Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis

Journal of Viral Hepatitis

Volumn 16, Issue 9, 2009, Pages 612-620

  Kovalenko, E ^a   Tacke, F ^a   Gressner, O A ^a   Zimmermann, H W ^a   Lahme, B ^a   Janetzko, A ^b   Wiederholt, T ^a   Berg, T ^c   Muller T ^c   Trautwein, C ^a   Gressner, A M ^a   Weiskirchen, Ralf ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b DRG Instruments GmbH   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Connective tissue growth factor; CTGF; Hepatitis C; Liver fibrosis; Noninvasive biomarker; Promoter polymorphisms

Indexed keywords

BIOLOGICAL MARKER; CONNECTIVE TISSUE GROWTH FACTOR;

ADOLESCENT; ADULT; AGED; ARTICLE; CHRONIC LIVER DISEASE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; DNA POLYMORPHISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROGENESIS; GENE FREQUENCY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIVER CIRRHOSIS; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; BIOLOGICAL MARKERS; CONNECTIVE TISSUE GROWTH FACTOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE FREQUENCY; GENETIC MARKERS; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROGNOSIS; YOUNG ADULT;

EID: 68949198361     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2009.01110.x     Document Type: Article

References (35)

1. Moussad EE, Brigstock DR. Connective tissue growth factor: what's in a name? Mol Genet Metab 2000 71 : 276 292.
2. Gressner OA, Gressner AM. Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases. Liver Int 2008 28 : 1065 1079.
3. Abreu JG, Ketpura NI, Reversade B, De Robertis EM. Connective tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β. Nat Cell Biol 2002 4 : 599 604.
4. Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008 214 : 199 210.
5. Dziadzio M, Usinger W, Leask A et al. N-terminal connective tissue growth factor is a marker of the fibrotic phenotype in scleroderma. QJM 2005 98 : 485 492.
6. Munemasa S, Sakai A, Kuroda Y et al. Connective tissue growth factor is an indicator of bone involvement in multiple myeloma, but matrix metalloproteinase-9 is not. Br J Haematol 2007 139 : 41 50.
7. Roestenberg P, van Nieuwenhoven FA, Wieten L et al. Connective tissue growth factor is increased in plasma of type 1 diabetic patients with nephropathy. Diabetes Care 2004 27 : 1164 1170.
8. Tamatani T, Kobayashi H, Tezuka K et al. Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia. Biochem Biophys Res Commun 1998 251 : 748 752.
9. Morikawa H, Tamori A, Nishiguchi S et al. Expression of connective tissue growth factor in the human liver with idiopathic portal hypertension. Mol Med 2007 13 : 240 245.
10. Gressner OA, Lahme B, Demirci I, Gressner AM, Weiskirchen R. Differential effects of TGF-β on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes. J Hepatol 2007 47 : 699 710.
11. Gressner OA, Lahme B, Siluschek M et al. Activation of TGF-β within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor. J Cell Mol Med 2008 12 : 2717 2730.
12. Sladek R, Hudson TJ. Elucidating cis- and trans-regulation variation using genetical genomics. Trends Genet 2006 22 : 245 250.
13. Blom IE, van Dijk AJ, de Weger RA, Tilanus MG, Goldschmeding R. Identification of human ccn2 (connective tissue growth factor) promoter polymorphisms. Mol Pathol 2001 54 : 192 196.
14. Fonseca C, Lindahl GE, Ponticos M et al. A polymorphism in the CTGF promoter region associated with systemic sclerosis. N Engl J Med 2007 357 : 1210 1220.
15. Gourh P, Mayes MD, Arnett FC. CTGF polymorphism associated with systemic sclerosis. N Engl J Med 2008 358 : 308 309.
16. Wang H, Mengsteab S, Tag CG et al. Transforming growth factor-β1 gene polymorphisms are associated with progression of liver fibrosis in Caucasians with chronic hepatitis C infection. World J Gastroenterol 2005 11 : 1929 1936.
17. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 1994 19 : 1513 1520.
18. Yagmur E, Weiskirchen R, Gressner AM, Trautwein C, Tacke F. Insulin resistance in liver cirrhosis is not associated with circulating retinol-binding protein 4. Diabetes Care 2007 30 : 1168 1172.
19. Yagmur E, Trautwein C, Gressner AM, Tacke F. Resistin serum levels are associated with insulin resistance, disease severity, clinical complications, and prognosis in patients with chronic liver diseases. Am J Gastroenterol 2006 101 : 1244 1252.
20. Inkinen K, Wolff H, Lindroos P, Ahonen J. Connective tissue growth factor and its correlation to other growth factors in experimental granulation tissue. Connect Tissue Res 2003 44 : 19 29.
21. Abou-Shady M, Friess H, Zimmermann A et al. Connective tissue growth factor in human liver cirrhosis. Liver 2000 20 : 296 304.
22. Grainger DJ, Mosedale DE, Metcalfe JC. TGF-β in blood: a complex problem. Cytokine Growth Factor Rev 2000 11 : 133 145.
23. Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008 134 : 1655 1669.
24. Paradis V, Dargere D, Vidaud M et al. Expression of connective tissue growth factor in experimental rat and human liver fibrosis. Hepatology 1999 30 : 968 976.
25. Ozaki S, Sato Y, Yasoshima M, Harada K, Nakanuma Y. Diffuse expression of heparan sulfate proteoglycan and connective tissue growth factor in fibrous septa with many mast cells relate to unresolving hepatic fibrosis of congenital hepatic fibrosis. Liver Int 2005 25 : 817 828.
26. Sato S, Nagaoka T, Hasegawa M et al. Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis. J Rheumatol 2000 27 : 149 154.
27. Lasky JA. Connective tissue growth factor mRNA expression is upregulated in bleomycin-indicing lung fibrosis. Am J Physiol 1998 275 : 365 371.
28. Allen JT, Knight RA, Bloor CA, Spiteri MA. Enhanced insulin-like growth factor binding protein-related protein 2 (connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. Am J Respir Cell Mol Biol 1999 21 : 693 700.
29. Di Mola FF. Connective tissue growth factor is a regulator for fibrosis in human chronic pancreatitis. Ann Surg 1999 230 : 63 71.
30. Nelson Dr, Gonzalez-Peralta RP, Qian K et al. Transforming growth factor-β1 in chronic hepatitis C. J Viral Hepat 1997 4 : 29 35.
31. Ray S, Broor SL, Vaishnav Y et al. Transforming growth factor β in hepatitis C virus infection: in vivo and in vitro findings. J Gastroenterol Hepatol 2003 18 : 393 403.
32. Flisiak R, Prokopowicz D, Jaroszewicz J, Flisiak I. Plasma transforming growth factor-β1 in acute viral hepatitis. Med Sci Monit 2005 11 : CR304 CR308.
33. Kirmaz C, Terzioglu E, Topalak O et al. Serum transforming growth factor-β1 (TGF-β1) in patients with cirrhosis, chronic hepatitis B and chronic hepatitis C. Eur Cytokine Netw 2004 15 : 112 116.
34. Taniguchi H, Kato N, Otsuka M et al. Hepatitis C virus core protein upregulates transforming growth factor-β1 transcription. J Med Virol 2004 72 : 52 59.
35. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005 21 : 263 265.