Ectopic expression of α-synuclein affects the migration of neural stem cells in mouse subventricular zone

Journal of Neurochemistry

Volumn 115, Issue 4, 2010, Pages 854-863

  Tani, Momo ^a   Hayakawa, Hideki ^a   Yasuda, Toru ^a   Nihira, Tomoko ^a   Hattori, Nobutaka ^a   Mizuno, Yoshikuni ^a   Mochizuki, Hideki ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

synuclein; Fluorescence activated cell sorting; Neural stem cell; Parkinson's disease; Subventricular zone

Indexed keywords

ALPHA SYNUCLEIN; RETROVIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE PROGRESSION; CELL MIGRATION; CONTROLLED STUDY; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MORPHOLOGY; MOUSE; NEURAL STEM CELL; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SUBVENTRICULAR ZONE;

ALPHA-SYNUCLEIN; ANIMALS; CELL CYCLE; CELL DIFFERENTIATION; CELL MOVEMENT; CELLS, CULTURED; CEREBRAL VENTRICLES; CHORISTOMA; FETAL STEM CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MICE; MICE, INBRED C57BL; NEURONS; PHENOTYPE;

MUS;

EID: 77958523739     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06727.x     Document Type: Article

References (37)

1. Anton E. S., Ghashghaei H. T., Weber J. L. et al. (2004) Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat. Neurosci. 7, 1319-1328.
2. Beach T. G., White 3rd C. L., Hladik C. L. et al. (2009) Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders. Acta Neuropathol. 117, 169-174.
3. De Chevigny A., Cooper O., Vinuela A., Reske-Nielsen C., Lagace D. C., Eisch A. J. and Isacson O. (2008) Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-depleted striatum. Stem Cells 26, 2349-2360.
4. Conover J. C., Doetsch F., Garcia-Verdugo J. M., Gale N. W., Yancopoulos G. D. and Alvarez-Buylla A. (2000) Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone. Nat. Neurosci. 3, 1091-1097.
5. Cooper O. and Isacson O. (2004) Intrastriatal transforming growth factor alpha delivery to a model of Parkinson's disease induces proliferation and migration of endogenous adult neural progenitor cells without differentiation into dopaminergic neurons. J. Neurosci. 24, 8924-8931.
6. Crews L., Mizuno H., Desplats P., Rockenstein E., Adame A., Patrick C., Winner B., Winkler J. and Masliah E. (2008) Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice. J. Neurosci. 28, 4250-4260.
7. Desplats P., Lee H. J., Bae E. J., Patrick C., Rockenstein E., Crews L., Spencer B., Masliah E. and Lee S. J. (2009) Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc. Natl Acad. Sci. USA 106, 13010-13015.
8. Fleming S. M., Tetreault N. A., Mulligan C. K., Hutson C. B., Masliah E. and Chesselet M. F. (2008) Olfactory deficits in mice overexpressing human wildtype alpha-synuclein. Eur. J. Neurosci. 28, 247-256.
9. Hirota Y., Ohshima T., Kaneko N., Ikeda M., Iwasato T., Kulkarni A. B., Mikoshiba K., Okano H. and Sawamoto K. (2007) Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone. J. Neurosci. 27, 12829-12838.
10. Hoglinger G. U., Rizk P., Muriel M. P., Duyckaerts C., Oertel W. H., Caille I. and Hirsch E. C. (2004) Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Nat. Neurosci. 7, 726-735.
11. Huisman E., Uylings H. B. and Hoogland P. V. (2004) A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson's disease. Mov. Disord. 19, 687-692.
12. Koizumi H., Higginbotham H., Poon T., Tanaka T., Brinkman B. C. and Gleeson J. G. (2006) Doublecortin maintains bipolar shape and nuclear translocation during migration in the adult forebrain. Nat. Neurosci. 9, 779-786.
13. Kordower J. H., Chu Y., Hauser R. A., Freeman T. B. and Olanow C. W. (2008a) Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat. Med. 14, 504-506.
14. Kordower J. H., Chu Y., Hauser R. A., Olanow C. W. and Freeman T. B. (2008b) Transplanted dopaminergic neurons develop PD pathologic changes: a second case report. Mov. Disord. 23, 2303-2306.
15. Kruger R., Kuhn W., Muller T., Woitalla D., Graeber M., Kosel S., Przuntek H., Epplen J. T., Schols L. and Riess O. (1998) Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat. Genet. 18, 106-108.
16. Li J. Y., Englund E., Holton J. L. et al. (2008) Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat. Med. 14, 501-503.
17. Marxreiter F., Nuber S., Kandasamy M. et al. (2009) Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein. Eur. J. Neurosci. 29, 879-890.
18. Nagato M., Heike T., Kato T., Yamanaka Y., Yoshimoto M., Shimazaki T., Okano H. and Nakahata T. (2005) Prospective characterization of neural stem cells by flow cytometry analysis using a combination of surface markers. J. Neurosci. Res. 80, 456-466.
19. Ng K. L., Li J. D., Cheng M. Y., Leslie F. M., Lee A. G. and Zhou Q. Y. (2005) Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling. Science 308, 1923-1927.
20. Nishioka K., Hayashi S., Farrer M. J. et al. (2006) Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease. Ann. Neurol. 59, 298-309.
21. Oizumi H., Hayashita-Kinoh H., Hayakawa H. et al. (2008) Alteration in the differentiation-related molecular expression in the subventricular zone in a mouse model of Parkinson's disease. Neurosci. Res. 60, 15-21.
22. Pastrana E., Cheng L. C. and Doetsch F. (2009) Simultaneous prospective purification of adult subventricular zone neural stem cells and their progeny. Proc. Natl Acad. Sci. USA 106, 6387-6392.
23. Polymeropoulos M. H., Lavedan C., Leroy E. et al. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276, 2045-2047.
24. Ponsen M. M., Stoffers D., Twisk J. W., Wolters E. Ch. and Berendse H. W. (2009) Hyposmia and executive dysfunction as predictors of future Parkinson's disease: a prospective study. Mov. Disord. 24, 1060-1065.
25. Pruszak J., Sonntag K. C., Aung M. H., Sanchez-Pernaute R. and Isacson O. (2007) Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations. Stem Cells 25, 2257-2268.
26. Ross G. W., Petrovitch H., Abbott R. D., Tanner C. M., Popper J., Masaki K., Launer L. and White L. R. (2008) Association of olfactory dysfunction with risk for future Parkinson's disease. Ann. Neurol. 63, 167-173.
27. Sawamoto K., Wichterle H., Gonzalez-Perez O. et al. (2006) New neurons follow the flow of cerebrospinal fluid in the adult brain. Science 311, 629-632.
28. Sengoku R., Saito Y., Ikemura M. et al. (2008) Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb. J. Neuropathol. Exp. Neurol. 67, 1072-1083.
29. Shults C. W. (2006) Lewy bodies. Proc. Natl Acad. Sci. USA 103, 1661-1668.
30. Singleton A. B., Farrer M., Johnson J. et al. (2003) Alpha-synuclein locus triplication causes Parkinson's disease. Science 302, 841.
31. Suzuki A., Obi K., Urabe T., Hayakawa H., Yamada M., Kaneko S., Onodera M., Mizuno Y. and Mochizuki H. (2002) Feasibility of ex vivo gene therapy for neurological disorders using the new retroviral vector GCDNsap packaged in the vesicular stomatitis virus G protein. J. Neurochem. 82, 953-960.
32. Wernig M., Zhao J. P., Pruszak J. et al. (2008) Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc. Natl Acad. Sci. USA 105, 5856-5861.
33. Winner B., Lie D. C., Rockenstein E., Aigner R., Aigner L., Masliah E., Kuhn H. G. and Winkler J. (2004) Human wild-type alpha-synuclein impairs neurogenesis. J. Neuropathol. Exp. Neurol. 63, 1155-1166.
34. Winner B., Desplats P., Hagl C. et al. (2009) Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model. Exp. Neurol. 219, 543-552.
35. Wong K., Ren X. R., Huang Y. Z. et al. (2001) Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. Cell 107, 209-221.
36. Yamada M., Onodera M., Mizuno Y. and Mochizuki H. (2004) Neurogenesis in olfactory bulb identified by retroviral labeling in normal and 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-treated adult mice. Neuroscience 124, 173-181.
37. Zarranz J. J., Alegre J., Gomez-Esteban J. C. et al. (2004) The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol. 55, 164-173.