Interdependent phosphorylation within the kinase domain T-loop regulates CHK2 activity

Journal of Biological Chemistry

Volumn 285, Issue 43, 2010, Pages 33348-33357

  Guo, Xin ^a   Ward, Michael D ^a   Tiedebohl, Jessica B ^a   Oden, Yvonne M ^a   Nyalwidhe, Julius O ^a   Semmes, O John ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHOSPHORYLATION; CELLULAR DNA DAMAGE; CHROMATIN LOCALIZATION; EXCHANGE REGIONS; IN-DEPTH ANALYSIS; INDUCED DAMAGE; KINASE ACTIVATION; KINASE ACTIVITY; KINASE DOMAINS; KINASE FUNCTION; LOOP REGIONS; MASS SPECTROMETRY ANALYSIS; NUCLEAR LOCALIZATION; PHOSPHORYLATION SITES; SUBCELLULAR DISTRIBUTION; UBIQUITYLATION; WILD TYPES;

CHEMICAL ACTIVATION; CHROMOSOMES; MASS SPECTROMETRY;

PHOSPHORYLATION;

CHECKPOINT KINASE 2;

AMINO ACID SEQUENCE; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CHROMATIN; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; IONIZING RADIATION; MASS SPECTROMETRY; MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SUBSTITUTION; CELL LINE; CELL NUCLEUS; CHROMATIN; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVATION; HUMANS; MUTATION, MISSENSE; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RADIATION, IONIZING; UBIQUITINATION;

EID: 77958456528     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.149609     Document Type: Article

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