Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells

Journal of Molecular Endocrinology

Volumn 39, Issue 3-4, 2007, Pages 239-247

  Ichikawa, T ^a   Horie Inoue, K ^a   Ikeda, K ^a   Blumberg, B ^b   Inoue, S ^a,c  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FARNOQUINONE; GROWTH DIFFERENTIATION FACTOR 15; GROWTH FACTOR; HYPOCALCIN; HYPOCALCIN 2; MENAQUINONE; MENAQUINONE 7; MENATETRENONE; PHYTOMENADIONE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VITAMIN K DEPENDENT CARBOXYLASE; BONE MORPHOGENETIC PROTEIN; DRUG DERIVATIVE; GDF15 PROTEIN, HUMAN; GLUTAMYL CARBOXYLASE; GLYCOPROTEIN; LIGASE; SIGNAL PEPTIDE; STC2 PROTEIN, HUMAN; STEROID RECEPTOR; SXR RECEPTOR;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; BONE DEVELOPMENT; CELL PROLIFERATION; CHONDROGENESIS; CONTROLLED STUDY; DNA MICROARRAY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OSTEOBLAST; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL CULTURE; DRUG EFFECT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHOSPHORYLATION;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CARBON-CARBON LIGASES; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLYCOPROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOBLASTS; PHOSPHORYLATION; RECEPTORS, STEROID; VITAMIN K 2;

EID: 35748957196     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/JME-07-0048     Document Type: Article

References (41)

1. 2 modulates proliferation and function of osteoblastic cells in vitro. Biochemical and Biophysical Research Communications 187 814-820.
2. Albertoni M, Shaw PH, Nozaki M, Godard S, Tenan M, Hamou MF, Fairlie DW, Breit SN, Paralkar VM, de Tribolet N et al. 2002 Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1. Oncogene 21 4212-4219.
3. Baek SJ, Kim KS, Nixon JB, Wilson LC & Eling TE 2001 Cyclooxygenase inhibitors regulate the expression of a TGF-β superfamily member that has proapoptotic and antitumorigenic activities. Molecular Pharmacology 59 901-908.
4. Baek SJ, Kim JS, Moore SM, Lee SH, Martinez J & Eling TE 2005 Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein. Molecular Pharmacology 67 356-364.
5. Bootcov MR, Bauskin AR, Valenzuela SM, Moore AG, Bansal M, He XY, Zhang HP, Donnellan M, Mahler S, Pryor K et al. 1997 MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily. PNAS 94 11514-11519.
6. Booth SL, Tucker KL, Chen H, Hannan MT, Gagnon DR, Cupples LA, Wilson PW, Ordovas J, Schaefer EJ, Dawson-Hughes B et al. 2000 Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. American Journal of Clinical Nutrition 71 1201-1208.
7. Bouras T, Southey MC, Chang AC, Reddel RR, Willhite D, Glynne R, Henderson MA, Armes JE & Venter DJ 2002 Stanniocalcin 2 is an estrogen-responsive gene coexpressed with the estrogen receptor in human breast cancer. Cancer Research 62 1289-1295.
8. Charpentier AH, Bednarek AK, Daniel RL, Hawkins KA, Latin KJ, Gaddis S, MacLeod MC & Mdaz CM 2000 Effects of estrogen on global gene expression: identification of novel targets of estrogen action. Cancer Research 60 5977-5983.
9. Diller L, Kassel J, Nelson CE, Gryka MA, Litwak G, Gebhardt M, Bressac B, Ozturk M, Baker SJ, Vogelstein B et al. 1990 p53 functions as a cell cycle control protein in osteosarcomas. Molecular and Cellular Biology 10 5772-5781.
10. Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M et al. 2005 Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434 514-520.
11. Filvaroff EH, Guillet S, Zlot C, Bao M, Ingle G, Steinmetz H, Hoeffel J, Bunting S, Ross J, Carano RA et al. 2002 Stanniocalcin 1 alters muscle and bone structure and function in transgenic mice. Endocrinology 143 3681-5690.
12. Gagliardi AD, Kuo EY, Raulic S, Wagner GF & DiMattia GE 2005 Human stanniocalcin-2 exhibits potent growth-suppressive properties in transgenic mice independently of growth hormone and IGFs. American Journal of Physiology. Endocrinology and Metabolism 288 E92-E105.
13. Hromas R, Hufford M, Sutton J, Xu D, Li Y & Lu L 1997 PLAB, a novel placental bone morphogenetic protein. Biochimica et Biophysica Acta 1354 40-44.
14. 2-activated transcription of extracellular matrix-related genes and collagen accumulation in osteoblastic cells. Journal of Biological Chemistry 281 16927-16934.
15. Jiang WQ, Chang AC, Satoh M, Furuichi Y, Tam PP & Reddel RR 2000 The distribution of stanniocalcin 1 protein in fetal mouse tissues suggests a role in bone and muscle development. Journal of Endocrinology 165 457-466.
16. Li PX, Wong J, Ayed A, Ngo D, Brade AM, Arrowsmith C, Austin RC & Klamut HJ 2000 Placental transforming growth factor-beta is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression. Journal of Biological Chemistry 275 20127-20135.
17. Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR & Karsenty G 1997 Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386 78-81.
18. Luo CW, Pisarska MD & Hsueh AJ 2005 Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary. Endocrinology 146 469-476.
19. Ma Y, Pitson S, Hercus T, Murphy J, Lopez A & Woodcock J 2005 Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism. Journal of Biological Chemistry 280 26011-26017.
20. Madsen KL, Tavernini MM, Yachimec C, Mendrick DL, Alfonso PJ, Buergin M, Olsen HS, Antonaccio MJ, Thomson AB & Fedorak RN 1998 Stanniocalcin: a novel protein regulating calcium and phosphate transport across mammalian intestine. American Journal of Physiology 274 G96-G102.
21. Masuda H, Miller C, Koeffler HP, Battifora H & Cline MJ 1987 Rearrangement of the p53 gene in human osteogenic sarcomas. PNAS 84 7716-7719.
22. Nazarova N, Qiao S, Golovko O, Lou YR & Tuohimaa P 2004 Calcitriol-induced prostate-derived factor: autocrine control of prostate cancer cell growth. International Journal of Cancer 112 951-958.
23. Nishimoto SK & Price PA 1985 The vitamin K-dependent bone protein is accumulated within cultured osteosarcoma cells in the presence of the vitamin K antagonist warfarin. Journal of Biological Chemistry 260 2832-2836.
24. Olsen HS, Cepeda MA, Zhang QQ, Rosen CA & Vozzolo BL 1996 Human stanniocalcin: a possible hormonal regulator of mineral metabolism. PNAS 93 1792-1796.
25. 2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation. Hepatology 40 243-251.
26. Paralkar VM, Vail AL, Grasser WA, Brown TA, Xu H, Vukicevic S, Ke HZ, Qi H, Owen TA & Thompson DD 1998 Cloning and characterization of a novel member of the transforming growth factor-β/bone morphogenetic protein family. Journal of Biological Chemistry 273 13760-13767.
27. Schlittenhardt D, Schober A, Strelau J, Bonaterra GA, Schmiedt W, Unsicker K, Metz J & Kinscherf R 2004 Involvement of growth differentiation factor-15/macrophage inhibitory cytokine-1 (GDF-15/ MIC-1) in oxLDL-induced apoptosis of human macrophages in vitro and in arteriosclerotic lesions. Cell and Tissue Research 318 325-333.
28. Selvamurugan N, Pulumati MR, Tyson DR & Partridge NC 2000 Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor α1. Journal of Biological Chemistry 275 5037-5042.
29. Shanahan CM & Weissberg PL 1998 Smooth muscle cell heterogeneity: patterns of gene expression in vascular smooth muscle cells in vitro and in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology 18 333-338.
30. Shim M & Eling TE 2005 Protein kinase C-dependent regulation of NAG-1/placental bone morphogenic protein/MIC-1 expression in LNCaP prostate carcinoma cells. Journal of Biological Chemistry 280 18636-18642.
31. 2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. Journal of Bone and Mineral Research 15 515-521.
32. 2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR. Journal of Biological Chemistry 278 43919-43927.
33. Tan M, Wang Y, Guan K & Sun Y 2000 PTGF-β, a type β transforming growth factor (TGF-β) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-β signaling pathway. PNAS 97 109-114.
34. Thomas R, True LD, Lange PH & Vessella RL 2001 Placental bone morphogenetic protein (PLAB) gene expression in normal, pre-malignant and malignant human prostate: relation to tumor development and progression. International Journal of Cancer 93 47-52.
35. Uldry M, Yang W, St-Pierre J, Lin J, Seale P & Spiegelman BM 2006 Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differendation. Cell Metabolism 3 333-341.
36. Varghese R, Gagliardi AD, Bialek PE, Yee SP, Wagner GF & Dimattia GE 2002 Overexpression of human stanniocalcin affects growth and reproduction in transgenic mice. Endocrinology 143 868-876.
37. Vergnand P, Garuero P, Meunier PJ, Breart G, Kamihagi K & Delmas PD 1997 Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study. Journal of Clinical Endocrinology and Metabolism 82 719-724.
38. Wagner GF, Vozzolo BL, Jaworski E, Haddad M, Kline RL, Olsen HS, Rosen CA, Davidson MB & Renfro JL 1997 Human stanniocalcin inhibits renal phosphate excretion in the rat. Journal of Bone and Mineral Research 12 165-171.
39. Yamaguchi K, Lee SH, Eling TE & Baek SJ 2004 Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway. Journal of Biological Chemistry 279 49617-49623.
40. Yoshiko Y, Son A, Maeda S, Igarashi A, Takano S, Hu J & Maeda N 1999 Evidence for stanniocalcin gene expression in mammalian bone. Endocrinology 140 1869-1874.
41. Yoshiko Y, Maeda N & Aubin JE 2003 Stanniocalcin 1 stimulates osteoblast differentiation in rat calvaria cell cultures. Endocrinology 144 4134-4143.