Pharmaceutically engineering powders using FHMG: The effects of process parameters and formulation variables

Chemical Engineering Research and Design

Volumn 85, Issue 7 A, 2007, Pages 981-986

  Walker, G ^a   Bell, S ^a   Vann, M ^a   Zhai, H ^a   Jones, D ^a   Andrews, G ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Fluidized hot melt granulation; Granule growth mechanism; Growth regime map; Pharmaceutical granulation

Indexed keywords

AGGLOMERATION; BINDERS; COALESCENCE; DRUG PRODUCTS; FLUIDIZATION; FLUIDIZED BEDS; MIXING;

FLUIDIZED HOT MELT GRANULATION; GRANULE GROWTH MECHANISM; GROWTH REGIME MAP; PHARMACEUTICAL GRANULATION;

GRANULATION;

AGGLOMERATION; BINDERS; COALESCENCE; DRUG PRODUCTS; FLUIDIZATION; FLUIDIZED BEDS; GRANULATION; MIXING;

EID: 34547759359     PISSN: 02638762     EISSN: None     Source Type: Journal    
DOI: 10.1205/cherd06186     Document Type: Article

References (17)

1. Abberger, T., Seo, A. and Schaefer, T., 2002, The effect of droplet size and powder particle size on the mechanisms of nucleation and growth in fluid bed melt agglomeration, International Journal of Pharmaceutics, 249: 185-197.
2. Fung, K.Y. and Ng, K.M., 2003, Product-centred processing; pharmaceutical tablets and capsules. AIChE J, 49: 1193-1215.
3. Gao, J.Z.H., Jain, A., Motherham, R., Gray, D.B. and Hussain, M.A., 2002, Fluid bed granulation of poorly water soluable, low density, micronised drug: comparison with high shear granulation, International Journal of Pharmaceutics, 237: 1-14.
4. Iveson, S. and Litster, J., 1998, Growth regime map for liquid-bound granules, AIChE J, 44: 1510-1518.
5. Iveson, S.M., Lister, J.D., Hapgood, K. and Ennis, B.J., 2001a, Nucleation, growth and breakage phenomena in agitated wet granulation processes: a review, Powder Technol, 117: 3-39.
6. Iveson, S.M., Wauters, P.A.L., Forrest, S., Litster, J.D., Meesters, G.M.H. and Scarlett, B., 2001b, Growth regime map for liquid-bound granules: further development and experimental validation, Powder Technol, 117: 83-97.
7. Kidokoro, M., Haramiishi, Y., Sagasaki, S. and Yamamoto, Y., 2002, Application of fluidised hot-melt granulation (FHMG) for the preparation of granules for tableting, Drug Development and Industrial Pharmacy, 28: 67-76.
8. Kidokoro, M., Sasaki, K., Haramiishi, Y. and Matahira, N., 2003, Effect of crystalline behavior of PEG 6000 on the properties of granules prepared by fluidised hot melt granulation, Chemical and Pharmaceutical Bulletin, 51: 467-493.
9. Laitinen, N., Antikainen, O., Rantanen, J. and Yliruusi, J., 2004, New perspectives for visual characterisation of pharmaceutical solids, Journal of Pharmaceutical Sciences, 93: 165-176.
10. Lui, L.X., Litster, J.D., Iveson, S.M. and Ennis, B.J., 2000, Coalescence of deformable granules in wet granulation processes, AIChE J, 46: 529-539.
11. Schaefer, T. and Mathieson, C., 1996, Melt pelletization in a high shear mixer: IX. Effects of binder particle size, International Journal of Pharmaceutics, 139: 139-148.
12. Stepanek, F. and Ansari, M.A., 2005, Computer simulation of granule microstructure formation, Chem Eng Sci, 60: 4019-4029.
13. Sun, C.C. and Grant, D.J.W., 2001, Effects of intial particle size on the tableting properties of L-lysine monohydrochloride dihydrate powder, International Journal of Pharmaceutics, 215: 221-228.
14. Walker, G.M., Holland, C.R., Ahmad, M.M.N. and Craig, Q.M.D., 2005, Influence of process parameters on fluidised hot-melt granulation and tablet pressing of pharmaceutical powders, Chem Eng Sci, 60: 3867-3877.
15. Walker, G.M., Andrews, G. and Jones, D., 2006a, Effect of process parameters on the melt granulation of pharmaceutical powders. Powder Technol, 165: 161-166.
16. Walker, G.M., Bell, S., Douglas, P., Andrews, G. and Jones, D., 2007, Melt fluidised bed granulation of pharmaceutical powders: Improvements in drug bioavailability, Chem Eng Sci, pending publication, FBA24, 62: 451-462.
17. Wen, C.Y. and Yu, Y.H., 1966, A generalised method for predicting the minimum fluidisation velocity, AIChE J, 12: 610-613.