Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: Implications for latency

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 14, 2008, Pages 5453-5458

  Murphy, Eain ^b   Vaníček, Jiří ^a,c   Robins, Harlan ^d   Shenk, Thomas ^b   Levine, Arnold J ^a  

^a INSTITUTE FOR ADVANCED STUDY   (United States)

^b PRINCETON UNIVERSITY   (United States)

^c EPFL   (Switzerland)

^d Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Immune evasion; miRNAs; Reactivation

Indexed keywords

IMMEDIATE EARLY PROTEIN; MESSENGER RNA;

ARTICLE; EMBRYO; EPSTEIN BARR VIRUS; GENE CONTROL; GENE EXPRESSION; GENE REPRESSION; GENETIC ALGORITHM; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 8; IMMEDIATE EARLY GENE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RNA ANALYSIS; VIRUS GENE; VIRUS LATENCY;

ALGORITHMS; CYTOMEGALOVIRUS; GENE EXPRESSION REGULATION, VIRAL; GENES, IMMEDIATE-EARLY; HERPESVIRIDAE; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 4, HUMAN; HERPESVIRUS 8, HUMAN; HUMANS; MICRORNAS; SIMPLEXVIRUS; VIRUS LATENCY;

HERPESVIRIDAE; HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 4; HUMAN HERPESVIRUS 5; HUMAN HERPESVIRUS 8;

EID: 44449105456     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0711910105     Document Type: Article

References (35)

1. Ambros V (2004) The functions of animal microRNAs. Nature 431:350-355.
2. Bartel DP (2004) MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116:281-297.
3. Cullen BR (2006) Viruses and microRNAs. Nat Genet 38(Suppl):S25-S30.
4. Pfeffer S, et al. (2005) Identification of microRNAs of the herpesvirus family. Nat Methods 2:269-276.
5. Cai X, et al. (2006) Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed. PLoS Pathog 2:e23.
6. Grundhoff A, Sullivan CS, Ganem D (2006) A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses. RNA 12:733-750.
7. Grey F, Antoniewicz A, Allen E, Saugstad J, McShea A, Carrington JC, Nelson J (2005) Identification and characterization of human cytomegalovirus-encoded microRNAs. J Virol 79:12095-12099.
8. Dunn W, et al. (2005) Human cytomegalovirus expresses novel microRNAs during productive viral infection. Cell Microbiol 7:1684-1695.
9. Cui C, et al. (2006) Prediction and identification of herpes simplex virus 1-encoded microRNAs. J Virol 80:5499-5508.
10. Gupta A, Gartner JJ, Sethupathy P, Hatzigeorgiou AG, Fraser NW (2006) Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript. Nature 442:82-85.
11. Cai X, et al. (2005) Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proc Natl Acad Sci USA 102:5570-5575.
12. Samols MA, Hu J, Skalsky RL, Renne R (2005) Cloning and identification of a microRNA cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirus. J Virol 79:9301-9305.
13. Harris RA, Everett RD, Zhu XX, Silverstein S, Preston CM (1989) Herpes simplex virus type 1 immediate-early protein Vmw110 reactivates latent herpes simplex virus type 2 in an in vitro latency system. J Virol 63:3513-3515.
14. Zhu XX, Chen JX, Young CS, Silverstein S (1990) Reactivation of latent herpes simplex virus by adenovirus recombinants encoding mutant IE-0 gene products. J Virol 64:4489-4498.
15. Countryman J, Miller G (1985) Activation of expression of latent Epstein-Barr herpes-virus after gene transfer with a small cloned subfragment of heterogeneous viral DNA Proc Natl Acad Sci USA 82:4085-4089.
16. Sun R, et al. (1998) A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc Natl Acad Sci USA 95:10866-10871.
17. Lukac DM, Renne R, Kirshner JR, Ganem D (1998) Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein. Virology 252:304-312.
18. Stern-Ginossar N, et al. (2007) Host immune system gene targeting by a viral miRNA. Science 317:376-381.
19. Samols MA, et al. (2007) Identification of cellular genes targeted by KSHV-encoded microRNAs. PLoS Pathog 3:e65.
20. Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15-20.
21. Robins H, Press WH (2005) Human microRNAs target a functionally distinct population of genes with AT-rich 3′ UTRs. Proc Natl Acad Sci USA 102:15557-15562.
22. Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc B 57:289-300.
23. Mocarski ES, Shenk T, Pass RF (2007) in Fields Virology, eds Knipe DM, Howley PM (Lippincott, Williams and Wilkins, Philadelphia, PA), pp. 2702-2772.
24. Mocarski ES, Kemble GW, Lyle JM, Greaves RF (1996) A deletion mutant in the human cytomegalovirus gene encoding IE1(491aa) is replication defective due to a failure in autoregulation. Proc Natl Acad Sci USA 93:11321-11326.
25. Gawn JM, Greaves RF (2002) Absence of IE1 p72 protein function during low-multiplicity infection by human cytomegalovirus results in a broad block to viral delayed-early gene expression. J Virol 76:4441-4455.
26. Nevels M, Paulus C, Shenk T (2004) Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation. Proc Natl Acad Sci USA 101:17234-17239.
27. Yu D, Silva MC, Shenk T (2003) Functional map of human cytomegalovirus AD169 defined by global mutational analysis. Proc Natl Acad Sci USA 100:12396-12401.
28. Prichard MN, Duke GM, Mocarski ES (1996) Human cytomegalovirus uracil DNA glycosylase is required for the normal temporal regulation of bothDNAsynthesis and viral replication. J Virol 70:3018-3025.
29. Macias MP, Huang L, Lashmit PE, Stinski MF (1996) Cellular or viral protein binding to a cytomegalovirus promoter transcription initiation site: effects on transcription. J Virol 70:3628-3635.
30. Reeves M, et al. (2006) Autorepression of the human cytomegalovirus major immediate-early promoter/enhancer at late times of infection is mediated by the recruitment of chromatin remodeling enzymes by IE86. J Virol 80:9998-10009.
31. Grey F, Meyers H, White EA, Spector DH, Nelson J (2007) A human cytomegalovirus-encoded microRNA regulates expression of multiple viral genes involved in replication. PLoS pathogens 3:e163.
32. Pfeffer S, et al. (2004) Identification of virus-encoded microRNAs. Science 304:734-736.
33. Hahn G, et al. (2002) The human cytomegalovirus ribonucleotide reductase homolog UL45 is dispensable for growth in endothelial cells, as determined by a BAC-cloned clinical isolate of human cytomegalovirus with preserved wild-type characteristics. J Virol 76:9551-9555.
34. Warming S, Costantino N, Court DL, Jenkins NA, Copeland NG (2005) Simple and highly efficient BAC recombineering using galK selection. Nucleic Acids Res 33:e36.
35. Chen C, et al. (2005) Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 33:e179.