Introduction to hepatic drug metabolizing enzyme induction in drug safety evaluation studies

Toxicologic Pathology

Volumn 38, Issue 5, 2010, Pages 796-798

  Botts, Suzanne ^a   Ennulat, Daniela ^b   Francke Carroll, Sabine ^c   Graham, Mark ^d   Maronpot, Robert R ^e   Mohutsky, Michael ^f  

^a HOFFMANN LA ROCHE INC   (United States)

^b GLAXOSMITHKLINE   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d ASTRAZENECA   (United Kingdom)

^e Maronpot Consulting LLC   (United States)

^f ELI LILLY AND COMPANY   (United States)

Author keywords

hepatic drug metabolizing enzyme induction

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2C; CYTOCHROME P450 2D; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; DRUG METABOLIZING ENZYME; XENOBIOTIC AGENT;

CARCINOGENESIS; DRUG SAFETY; ENVIRONMENTAL HEALTH; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME SYNTHESIS; GENE REPRESSION; HOMEOSTASIS; HUMAN; INDUSTRY; LIVER; LIVER HYPERPLASIA; LIVER HYPERTROPHY; LIVER TOXICITY; LIVER WEIGHT; NONHUMAN; PATHOLOGIST; PATIENT SAFETY; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SCIENTIST;

ANIMALS; ENZYME INDUCTION; HUMANS; LIVER; XENOBIOTICS;

ANIMALIA;

EID: 77958592171     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623310374330     Document Type: Review

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