CCN5 modulates the antiproliferative effect of heparin and regulates cell motility in vascular smooth muscle cells

Cell Communication and Signaling

Volumn 1, Issue , 2003, Pages

  Lake, Andrew C ^a   Castellot Jr , John J ^b  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CCN genefamily; Heparin; Motility; Proliferation; RNAi; Smooth muscle

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; GELATINASE A; HEPARIN; PROTEIN; PROTEIN CCN5;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CELL MOTILITY; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOSKELETON; DRUG DESIGN; DRUG EXPOSURE; ENZYME ACTIVITY; EXPRESSION VECTOR; GENE INDUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; RAT; REGULATORY MECHANISM; RNA INTERFERENCE; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR DISEASE; VASCULAR SMOOTH MUSCLE;

ADENOVIRIDAE;

EID: 33751557261     PISSN: 1478811X     EISSN: None     Source Type: Journal    
DOI: 10.1186/1478-811X-1-5     Document Type: Article

References (39)

1. Mishra-Gorur K, Delmolino LM, Castellot J.J. Jr.: Biological functions of heparan sulfate and heparan sulfate proteoglycans. Trends Glycosci Glycotechnol 1998, 10:193-210.
2. Ayer-Lelievre C, Brigstock D, Lau L, Pennica D, Perbal B, Yeger H: Report and abstracts on the first international workshop on the CCN family of genes. Mol Pathol 2001, 54:105-120.
3. Delmolino LM, Stearns NA, Castellot J.J. Jr.: COP-1, a member of the CCN family, is a heparin-induced growth arrest specific gene in vascular smooth muscle cells. J Cell Physiol 2001, 188:45-55.
4. Lake AC, Bialik A, Walsh K, Castellot J.J., Jr.: CCN5 is a growth arrest-specific gene that regulates smooth muscle cell proliferation and motility. Am J Pathol 2003, 162:219-231.
5. Bork P: The modular architecture of a new family of growth regulators related to connective tissue growth factor. FEBS Lett 1993, 327:125-130.
6. Oemar BS, Luscher TF: Connective tissue growth factor. Friend or foe? Arterioscler Thromb Vasc Biol 1997, 17:1483-1489.
7. Lau LF, Lam SC: The CCN family of angiogenic regulators: the integrin connection. Exp Cell Res 1999, 248:44-57.
8. Brigstock DR: The connective tissue growth factor/cysteinerich 61/ nephroblastoma overexpressed (CCN) family. Endocr Rev 1999, 20:189-206.
9. Perbal B: NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues. Mol Pathol 2001, 54:57-79.
10. Bornstein P, Sage EH: Matricellular proteins: extracellular modulators of cell function. Curr Opin Cell Biol 2002, 14:608-616.
11. Delmolino LM, Stearns NA, Castellot J.J. Jr.: Heparin induces a member of the CCN family which has characteristics of a growth arrest specific gene. Mol Biol Cell 1997, 8:287a.
12. Zhang R, Averboukh L, Zhu W, Zhang H, Jo H, Dempsey PJ, Coffey RJ, Pardee AB, Liang P: Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation. Mol Cell Biol 1998, 18:6131-6141.
13. Pennica D, Swanson TA, Welsh JW, Roy MA, Lawrence DA, Lee J, Brush J, Taneyhill LA, Deuel B, Lew M, Watanabe C, Cohen RL, Melhem MF, Finley GG, Quirke P, Goddard AD, Hillan KJ, Gurney AL, Botstein D, Levine AJ: WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc Natl Acad Sci U S A 1998, 95:14717-14722.
14. Kumar S, Hand AT, Connor JR, Dodds RA, Ryan PJ, Trill JJ, Fisher SM, Nuttall ME, Lipshutz DB, Zou C, Hwang SM, Votta BJ, James IE, Rieman DJ, Gowen M, Lee JC: Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions. J Biol Chem 1999, 274:17123-17131.
15. Champagne MJ, Dumas P, Orlov SN, Bennett MR, Hamet P, Tremblay J: Protection against necrosis but not apoptosis by heat-stress proteins in vascular smooth muscle cells: evidence for distinct modes of cell death. Hypertension 1999, 33:906-913.
16. Clowes AW, Kamowsky MJ: Suppression by heparin of smooth muscle cell proliferation in injured arteries. Nature 1977, 265:625-626.
17. Castellot J.J., Jr., Wright TC, Kamovsky MJ: Regulation of vascular smooth muscle cell growth by heparin and heparan sulfates. [Review]. Seminars in Thrombasis & Hemostasis 1987, 13:489-503.
18. Majack RA, Clowes AW: Inhibition of vascular smooth muscle cell migration by heparin- like glycosaminoglycans. J Cell Physiol 1984, 118:253-256.
19. Lemire JM, Merrilees MJ, Braun KR, Wight TN: Overexpression of the V3 variant of versican alters arterial smooth muscle cell adhesion, migration, and proliferation in vitro. J Cell Physiol 2002, 190:38-45.
20. Celentano DC, Frishman WH: Matrix metalloproteinases and coronary artery disease: a novel therapeutic target. J Clin Pharmacol 1997, 37:991-1000.
21. Pauly RR, Passaniti A, Bilato C, Monticone R, Cheng L, Papadopoulos N, Gluzband YA, Smith L, Weinstein C, Lakatta EG,.: Migration of cultured vascular smooth muscle cells through a basement membrane barrier requires type IV collagenase activity and is inhibited by cellular differentiation. Circ Res 1994, 75:41-54.
22. Mason DP, Kenagy RD, Hasenstab D, Bowen-Pope DF, Seifert RA, Coats S, Hawkins SM, Clowes AW: Matrix metalloproteinase-9 overexpression enhances vascular smooth muscle cell migration and alters remodeling in the injured rat carotid artery. Circ Res 1999, 85:1179-1185.
23. Baker AH, Zaltsman AB, George SJ, Newby AC: Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion; proliferation, and death in vitro. TIMP-3 promotes apoptosis. J Clin Invest 1998, 101:1478-1487.
24. Hou G, Mulholland D, Gronska MA, Bendeck MP: Type VIII collagen stimulates smooth muscle cell migration and matrix metalloproteinase synthesis after arterial injury. Am J Pathol 2000, 156:467-476.
25. Zempo N, Koyama N, Kenagy RD, Lea HJ, Clowes AW: Regulation of vascular smooth muscle cell migration and proliferation in vitro and in injured rat arteries by a synthetic matrix metalloproteinase inhibitor. Arteriosclerosis, Thrombosis & Vascular Biology 1996, 16:28-33.
26. Brown DL, Hibbs MS, Kearney M, Loushin C, Isner JM: Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina. Circulation 1995, 91:2125-2131.
27. Brown DL, Hibbs MS, Kearney M, Isner JM: Differential expression of 92-kDa gelatinase in primary atherosclerotic versus restenotic coronary lesions. Am J Cordial 1997, 79:878-882.
28. Palumbo R, Gaetano C, Melillo G, Toschi E, Remuzzi A, Capogrossi MC: Shear stress downregulation of platelet-derived growth factor receptor- beta and matrix metalloprotease-2 is associated with inhibition of smooth muscle cell invasion and migration. Circulation 2000, 102:225-230.
29. Fan WH, Pech M, Karnovsky MJ: Connective tissue growth factor (CTGF) stimulates vascular smooth muscle cell growth and migration in vitro. Eur J Cell Biol 2000, 79:915-923.
30. Fan WH, Karnovsky MJ: Increased MMP-2 expression in connective tissue growth factor over- expression vascular smooth muscle cells. J Biol Chem 2002, 277:9800-9805.
31. Kondo S, Kubota S, Shimo T, Nishida T, Yosimichi G, Eguchi T, Sugahara T, Takigawa M: Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases. Carcinogenesis 2002, 23:769-776.
32. Oemar BS, Werner A, Garnier JM, Do DD, Godoy N, Nauk M, Marz W, Rupp J, Pech M, Luscher TF: Human Connective Tissue Growth Factor is expressed in Advanced Atherosclerotic Lesions. Circulation 1997, 95:831-839.
33. Crean JK, Finlay D, Murphy M, Moss C, Godson C, Martin F, Brady HR: The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells. J Biol Chem 2002, 277:44187-44194.
34. Hood JD, Cheresh DA: Role of integrins in cell invasion and migration. Nat Rev Cancer 2002, 2:91-100.
35. Soon LL, Yie TA, Shvarts A, Levine AJ, Su F, Tchou-Wong KM: Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation. J Biol Chem 2003, 278:11465-11470.
36. Castellot J.J. Jr., Favreau LV, Kamovsky MJ, Rosenberg RD: Inhibition of vascular smooth muscle cell growth by eadothelial cell-derived heparin. Possible role of a platelet endoglycosidase. J Biol Chem 1982, 257:11256-11260.
37. Castellot J.J. Jr., Pukac LA, Caleb BL, Wright T.C. Jr., Karnovsky MJ: Heparin selectively inhibits a protein kinase C-dependent mechanism of cell cycle progression in calf aortic smooth muscle cells [published erratum appears in J Cell Biol 1990 Mar; 110(3): 863]. J Cell Biol 1989, 109:3147-3155.
38. Tuschl T, Zamore PD, Lehmann R, Bartel DP, Sharp PA: Targeted mRNA degradation by double-stranded RNA in vitro. Genes Dev 1999, 13:3191-3197.
39. Castellot J.J. Jr., Cochran DL, Kamovsky MJ: Effect of heparin on vascular smooth muscle cells. I. Cell metabolism. J Cell Physiol 1985, 124:21-28.