Low shear granulation of pharmaceutical powders: Effect of formulation on granulation and tablet properties

Chemical Engineering Journal

Volumn 164, Issue 2-3, 2010, Pages 442-448

  Ma, H ^a   Andrews, G P ^a   Jones, D S ^a   Walker, G M ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Low shear granulation; Pharmaceutical formulation; Tablet properties

Indexed keywords

BINDER CONTENT; BINDER VISCOSITY; DIFFERENT SIZES; EXPERIMENTAL STUDIES; FACTORIAL DESIGN; FOOD INDUSTRIES; GRANULATION MECHANISM; LIQUID SOLIDS; MASS MEAN DIAMETERS; PHARMACEUTICAL FORMULATION; PHARMACEUTICAL POWDER; PROCESS PARAMETERS; PROCESSING CONDITION; SHEAR GRANULATION; SHEAR RATES; TABLET PROPERTIES; UNIT OPERATION; WET GRANULATION;

AGGLOMERATION; BINDERS; DRUG PRODUCTS; LIQUIDS; MECHANICAL PROPERTIES; POWDERS; SHEAR DEFORMATION; STARCH; SUGARS; VISCOSITY;

GRANULATION;

EID: 77958150565     PISSN: 13858947     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cej.2009.11.014     Document Type: Article

References (19)

1. Pietsch W. Size Enlargement by Agglomeration 1991, John Wiley and Sons, Chichester.
2. US Pharmacopeia XXVII. Uniformity of Dosage Units 2004, vol. 905. United States Pharmacopeial Convention, Rockville, MD, pp. 2396-2397.
3. Iveson S.M., Litster J.D., Hapgood K., Ennis B.J. Nucleation, growth and breakage phenomena in agitated wet granulation processes. Powder Technology 2001, 117:3-39.
4. Iveson S.M., Wauters P.A.L., Forrest S., Litster J.D., Meesters G.M.H., Scarlett B. Growth regime map for liquid-bound granules: further development and experimental validation. Powder Technology 2001, 117:83-97.
5. Ennis B.J., Litster J.D. Particle size enlargement. Perry's Chemical Engineers' Handbook 1997, 20-56. McGrath-Hill, New York. 7th ed. R. Perry, D. Green (Eds.).
6. Carstenen J. Pharmaceutical Principles of Solid Dosage Forms 1993, Technomic, Lancaster, pp. 15-30.
7. U.S Department of Health and Human Services Food and Drugs Administration, 2004. Guidance for Industry PAT, Pharmaceutical cGMP's, September 2004.
8. Tu W.D., Ingram A., Seville J., Hsiau S.S. Exploring the regime map for high-shear mixer granulation. Chemical Engineering Journal 2009, 145(3):505-513.
9. van den Dries K., Vromans H. Quantitative proof of liquid penetration-involved granule formation in a high shear mixer. Powder Technology 2009, 189(2):165-171.
10. Smirani-Khayati N., Falk V., Bardin-Monnier N., Marchal-Heussler L. Binder liquid distribution during granulation process and its relationship to granule size distribution. Powder Technology 2009, 195(2):105-112.
11. Walker G.M., Bell S., Vann M., Andrews G., Jones D. Pharmaceutically engineering powders using fhmg-the effects of process parameters and formulation variables. Chemical Engineering Research and Design 2007, 85(A7):981.
12. Vemavarapu C., Surapaneni M., Hussain M., Badawy S. Role of drug substance material properties in the processibility and performance of a wet granulated product. International Journal of Pharmaceutics 2009, 374(1-2):96-105.
13. Jain S. Mechanical properties of powders for compaction and tableting: an overview. Pharmaceutical Science and Technology Today 1999, 2(1):20-31.
14. Kawakita K., Ludde K.-H. Some considerations on powder compression equations. Powder Technology 1970, 4:61-68.
15. Adams M.J., McKeown R. Micromechanical analysis of the pressure volume relationships for powders under confined uniaxial compression. Powder Technology 1996, 88:155-163.
16. Walker G.M., Holland C., Ahmad M., Craig D.Q.M. Influence of process parameters on fluidized hot-melt granulation and tablet pressing of pharmaceutical powders. Chemical Engineering Science 2005, 60:3867-3877.
17. Mukhopadhyay D., Saville D., Tucker I.G. Crosslinking of drug-alginate granules. Part 2. Effect of granule preparation and composition on granule properties. International Journal of Pharmaceutics 2008, 356(1-2):193-199.
18. Bouwman A.M., Visser M.R., Meesters G.M.H., Frijlink H.W. The use of Stokes deformation number as a predictive tool for material exchange behaviour of granules in the 'equilibrium phase' in high shear granulation. International Journal of Pharmaceutics 2006, 318(1-2):78-85.
19. Walker G.M., Dunne N., Orr J.F. Liquid particle interactions in orthopeadic bone cements. Chemical Engineering Journal 2008, 139:489-494.