CCN5: Biology and pathophysiology

Journal of Cell Communication and Signaling

Volumn 4, Issue 3, 2010, Pages 119-130

  Russo, Joshua W ^a   Castellot Jr , John J ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

CCN proteins; Matricellular; Nuclear localization; Review

Indexed keywords

CCN PROTEIN; CCN5 PROTEIN; CELL SURFACE RECEPTOR; EPIDERMAL GROWTH FACTOR; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; PROGESTERONE; PROTEIN P53; SOMATOMEDIN BINDING PROTEIN; THROMBOSPONDIN 1; TRANSCRIPTION FACTOR ELK 1; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; WNT PROTEIN;

ADRENAL HYPERPLASIA; ANGIOGENESIS; ARTERY OCCLUSION; ATHEROSCLEROSIS; BLASTOCYST; BLOOD VESSEL; BRAIN; BREAST CANCER; BREAST CARCINOMA; BRONCHIOLE; CANCER CELL CULTURE; CARCINOGENESIS; CARTILAGE; CELL ADHESION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CORRELATION ANALYSIS; DIGESTIVE SYSTEM; DUODENUM; ENDOCRINE GLAND; ENDOTHELIUM CELL; ENZYME ACTIVITY; EPIDERMIS; EXTRACELLULAR MATRIX; FIBROSIS; GENE CONTROL; GENE MAPPING; GENE OVEREXPRESSION; HAIR; HEART; HEART MUSCLE; HEPATITIS C VIRUS; HUMAN; INTRACELLULAR SIGNALING; KIDNEY; LIVER; LIVER CELL CARCINOMA; LUNG; MENINX; MESENCHYME CELL; MICROVILLUS; MORULA; NONHUMAN; OLFACTORY BULB; ONCOGENE; ONCOGENE H RAS; OSTEOBLAST; OVARY; PANCREAS; PANCREAS ADENOCARCINOMA; PANCREAS CARCINOMA; PATHOPHYSIOLOGY; PERICHONDRIUM; PLACENTA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SKIN CARCINOMA; SMOOTH MUSCLE FIBER; SPLEEN; STOMACH; THYMUS; UTERINE TUBE; UTERUS; UTERUS MYOMA;

EID: 77958510985     PISSN: 18739601     EISSN: 1873961X     Source Type: Journal    
DOI: 10.1007/s12079-010-0098-7     Document Type: Review

References (47)

1. O Aprelikova M Wood S Tackett GV Chandramouli JC Barrett 2006 Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection Cancer Res 66 5641 5647 1:CAS:528:DC%2BD28XltFyjt7s%3D 10.1158/0008-5472.CAN-05- 3345 16740701 (Pubitemid 43927116)
2. S Banerjee N Saxena K Sengupta O Tawfik MS Mayo SK Banerjee 2003 WISP-2 gene in human breast cancer: estrogen and progesterone inducible expression and regulation of tumor cell proliferation Neoplasia 5 63 73 1:CAS:528: DC%2BD3sXhs12ltLk%3D 12659671
3. S Banerjee K Sengupta NK Saxena K Dhar SK Banerjee 2005 Epidermal growth factor induces WISP-2/CCN5 expression in estrogen receptor-alpha-positive breast tumor cells through multiple molecular cross-talks Mol Cancer Res 3 151 162 1:CAS:528:DC%2BD2MXislamurg%3D 10.1158/1541-7786.MCR-04-0130 15798095 (Pubitemid 40524898)
4. S Banerjee G Dhar I Haque S Kambhampati S Mehta K Sengupta O Tawfik TA Phillips SK Banerjee 2008 CCN5/WISP-2 expression in breast adenocarcinoma is associated with less frequent progression of the disease and suppresses the invasive phenotypes of tumor cells Cancer Res 68 7606 7612 1:CAS:528: DC%2BD1cXhtFWltbzN 10.1158/0008-5472.CAN-08-1461 18794149
5. P Bork 1993 The modular architecture of a new family of growth regulators related to connective tissue growth factor FEBS Lett 327 125 130 1:CAS:528:DyaK3sXlsFaiurc%3D 10.1016/0014-5793(93)80155-N 7687569 (Pubitemid 23211174)
6. CC Chen LF Lau 2009 Functions and mechanisms of action of CCN matricellular proteins Int J Biochem Cell Biol 41 771 783 1:CAS:528: DC%2BD1MXitFSmtL0%3D 10.1016/j.biocel.2008.07.025 18775791
7. SR Davies G Watkins RE Mansel WG Jiang 2007 Differential expression and prognostic implications of the CCN family members WISP-1, WISP-2, and WISP-3 in human breast cancer Ann Surg Oncol 14 1909 1918 10.1245/s10434-007-9376-x 17406949 (Pubitemid 46870943)
8. LM Delmolino NA Stearns JJ Castellot Jr 1997 Heparin induces a member of the CCN family which has characteristics of a growth arrest gene Mol Biol Cell 8 287a
9. LM Delmolino NA Stearns JJ Castellot Jr 2001 COP-1, a member of the CCN family, is a heparin-induced growth arrest specific gene in vascular smooth muscle cells J Cell Physiol 188 45 55 1:CAS:528:DC%2BD3MXktVaisLY%3D 10.1002/jcp.1100 11382921 (Pubitemid 32476495)
10. G Dhar S Mehta S Banerjee A Gardner BM McCarty SC Mathur DR Campbell S Kambhampati SK Banerjee 2007 Loss of WISP-2/CCN5 signaling in human pancreatic cancer: a potential mechanism for epithelial-mesenchymal-transition Cancer Lett 254 63 70 1:CAS:528:DC%2BD2sXnvFylsL8%3D 10.1016/j.canlet.2007.02.012 17383817 (Pubitemid 47058806)
11. K Dhar S Banerjee G Dhar K Sengupta SK Banerjee 2007 Insulin-like growth factor-1 (IGF-1) induces WISP-2/CCN5 via multiple molecular cross-talks and is essential for mitogenic switch by IGF-1 axis in estrogen receptor-positive breast tumor cells Cancer Res 67 1520 1526 1:CAS:528:DC%2BD2sXhvVWqs7k%3D 10.1158/0008-5472.CAN-06-3753 17308090 (Pubitemid 46383375)
12. G Dhar S Banerjee K Dhar O Tawfik MS Mayo PJ Vanveldhuizen SK Banerjee 2008 Gain of oncogenic function of p53 mutants induces invasive phenotypes in human breast cancer cells by silencing CCN5/WISP-2 Cancer Res 68 4580 4587 1:CAS:528:DC%2BD1cXnt1aqt7g%3D 10.1158/0008-5472.CAN-08-0316 18559502
13. A Fritah C Saucier O De Wever M Bracke I Bieche R Lidereau C Gespach S Drouot G Redeuilh M Sabbah 2008 Role of WISP-2/CCN5 in the maintenance of a differentiated and noninvasive phenotype in human breast cancer cells Mol Cell Biol 28 1114 1123 1:CAS:528:DC%2BD1cXhsVWqu7o%3D 10.1128/MCB.01335-07 18070926 (Pubitemid 351160067)
14. T Fukutomi Y Zhou S Kawai H Eguchi JR Wands J Li 2005 Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression Hepatology 41 1096 1105 1:CAS:528:DC%2BD2MXksF2hsbs%3D 10.1002/hep.20668 15841445 (Pubitemid 40593917)
15. MR Gray JA Malmquist M Sullivan M Blea JJ Castellot Jr 2007 CCN5 Expression in mammals. II. Adult rodent tissues J Cell Commun Signal 1 145 158 10.1007/s12079-007-0013-z 18481204
16. G Hashimoto I Inoki Y Fujii T Aoki E Ikeda Y Okada 2002 Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165 J Biol Chem 277 36288 36295 1:CAS:528:DC%2BD38XnsVCjtrY%3D 10.1074/jbc.M201674200 12114504
17. KP Holbourn B Perbal K Ravi Acharya 2009 Proteins on the catwalk: modelling the structural domains of the CCN family of proteins J Cell Commun Signal 3 25 41 10.1007/s12079-009-0048-4 19424823
18. Iliopoulos D, Bimpaki EI, Nesterova M, Stratakis CA (2009) MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling. Cancer Res 69(8):3278-3782
19. H Inadera 2003 Estrogen-induced genes, WISP-2 and pS2, respond divergently to protein kinase pathway Biochem Biophys Res Commun 309 272 278 1:CAS:528:DC%2BD3sXmvVKntbg%3D 10.1016/j.bbrc.2003.07.001 12951045 (Pubitemid 37025887)
20. H Inadera S Hashimoto HY Dong T Suzuki S Nagai T Yamashita N Toyoda K Matsushima 2000 WISP-2 as a novel estrogen-responsive gene in human breast cancer cells Biochem Biophys Res Commun 275 108 114 1:CAS:528: DC%2BD3cXls1CntLo%3D 10.1006/bbrc.2000.3276 10944450 (Pubitemid 30663638)
21. H Inadera HY Dong K Matsushima 2002 WISP-2 is a secreted protein and can be a marker of estrogen exposure in MCF-7 cells Biochem Biophys Res Commun 294 602 608 1:CAS:528:DC%2BD38XksVartrg%3D 10.1016/S0006-291X(02)00530-2 12056810 (Pubitemid 34694052)
22. H Inadera A Shimomura S Tachibana 2009 Effect of Wnt-1 inducible signaling pathway protein-2 (WISP-2/CCN5), a downstream protein of Wnt signaling, on adipocyte differentiation Biochem Biophys Res Commun 379 969 974 1:CAS:528:DC%2BD1MXhs1amsbs%3D 10.1016/j.bbrc.2008.12.185 19135425
23. SA Johnsen C Gungor T Prenzel S Riethdorf L Riethdorf N Taniguchi-Ishigaki T Rau B Tursun JD Furlow G Sauter M Scheffner K Pantel F Gannon I Bach 2009 Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer Cancer Res 69 128 136 1:CAS:528:DC%2BD1MXmvFel 10.1158/0008-5472.CAN-08-1630 19117995
24. JA Jones MR Gray BE Oliveira M Koch JJ Castellot Jr 2007 CCN5 expression in mammals: I. Embryonic and fetal tissues of mouse and human J Cell Commun Signal 1 127 143 10.1007/s12079-007-0012-0 18481203
25. ED Karagiannis AS Popel 2007 Peptides derived from type I thrombospondin repeat-containing proteins of the CCN family inhibit proliferation and migration of endothelial cells Int J Biochem Cell Biol 39 2314 2323 1:CAS:528: DC%2BD2sXhtFWgsLrI 10.1016/j.biocel.2007.06.018 17707681 (Pubitemid 47484285)
26. S Kubota M Takigawa 2007 CCN family proteins and angiogenesis: from embryo to adulthood Angiogenesis 10 1 11 1:CAS:528:DC%2BD2sXisVejtbw%3D 10.1007/s10456-006-9058-5 17149534 (Pubitemid 46356220)
27. S Kumar AT Hand JR Connor RA Dodds PJ Ryan JJ Trill SM Fisher ME Nuttall DB Lipshutz C Zou SM Hwang BJ Votta IE James DJ Rieman M Gowen JC Lee 1999 Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions J Biol Chem 274 17123 17131 1:CAS:528:DyaK1MXjvVGkurg%3D 10.1074/jbc.274.24.17123 10358067 (Pubitemid 29275173)
28. AC Lake JJ Castellot Jr 2003 CCN5 modulates the antiproliferative effect of heparin and regulates cell motility in vascular smooth muscle cells Cell Commun Signal 1 5 10.1186/1478-811X-1-5 14636425 (Pubitemid 44842833)
29. AC Lake A Bialik K Walsh JJ Castellot Jr 2003 CCN5 is a growth arrest-specific gene that regulates smooth muscle cell proliferation and motility Am J Pathol 162 219 231 1:CAS:528:DC%2BD3sXlsFyquw%3D%3D 12507905
30. HR Mason D Grove-Strawser BS Rubin RA Nowak JJ Castellot Jr 2004 Estrogen induces CCN5 expression in the rat uterus in vivo Endocrinology 145 976 982 1:CAS:528:DC%2BD2cXovFSktQ%3D%3D 10.1210/en.2003-0823 14605002 (Pubitemid 38183842)
31. HR Mason AC Lake JE Wubben RA Nowak JJ Castellot Jr 2004 The growth arrest-specific gene CCN5 is deficient in human leiomyomas and inhibits the proliferation and motility of cultured human uterine smooth muscle cells Mol Hum Reprod 10 181 187 1:CAS:528:DC%2BD2cXhslWksbk%3D 10.1093/molehr/gah028 14981145 (Pubitemid 38456020)
32. EJ McManus K Sakamoto LJ Armit L Ronaldson N Shpiro R Marquez DR Alessi 2005 Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis EMBO J 24 1571 1583 1:CAS:528:DC%2BD2MXktFequrc%3D 10.1038/sj.emboj.7600633 15791206 (Pubitemid 40646447)
33. FE Mo AG Muntean CC Chen DB Stolz SC Watkins LF Lau 2002 CYR61 (CCN1) is essential for placental development and vascular integrity Mol Cell Biol 22 8709 8720 1:CAS:528:DC%2BD38XptlGrtr0%3D 10.1128/MCB.22.24.8709-8720.2002 12446788 (Pubitemid 35397184)
34. MS Parisi E Gazzerro S Rydziel E Canalis 2006 Expression and regulation of CCN genes in murine osteoblasts Bone 38 671 677 1:CAS:528: DC%2BD28XjvFSjtrs%3D 10.1016/j.bone.2005.10.005 16311085
35. J Pecha D Ankrapp C Jiang W Tang I Hoshino K Bruck KU Wagner H Xiao 2007 Deletion of Tip30 leads to rapid immortalization of murine mammary epithelial cells and ductal hyperplasia in the mammary gland Oncogene 26 7423 7431 1:CAS:528:DC%2BD2sXhtlCrsLfL 10.1038/sj.onc.1210548 17533366 (Pubitemid 350158711)
36. D Pennica TA Swanson JW Welsh MA Roy DA Lawrence J Lee J Brush LA Taneyhill B Deuel M Lew C Watanabe RL Cohen MF Melhem GG Finley P Quirke AD Goddard KJ Hillan AL Gurney D Botstein AJ Levine 1998 WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors Proc Natl Acad Sci USA 95 14717 14722 1:CAS:528:DyaK1cXotVGmtL8%3D 10.1073/pnas.95.25. 14717 9843955 (Pubitemid 29003696)
37. T Quan S Shin Z Qin GJ Fisher 2009 Expression of CCN family of genes in human skin in vivo and alterations by solar-simulated ultraviolet irradiation J Cell Commun Signal 3 19 23 10.1007/s12079-009-0044-8 19319669
38. JA Robinson M Chatterjee-Kishore PJ Yaworsky DM Cullen W Zhao C Li Y Kharode L Sauter P Babij EL Brown AA Hill MP Akhter ML Johnson RR Recker BS Komm FJ Bex 2006 Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone J Biol Chem 281 31720 31728 1:CAS:528: DC%2BD28XhtVOrtr3F 10.1074/jbc.M602308200 16908522 (Pubitemid 46043263)
39. N Saxena S Banerjee K Sengupta MN Zoubine SK Banerjee 2001 Differential expression of WISP-1 and WISP-2 genes in normal and transformed human breast cell lines Mol Cell Biochem 228 99 104 1:CAS:528:DC%2BD38Xht1KqsLk%3D 10.1023/A:1013338912642 11855747 (Pubitemid 34121441)
40. N Schutze U Noth J Schneidereit C Hendrich F Jakob 2005 Differential expression of CCN-family members in primary human bone marrow-derived mesenchymal stem cells during osteogenic, chondrogenic and adipogenic differentiation Cell Commun Signal 3 5 10.1186/1478-811X-3-5 15773998 (Pubitemid 44848533)
41. K Sengupta S Banerjee K Dhar NK Saxena S Mehta DR Campbell SK Banerjee 2006 WISP-2/CCN5 is involved as a novel signaling intermediate in phorbol ester-protein kinase Calpha-mediated breast tumor cell proliferation Biochemistry 45 10698 10709 1:CAS:528:DC%2BD28XnvValtr0%3D 10.1021/bi060888p 16939222 (Pubitemid 44320485)
42. A Suzuki K Ozono T Kubota H Kondou K Tachikawa T Michigami 2008 PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase-3beta in osteoblastic Saos-2 cells J Cell Biochem 104 304 317 1:CAS:528:DC%2BD1cXhtFant7zP 10.1002/jcb.21626 17990294
43. Tanaka I, Morikawa M, Okuse T, Shirakawa M, Imai K (2005) Expression and regulation of WISP2 in rheumatoid arthritic synovium. Biochem Biophys Res Commun 334(4):973-997
44. S Visser X Yang 2010 Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray Gene 449 22 29 1:CAS:528:DC%2BD1MXhtleku7jJ 10.1016/j.gene.2009.09.008 19799973
45. R Zhang L Averboukh W Zhu H Zhang H Jo PJ Dempsey RJ Coffey AB Pardee P Liang 1998 Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation Mol Cell Biol 18 6131 6141 1:CAS:528:DyaK1cXmsVKksLo%3D 9742130
46. N Zhong RP Gersch M Hadjiargyrou 2006 Wnt signaling activation during bone regeneration and the role of dishevelled in chondrocyte proliferation and differentiation Bone 39 5 16 1:CAS:528:DC%2BD28Xls1ejtrg%3D 10.1016/j.bone.2005. 12.008 16459154 (Pubitemid 43831768)
47. MN Zoubine S Banerjee NK Saxena DR Campbell SK Banerjee 2001 WISP-2: a serum-inducible gene differentially expressed in human normal breast epithelial cells and in MCF-7 breast tumor cells Biochem Biophys Res Commun 282 421 425 1:CAS:528:DC%2BD3MXitlejtbY%3D 10.1006/bbrc.2001.4584 11401475 (Pubitemid 32917886)