Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 10, 2010, Pages 4913-4920

  Tolmachova, Tanya ^a   Wavre Shapton, Silene T ^a,b   Barnard, Alun R ^c   MacLaren, Robert E ^c,d   Futter, Clare E ^b   Seabra, Miguel C ^a,e,f  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d MOORFIELDS EYE HOSPITAL   (United Kingdom)

^e NOVA MEDICAL SCHOOL   (Portugal)

^f INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CHM GENE; CHOROIDEREMIA; CONTROLLED STUDY; DEGENERATION; ELECTRORETINOGRAPHY; GENE; HISTOPATHOLOGY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PHOTORECEPTOR; PHOTORECEPTOR DEGENERATION; PIGMENT EPITHELIUM; PRIORITY JOURNAL; REP1 GENE; SCANNING LASER OPHTHALMOSCOPY; ANIMAL; C57BL MOUSE; DISEASE MODEL; ELECTRON MICROSCOPY; FEMALE; GENETICS; MALE; MOUSE MUTANT; OPHTHALMOSCOPY; PATHOLOGY; PHOTORECEPTOR CELL; RETINA DEGENERATION; TRANSGENIC MOUSE;

CHM PROTEIN, HUMAN; EYE PROTEIN; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; INTERSTITIAL RETINOL-BINDING PROTEIN; RETINOL BINDING PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CHOROIDEREMIA; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; EYE PROTEINS; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; OPHTHALMOSCOPY; PHOTORECEPTOR CELLS, VERTEBRATE; RETINAL DEGENERATION; RETINAL PIGMENT EPITHELIUM; RETINOL-BINDING PROTEINS;

EID: 77958126469     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-4892     Document Type: Article

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