Adeno-associated virus-mediated IL-10 gene transfer suppresses lacrimal gland immunopathology in a rabbit model of autoimmune dacryoadenitis

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 10, 2010, Pages 5137-5144

  Thomas, Padmaja B ^a   Samant, Deedar M ^a   Selvam, Shivaram ^a   Wei, Rui Hua ^a   Wang, Yanru ^b   Stevenson, Douglas ^a   Schechter, Joel E ^a,c,d   Apparailly, Florence ^e,f,g   Mircheff, Austin K ^a,b,c   Trousdale, Melvin D ^a,c  

^a DOHENY EYE INSTITUTE   (United States)

^b The Departments of Physiology and Biophysics   (United States)

^c The Departments of Ophthalmology   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e HÔPITAL SAINT ELOI   (France)

^f UNIV MONTPELLIER   (France)

^g LAPEYRONIE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD18 ANTIGEN; DOXYCYCLINE; INTERLEUKIN 10; PARVOVIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DACRYOADENITIS; AUTOIMMUNE DISEASE; CD4 CD8 RATIO; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LACRIMAL GLAND DISEASE; LYMPHOCYTE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RABBIT; REGULATORY T LYMPHOCYTE; VIRAL GENE THERAPY; ADENO ASSOCIATED VIRUS; ANIMAL; CULTURE TECHNIQUE; DACRYOCYSTITIS; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE THERAPY; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; IMMUNOLOGY; LACRIMAL APPARATUS; LACRIMAL FLUID; PATHOLOGY; SECRETION; TRANSGENE;

ANIMALS; AUTOIMMUNE DISEASES; CELL CULTURE TECHNIQUES; DACRYOCYSTITIS; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; INTERLEUKIN-10; LACRIMAL APPARATUS; RABBITS; TEARS; TRANSDUCTION, GENETIC; TRANSGENES;

EID: 77958144586     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-5423     Document Type: Article

References (31)

1. de Saint Jean M, Nakamura T, Wang Y, Trousdale MD, Schechter JE, Mircheff AK. Suppression of lymphocyte proliferation and regulation of dendritic cell phenotype by soluble mediators from rat lacrimal epithelial cells. Scand J Immunol. 2009;70:53-62.
2. Rehman KK, Trucco M, Wang Z, Xiao X, Robbins PD. AAV8- mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice. Mol Ther. 2008;16: 1409-1416.
3. Apparailly F, Verwaerde C, Jacquet C, Auriault C, Sany J, Jorgensen C. Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis. J Immunol. 1998;160:5213-5220.
4. Johnston LC, Su X, Maguire-Zeiss K, et al. Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease. Mol Ther. 2008;16:1392-1399.
5. Perez N, Plence P, Millet V, et al. Tetracycline transcriptional silencer tightly controls transgene expression after in vivo intramuscular electrotransfer: application to interleukin 10 therapy in experimental arthritis. Hum Gene Ther. 2002;13:2161-2172.
6. Smith JR, Verwaerde C, Rolling F, et al. Tetracycline-inducible viral interleukin-10 intraocular gene transfer, using adeno-associated virus in experimental autoimmune uveoretinitis. Hum Gene Ther. 2005;16:1037-1046.
7. Zhu Z, Stevenson D, Schechter JE, et al. Prophylactic effect of IL-10 gene transfer on induced autoimmune dacryoadenitis. Invest Ophthalmol Vis Sci. 2004;45:1375-1381.
8. Nonaka-Sarukawa M, Okada T, Ito T, et al. Adeno-associated virus vector-mediated systemic interleukin-10 expression ameliorates hypertensive organ damage in Dahl salt-sensitive rats. J Gene Med. 2008;10:368-374.
9. Guo Z, Song D, Azzarolo AM, et al. Autologous lacrimal-lymphoid mixed-cell reactions induce dacryoadenitis in rabbits. Exp Eye Res. 2000;71:23-31.
10. Zhu Z, Stevenson D, Schechter JE, Mircheff AK, Atkinson R, Trousdale MD. Lacrimal histopathology and ocular surface disease in a rabbit model of autoimmune dacryoadenitis. Cornea. 2003;22:25-32.
11. Thomas PB, Samant DM, Zhu Z, et al. Long term topical cyclosporine treatment improves tear production and reduces keratoconjunctivitis in rabbits with induced autoimmune dacryoadenitis. JOPT. 2009;25:285-292.
12. Flotte T, Agarwal A, Wang J, et al. Efficient ex vivo transduction of pancreatic islet cells with recombinant adeno-associated virus vectors. Diabetes. 2001;50:515-520.
13. Rehman KK, Wang Z, Bottino R, et al. Efficient gene delivery to human and rodent islets with double-stranded (ds) AAV-based vectors. Gene Ther. 2005;12:1313-1323.
14. Guo Z, Azzarolo AM, Schechter JE, et al. Lacrimal gland epithelial cells stimulate proliferation in autologous lymphocyte preparations. Exp Eye Res. 2000;71:11-22.
15. Apparailly F, Millet V, Noel D, Jacquet C, Sany J, Jorgensen C. Tetracycline-inducible interleukin-10 gene transfer mediated by an adeno-associated virus: application to experimental arthritis. Hum Gene Ther. 2002;13:1179-1188.
16. Zhu Z, Stevenson D, Schechter JE, et al. Tumor necrosis factor inhibitor gene expression suppresses lacrimal gland immunopathology in a rabbit model of autoimmune dacryoadenitis. Cornea. 2003;22:343-351.
17. Trousdale MD, Zhu Z, Stevenson D, Schechter JE, Ritter T, Mircheff AK. Expression of TNF inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis. J Autoimmune Dis. 2005;2:6.
18. Adesanya MR, Redman RS, Baum BJ, O'Connell BC. Immediate inflammatory responses to adenovirus-mediated gene transfer in rat salivary glands. Hum Gene Ther. 1996;7:1085-1093.
19. Muzyczka N. Use of adeno-associated virus as a general transduction vector for mammalian cells. Curr Top Microbiol Immunol. 1992;158:97-129.
20. Rabinowitz JE, Samulski J. Adeno-associated virus expression systems for gene transfer. Curr Opin Biotechnol. 1998;9:470-475.
21. Beardsley RM, De Paiva CS, Power DF, Pflugfelder SC. Desiccating stress decreases apical corneal epithelial cell size-modulation by the metalloproteinase inhibitor doxycycline. Cornea. 2008;27: 935-940.
22. Kok MR, Yamano S, Lodde BM, et al. Local adeno-associated virusmediated interleukin 10 gene transfer has disease-modifying effects in a murine model of Sjögren's syndrome. Hum Gene Ther. 2003;14:1605-1618.
23. Yoshioka T, Okada T, Maeda Y, et al. Adeno-associated virus vectormediated interleukin-10 gene transfer inhibits atherosclerosis in apolipoprotein E-deficient mice. Gene Ther. 2004;11:1772-1779.
24. Broderick CA, Smith AJ, Balaggan KS, et al. Local administration of an adeno-associated viral vector expressing IL-10 reduces monocyte infiltration and subsequent photoreceptor damage during experimental autoimmune uveitis. Mol Ther. 2005;12:369-373.
25. Watanabe M, Kashiwakura Y, Kusumi N, et al. Adeno-associated virus-mediated human IL-10 gene transfer suppresses the development of experimental autoimmune orchitis. Gene Ther. 2005;12: 1126-1132.
26. Lee HC, Kim SJ, Kim KS, Shin HC, Yoon JW. Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue. Nature. 2000;408:483-488.
27. Song S, Morgan M, Ellis T, et al. Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adenoassociated virus vectors. Proc Natl Acad Sci U S A. 1998;95: 14384-14388.
28. Mircheff AK, Warren DW, Wood RL. Hormonal support of lacrimal function, primary lacrimal deficiency, autoimmunity, and peripheral tolerance in the lacrimal gland. Ocular Immunol Inflamm. 1996;4:145-172.
29. Ma Y, Thornton S, Duwel LE, et al. Inhibition of collagen-induced arthritis in mice by viral IL-10 gene transfer. J Immunol. 1998;161: 1516-1524.
30. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin- 10 and the interleukin-10 receptor. Annu Rev Immunol. 2001; 19:683-765.
31. Scott G, Yiu SC, Wasilewski D, Song J, Smith RE. Combined esterified estrogen and methyltestosterone treatment for dry eye syndrome in postmenopausal women. Am J Ophthalmol. 2005; 139:1109-1110.