17α-Ethinylestradiol rapidly alters transcript levels of murine coagulation genes via estrogen receptor α

Journal of Thrombosis and Haemostasis

Volumn 8, Issue 8, 2010, Pages 1838-1846

  Cleuren, Audrey C A ^a   Van Der Linden, I K ^a   De Visser, Y P ^a   Wagenaar, G T M ^a   Reitsma, P H ^a   Van Vlijmen, B J M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Coagulation; Estrogen; Liver; Mice; MRNA

Indexed keywords

ALPHA 2 ANTIPLASMIN; ANTITHROMBIN; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 12; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ETHINYLESTRADIOL; FATTY ACID BINDING PROTEIN; FIBRINOGEN; FULVESTRANT; HEPARIN COFACTOR II; MESSENGER RNA; PROTEIN C; PROTEIN S; PROTHROMBIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; DRUG DOSE COMPARISON; FEMALE; GENETIC TRANSCRIPTION; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ADMINISTRATION, ORAL; ANIMALS; BLOOD COAGULATION; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ETHINYL ESTRADIOL; FEMALE; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RNA, MESSENGER; TIME FACTORS;

EID: 77958520738     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2010.03930.x     Document Type: Article

References (24)

1. Rosendaal FR. Venous thrombosis: the role of genes, environment, and behavior. Hematology Am Soc Hematol Educ Program 2005, 1-12.
2. Middeldorp S. Oral contraceptives and the risk of venous thromboembolism. Gend Med 2005, 2(Suppl. A):S3-9.
3. Vehkavaara S, Silveira A, Hakala-Ala-Pietila T, Virkamaki A, Hovatta O, Hamsten A, Taskinen MR, Yki-Jarvinen H. Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women. Thromb Haemost 2001, 85:619-25.
4. Canonico M, Oger E, Plu-Bureau G, Conard J, Meyer G, Levesque H, Levesque H, Trillot N, Barrellier MT, Wahl D, Emmerich J, Scarabin PY. Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study. Circulation 2007, 115:840-5.
5. Jick S, Kaye JA, Li L, Jick H. Further results on the risk of nonfatal venous thromboembolism in users of the contraceptive transdermal patch compared to users of oral contraceptives containing norgestimate and 35 microg of ethinyl estradiol. Contraception 2007, 76:4-7.
6. Johnson JV, Lowell J, Badger GJ, Rosing J, Tchaikovski S, Cushman M. Effects of oral and transdermal hormonal contraception on vascular risk markers: a randomized controlled trial. Obstet Gynecol 2008, 111:278-84.
7. Farsetti A, Misiti S, Citarella F, Felici A, Andreoli M, Fantoni A, Sacchi A, Pontecorvi A. Molecular basis of estrogen regulation of Hageman factor XII gene expression. Endocrinology 1995, 136:5076-83.
8. Di Bitondo R, Hall AJ, Peake IR, Iacoviello L, Winship PR. Oestrogenic repression of human coagulation factor VII expression mediated through an oestrogen response element sequence motif in the promoter region. Hum Mol Genet 2002, 11:723-31.
9. Bourdeau V, Deschenes J, Metivier R, Nagai Y, Nguyen D, Bretschneider N, Gannon F, White JH, Mader S. Genome-wide identification of high-affinity estrogen response elements in human and mouse. Mol Endocrinol 2004, 18:1411-27.
10. Gao H, Falt S, Sandelin A, Gustafsson JA, Dahlman-Wright K. Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver. Mol Endocrinol 2008, 22:10-22.
11. Moverare S, Skrtic S, Lindberg MK, Dahlman-Wright K, Ohlsson C. Estrogen increases coagulation factor V mRNA levels via both estrogen receptor-alpha and -beta in murine bone marrow/bone. Eur J Endocrinol 2004, 151:259-63.
12. Tchaikovski SN, van Vlijmen BJ, Rosing J, Tans G. Development of a calibrated automated thrombography based thrombin generation test in mouse plasma. J Thromb Haemost 2007, 5:2079-86.
13. Nagai N, Lijnen HR, Cleuren AC, Rosendaal FR, van Hoef B, Hoylaerts MF, van Vlijmen BJ. Factor V Leiden mutation is associated with enhanced arterial thrombotic tendency in lean but not in obese mice. Thromb Haemost 2007, 98:858-63.
14. de Visser YP, Walther FJ, Laghmani EH, Boersma H, van der Laarse A, Wagenaar GT. Sildenafil attenuates pulmonary inflammation and fibrin deposition, mortality and right ventricular hypertrophy in neonatal hyperoxic lung injury. Respir Res 2009, 10:30.
15. Cleuren AC, van Hoef B, Hoylaerts MF, van Vlijmen BJ, Lijnen HR. Short-term ethinylestradiol treatment suppresses inferior caval vein thrombosis in obese mice. Thromb Haemost 2009, 102:993-1000.
16. Lansink M, Jong M, Bijsterbosch M, Bekkers M, Toet K, Havekes L, Emeis J, Kooistra T. Increased clearance explains lower plasma levels of tissue-type plasminogen activator by estradiol: evidence for potently enhanced mannose receptor expression in mice. Blood 1999, 94:1330-6.
17. Lindberg MK, Moverare S, Skrtic S, Gao H, Dahlman-Wright K, Gustafsson JA, Ohlsson C. Estrogen receptor (ER)-beta reduces ERalpha-regulated gene transcription, supporting a 'ying yang' relationship between ERalpha and ERbeta in mice. Mol Endocrinol 2003, 17:203-8.
18. Yamamoto Y, Moore R, Hess HA, Guo GL, Gonzalez FJ, Korach KS, Maronpot RR, Negishi M. Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity. J Biol Chem 2006, 281:16625-31.
19. Wong JH, Dukes J, Levy RE, Sos B, Mason SE, Fong TS, Weiss EJ. Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns. J Clin Invest 2008, 118:2969-78.
20. Ahlbory-Dieker DL, Stride BD, Leder G, Schkoldow J, Trolenberg S, Seidel H, Otto C, Sommer A, Parker MG, Schutz G, Wintermantel TM. DNA binding by estrogen receptor-alpha is essential for the transcriptional response to estrogen in the liver and the uterus. Mol Endocrinol 2009, 23:1544-55.
21. Gao H, Bryzgalova G, Hedman E, Khan A, Efendic S, Gustafsson JA, Dahlman-Wright K. Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3. Mol Endocrinol 2006, 20:1287-99.
22. Farsetti A, Moretti F, Narducci M, Misiti S, Nanni S, Andreoli M, Sacchi A, Pontecorvi A. Orphan receptor hepatocyte nuclear factor-4 antagonizes estrogen receptor alpha-mediated induction of human coagulation factor XII gene. Endocrinology 1998, 139:4581-9.
23. Stauffer DR, Chukwumezie BN, Wilberding JA, Rosen ED, Castellino FJ. Characterization of transcriptional regulatory elements in the promoter region of the murine blood coagulation factor VII gene. J Biol Chem 1998, 273:2277-87.
24. Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fok EA, Silver PA, Gingeras TR, Liu XS, Brown M. Genome-wide analysis of estrogen receptor binding sites. Nat Genet 2006, 38:1289-97.