Protein kinase D1 regulates VEGF-A-induced αvβ3 integrin trafficking and endothelial cell migration

Traffic

Volumn 11, Issue 8, 2010, Pages 1107-1118

  di Blasio, Laura ^a,b   Droetto, Sara ^a,b   Norman, Jim ^c   Bussolino, Federico ^a,b   Primo, Luca ^a,d  

^a CANDIOLO CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^d UNIVERSITY OF TURIN   (Italy)

Author keywords

Angiogenesis; Cell migration; Endocytosis; Integrins; Recycling

Indexed keywords

COLLAGEN TYPE 1; PROTEIN KINASE D; PROTEIN KINASE D1; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR; VITRONECTIN RECEPTOR; HYBRID PROTEIN; PROTEIN KINASE C; VITRONECTIN;

ANGIOGENESIS; ARTICLE; CELL MEMBRANE; CELL MIGRATION; CELL MOTILITY; COMPLEX FORMATION; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; ENDOTHELIUM CELL; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CELL MOTION; CELL SURFACE; CYTOLOGY; FOCAL ADHESION; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT;

ANIMALS; CELL MOVEMENT; CELL SURFACE EXTENSIONS; CELLS, CULTURED; ENDOCYTOSIS; ENDOSOMES; ENDOTHELIAL CELLS; FOCAL ADHESIONS; HUMANS; INTEGRIN ALPHAVBETA3; PROTEIN KINASE C; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VITRONECTIN;

EID: 77958116797     PISSN: 13989219     EISSN: 16000854     Source Type: Journal    
DOI: 10.1111/j.1600-0854.2010.01077.x     Document Type: Article

References (31)

1. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995;1:27-31.
2. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002;110:673-687.
3. Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X, Sheppard D, Hynes RO, Hodivala-Dilke KM. Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med 2002;8:27-34.
4. Robinson SD, Reynolds LE, Wyder L, Hicklin DJ, Hodivala-Dilke KM. Beta3-integrin regulates vascular endothelial growth factor-Adependent permeability. Arterioscler Thromb Vasc Biol 2004;24: 2108-2114.
5. Mahabeleshwar GH, Feng W, Phillips DR, Byzova TV. Integrin signaling is critical for pathological angiogenesis. J Exp Med 2006;203:2495-2507.
6. Soldi R, Mitola S, Strasly M, Defilippi P, Tarone G, Bussolino F. Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. Embo J 1999;18:882-892.
7. Byzova TV, Goldman CK, Pampori N, Thomas KA, Bett A, Shattil SJ, Plow EF. A mechanism for modulation of cellular responses to VEGF: activation of the integrins. Mol Cell 2000;6:851-860.
8. Mahabeleshwar GH, Feng W, Reddy K, Plow EF, Byzova TV. Mechanisms of integrin-vascular endothelial growth factor receptor crossactivation in angiogenesis. Circ Res 2007;101:570-580.
9. Valverde AM, Sinnett-Smith J, Van Lint J, Rozengurt E. Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain. Proc Natl Acad Sci U S A 1994;91:8572-8576.
10. Johannes FJ, Prestle J, Eis S, Oberhagemann P, Pfizenmaier K. PKCu is a novel, atypicalmember of the protein kinase C family. J Biol Chem 1994;269:6140-6148.
11. Rozengurt E, Rey O, Waldron RT. Protein kinase D signaling. J Biol Chem 2005;280:13205-13208.
12. Qin L, Zeng H, Zhao D. Requirement of protein kinase D tyrosine phosphorylation for VEGF-A165-induced angiogenesis through its interaction and regulation of phospholipase Cgamma phosphorylation. J Biol Chem 2006;281:32550-32558.
13. Wong C, Jin ZG. Protein kinase C-dependent protein kinase D activation modulates ERK signal pathway and endothelial cell proliferation by vascular endothelial growth factor. J Biol Chem 2005;280:33262-33269.
14. Hao Q, Wang L, Zhao ZJ, Tang H. Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis. J Biol Chem 2009;284:799-806.
15. Kalluri R. Basement membranes: structure, assembly and role in tumour angiogenesis. Nat Rev Cancer 2003;3:422-433.
16. Roberts M, Barry S, Woods A, van der Sluijs P, Norman J. PDGFregulated rab4-dependent recycling of alphavbeta3 integrin from early endosomes is necessary for cell adhesion and spreading. Curr Biol 2001;11:1392-1402.
17. Avraamides CJ, Garmy-Susini B, Varner JA. Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer 2008;8:604-617.
18. Hynes RO. A reevaluation of integrins as regulators of angiogenesis. Nat Med 2002;8:918-921.
19. De S, Razorenova O, McCabe NP, O'Toole T, Qin J, Byzova TV. VEGFintegrin interplay controls tumor growth and vascularization. Proc Natl Acad Sci U S A 2005;102:7589-7594.
20. Cascone I, Napione L, Maniero F, Serini G, Bussolino F. Stable interaction between alpha5beta1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1. J Cell Biol 2005;170:993-1004.
21. Wang JF, Zhang XF, Groopman JE. Stimulation of beta 1 integrin induces tyrosine phosphorylation of vascular endothelial growth factor receptor-3 and modulates cell migration. J Biol Chem 2001;276:41950-41957.
22. Silva R, D'Amico G, Hodivala-Dilke KM, Reynolds LE. Integrins: the keys to unlocking angiogenesis. Arterioscler Thromb Vasc Biol 2008;28:1703-1713.
23. White DP, Caswell PT, Norman JC. alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration. J Cell Biol 2007;177: 515-525.
24. Woods AJ, White DP, Caswell PT, Norman JC. PKD1/PKCmu promotes alphavbeta3 integrin recycling and delivery to nascent focal adhesions. Embo J 2004;23:2531-2543.
25. Ha CH, Jhun BS, Kao HY, Jin ZG. VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis. Arterioscler Thromb Vasc Biol 2008;28:1782-1788.
26. Caswell PT, Norman JC. Integrin trafficking and the control of cell migration. Traffic 2006;7:14-21.
27. Pellinen T, Ivaska J. Integrin traffic. J Cell Sci 2006;119:3723-3731.
28. Bussolino F, Di Renzo MF, Ziche M, Bocchietto E, OliveroM, Naldini L, Gaudino G, Tamagnone L, Coffer A, Comoglio PM. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol 1992;119:629-641.
29. Piva R, Chiarle R, Manazza AD, Taulli R, Simmons W, Ambrogio C, D'Escamard V, Pellegrino E, Ponzetto C, Palestro G, Inghirami G. Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas. Blood 2006;107:689-697.
30. Primo L, Ferrandi C, Roca C, Marchio S, di Blasio L, Alessio M, Bussolino F. Identification of CD36 molecular features required for its in vitro angiostatic activity. FASEB J 2005;19:1713-1715.
31. Nishimura T, Kaibuchi K. Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Dev Cell 2007;13:15-28.