Non-dioxin-like PCBs interact with benzo[a]pyrene-induced p53-responses and inhibit apoptosis

Toxicology and Applied Pharmacology

Volumn 249, Issue 2, 2010, Pages 166-177

  Al Anati, Lauy ^a   Högberg, Johan ^a   Stenius, Ulla ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Benzo(a)pyrene; HepG2; Mdm2; NDL PCBs; P53

Indexed keywords

BENZO[A]PYRENE; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLYCHLORINATED BIPHENYL DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PROTEIN BCL 2; PROTEIN MDM2; PROTEIN NOXA; PROTEIN P21; PROTEIN P53; RAF PROTEIN; SERINE; THREONINE; TRANSCRIPTION FACTOR FKHRL1;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOPLASM; ENVIRONMENTAL EXPOSURE; HUMAN; HUMAN CELL; POLLUTANT; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

APOPTOSIS; BENZO(A)PYRENE; CELL DEATH; ENVIRONMENTAL POLLUTANTS; HEP G2 CELLS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; POLYCHLORINATED BIPHENYLS; PROTO-ONCOGENE PROTEINS C-MDM2; RAF KINASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77958184606     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.09.004     Document Type: Article

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