic melanoma cells using two-color photoacoustic flow cytometry with a diode laser. Cancer Res 2009; 69: 7926-7934.
34. Galanzha EI, Kokoska MS, Shashkov EV, Kim JW, Tuchin VV, Zharov VP. In vivo fiber-based multicolor photoacoustic detection and photothermal purging of metastasis in sentinel lymph nodes targeted by nanoparticles. J Biophotonics 2009; 2: 528-539.
35. Galanzha EI, Shashkov EV, Kokoska MS, Myhill JA, Zharov VP. In vivo non-invasive detection of metastic melanoma in vasculature and sentinel lymph nodes by photoacoustic cytometry. Lasers Surg Med 2008; s20:81.
36. Galanzha EI, Shashkov EV, Kelly T, Kim JW, Yang LL, Zharov VP. In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells. Nat Nanotechnol 2009; 4: 855-860.
37. McCormack D, Al-Shaer M, Goldschmidt BS, Dale PS, Henry C, Papageorgio C, Bhattacharyya K, Viator JA. Photoacoustic detection of melanoma micrometastasis in sentinel lymph nodes. J Biomech Eng 2009; 131: 074519.
38. Galanzha EI, Shashkov EV, Tuchin VV, Zharov VP. In vivo multispectral, multiparameter, photoacoustic lymph flow cytometry with natural cell focusing, label-free detection and multicolor nanoparticle probes. Cytometry Part A 2008; 73A: 884-894.
39. Bialkowski SE. Photothermal spectroscopy methods for chemical analysis. New York: A Wiley-Interscience Publication; 1996. 584 p.
40. Lu SJ, Min W, Chong SS, Holtom GR, Xie XS. Label-free imaging of heme proteins with two-photon excited photothermal lens microscopy. Appl Phys Lett 2010; 96: 113701-113703.
41. Lasne D, Blab GA, De Giorgi F, Ichas F, Lounis B, Cognet L. Label-free optical imaging of mitochondria in live cells. Opt Express 2007; 15: 14184-14193.
42. Tanaka Y, Sato K, Shimizu T, Yamato M, Okano T, Kitamori T. Biological cells on microchips: New technologies and applications. Biosens Bioelectron 2007; 23: 449-458.
43. Zharov VP, Letfullin RR, Galitovskaya EN. Microbubbles-overlapping mode for laser killing of cancer cells with absorbing nanoparticle clusters. J Phys D: Appl Phys 2005; 38: 2571-2581.
44. Mitchell LA, Gao J, Wal RV, Gigliotti A, Burchiel SW, McDonald JD. Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes. Toxicol Sci 2007; 100: 203-214.
45. Li Z, Hulderman T, Salmen R, Chapman R, Leonard SS, Young SH, Shvedova A, Luster MI, Simeonova PP. Cardiovascular effects of pulmonary exposure to single-wall carbon nanotubes. Environ Health Perspect 2007; 115: 377-382.
46. Hauck TS, Ghazani AA, Chan WCW. Assessing the effect of surface chemistry on gold nanorod uptake, toxicity, and gene expression in mammalian cells. Small 2008; 4: 153-159.
47. Takagi A, Hirose A, Nishimura T, Fukumori N, Ogata A, Ohashi N, Kitajima S, Kanno J. Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci 2008; 33: 105-116.
48. Taylor CR, Levenson RM. Quantification of immunohistochemistry-issues concerning methods, utility and semiquantitative assessment II. Histopathol 2006; 49: 411-424.
49. Kim D, Jeong YY, Jon S. A drug-loaded aptamer-gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer. ACS Nano 2010; 4: 3689-3696.
50. Purchase R, Volker S. Spectral hole burning: Examples from photosynthesis. Photosynth Res 2009; 101: 245-266.
51. Pierre S, Scholich K. Toponomics: Studying protein-protein interactions and protein networks in intact tissue. Mol Biosyst 2010; 6: 641-647.
52. Tajiri K, Kishi H, Ozawa T, Sugiyama T, Muraguchi A. SFMAC: A novel method for analyzing multiple parameters on lymphocytes with a single fluorophore in cell-microarray system. Cytometry Part A 2009; 75A: 282-288.
53. Nedosekin DA, Sarimollaoglu M, Shashkov EV, Galanzha EI, Zharov VP. Ultra-fast photoacoustic flow cytometry with a 0.5 MHz pulse repetition rate nanosecond laser. Opt Express 2010; 18: 8605-8620.
54. Huo L, Xi J, Wu Y, Li X. Forward-viewing resonant fiber-optic scanning endoscope of appropriate scanning speed for 3D OCT imaging. Opt Express 2010; 18: 14375-14384.
55. Zharov VP, Galanzha EI, Ferguson S, Tuchin VV. Confocal photothermal flow cytometry in vivo. Proc SPIE 2005; 5697: 167-176.
56. Zharov VP, Letokhov VS. Laser optoacoustic spectroscopy. New York: Springer-Verlag; 1986. 327 p.
57. Zharov VP. Far-field photothermal microscopy beyond the diffraction limit. Opt Lett 2003; 28: 1314-1316.